• 보건교육건강증진학회지
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• 제26권1호
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• pp.117-128
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• 2009

Objectives: The purpose of this study was to assess the effect of mothers education attainment on prevalence of dental caries among their preschool children. Methods: Data were obtained from the third 2006 Korea National Oral Health Survey. A total of 515 preschool children aged 2 to 7 years and their mothers were selected in this study. We used mother's education level as her socioeconomic position and controlled children's tooth brushing frequency, tooth brushing before bed, the frequency of eating snack, and the preventive dental visit. Whether children experienced dental caries or not and the number of decayed or filled or missing tooth surface they had were used as outcome variables. Results: The proportion of children affected with dental caries was 46.21%. The mother's education level affected children's caries significantly (p<0.05) and children whose mother attended less than high school had more possibility of having caries than children whose mother graduated from college or more (p<0.05). This effect was still significant and got larger(p<0.05), even after controlling children's dental health behavior. Conclusion: This study showed that mother's education level affected the prevalence of caries among their preschool children. In addition, this result indicated a need for more definite policy for children's dental health in lower socioeconomic class with general dental education.

• 보건교육건강증진학회지
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• 제26권1호
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• pp.63-80
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• 2009

Objectives: This study identified how personal characteristics, healthy behavior and social capital might influence on physical activity of adults. Methods: This study used data from the health survey of a city of Korea. We surveyed 1,000 adults sampled by stratified sampling methods from 67,889 households. Outcome variable was the stage of physical activity which was broken into 5 categories. Sociodemographic factors, healthy behavior, self-rated health status and social capital were used as control variables. Sociodemographic factors included age, sex, educational status, economic status measured by deprivation score, residential period within survey city. Social capital was measured by Integrated Questionnaire for the Measurement of Social Capital (SC-IQ). This study used chi-square test and ordered logistic regression models to examine the associations between independent variables and physical activity. Variables were added to the regression model in three groups using a hierarchical approach. Results: Physical activity was significantly more likely to become active if they have higher educational status, healthier behavior. Among the six dimensions of SC-IQ, only "groups and networks" that is structural dimensions of social capital and "trust and solidarity" that is cognitive dimensions of social capital were significantly related to physical activity of adults. We found that a person having higher density of membership and having larger size of networks showed the high possibility of active physical activity. A person having high solidarity was significantly associated with physical activity, but general trust was inversely related to physical activity. Output dimensions of social capital did not show significant relationship to physical activity. Conclusion: We found that social capital is useful concept to explain health behaviors like physical activity. However we must consider social, cultural and political context of the study to evaluate the effect of social capital to health status and health determinants and to capture the exact meaning of relationship between them. We suggest further researches to refine the concept of social capital and to explain the relationship of social capital to diverse health determinants.

• Preventive Nutrition and Food Science
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• 제20권1호
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• pp.73-77
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• 2015

As an approach to search for chemopreventive agents, we tested p-coumaric acid, 3-methoxy-p-coumaric acid (ferulic acid), and 3,5-dimethoxy-p-coumaric acid (sinapic acid) in B16/F10 melanoma cells. Intracellular melanin contents were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and cytotoxicity of the compounds were examined by lactate dehydrogenase (LDH) release. p-Coumaric acid showed inhibitory effect on melanogenesis, but ferulic acid increased melanin content, and sinapic acid had almost no effect on melanogenesis. Treatment with ferulic acid resulted in a 2 to 3 fold elevation in the production of melanin. Correlatively, cell viability decreased in a dose-dependent manner when treated with ferulic acid. However, ferulic acid did not affect the LDH release from the cells. Treatment with sinapic acid resulted in a 50~60% elevation in the release of LDH when treated with a $200{\mu}g/mL$ concentration and showed neither cytostasis nor increase of melanin synthesis in a dose-dependent manner. Taken together, p-coumaric acid inhibits melanogenesis, ferulic acid induces melanogenesis, and sinapic acid exerts cytotoxic effects in B16/F10 murine melanoma cells. The results indicate that the addition of methoxy groups to p-coumaric acid shows the melanogenic or cytotoxic effects in melanoma cells compared to the original compound. Therefore, this study suggests the possibility that methoxylated p-coumaric acid, ferulic acid can be used as a chemopreventive agent.

• Preventive Nutrition and Food Science
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• 제16권4호
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• pp.357-363
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• 2011

Recently, we found that Arthrobacter crystallopoietes N-08 isolated from soil directly produces trehalose from maltose by a resting cell reaction. In this study, the optimal set of conditions and substrate specificity for the trehalose production using resting cells was investigated. Optimum temperature and pH of the resting cell reaction were $55^{\circ}C$ and pH 5.5, respectively, and the reaction was stable for two hours at $37{\sim}55^{\circ}C$ and for one hour at the wide pH ranges of 3~9. Various disaccharide substrates with different glycosidic linkages, such as maltose, isomaltose, cellobiose, nigerose, sophorose, and laminaribiose, were converted into trehalose-like spots in thin layer chromatography (TLC). These results indicated broad substrate specificity of this reaction and the possibility that cellobiose could be converted into other trehalose anomers such as ${\alpha},{\beta}$- and ${\beta},{\beta}$-trehalose. Therefore, the product after the resting cell reaction with cellobiose was purified by ${\beta}$-glucosidase treatment and Dowex-1 ($OH^-$) column chromatography and its structure was analyzed. Component sugar and methylation analyses indicated that this cellobiose-conversion product was composed of only non-reducing terminal glucopyranoside. MALDI-TOF and ESI-MS/MS analyses suggested that this oligosaccharide contained a non-reducing disaccharide unit with a 1,1-glucosidic linkage. When this disaccharide was analyzed by $^1H$-NMR and $^{13}C$-NMR, it gave the same signals with ${\alpha}$-D-glucopyranosyl-(1,1)-${\alpha}$-D-glucopyranoside. These results suggest that cellobiose can be converted to ${\alpha},{\alpha}$-trehalose by the resting cells of A. crystallopoietes N-08.

• 생물정신의학
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• 제11권2호
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• pp.146-154
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• 2004

Objective:Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism. The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population. Method:We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk (HHRR). And the ADHD children were compared with 212 age and gender matched normal controls. Results:There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD. Conclusions:Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.

• Molecular & Cellular Toxicology
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• 제5권2호
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• pp.160-164
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• 2009

Notch signaling plays a crucial role in development of the nervous system. Neurodevelopmental hypothesis on etiology of schizophrenia has been implicated. The aim of this study is to determine whether single nucleotide polymorphisms (SNPs) of Notch homolog 4 (Drosophila) (NOTCH4) gene are associated with schizophrenia. This study included 283 schizophrenia patients diagnosed according to DSM-IV and 301 normal control subjects. Control subjects without history of psychiatric disorders were recruited. Four missense SNPs [rs915894 (exon 3, Lys117Gln), rs2071282 (exon 4, Pro204Leu), rs422951 (exon 6, Thr320Ala), and rs17604492 (exon 18, Gly942Arg)] of NOTCH4 gene were genotyped by the direct sequencing method. Multiple logistic regression models (codominant, dominant, and recessive models) were employed to evaluate odds ratio, 95% confidence interval, and p value. For analysis of genetic data, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were also used. Of 4 SNPs, rs2071282 was weekly associated with schizophrenia in two alternative models (codominant model, P=0.049; dominant, P=0.041). However, these associations were not significant after Bonferroni correction. At 4 SNPs, one linkage disequilibrium (LD) block was made. This block consisted of rs915894 and rs2071282. In haplotype analysis, AC haplotype was weakly associated with schizophrenia (dominant, P=0.04). This association was disappeared after Bonferroni correction. Our result shows possibility that some SNPs of NOTCH4 gene may be weekly associated with development of schizophrenia in Korean population. However, replication result by other population will be needed.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.3-5
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• 2008

An increase in oil and gas plants caused by development of process industry have brought into the increase in use of flammable and toxic materials in the complex process under high temperature and pressure. There is always possibility of fire and explosion of dangerous chemicals, which exist as raw materials, intermediates, and finished goods whether used or stored in the industrial plants. Since there is the need of efforts on disaster damage reduction or mitigation process, we have been conducting a research to relate explosion model on the background of real 3D terrain model. By predicting the extent of damage caused by recent disasters, we will be able to improve efficiency of recovery and, sure, to take preventive measure and emergency counterplan in response to unprepared disaster. For disaster damage prediction, it is general to conduct quantitative risk assessment, using engineering model for environmental description of the target area. There are different engineering models, according to type of disaster, to be used for industry disaster such as UVCE (Unconfined Vapour Cloud Explosion), BLEVE (Boiling Liquid Evaporation Vapour Explosion), Fireball and so on, among them, we estimate explosion damage through UVCE model which is used in the event of explosion of high frequency and severe damage. When flammable gas in a tank is released to the air, firing it brings about explosion, then we can assess the effect of explosion. As 3D terrain information data is utilized to predict and estimate the extent of damage for each human and material. 3D terrain data with synthetic environment (SEDRIS) gives us more accurate damage prediction for industrial disaster and this research will show appropriate prediction results.

• Structural Engineering and Mechanics
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• 제64권3호
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• pp.347-352
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• 2017

The poor maintenance practice increases the possibility of system failure. Subsequently, the consequences of failure fall on the aspects of output, safety and healthy, environmental integrity, system quality, and customer satisfaction. Conditionbased maintenance is seen as a potential strategy to improve performance. Whereby, the key success factor of this maintenance strategy is identified as the system inspection. This study aims to investigate the association between system breakdown rate and frequency of inspection. A mixed method approach is implemented by distributing questionnaire and interviewing for data collection. Subsequently, descriptive analysis, correlation analysis and regression are adopted to analyse the collected data from 100 respondents and the results are validated with interview data of 10 interviewees. The research result establishes significant relationship between the system breakdown rate and the frequency of inspection. Additionally, the result of regression analysis confirms that the frequency of inspection is the significant predictor of system breakdown rate. Planning of accurate inspection frequency is crucial to secure the system performance. Hence, the research signifies the importance to carry out regular inspection towards the building systems and components. As a recommendation, the maintenance personnel should assess the risk criticality of the building systems. Then, continuously monitor the condition of critical building systems; regularly inspect the condition of non-critical building systems and randomly inspect all of them.

• 대한한방종양학회지
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• 제7권1호
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• pp.117-129
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• 2001

Objectives: We compared the therapeutic response, the treatment-related toxicity, and the improvement of subjective symptoms between the chemotherapy alone group and the western-oriental combined treatment group and evaluated the role of oriental medicine for the improvement of chemotherapy-related toxicity in the advanced gastric cancer and hepatocellular carcinoma. Methods: We evaluated 36 gastric cancer or hepatocellular carcinoma patients(chemotherapy alone group 25 patients, combined treatment group 11 patients) who had been treated in Wonju Christian Hospital and Hana Hospital of Oriental Medicine between June 1999 and October 2000. Enrolled patients' general medical records, results of laboratory and imaging studies, treatment-related toxicities, and subjective symptoms were recorded regularly according to the planned protocol. Therapeutic responses were estimated according to the WHO response criteria and the changes of tumor marker value such as CEA, CA 72-4 and AFP. Results: 1. There was no significant difference of therapeutic response by the WHO response criteria between the two groups(p=.459). 2. There was a significant decrease of tumor marker value in the combined treatment group compared to the chemotherapy alone group(p=.023). 3. There was less comprehensive treatment-related toxicity in the combined treatment group compared to the chemotherapy alone group(p=.037), but there was not a significant difference of comprehensive improvement of subjective symptoms between the two groups(p=.091). Conclusions: Based on the above results, we could expect the possibility of improvements in therapeutic response and treatment-related toxicity with the western-oriental combined anticancer treatment.

• 한국산학기술학회논문지
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• 제11권1호
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• pp.361-367
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• 2010

이 연구는 2007년 1월 1일부터 동년 12월 31일까지 1년간 대전 소재 일개대학병원에서 수술 취소된 총 146명의 환자를 대상으로 하였으며, 계획된 수술의 취소율을 극소화하여 병원 경영의 합리적 개선과 진료 만족도를 증가시키고자하는 목적에서 이루어졌다. 조사대상자의 성별 분포를 보면, 남자 56.8%, 여자 43.2%로 여자보다 남자가 높은 분포를 보였다. 수술 취소 원인을 살펴보면 수술취소까지 이르지 않을 수 있었던 사항과 불가항력적으로 수술을 취소해야 할 사항으로 나눌 수 있는데, 이런 분류를 통해 전체 수술 취소 사유 중 60.0%는 예방이 가능했던 사항이라고 했다. 본 연구결과를 기초로 타 연구자와 병원관리자에게 수술 취소율 감소 개선을 위한 정책방향의 수립을 제언한다.