• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.33 no.4
• /
• pp.1651-1664
• /
• 2013

Precise analysis on deterioration processes of road pavements is not so simple matter due to severe uncertainty originated from a lot of explanatory variables engaged in. For those reasons, most analytical models for pavement deterioration prediction have often preferred to probabilistic approaches than deterministic models. However, the general probabilistic approaches that treat overall characteristics of population or entire sample would not be suitable for providing detail or localized information on their changing process. Considering the aspects, this paper aimed to suggest a stochastic disaggregation method to analyze the localized deterioration speeds and its variances changed by time and condition states. In addition, life expectancies and their uncertainty were estimated by probabilistic algorithm using the disaggregated stochastic process. For an empirical study, pavement inspection data (crack) accumulated from 2003 to 2010 from Korean national highway network was applied. This study can contribute to securing reliability of life cycle cost analysis, which is one of the primary analyses in road asset management, with much advanced deterioration forecasting functions. In addition, it would be meaningful trials as fundamental research for preventive maintenance strategy that demands essential understanding on changing process of the deterioration speed of pavement.

• Development and Reproduction
• /
• v.19 no.3
• /
• pp.119-126
• /
• 2015

The suitable feeder cell layer is important for culture of embryonic stem (ES) cells. In this study, we investigated the effect of two kinds of the feeder cell, MEF cells and STO cells, layer to mouse ES (mES) cell culture for maintenance of stemness. We compare the colony formations, alkaline phosphatase (AP) activities, expression of pluripotency marker genes and proteins of D3 cell colonies cultured on MEF feeder cell layer (D3/MEF) or STO cell layers (D3/STO) compared to feeder free condition (D3/-) as a control group. Although there were no differences to colony formations and AP activities, interestingly, the transcripts level of pluripotency marker genes, Pou5f1 and Nanog were highly expressed in D3/MEF (79 and 93) than D3/STO (61and 77) or D3/- (65 and 81). Also, pluripotency marker proteins, NANOG and SOX-2, were more synthesized in D3/MEF ($72.8{\pm}7.69$ and $81.2{\pm}3.56$) than D3/STO ($32.0{\pm}4.30$ and $56.0{\pm}4.90$) or D3/- ($55.0{\pm}4.64$ and $62.0{\pm}6.20$). These results suggest that MEF feeder cell layer is more suitable to mES cell culture.

• The Journal of Korea Assosiation for Disability and Oral Health
• /
• v.1 no.1
• /
• pp.18-24
• /
• 2005

The purposes of this study were 1) to investigate the oral health problem of the disabled according to the handicapped types, 2) to collect the empirical data for developing and establishing the oral health policies for the handicapped, and 3) to find out the major obstacles against the dental services and oral health promotion. The handicapped subjects were collected by designed cluster sampling and interviewed with structured questionnaire in order to measure the oral health knowledge and behaviors. The subjects were attending the special schools and private or public welfare institutions for crippled disorder, encephalopathy disorder, mental retardation, visual disturbance, hearing defect, and developmental disorder. Oral examination was conducted by 13 trained dentists. 1,476 of handicapped people were finally surveyed. The results were as follows; The experiences of visiting dental office during the last one year in 18~64 year-old disabled people were 48.86% in crippled disorder, 52.50% in mental retardation, 58.24% in visual disturbance, 39.29% in hearing defect, respectively. To improve this challenging situation, we should find out the obstacles against the dental service and oral hygiene maintenance by the types of handicap, and develop the oral health policies which could support and advocate the Korean disabled.

• Convergence Security Journal
• /
• v.14 no.3_2
• /
• pp.93-98
• /
• 2014

In a recent survey conducted among Seoul citizens, the demand for crime prevention in addition to settlement of environmental problem and traffic system improvement turned out to be the highest. In particular, the demand for prevention of crimes in residential areas was higher than any other items. The crime rates are especially high in deteriorated residential districts, which indicates the relation between crimes and physical environmental factors. In other words, proper measures for surroundings can prevent crimes. While there may be various ways to keep the residents from crimes safely, CPTED, a crime preventive method in a way of improving the physical surroundings is one of the most noteworthy solutions. The principles of CPTED involves the basic principles such as Natural Surveillance, access control, and securing of territoriality and additional principles of strengthening of Activity Support and Maintenance & Management. This study aims to present a method to lower and prevent crime occurrences by applying the principles of CPTED in deteriorated Apartment Housing in the middle of a city.

• Preventive Nutrition and Food Science
• /
• v.19 no.3
• /
• pp.178-186
• /
• 2014

Many recent studies have focused on maintaining a healthy life by preventing and/or postponing the aging process. Numerous studies have reported that continuous exposure to reactive oxygen species can stimulate skin aging and that excessive accumulation of fat can cause an impaired skin barrier and tissue structure alterations. Thus, the maintenance of antioxidant homeostasis and the suppression of adipose accumulation are important strategies for skin anti-aging. Here, we prepared three types of extracts [whole juice, acetone-perchloric acid (PCA), and ethanol] from 20 fruits and medicinal herbs native to the Gyeongnam area of Korea. The total phenolic content of each extract was analyzed, and we observed higher total phenolic contents in the medicinal herbs. Consistent with this, the results of the oxygen radical absorbance activity capacity assay indicated that the in vitro antioxidant activities of the medicinal herb extracts were stronger than those of the fruit extracts. The fruits and medicinal herbs had strong effects on cell-based systems, including $H_2O_2$-induced oxidative stress in human keratinocytes and 3T3-L1 lipid accumulation. Nishimura Wase persimmon, Taishu persimmon, wrinkled giant hyssop, sweet wormwood, Chinese cedar, red perilla, tan shen, hiyodori-jogo, and cramp bark may be natural anti-aging materials with effective antioxidant and anti-adipogenic activities. Taken together, our findings may provide scientific evidence supporting the development of functional foods and nutraceuticals from fruits and medicinal herbs.

• Preventive Nutrition and Food Science
• /
• v.21 no.4
• /
• pp.310-316
• /
• 2016

In this study, the anti-osteoarthritis effects of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas extract (CPAE), observed and confirmed in previously clinical studies were further investigated by in vitro and in vivo studies. Anabolic biomarkers related to healthy cartilage maintenance, such as aggrecan, type II collagen ${\alpha}$-1 (Col2a1), sex determining region Y-box-9 (Sox-9), and catabolic biomarkers related to osteoarthritis, such as cyclooxygenase-2 (Cox-2), matrix metalloproteinase-13 (Mmp13), and nuclear factor kappa-light-chain-enhancer of activated B cells ($Nf{\kappa}b$), were evaluated by quantitative reverse transcriptase polymerase chain reaction and reporter gene assay. In vitro study results showed significant changes in both anabolic and catabolic biomarkers. For anabolic factors, significant changes in the level of aggrecan (P<0.05), Col2a1 (P<0.05), and Sox-9 (P<0.01) activation were shown after treatment of cartilage cells with CPAE (50 ng/mL) with similar efficacy compared to insulin growth factor, the positive control (100 ng/mL). For catabolic factors, significant changes in the inhibition activity of Cox-2 (P<0.05), Mmp13 (P<0.01), and $Nf{\kappa}b$ (P<0.05) were shown for CPAE (50 ng/mL) with similar efficacy compared to Celecoxib, the positive control ($10{\mu}M$). In the in vivo carrageenan-induced paw edema model study results showed that CPAE-treated groups (100 mg/kg) and Celecoxib-treated groups (60 mg/kg) showed comparably significant efficacy of inhibition by 37.1% and 52.1%, respectively. Furthermore, CPAE (200 mg/kg) showed similar effect to Celecoxib (60 mg/kg) with an inhibition rate of 54.3%. This result confirms that CPAE effectively inhibited the inflammation-induced osteoarthritis symptoms.

• Journal of radiological science and technology
• /
• v.38 no.4
• /
• pp.395-401
• /
• 2015

The purpose is to determine the degree of contamination of the equipment for infection control in chest radiography of the radiology department. We confirmed by chemical and bacterial identification of bacteria of the equipment and established a preventive maintenance plan. Chest X-ray radiography contact area on the instrument patients shoulder, hand, chin, chest lateral radiography patient contact areas with a 70% isopropyl alcohol cotton swab were compared to identify the bacteria before and after sterilization on the patient contact area in the chest radiography equipment of the department. The gram positive Staphylococcus was isolated from side shoots handle before disinfection in the chest radiography equipment. For the final identification of antibiotic tested that it was determined by performing the nobobiocin to the sensitive Staphylococcus epidermidis. Chest radiography equipment before disinfecting the handle side of Staphylococcus epidermidis bacteria were detected using a disinfectant should be to prevent hospital infections.

• Biomolecules & Therapeutics
• /
• v.20 no.1
• /
• pp.68-74
• /
• 2012

Anthocyanins have received growing attention as dietary antioxidants for the prevention of oxidative damage. Astrocytes, which are specialized glial cells, exert numerous essential, complex functions in both healthy and diseased central nervous system (CNS) through a process known as reactive astrogilosis. Therefore, the maintenance of glial cell viability may be important because of its role as a key modulator of neuropathological events. The aim of this study was to investigate the effect of anthocyanin on the survival of glial cells exposed to oxidative stress. Our results demonstrated that anthocyanin extracts from black soybean increased survival of U87 glioma cells in a dose dependent manner upon oxygen-glucose deprivation (OGD), accompanied by decrease levels of reactive oxygen species (ROS). While treatment cells with anthocyanin extracts or OGD stress individually activated autophagy induction, the effect was signifi cantly augmented by pretreatment cells with anthocyanin extracts prior to OGD. The contribution of autophagy induction to the protective effects of anthocyanin was verifi ed by the observation that silencing the Atg5 expression, an essential regulator of autophagy induction, reversed the cytoprotective effect of anthocyanin extracts against OGD stress. Treatment of U87 cells with rapamycin, an autophagy inducer, increased cell survival upon OGD stress comparable to anthocyanin, indicating that autophagy functions as a survival mechanism against oxidative stress-induced cytotoxicity in glial cells. Our results, therefore, provide a rationale for the use of anthocyanin as a preventive agent for brain dysfunction caused by oxidative damage, such as a stroke.

• Proceedings of the Korean Radioactive Waste Society Conference
• /
• 2005.06a
• /
• pp.145-150
• /
• 2005

To dispose of radwaste in a repository, the safety of disposal must be ensured. This study developed a program for estimating radionuclide accumulation of radwaste, based on the material balance method, one of the indirect methods, and performed application evaluation during the 9th preventive maintenance period of Gori Plant 4, one of the commercial power plants in Korea. First of all, to ensure the technique developed in this study is assessed accurately, this study utilized the data regarding the radionuclide removal in the purification system during the shutdown water chemistry control, and a related estimation technique called SCALP. The target nuclide was Co-60, and it turned out that the relative error was less than $1\%$. The estimation result was compared with the result of direct measurement of the radwaste during the corresponding period as presented by commercial power plants. The result showed that the quantity of Co-60 measured by the direct method was about $50\%$ less than that calculated by the technique developed in this study.

• Journal of Korean society of Dental Hygiene
• /
• v.15 no.6
• /
• pp.973-981
• /
• 2015

Objectives: The purpose of the study is to investigate the correlation with subjective oral health status and food preference in elderly people. Methods: Data were extracted from the fifth Korea National Health and Nutrition Survey 2010-2012. The survey data included general characteristics of the subjects, food preference, and subjective oral health status. Food preference was analyzed by assigning score to 63 food categories. The subjective oral health status consisted of toothache within a month, self-perception of oral health, chewing difficulty, mastication difficulty, and speaking difficulty. Data were analyzed by frequency analysis, descriptive statistics, ${\chi}^2$ test, t-test, and ANOVA using SPSS 22.0 program. Results: Elderly men had a tendency to have a liking for all food categories except for fruit. Difficulty in chewing and mastication was shown in those who had older age, lower education, lower monthly income, and national basic livelihood security. Difficulty in speaking was found in those who had older age, lower education, and national basic livelihood security. Self perception of oral health status was closely related to food preference for pulses and potatoes, fish, vegetables and others(p<0.05). Difficulties in chewing and mastication had relation to all food categories excepting cereals, lipids and sugars(p<0.05). Speaking difficulty were significantly different in pulses, potatoes, meat, eggs, vegetables, fruits, milk, dairy products, and others(p<0.05). Conclusions: Poor subjective oral health status was closely related to food preference. It is necessary to educate that maintenance of good oral health is to ingest the balanced nutrition in the elderly people.