• IMMUNE NETWORK
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• v.7 no.2
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• pp.66-74
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• 2007

Background: The genus Flavivirus consists of many emerging arboviruses, including Dengue virus (DV), Japanese encephalitis virus (JEV) and West Nile virus (WNV). Effective preventive vaccines remain elusive for these diseases. Mice are being increasingly used as the animal model for vaccine studies. However, the pathogenic mechanisms of these viruses are not clearly understood. Here, we investigated the interaction of DV and JEV with murine bone marrow-derived dendritic cells (bmDC). Methods: ELISA and FACS analysis were employed to investigate cytokine production and phenotypic changes of DCs obtained from bone marrow following flavivirus infection. Results: We observed that these viruses altered the cytokine profile and phenotypic markers. Although both viruses belong to the same family, JEV-infected bmDC produced anti-inflammatory cytokine (IL-10) along with pro-inflammatory cytokines, whereas DV infection induced production of large amounts of pro-inflammatory cytokines (IL-6 and TNF-${\alpha}$) and no IL-10 from murine bmDCs. Both flaviviruses also up-regulated the expression of co-stimulatory molecules such as CD40, CD80 and CD86. JEV infection led to down-regulation of MHC II expression on infected bmDCs. We also found that cytokine production induced by JEV and DV is MyD88-dependent. This dependence was complete for DV, as cytokine production was completely abolished in the absence of MyD88. With regard to JEV, the absence of MyD88 led to a partial reduction in cytokine levels. Conclusion: Here, we demonstrate that MyD88 plays an important role in the pathogenesis of flaviviruses. Our study provides insight into the pathogenesis of JEV and DV in the murine model.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.3
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• pp.31-41
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• 2021

This exploratory study focuses on ascertaining the cross-cultural differences in the perception of entrepreneurial orientation among university students in Korea, China, and Japan. Total 670 university students from the three culturally diverse environments were administered questionnaires designed to determine the differences in individual entrepreneurship orientation(IEO). Data was analyzed using IBM SPSS Statistics 23 version. ANOVA was used to test the established hypotheses. Statistically significant differences were found among the three groups of university students in IEO. China displayed the highest level of IEO followed by Korea and then Japan. Japan is less likely to be committed to entrepreneurial activity than Korea and China. The finding implies the sociocultural effect may come into play when young people forms positive attitude on entrepreneurship, that is identical to the arguments of prior studies. This study, however, has contributed to the literature by adding empirical evidence first time on different perceptions of IEO sub-scales by Korean, Chinese and Japanese university students. Theoretical and practical implication have been presented, where the importance of nurturing pro-activeness was stressed for Korean university students, most of all.

• Journal of architectural history
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• v.23 no.5
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• pp.47-60
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• 2014

Urban-Hanok emerged as a result of urbanization of Hanok in the modern period. In particular, Urban-Hanok has been mass-produced from the early 1920s, when the population is concentrated in cities, until the middle. Large-scale development by the professional developer has been developed in large-scale land rather than individual client because housing shortage was serious problem. 11 Gahoe-dong was made in 1935-36 is representative Urban-hanok area of Bukchon. It was formed through division of large-scale Land in 1930's. In the 1930's, the large-scale development projects of Urban-Hanok was triggered by the two events. One is Land Investigation Project performed by the Japanese government to capitalization of property, another is the pro-japanese bought the large scale-land in Gahoe-dong at bargain price from The Japanese government. Each lot has still a topographical characteristics such as land-dividing quality, the way of development, characteristic quality of urban-tissue. 11 Gahoe-dong, Urban-hanok area was developed two ways. First, development have been adapted to the topography. The lots have reflected topographical conditions such as land cutting area, a retaining wall, land-diving was maintaining the original topography almost. Second, it was street oriented development. The lots have developed sequentially along the street. So, the lots's shape and size is different each. For this reason, this area distribute various type of Hanok.

• Korean journal of communication and information
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• v.64
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• pp.85-108
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• 2013

This paper aims to review Ahn Jae-Hong's studies on the history of the Korean press from the perspective of research history focussing his "Josun Shinmun Sosa(A Short History of the Korean Press)" published in 1935. For this purpose major discussions with respect to journalistic history during the Japanese occupation period are reviewed. The result reveals that Ahn Jae-Hong's studies using a comparative method and a social historical approach are judged to be the most representative outcomes at that time. The "Josun Shinmun Sosa" first explains "Inhaeng Jobo" and "Jeobo" as an origin of newspaper, and then explains various subjects on newspaper phenomena in the latter era of the Chosun Dynasty such as participants of major newspapers, the tone of newspapers, the analysis of newspaper character through evaluation of main articles, the system of newspaper, newspaper advertisements, pro-Japanese newspapers, newspapers managed by Japanese, newspapers for overseas Korean, etc. But partly it gives a general description rather than a detailed research due to the nature of contributions to the newspaper, and also includes an objective analysis and a subjective impression together. Nevertheless his researches can be valued as pioneering pieces of work as they comprehensively handled various objects of study on newspapers and gave new angle and orientation of interpretation on the newspaper phenomena at that time. Also it is judged that they had an effect on the period division as well as the description methods for the study of the history of the Korean press.

• International Journal of Industrial Entomology and Biomaterials
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• v.45 no.1
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• pp.17-21
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• 2022

The present study aimed to determine whether a hemolymph prepared from Antheraea yamamai larvae had the same biological activities using a Bombyx mori hemolymph prior to exposure to lipopolysaccharide (LPS) in order to induce an inflammatory response. The effects of the hemolymph were determined using a reverse transcription-quantitative polymerase chain reaction to assess the expression of pro-inflammatory molecules. The A. yamamai hemolymph exerted anti-inflammatory effects on LPS-activated human monocytic leukemia cells via Toll-like receptor (TLR) 4-mediated suppression, similar to the B. mori hemocyte extract. Treatment with the A. yamamai hemolymph significantly suppressed LPS-induced upregulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression at all tested concentrations compared with the control, similar to the B. mori immune-challenged hemolymph. Finally, the A. yamamai hemolymph, like the B. mori immune-challenged hemolymph, suppressed all of these concentrations in a dose-independent manner. These results demonstrate that the hemolymph of A. yamamai exhibited important biologically active substances. Further in-depth functional studies are required to fully understand the mechanisms underlying the biological activities of wild-type silkworm hemolymphs.

• Journal of architectural history
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• v.32 no.4
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• pp.51-62
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• 2023

Gyeongbokgungdo depicts the composition and layout of Gyeongbokgung Palace before the Japanese Invasion of Korea in 1592, as well as a monument related to pro-jamrye held at the site of Gyeongbokgung Palace in Yeongjo. Based on literature such as Dongguk Yeoji Seungram, such as Gyeongbokgungdo painted major buildings, government offices, and buildings in the backyard. In addition, the literature and the foot of the mountain, waterway, and Pond, which were identified as the site identified during the reconstruction process, are reflected, and some of the Gyeongbokgungdo contain reconstruction records. As such, Gyeongbokgungdo depicts Gyeongbokgung Palace in the early Joseon Dynasty and facilities built after the Imjin War based on the literature, and seems to have been produced around the time of reconstruction as it reflects the mountain and water system. In addition, the layout of the main hall of Gyeongbokgungdo was partially reflected in the reconstructed Gyeongbokgung Palace and used as a material to understand the layout of Gyeongbokgung Palace in the early Joseon Dynasty.

• Korean Journal of Heritage: History & Science
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• v.49 no.1
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• pp.84-97
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• 2016

One of the assimilation policies of Japanese imperialism for the permanent domination in the colonial Joseon is the theory of integration of Japan and Joseon. The theory of integration of Japan and Joseon is a logic that Joseon (Korea) and Japan (Wae) were connected to the same ancestor on the basis of ancient myths. Also it is the assimilation ideology to justify the Colonial rule of those days through the objectification of historical identity or affinity of political and cultural relations of ancient Korean peninsula and Japan (Wae). Japan reorganized our history to meet the colonial point of view, as part of the assimilation policies based on the theory of integration of Japan and Joseon. On the other hand Japan attempted to objectify them through archaeological research and the reinterpretation of the historical remains. The survey, reinterpretation and tourist of the historic sites in historic cities such as Gyeongju and Buyeo were promoted in this context. In particular, the Buyeo, a capital of Baekje, was emphasized upon the close relevance and affinity between Sabi, Baekje and ancient Asuka (飛鳥) in Japan through research and reinterpretation on the Historic Sites. Based on them, Historic Sites Tourism was conducted by reconstructed historic sites toward the colonial Korean. In addition, after the Sino-Japanese war in 1937, Japan tried to realize the politics of space by upgrading and idealizing Buyeo as homeland or Shinto (神都) related to Japanese ancient mythology of the Asuka culture. This paper investigated in what context research, reinterpret and tourist of the historic sites progressed on Buyeo area and how it had soaked through the general public in the Japanese colonial era. First, it is on historic sites. Historic sites research on Buyeo area made an attempt by Sekino Tadashi in 1909 for the first time and the re-excavation of the old burial mounds and temple sites during the Japanese colonial period. Sekino set up a cultural relationship and influences between the ancient China (梁), Korea (百濟) and Japan (倭). Also, he emphasized that Sabi, Baekje largely received influence of Chinese culture and Baekje and Japan Asuka culture had closely relations and affinity. These views had been consistent during the Japanese colonial period. Second, it is the reinterpretation on Historic sites. Buyeo Historic Sites Preservation Society (Buyeo Gojeok Bojonhoe) was established in 1915 and Osaka Kintaro, curator of Baekje exhibition hall redefined the relationship between ancient Japan and Baekje as perspective of the assimilation ideology through the post contextual interpretation. In particular, they emphasized on the close relevance between Baekje's Historic sites and Japan, through the reinterpretation of Nakhwaam, Goransa and Cheongmasanseong. Third, it is the tourist on Historic sites. Buyeo Historic Sites Preservation Society played a leading role in Tourist on Historic sites at the Buyeo region. The main tourist destinations and course were restructured through a reinterpretation on the historic sites. Japan would like to show Buyeo as ideology area, homeland of ancient Japanese culture, toward the Koreans under Japanese colonial era. Thus, research, reinterpretation, and tourism on Historic sites were promoted while they were closely related to each other. The promoting body was Joseon Chongdokbu and pro-Japanese interest group. It's point was 'made' and 'shown' by the eyes of others and a rediscovery of Buyeo as representational space of colony.

• Cross-Cultural Studies
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• v.48
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• pp.31-66
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• 2017

This study examines ways of recognizing and aspects of describing Korean modern literature revealed by each literary history from the viewpoint of 'transculturation', focusing on Lim Jeon-Hye's "History of Korean Literature in Japan until 1945", Shirakawa Yutaka's "Footsteps of Korean Modern Literature", and Saegusa Toshikatsu's "Taste of Korean Literature" from the history of Korean literature written in Japan. First, Lim Jeon-Hye periodically examines Korean literature written in Japan, focusing on literary activities of Korean students in Japan and the proletarian literature movement, and addresses points of active cultural negotiation, mutual understanding and political solidarity between Korea and Japan. Shirakawa Yutaka focuses on the concurrency and connection of Korea, China, and Japan in the process of modern literary formation, covering Japanese language literature and pro-Japanese literature with great care, and describes the middle-layer position as a mediating researcher in the conflicting boundaries between Korea and Japan. Saegusa Toshikatsu provides interesting transcultural momentum in exploring internal logic and denotation of Korean literature via comparative literature review encompassing East Asia, implementation of literary forms and themes connecting tradition and modernity, and an out-of-boundary point of view to overlook 'pro-Japanese literature', etc. Transcultural aspects in this literary history to examine are as follow. First, the history of Korean modern literature based on 'national literature history' is catabolized in the magnetic field of the 'colonial experience' and 'national nationalism' and considered in multifaceted context. Second, they provide the possibility of three-dimensional and micro-narrative description of literature that complement the narrative aspect of existing Korean literature history. Third, they provide an opportunity to expand and open the description of literature history through acceptance of comparative literary perspectives encompassing East Asia. Fourth, through discovery of Korean-Japanese literature and Japanese language literature, they contribute to broadening the history of Korean modern literature and enriching foundations.

• Korean journal of communication and information
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• v.52
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• pp.135-153
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• 2010

Dong-a Ilbo tried to assume leadership of opinion in preceding the movement against the trusteeship as a mouthpiece for the Han-Min Party. Dong-a Ilbo was to try to promote the atmosphere of anti-trusteeship=anti-communism=anti-Soviet Union, distorting the decision of a conference of three foreign affairs ministers in Moscow. It was not an incorrect report, but the false report. As a result, the formula of an anti-trusteeship=anti-Soviet Union=anti-communism=patriotism, and a pro-trusteeship=pro-Soviet Union=pro-Communism=traitor was formed. And the important problems of land reform and pro-Japanese‘ clearance were missing. Historically, political newspapers had appeared in the periods of very important political change. Political newspapers played a role as mouthpiece for political party or group. Dong-a Ilbo was such a political newspaper. It was that Dong-a Ilbo tried to change the social atmosphere in preceding the movement against the trusteeship as a mouthpiece for the Han-Min Party. And history was distorted.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.51 no.2
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• pp.127-134
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• 2018

Arteriosclerosis is the major cause of coronary artery and cerebrovascular disease, which are leading causes of death. Pro-inflammatory cytokines induce injury to vascular endothelial cells by increasing cell adhesion molecules, leading to vascular inflammation, a major risk factor for the development of arteriosclerosis. In the current study, we investigated the inhibitory effect of enzymatic hydrolysate from Japanese mud shrimp Upogebia major on the inflammation of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$)-stimulated human umbilical vein endothelial cells (HUVECs). We first evaluated the antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities of eight U. major enzymatic hydrolysates: alcalase, papain, ${\alpha}$-chymotrypsin (${\alpha}-Chy$), trypsin, pepsin, neutrase, protamex and flavourzyme. Of these, ${\alpha}-Chy$ exhibited potent antioxidant and ACE inhibitory activities. The ${\alpha}-Chy$ hydrolysate was fractionated by two ultrafiltration membranes of 3 and 10 kDa. The ${\alpha}-Chy$ hydrolysate of U. major and its molecular weight cut-off fractions resulted in a significant reduction in NO production and a decrease in cell adhesion molecules [vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and endothelial-selectin (E-selectin)] and pro-inflammatory cytokines [interleukin-6 (IL-6), interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1)] in $TNF-{\alpha}$-stimulated HUVECs. These results suggest that enzymatic hydrolysate from U. major can be used in the control and prevention of vascular inflammation and arteriosclerosis.