• Biomolecules & Therapeutics
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• 제18권1호
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• pp.39-47
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• 2010

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor involved in neuronal differentiation, plasticity, survival and regeneration. BDNF draws massive attention mainly due to the potential as a therapeutic target in neurological diseases such as depression and Alzheimer's disease. In a primary screening for the natural compounds enhancing BDNF release from cultured rat primary cortical neuron, we found that compounds such as baicalein, tanshinone IIa, cinnamic acid, epiberberine, genistein and wogonin among many others increased BDNF release. All the compounds at $0.1{\mu}M$ of concentration barely showed stimulatory effect on BDNF induction, however, their combination (mixture 1; baicalein, tanshinone IIa and cinnamic acid, mixture 2; epiberberine, genistein and wogonin) showed synergistic increase in BDNF release as well as mRNA and protein expression. The level of BDNF expression was comparable to the maximum BDNF stimulation attainable by a positive control oroxylin A ($20{\mu}M$) without cell toxicity as determined by MTT analysis. Both mixtures synergistically increased the phosphorylation of extracellular signal-regulated kinase (ERK) as well as cAMP response element binding protein (CREB), an immediate and essential regulator of BDNF expression. Similar to these results, mixture of these compounds synergistically inhibited the up-regulation of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide treatments in rat primary astrocytes. These results suggest that the combinatorial treatment of natural compounds in lower concentration might be a useful strategy to obtain sufficient BDNF stimulation in neurological disease condition such as depression, while minimizing potential side effects and toxicity of higher concentration of a single compound.

• 상하수도학회지
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• 제28권1호
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• pp.13-23
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• 2014

A lab-scale Anaerobic Baffled Reactor (ABR) was applied to treat a primary sludge taken from a municipal wastewater treatment plant. In this experiment, acidogenic reaction was promoted by operating the ABR with short hydraulic retention time (HRT) to produce sufficient volatile fatty acids (VFA) instead of production of methane. The performance of ABR on the VFA production and total solids reduction was observed with different operating conditions with 2, 4, 6, and 8 days of HRT. Corresponding organic loading rates were 6.7, 3.4, 2.2, and $1.6kgCOD_{cr}/m^3{\cdot}day$. As HRT increased the removal rate of TCOD was also increased (82.5, 84.2, 96.9, and 95.9 % in average for HRT of 2, 4, 6, and 8 days, respectively) because the settlement of solids was enhanced in the baffle by the decrease of upflow velocity. At HRT of 2 days the average concentration of VFA in the effluent was measured at $1,306{\pm}552$ mgCOD/L corresponding to 107 % increment as compared to the VFA concentration in the influent. However, as HRT increased VFA concentraiotn was decreased to $143{\pm}552$ mgCOD/L at HRT of 8 days. The reduction rates of total solids were 12.2, 26.5, 24.8, and 43.0 % for HRT of 2, 4, 6, and 8 days. As HRT increased the hydrolysis of organic particulate matters in the reactor was enhanced due to the increasing of solids retention time in the baffle zone with low upflow velocity in long HRT condition. Consequently, we found that a primary sludge became a good source of VFA production by the application of ABR process with HRT less than 4 days and the 12-26 % of total solids reduction was expected at these conditions.

• Preventive Nutrition and Food Science
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• 제7권4호
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• pp.347-352
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• 2002

The present study was undertaken to evaluate the anti-rheumatoidal arthritis effect of the R. verniciflua heartwood extract, its EtOAc fraction, and its primary flavonoids, sulfuretin and fustin. All test samples showed variably significant inhibitory effects on hind paw edema and trypsin inhibitor activity induced by Freund's complete adjuvant reagent (FCA reagent), and on vascular permeability caused by acetic acid. Treatment with 10 mg/kg (i.p.) sulfuretin for seven days inhibited edema formation by 54.2$\pm$3.0%. Test samples, especially sulfuretin, shifted the values of biochemical parameters such as serum-cholesterol, serum-triglyceride and serum-total protein toward the normal and restored the numbers of leucocytes and platelets. These results suggest that the heartwood of R. verniciflua reduces immunological injuries caused by FCA reagent provides evidence that suluretin is an active anti-rheumatoid arthritis agent.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1999년도 제3회 압연심포지엄 논문집 압연기술의 미래개척 (Exploitation of Future Rolling Technologies)
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• pp.390-398
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• 1999

The thermomechanical control process(in hot rolling strip mill) was employed to produce 2.25Cr-1Mo steel, which is to be construction material for the steam generator for power plant. Although the Conventional processes has been the primary means of producing the 2.25Cr-1Mo steel, an alternative method was used to meet the specification of ASTM heat treatment for A387-22-Classl using autotempering after coiling in hot rolling strip mill. The microstructures, tensile properties at various temperatures, and creep-rupture properties have been investigated to compare the properties with those of materials produced by the conventional process and to certify the application of the thermomechanical control process to an actual process of manufacturing 2.25-Cr-1Mo steel, this in turn, will reduce the cost of the process. About 14 to 34% glanular bainite (remainder proetectoid ferrite) formed in a coil, and this variety of volume fraction stems from the different cooling rates, which varies with position of the coil after coiling. Tensile testing from room temperature to 700$^{\circ}C$ indicated that strength increases with test temperature showing peaks at around 600$^{\circ}C$. Creep-rupture properties have been being investigated at the temperature of 500$^{\circ}C$ with 27.5, 32kg/$\textrm{mm}^2$ loads and have showed no rupture for over 1000 hours.

• 상하수도학회지
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• 제24권4호
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• pp.463-474
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• 2010

In this study, chemical coagulation conditions for treating combined sewer overflow(CSO) occurred during rainy season were evaluated by jar tests with aluminum sulfate[$Al_2(SO_4)_3{\cdot}17H_2O$] and ferric chloride[$FeCl_3{\cdot}6H_2O$]. The raw domestic sewage sampled from the primary sedimentation tank at a local sewage treatment plant was filtered through $150{\mu}m$ sieve before using. Point of zero charge(PZC) for various dose of aluminum sulfate occurred at pH 5.8-6.5, while for ferric chloride occurred at pH 5.3-6.0 in term of streaming current(SC) values. Charge neutralization ability of aluminum sulfate was bigger than that of ferric chloride. Optimum pH and dose of aluminum sulfate and ferric chloride were 6.2, 0.438mM and 5.8, 0.925mM, respectively. Removal efficiencies of TCOD, turbidity, SS and TP were 75, 97, 95, 96% with aluminum sulfate and 74, 96, 98, 99% with ferric chloride at their optimum coagulation conditions. More efficient removal of SS, TP and small particles was possible with ferric chloride at optimum coagulation conditions. Both SC values and COD removal started to increase where soluble phosphorus was completely removed.

• 대한토목학회논문집
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• 제8권3호
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• pp.113-118
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• 1988

도시하수(都市下水) 처리시설(處理施設)로부터 생산(生産)되는 1차(次)와 2차(次) 슬러지의 생물학적(生物學的) 분해불능정도(分解不能程度)를 실험실(實驗室) 호기성(好氣性)과 혐기성(嫌氣性) 소화조(消化槽)를 운전(運轉)시켜 비교(比較)하였다. 1차(次) 슬러지의 분해불능(分解不能) 함량(含量)은 45~47%, 2차(次) 슬러지는 58~68%로 나타났으며 최대(最大) $CH_4$ 가스 생산량(生産量)은 kgVS제거(除去)당 1차(次)의 경우(境遇)에는 $0.76m^3$, 2차(次)의 경우(境遇)는 $0.54m^3$ 이었다. 1차(次)와 2차(次)슬러지의 소화(消化)가스 내(內)의 $CH_4$ 함량(含量)은 63%와 65%였다.

• 한국재료학회지
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• 제9권2호
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• pp.217-225
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• 1999

The effect on the pitting corrosion resistance of laser welding and surface treatment developed as a repair method of stream generator tubing material that was a major component of primary system at nuclear power plant was observed. Some heat-treated Alloy 600 tubing materials used at domestic nuclear power plants were laser-surface observed. Some heat-treated Alloy 600 tubing materials used at domestic nuclear power plants were laser-surface melted and the microstructural characteristics were examined. The pitting corrosion resistance was examined through Ep(pitting potential) and degree of pit generation by means of the electrochemical tests and the immersion tests respectively. The pit formation characteristics were investigated through microstructural changes and the pit initiation site and pit morphology. The test results showed that the pitting corrosion resistances was increased in the order of the followings; sensitized Alloy 600, solution annealed alloy600, and laser surface melted Alloy 600. Pits were initiated preferably at Ti-containing inclusions and their surroundings in all tested specimens and it is believed that higher pitting resistance of laser-surface treated Alloy 600 was caused by fine, homogeneous distribution of non-soluble inclusions, the disappearance of grain boundary, and the formation of dense, stable oxide film. The major element of corrosion products filled in the pit was Cr. On the other hand, Fe was enriched in the deposit formed on the pit.

• Applied Biological Chemistry
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• 제40권2호
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• pp.139-143
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• 1997

새로운 살균제를 개발할 목적으로 2-이미노티아졸린 유도체를 합성하여 그 생물활성을 시험하였다. 1차아민과 이소티오시아네이트를 결합시켜 티오우레아 유도체를 제조한 다음 이것을 클로로아세트알데히드 또는 알파-할로케토산과 반응시켜 새로운 36종의 2-이미노티아졸린 유도체를 합성하였으며 이들의 6가지 중요한 식물병원균에 대한 항균력을 조사한 결과 티아졸린의 C-2 위치에 페닐이미노기, C-3 위치에 메틸, C-4 위치에 페닐카바모일메틸기, 그리고 C-5위치에 수소원자가 있을 때 벼 도열병균(Pyriculraria oryzae, rice blast)에 대한 항균활성이 가장 높았다.

• 한국물환경학회지
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• 제22권5호
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• pp.865-870
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• 2006

The behavior and influence of EPS on membrane fouling by changing of hydraulic retention time was investigated, using lab. scale submerged membrane bio-reactor, which was operated with gravitational filtration and fed supernatant of primary sedimentation in waste water treatment plant as influent. The membrane was adopted micro-filter of polyethylene hollow fiber. EPS was analysed as polysaccharides and protein especially, into soluble and bound EPS separately. The concentration of soluble EPS was increased at short HRT, then membrane fouling was rapidly progressed and flux was depressed. The most of EPS clogged membrane pore were polysaccharides, while protein was important parameter affected on membrane fouling because of it's more accumulating in the more term operating.

• 자원환경지질
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• 제15권3호
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• pp.113-122
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• 1982

The surveyed Boseong river, flows from south to north crossing Boseong gun Mirukg myon, Nodong myon, Yuleo myon, Bocgnae myon, Mundeog myon, and Seungju gun Nam myon, Jeonranam do. The geology of the surveyed area consists of age-unknown composite gneiss and schist, crystaline chlorite gneiss, porphyroblastic gneiss and granite gneiss, and metasediments of Myon Bong formation and Seologri formation. These metamorphic rocks are intruded by cretaceous biotite granite, granodiorite, and quartz diorite. The heavy sands occur in Quarternary alluvium and colluvium. The composition of the river bed is sand 60%, gravel 30%, and clay 10%. The gravel content of the river bed decreases as the increases. The average depth of auger boring is 0.87 m. The average heavy mineral composition of the heavy sand is monazite 6.83%, zircon 4.88%, ilmenite 11.36%, magnetite 8.36% and garnet 4.84%. The best heavy minerals separation procedure would be primary treatment of the sand by humphrey spiral and table, and retreatment of the table concentrate by magnetic separator. The minimum economically feasible capacity of gravity and magnetic separation plant would be 500 ton/hr when only the heavy minerals are recovered but it may be reduced to 100 ton/hr. capacity, if gravels and sands are added to the valuable products.