• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2002년도 국제심포지엄
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• pp.91-91
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• 2002

Considerable attention has been focused on the cryopreservation of semen and estrus induction in dog, as consequence of poor productivity caused by long anestrus period, in order to enhance the productivity of youngs and to preserve the breeds. The objectives of this study were to develop a treatment protocol for estrus induction. Fifty infertilie dogs (age 2∼3 years) were selected for the study and divided into three different estrus induction treatment groups. Group 1: dogs (n=15) were given clomifane (0.1 mg/kg) orally for five days at 12 hr intervals. Group 2: dogs (n=15) were given bromocriptine (50 $\mu\textrm{g}$/kg) orally for five days at 12 hr intervals, followed by single injection intravenously of 500 IU GnRH (Group 3, n=20) when pro-estrus occurred. After being treated, the dogs were evaluated for the rates of estrus induction and time interval lapses from treatment to beginning of the pro-estrus. The estrus induction rates were significantly (P<0.05) higher in both group 2 (9/15, 73.3%) and group 3 (16/20, 80.0%) than that of group 1 (9/15, 60.0%), but did not differ in the groups 2 and 3. No differences were observed in the time interval lapses from treatment to beginning of the pro-estrus in group 2 (7.7 ${\pm}$ 1.2 days) and group 3 (6.9 ${\pm}$ 2.0 days), but significantly (P<0.05) shorter than that of group 1 (9.5 ${\pm}$ 2.1 days). In conclusion, the estrus induction rate of dogs treated with a combination of GnRH and bromocriptine was more effective than use of clomifene or bromocriptine only.

• Industrial Engineering and Management Systems
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• 제6권2호
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• pp.136-145
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• 2007

The selection of suppliers and the determination of order quantities to be placed with those suppliers are important decisions in a supply chain. In this research, a non-linear mixed integer programming model is presented to select suppliers and determine the order quantities. The model considers the purchasing cost which takes into account quantity discount, the cost of transportation, the fixed cost for establishing suppliers, the cost for holding inventory, and the cost of receiving poor quality parts. The capacity constraints for suppliers, quality and lead-time requirements for the parts are also taken into account in the model. Since the purchasing cost, which is a decreasing step function of order quantities, introduces discontinuities to the non-linear objective function, it is not easy to employ traditional optimization methods. Thus, a heuristic algorithm, called particle swarm optimization (PSO), is used to find the (near) optimal solution. However, PSO usually generates initial solutions randomly. To improve the PSO solution quality, a heuristic procedure is proposed to find an initial solution based on the average unit cost including transportation, purchasing, inventory, and poor quality part cost. The results show that PSO with the proposed initial solution heuristic provides better solutions than those with PSO algorithm only.

• 인지과학
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• 제13권2호
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• pp.15-23
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• 2002

This paper reports an experiment on Broca's aphasics' comprehension of a class of English constructions involving empty categories. Based on Grodzinsky's (1986) account of chance-level performance of agrammatic understanding of movement constructions and their thematic role assignments. I show that Grodzinsky's notion of invisible empty categories can be further extended to include pronomical anaphors (PRO's) in Chomsky's (1981) sense and that the asymmetry in their poor comprehension of subject- and object-control constructions can be explained by the heuristic mechanism of the default thematic role assignment rule. eventually supporting Grodzinsky's claim that empty categories are not visible In agrammatic's syntactic representation.

• BMB Reports
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• 제35권2호
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• pp.165-171
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• 2002

A serine collagenolytic protease was purified from the internal organs of filefish Novoden modestrus, by ammonium sulfate, ion-exchange chromatography on a DEAE-Sephadex A-50, ion-exchange rechromatography on a DEAE-Sephadex A-50, and gel filtration on a Sephadex G-150 column. The molecular mass of the filefish serine collagenase was estimated to be 27.0 kDa by gel filtration and SDS-PAGE. The purified collagenase was optimally active at pH 7.0-8.0 and $55^{\circ}C$. The purified enzyme was rich in Ala, Ser, Leu, and Ile, but poor in Trp, Pro, Tyr, and Met. In addition, the purified collagenolytic enzyme was strongly inhibited by N-P-toluenesulfonyl-L-lysine chloromethyl ketone (TLCK), diisopropylfluorophosphate (DFP), and soybean trypsin inhibitor.

• World Technopolis Review
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• 제1권2호
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• pp.107-117
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• 2012

As reflected in the title, the main objective of the paper is to explore an appropriate approach to promote technological innovation for developing countries. Aiming to this goal, the paper studies three main innovation system approaches, whose implantation is being attempted in developing countries: first, national innovation systems (NIS), which was developed in OECD countries; second, the system of innovation for development (SID), which is a concept that tries to adapt NIS to developing countries; and third, inclusive innovation which is a pro-poor innovation system. Based on the strengths and the weaknesses of each concept and their potential adaptation in developing countries, the paper proposes an integrated approach of innovation system for developing countries. Compared to developed countries, the concept of innovation system in developing countries should be more complex because it involves not only the formal sector such as enterprises, universities, research institutes, government, and financial system but it also involves NGOs, informal companies, grassroots inventors, local and indigenous knowledge, etc. The last part of the paper discusses the ideas that innovation stakeholders in developing countries can use to promote their proper innovation system.

• Molecules and Cells
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• 제46권3호
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• pp.133-141
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• 2023

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes. KEAP1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of CULLIN 3 (CUL3)-based E3 ubiquitin ligase. KEAP1 regulates the activity of NRF2 and acts as a sensor for oxidative and electrophilic stresses. NRF2 has been found to be activated in many types of cancers with poor prognosis. Therapeutic strategies to control NRF2-overeactivated cancers have been considered not only by targeting cancer cells with NRF2 inhibitors or NRF2 synthetic lethal chemicals, but also by targeting host defense with NRF2 inducers. Understanding precise molecular mechanisms how the KEAP1-NRF2 system senses and regulates the cellular response is critical to overcome intractable NRF2-activated cancers.

• 한국환경농학회지
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• 제37권2호
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• pp.87-96
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• 2018

BACKGROUND: The vigorous shoot growth in upper part of apple tree canopy leads to poor fruit quality and flower bud formation in lower part of canopy. So, this study was conducted to develop the proper control method about the shoot growth in upper part of apple tree canopy. METHODS AND RESULTS: Trunks of 'Fuji'/M9 apple trees were cut (back pruned) to 2.5 m in tree height on 11 February (dormant) or 12 April (full bloom). Naphthalene acetic acid (NAA) was applied at 2.0% to cut surface when trunk was pruned. Prohexadione-calcium (Pro-Ca) was sprayed at 250 mg/L above 2.0 m in tree height at 23 April (petal fall). The NAA or Pro-Ca application after trunk was pruned at dormant (TR-2 and TR-3) significantly reduced shoot growth in upper part of canopy compared with the control (tree was only pruned at dormant, TR-1), but the percent of shoots showing the secondary growth of TR-3 was higher over 2 times than that of TR-2. The reduction of shoot growth in upper part of canopy by TR-2 and TR-3 increased the fruit red color from the lower part in the treating year and blooming of the lower part in the following year. CONCLUSION: Applying 2.0% NAA to cut surface of pruned apple trunk at dormant was the most effective way for stabilization of the tree vigor in upper part of the canopy in a high density apple orchard.

• 조명전기설비학회논문지
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• 제24권1호
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• pp.45-55
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• 2010

최근 서울시에는 도시의 야간경관을 풍성하게 하고 랜드마크성을 부여하는 미디어 파사드 건축물의 수가 증가하고 있지만 무분별한 미디어 파사드의 적용은 오히려 도시이미지를 저해하는 등의 문제가 제기되고 있다. 특히, 미디어 파사드는 기존 건물외관의 장식이나 경관조명에 비하여 조명면적이 크기 때문에 심미적 고려와 도시환경의 건강성을 위해서 지나친 밝기의 규제가 필요하다. 따라서 미디어 파사드 건축물의 야간조명 특성을 분석하여 지역 기준에 맞게 적절히 설계되어 있는지에 대한 검토가 필요하다. 본 연구의 목적은 미디어 파사드 건축물의 표면휘도와 색온도 등의 조명물리량을 측정하여 옥외 야간조명환경을 분석하는 것이다. 현재 서울에 위치한 대표성을 가진 5개 미디어 파사드 건축물을 선정하여 해당건물이 위치한 반대편도로의 측정점에서 CS-100 기기와 ProMetric-1400 기기를 이용하여 측정하였다. 미디어 파사드 조명부분의 표면휘도를 분석한 결과, 5개 건물 중 3개 건물의 휘도차는 크지 않아 디자인이 잘 된 것으로 났으나 5개 건물 중 4개 건물에서 서울시 기준인 $25[cd/m^2]$를 초과하는 것으로 나타났다. 또한, 색온도를 분석한 결과 대부분 5,500[K]이상의 한색이 측정되어 서울시 도로조명 색온도 기준인 4,000~5,000[K]의 범위를 벗어나는 것으로 나타났다.

• 조명전기설비학회논문지
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• 제24권6호
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• pp.18-26
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• 2010

도시공간의 안정과 쾌적함을 위하여 옥외조명은 우리 사회에서 필수적인 부분이 되었다. 그러나 옥외조명을 잘못 설치할 경우 조명에너지의 낭비뿐만 아니라 건축물 야간경관 훼손을 야기시킨다. 최근 야간 경관조명의 중요성이 부각되면서 지자체마다 야간경관 이미지 구축에 집중을 하고 있다. 그 중 해안가 주변의 옥외조명은 지역 내에 특화된 관광 상권을 구성하며 생동감 있는 도시 이미지를 부여하고 도시경쟁력을 강화 시킬 수 있다. 본 연구는 우리나라의 대표적 항구 도시인 부산의 해안가의 야간경관조명의 빛공해를 평가하는데 그 목적이 있다. 디지털 광학 계측기인 Radiant Imaging ProMetric-1400으로 광안리 해수욕장, 마린시티, 그리고 해운대 해수욕장 주변의 옥외조명을 측정하였다. 모든 옥외조명의 휘도는 국제조명위원회 권고기준과 비교했을 때 약 2~20배 정도 높게 나타났다. 주상복합 상부조명 및 해안에 면한 상가 저층부는 색채 및 휘도의 제한이 필요한 것으로 사료된다.

• Safety and Health at Work
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• 제12권4호
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• pp.536-543
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• 2021

Background: Sickness absenteeism is an area of concern in nursing and is more concerning given the recent impacts of the COVID-19 pandemic on healthcare. This study is one of two meta-analyses that examined sickness absenteeism in nursing. In this study, we examined demographic, lifestyle, and physical health predictors. Methods: We reviewed five databases (CINAHL, ProQuest Allied, ProQuest database theses, PsycINFO, and PubMed) for our search. We registered the systematic review (CRD de-identified) and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Additionally, we used the Population/Intervention/Comparison/Outcome Tool to improve our searches. Results: Following quality testing, 17 articles were used for quantitative synthesis. Female employees were at higher risks of sickness absenteeism than their male counterparts (OR = 1.73; 95% CI: 1.33-2.25). Nursing staff who rated their health as poor had a greater likelihood of experiencing sickness absence (OR = 1.38; 95% CI: 1.19-1.60). Also, previous sick leave predicted future leaves (OR = 3.35; 95% CI: 1.37-8.19). Moreover, experiencing musculoskeletal pain (OR = 2.41 95% CI: 1.77-3.27) increased the likelihood of sickness absence with greater odds when it is a back pain (OR = 3.05; 95% CI: 1.66-5.62). Increased age, physical activity, and sleep were not associated with sick leave. Conclusion: Several variables were statistically associated with the occurrence of sickness absenteeism. One primary concern is the limited research in this area despite alarming rates of sick leave in healthcare. More research is required to identify predictors of sickness absence, and thereby, implement preventative measures.