• Bulletin of the Korean Chemical Society
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• 제18권8호
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• pp.890-895
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• 1997

The approximate rates and stoichiometry of the reaction of excess lithium tripiperidinoaluminum hydride (LTPDA), an alicyclic aminoaluminum hydride, with selected organic compounds containing representative functional groups under the standardized conditions (tetrahydrofuran, 25°) were examined in order to define the reducing characteristics of the reagent for selective reductions. The reducing ability of LTPDA was also compared with those of the parent lithium aluminum hydride (LAH) and lithium tris(diethylamino)aluminum hydride (LTDEA), a representative aliphatic aminoaluminum hydride. In general, the reactivity of LTPDA toward organic functionalities is weaker than LTDEA and much weaker than LAH. LTPDA shows a unique reducing characteristics. Thus, benzyl alcohol, phenol and thiols evolve a quantitative amount of hydrogen rapidly. The rate of hydrogen evolution of primary, secondary and tertiary alcohols is distinctive. LTPDA reduces aldehydes, ketones, esters, acid chlorides and epoxides readily to the corresponding alcohols. Quinones, such as p-benzoquinone and anthraquinone, are reduced to the corresponding diols without hydrogen evolution. Tertiary amides and nitriles are also reduced readily to the corresponding amines. The reagent reduces nitro compounds and azobenzene to the amine stages. Disulfides are reduced to thiols, and sulfoxides and sulfones are converted to sulfides. Additionally, the reagent appears to be a good partial reducing agent to convert primary carboxamides into the corresponding aldehydes.

• 생명과학회지
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• 제18권8호
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• pp.1053-1058
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• 2008

글루타티온은 간 질환용 치료제 내지는 영양보충제로 시판되고 있다. 이전 실험에서 글루타티온 고함유 효모 Saccharomyces cerevisiae FF-8 균체(FF-8GY) 투여가 사염화탄소 및 알코올성 유발 간독성 개선효과를 나타내었다. 따라서, 알코올성 지방간의 산화 스트레스에 미치는 영향을 조사하기 위하여 시판되고 있는 글루타티온 고함유 효모 추출물(GYE)과 본 실험실에서 분리한 글루타티온 고함유 효모 FF-8GY을 비교실험 하였다. FF-8GY 또는 GYE 투여에 의한 간 조직 중의 산화스트레스 측정지표로서는 과산화지질(TBARS) 및 글루타티온 함량을 측정하였다. TBARS 농도는 간 조직 homogenize 분획에서 알코올 투여 대조군에 비해 FF-8GY 투여 실험군에서 5%수준에서 유의적으로 감소하였으며, GYE 투여에 의해서는 감소경향을 보였다. 간 조직 microsomal 및 mitochondria 분획에서도 같은 경향이 관찰되었다. 이때 간 조직 중의 글루타티온 농도는 정상군 보다 알코올 투여 대조군에서 5%수준에서 유의적으로 감소하였으며, 이러한 감소는 GYE 투여에 의해 더욱 감소되었으나 FF-8GY 투여에 의해서 정상군 수준까지 회복되는 것으로 나타났다. 한편 간조직의 손상정도를 나타내는 또 하나의 지표인 혈청 총단백질 및 알부민 농도는 알코올 처리 대조군에서 낮게 나타난 반면 FF-8GY 투여에 의해 정상군 수준 이상으로 증가하는 것으로 나타났다. 이상의 결과에서 글루타티온 고함유 효모 Saccharomyces cerevisiae FF-8 균체(FF-8GY)의 투여에 따른 알코올성 유발 산화스트레스의 경감 효과는 시판되고 있는 글루타티온 고함유 효모 추출물 보다 더욱 현저한 개선 효과가 있는 것으로 확인되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5159-5164
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• 2016

Objective: The dynamics of morbidity, disability and death rates due to malignant neoplasms in the population in Uralsk city of the Republic of Kazakhstan were studied for 2011-2015, with a focus on age and sex, as well as tumor location. Methods: Statistics for total morbidity, primary disability and mortality from cancer in the adult population of the city of Uralsk for 2011-2015 were calculated per 100 thousand. Estimation of morbidity was based on data from form - $N{\underline{o}}12$ ${\ll}$Report on the number of diseases registered in patients living in the area of health care organizations and patient population under medical observation". Evaluation of primary disability was based on form $N{\underline{o}}7$ ${\ll}$The distribution of newly recognized disabled by disease class, age, sex and disability groups" for 2011-2015 in Ural city and analysis of cancer was carried out using annual form 7 "Report on the sick, and diseases of malignant neoplasms". Result: The most common localizations of cancer were the trachea, bronchi, lungs, stomach and mammary glands. High death rates were noted for patients with cancer of the trachea, bronchi, lung, as compared to stomach and esophagus. Conclusion: The results of our investigation and data in the literature indicate that regional characteristics influence the impact of risk factors associated with cancer. An unfavorable environmental background contributes to ill health of urban populations, contributing to development of cancer. Moreover behavioral risk factors are very important, such as smoking, alcohol drinking, and an unhealthy diet. All these factors require urgent adoption of a package of measures for prevention, early detection and timely treatment. Detailed study of cancer is necessary to develop national programs and activities for prevention and control.

• 대한수의학회지
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• 제46권4호
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• pp.315-322
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• 2006

Ethanol abuse is associated with liver injury, neurotoxicity, modulation of immune responses, and increased risk for cancer, whereas moderate ethanol consumption exerts protective effects against liver injury. However, the underlying signal transduction mechanisms of insulin-like growth factors (IGFs) which play an important regulatory role in various metabolism mechanisms are not well understood. We investigated the effects of ethanol-induced p42/44 activity on IGF-I secretion, IGF-I receptor and IGFBP-1 secretion using radioimmunoassay and western blotting in primary cultured rat hepatocytes. The p42/44 activity, IGF-I secretion and IGF-I receptor activity significantly accelerated compared to control at 10 and 30 min after 200 mM ethanol treatment, but then it became suppressed at 180 min. In contrast, IGFBP-1 secretion was inhibited compared to control at 30 min after 200 mM ethanol treatment, but increased at 180 min. The IGF-I secretion, IGF-I receptor and p42/44 activity at 30 min after 200 mM ethanol treatment accelerated with increasing ethanol concentration but IGFBP-1 secretion inhibited (p<0.05). The increased IGF-I secretion, inhibited IGFBP-1 secretion and IGF-IR activity by ethanol-induced temporal p42/44 activity at 30 min after ethanol treatment was blocked by treatment with PD98059. Alcohol dehydrogenase (ADH) inhibitor, 4-methylpyramazole blocked the changes of IGF-I secretion, IGFBP-1 secretion, and IGF-IR activity by ethanol-induced p42/44 activity at 30 and 180 min. Taken together, these results suggest that ethanol is involved in the modulation of IGF-I and IGFBP-1 secretion and IGF-IR activity by p42/44 activity in primary cultured rat hepatocytes. In addition, changing of p42/44 activity by ethanol was caused with ADH.

• Bulletin of the Korean Chemical Society
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• 제15권10호
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• pp.881-888
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• 1994

The approximate rates and stoichiometry of the reaction of excess sodium tris(diethylamino)aluminum hydride (ST-DEA) with selected organic compounds containing representative functional groups under standardized conditions(tetrahydrofuran, $0{\circ}$) were studied in order to characterize the reducing characteristics of the reagent for selective reductions. The reducing ability of STDEA was also compared with those of the parent sodium aluminum hydride (SAH) and lithium tris(diethylamino)aluminum hydride (LTDEA). The reagent appears to be milder than LTDEA. Nevertheless, the reducing action of STDEA is very similar to that observed previously for LTDEA, as is the case of the corresponding parent sodium and lithium aluminum hydrides. STDEA shows a unique reducing characteristics. Thus, benzyl alcohol, phenol and 1-hexanol evolved hydrogen slowly, whereas 3-hexanol and 3-ethyl-3-pentanol, secondary and tertiary alcohols, were essentially inert to STDEA. Primary amine, such as n-hexylamine, evolved only 1 equivalent of hydrogen slowly. On the other hand, thiols examined were absolutely stable. STDEA reduced aidehydes and ketones rapidly to the corresponding alcohols. The stereoselectivity in the reduction of cyclic ketones by STDEA was similar to that by LTDEA. Quinones, such as p-benzoquinone and anthraquinone, were reduced to the corresponding 1,4-dihydroxycyclohexadienes without evolution of hydrogen. Carboxylic acids and anhydrides were reduced very slowly, whereas acid chlorides were reduced to the corresponding alcohols readily. Esters and epoxides were also reduced readily. Primary carboxamides consumed hydrides for reduction slowly with concurrent hydrogen evolution, but tertiary amides were readily reduced to the corresponding tertiary amines. The rate of reduction of aromatic nitriles was much faster than that of aliphatic nitriles. Nitrogen compounds examined were also reduced slowly. Finally, disulfide, sulfoxide, sulfone, and cyclohexyl tosylate were readily reduced without evolution of hydrogen. In addition to that, the reagent appears to be an excellent partial reducing agent: like LTDEA, STDEA converted ester and primary carboxamides to the corresponding aldehydes in good yields. Furthermore, the reagent reduced aromatic nitriles to the corresponding aldehydes chemoselectively in the presence of aliphatic nitriles. Consequently, STDEA can replace LTDEA effectively, with a higher selectivity, in most organic reductions.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제45권2호
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• pp.83-90
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• 2019

Objectives: This study evaluated the predictive factors for survival of patients with oral squamous cell carcinoma (OSCC) and investigated the overall and disease-specific survival (DSS) outcomes. Materials and Methods: A total of 67 consecutive patients who underwent surgery for OSCC from January 2006 to November 2014 were included in this study. Patients were classified according to age, sex, pTNM stages, primary sites, smoking and alcohol drinking habits, depth of invasion, perineural and lymphovascular invasion, cell differentiation and postoperative radiotherapy. Kaplan-Meier methods were used to estimate the survival categorized by patient groups. Cox regression methods were used to investigate the main independent predictors of survival. Results: Nineteen patients died of OSCC during follow-up periods. Another five patients died of other diseases including lung adenocarcinoma (n=1), cerebral infarction (n=1), general weakness (n=2), and pneumonia (n=1). The tongue (n=16) was the most common site for primary origin, followed by buccal mucosa (n=15), mandibular gingiva (n=15), maxillary gingiva (n=9), floor of mouth (n=9), retromolar trigone (n=2), and palate (n=1). Eleven patients had pTNM stage I disease, followed by stage II (n=22) and stage IV (n=34). No patients had pTNM stage III disease in this study. The overall survival of all patients was 64.2% and the DSS was 71.6%. DSS of patients with stage I and II disease was 100%. Stepwise Cox regression showed the two predictors for DSS were pTNM stage (P<0.0001, odds ratio=19.633) and presence of metastatic lymph nodes (P=0.0004, odds ratio=0.1039). Conclusion: OSCC has been associated with poor prognosis; however, there were improved survival outcomes compared with past studies. Advanced-stage disease and presence of metastatic lymph nodes were associated with poorer survival compared with early-stage OSCC and absence of neck node metastasis. Stage I and II OSCC were associated with excellent survival results in this study.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권3호
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• pp.162-168
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• 2011

Objectives: Alcohol problems of parents have an influence on not only their psychological problems but also on their children's psychosocial adaptation. The purpose of this study was to compare the emotional and behavioral problems, including school bullying and social skills, between children of alcoholics (COAs) and children of non-alcoholics (non-COAs). Methods: We recruited $4^{th}$ grade children (n=741) from 7 primary schools in Seoul and their parents as subjects. The self-rated psychiatric symptoms were assessed with the Korean version of the Children of Alcoholics Screening Test (CAST-K), the Children's Depression Inventory (CDI), the Rosenberg's Self-esteem Scale (RSES), the School Bullying Scale, the Social Skill Rating Scale and the Korean version of Alcohol Expectancy Questionnaire-Adolescent (AEQ-A). The Attention-deficit Hyperactivity Disorder Rating Scale-IV (ARS) was completed by the parents. Results: 518 children were non-COAs and 223 were COAs. The COAs showed higher CDI and ARS-IV scores and lower RSES scores than the non-COAs. Especially, the COAs also showed higher school bullying scale scores and lower cooperative scale scores on the social skill rating scales. But there was no difference of alcohol expectancy between the COAs and non-COAs. Conclusion: It was plausible that the COAs had more behavioral & psychosocial problems than the non-COAs among the school aged children. It is important to identify and intervene to solve the problems of peer relationships of school age COAs in order to prevent victimization by bullying and to improve psychosocial adaptation.

• 원예과학기술지
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• 제28권4호
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• pp.545-551
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• 2010

본 연구는 '신고' 배 품질저하의 주요원인으로 대두되고 있는 바람들이과의 확인을 위하여 과실 비중에 따른 배 과실의 품질특성과 바람들이 발생과의 관계를 구명하기 위하여 수행되었다. 수확된 과실들의 바람들이 증상 구분은 아르키메데스법을 이용 비중에 따라 구분하였고 과실들의 물성과 당함량을 측정되었다. 최종적인 바람들이과의 확인은 저장한 후 저장 90일째에 각각의 과실을 칼로 잘라 육안으로 확인하였다. 알코올 수용성 분획(Alcohol Soluble Solid)과 알코올불용성 분획(Alcohol Insoluble Solid)에서의 칼슘함량을 조사하였다. 비중에 따라 구분한 배 과실 group간 당함량과 산함량의 차이는 나타나지 않았으나 물성의 차이는 뚜렷했으며 특히 경도는 비중이 낮은 group일수록 낮게 나타났다. 수확시기가 늦을수록 비중이 낮은 과실이 많아졌으며 이러한 현상은 만개 후 174일과 181일에 수확한 과실들에서 더욱 뚜렷하게 나타났다. 수확기가 늦어질수록 비중이 낮은 과실과 정상과의 알코올불용성물질의 차이는 크게 나타났다. 또한, 비중이 낮은 과실과 정상과에서의 알코올불용성분획과 알코올수용성 분획에서의 칼슘함량은 수확시기가 늦어질수록 낮았으며, 알코올불용성분획에서 비중이 낮은 과실이 정상과보다 칼슘 함량이 낮았다. 결과적으로 비중이 낮아짐에 따라 나타나는 배 과실의 바람들이과 발생은 저장기간과 조건에 영향도 있지만 그보다 수확시기가 늦을수록 높아졌다. 수확시기가 늦을수록 세포벽에 결합되어 있던 칼슘의 함량이 감소되면서 세포벽의 견고성이 약화되어 바람들이 발생이 높아졌다.

• Nutrition Research and Practice
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• 제8권1호
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• pp.54-58
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• 2014

The liver is vulnerable to alcohol-related injury because it is the primary site of alcohol metabolism. Additionally, a number of potentially dangerous by-products are generated as alcohol is broken down in the liver. However, dietary supplements may prevent or relieve some of alcohol's deleterious effects. Therefore, this study was conducted to evaluate the prophylactic effect of aqueous extract of Sesamum indicum (SI) on ethanol induced toxicity in rats. Male Wistar albino rats were divided into control, ethanol, pre-treatment, simultaneous and post-treatment groups. In the prophylactic experiment, Sesamum indicum, (200 mg/kg body weight) was administered by oral gavage for 28 days; two hours before, simultaneously with or two hours after ethanol exposure. Toxicity was induced by administering 45% ethanol (4.8 g/kg bw) by oral gavage. Lipid peroxidation (TBARS) and reduced glutathione (GSH) levels and catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and gluthathione-S-transferase (GST) activities were then determined in the liver, serum triglyceride (TG) levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were monitored and histological examination was carried out. The results revealed that ethanol administration led to significant elevation of TBARS level while depleting in the level of GSH as well as CAT, GPx, SOD and GST activities. Similarly, TG level and ALT and AST activities were elevated. The SI pre-treated group significantly inhibited TBARS, restored GSH level, enhanced CAT, GPx, SOD and GST activities and significantly decreased the elevated level of serum TG, ALT and AST activities. SI treatment (simultaneously with ethanol) exhibited similar effects to those of the SI pre-treated groups, while the SI post-treated group did not show the same protection as the Pre-treated group. S. indicum possesses antioxidant and hepatoprotective properties, that eliminate the deleterious effects of toxic metabolites of ethanol.

• Animal Systematics, Evolution and Diversity
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• 제29권4호
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• pp.308-311
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• 2013

A sea urchin was collected from Geomundo Island of Jeollanam-do, Korea on July 3, 2009. This specimen was classified as Spatangus luetkeni A. Agassiz 1872 belonging to the family Spatangidae of order Spatangoida based on the morphological characteristics. This genus and species are newly recorded in Korea. It is distinct morphological characters that test is thick and strong, six to eight primary tubercles are in 1 and 4 interambulacra, sternum is equipped with little keel, and color in alcohol is dark violet. This species inhabits tropical waters and usually distributes over the West Pacific from southern Japan to New Zealand.