• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.155-168
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• 1999

Osteoporosis is one of the most important public health problems facing the aging population. Drug therapy for osteoporosis can be divided operationally into two main categories: drugs that inhibit bone resorption, and thus reduce bone turnover, and those that stimulate bone formation, exerting an anabolic effect. Antiresorptive agents such as estrogens, calcitonin, and bisphosphonates are most effective in the prevention of osteoporosis. Formation-stimulating agents such as sodium fluoride or monofluorophosphate, parathyroid hormone fragments, and anabolic steroids are of potential value in the treatment of established osteoporosis, where bone mass is already low and benefit from antiresorptive drugs is likely to be small Recently, raloxifene, a selective estrogen receptor modulator, has become available in various countries for clinical use in the treatment of involutional osteoporsis. This paper will review the use of these drugs in postmenopausal woman.

• Journal of Dairy Science and Biotechnology
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• v.22 no.2
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• pp.143-150
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• 2004

The osteoporosis is a disease characterized by lower bone mineral content, deterioration of bone tissue and a reduction in the protein and mineral matrix of the bone. The bone becomes more porous leading to increased bone fragility and risk of fracture, particularly of the hip, spine and wrist. Osteoporosis can result in disfigurement, lowered self·esteem, reduction or loss of mobility, and decreased independence. Adequate calcium intake through milk and milk products in childhood and adolescence is a decisive marker for obtaining a maximum bone mass (peak adult bone mass) and f3r the prevention of osteoporosis. Calcium is one of the most critical nutrients associated with the osteoporosis. Dietary calcium is of great significance for healthy skeletal growth and development. The bone mineral content and bone mineral density of young adults is directly related to the calcium intake through milk and dairy products. Milk and milk products are the important sources of calcium as the richness and bioavailability of this nutrient is very high as compared to other food products. If enough calcium is not supplemented through diet, calcium from the bone will be depleted to maintain the blood plasma calcium level. The article focuses on the various issues related to osteoporosis manifestation and the role of dietary calcium especially calcium derived from dairy products.

• The Korea Journal of Herbology
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• v.23 no.2
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• pp.19-24
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• 2008

Objectives : The present study had been undertaken to investigate the effects of Cynomorii Herba and Eucommiae Cortex on treatment of osteoporosis in ovariectomized rats. Methods : In this experiment, the rats of experimental groups were ovariectomized. Rats of medicinal groups were administered by water extracts of Cynomorii Herba or Eucommiae Cortex. The levels of bone mineral density and body weight were measured. Results : The levels of spinal bone mineral density was significantly increased in comparison with OVX group at 8 weeks after medication in Cynomorii Herba group. The levels of femoral and fibula-tibial bone mineral density were not significantly increased in comparison with OVX group after medication in Cynomorii Herba and Eucommiae Cortex group. The levels of body weight were not significantly decreased in comparison with OVX group after medication in Cynomorii Herba and Eucommiae Cortex group. Conclusions : Reviewing these experimetal results, it appears that Cynomorii Herba have efficacy on treatment of osteoporosis. And further study should be conducted to illustrate in depth the curing and prevention of osteoporosis.

• Journal of Dairy Science and Biotechnology
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• v.34 no.3
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• pp.157-164
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• 2016

Osteoporosis is a systemic skeletal disease characterized by decreased bone mass, which results in a markedly increased risk of traumatic fractures. This disease is a worldwide health problem with a high prevalence. Recently, various dietary components have been found to minimize the risk of developing osteoporosis through their ability to stimulate bone formation and optimize bone health. Among them, probiotics and fermented milk can have beneficial effects to human health. Bioactive compounds derived from probiotics in fermented milk can especially modulate physiological functions related to bone health. Here, we review the evidence to support these insights into newly found functionality of dairy foods for osteoporosis prevention.

• The Journal of Korean Physical Therapy
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• v.2 no.1
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• pp.113-122
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• 1990

Osteoporosis is a major underlying cause of bone fracture in postmenopausal women and older person in general, and so it is a major public health problem. It is a condition in which bone mass decreases, causing bones to be more susceptible to fracture. A trivial trauma can easily cause one or more bones to break in a person with severe osteoporosis. Physicians and patients alike are concerned with the optimum approach to the treatment and prevention of osteoporosis. The diagnostic method and proper use of agents, such as calcium, vitamin D, estrogen, and fluorides, as well as the role of exercise are issues that have generated major research efforts. So these are to be mentioned in this paper.

• Research in Community and Public Health Nursing
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• v.14 no.4
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• pp.629-638
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• 2003

Purpose: This study investigated the effects of knowledge and health belief on osteoporosis preventive health behaviors. Methods: The subjects of this study were 266 middle-aged women. Data were collected using a self-reporting questionnaire with 101 questions. The period of data collection was from the 3rd of January to the 28th of February 2003. Data were analyzed using SPSS 10.0 PC+ program. Results: The results were summarized as follows: 1. The average score of knowledge about osteoporosis was 16.93 out of 27. Particularly, middle-aged women had knowledge more about osteoporosis prevention measures than about risk factors. 2. Knowledge, self efficacy and barriers were significantly correlated with osteoporosis preventive health behaviors. 3. As for the relationship between subjects' general characteristics and their health preventive behaviors, the size of living district, economic status, BMI. family history of osteoporosis and perception of health status were found to have significant effects on health preventive behaviors. Conclusions: According to the results presented above, preventive health behaviors may be promoted by increasing knowledge and perceived self-efficacy as well as decreasing individuals' perceived barriers through health education.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3377-3381
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• 2014

Background: The incidence of colorectal cancer increases with vitamin D deficiency as shown in recently published studies. In addition, prospective investigations have indicated that low vitamin D levels may be associated with increased mortality of colorectal cancer, especially in stage III and IV cases. However, the exact incidence of vitamin D deficiency and the relation between vitamin D deficiency and osteopenia/osteporosis is still not known. The aim of this study is to identify severity of vitamin D deficiency and absolute risk factors of osteopenia/osteoporosis in colorectal cancer survivors. Materials and Methods: A total of 113 colorectal cancer survivors treated with surgery and/or chemotherapy ${\pm}$ radiotherapy were recruited from medical oncology outpatient clinics during routine follow-up visits in 2012-2013. Bone mineral densitometry (BMD) was performed, and serum 25-OH vitamin D levels were also checked on the same day of the questionnaire. The patients was divided into 2 groups, group A with normal BMD and group B with osteopenia/osteoporosis. Results: The median age of the study population was 58 (40-76). Thirty (30.0%) were female, whereas 79 (70.0%) were male. The median follow-up was 48 months (14-120 months). Vitamin D deficiency was found in 109 (96.5%); mild deficiency (20-30 ng/ml) in 19 (16.8%), moderate deficiency (10-20 ng/ml) in 54 (47.8%) and severe deficiency (<10 ng/ml) in 36 (31.9%). Osteopenia was evident in 58 (51.4%) patients whereas osteoporosis was noted in 17 (15.0%). Normal BMD was observed in 38 (33.6%). No apparent effects of type of surgery, presence of stoma, chemotherapy, radiotherapy and TNM stage were found regarding the risk of osteopenia and osteoporosis. Also, the severity of the vitamin D deficiency had no effect in the risk of osteopenia and osteporosis (p=0.93). In female patients, osteopenia/osteoporosis were observed in 79.5% patients as compared to 60.7% of male patients (p=0.04). Conclusions: In our study, vitamin D deficiency and osteopenia/osteoporosis was observed in 96.5% and 66.4% of colorectal cancer survivors, respectively. There is no defined absolute risk factor of osteopenia and osteoporosis in colorectal cancer survivors. To our knowledge, in the literature, our study is the first to evaluateall the risk factors of osteopenia and osteoporosis in colorectal cancer survivors.

• Korean Journal of Adult Nursing
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• v.25 no.5
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• pp.527-538
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• 2013

Purpose: The purpose of this study was to develop a model that explains causal relationships between post-menopausal women's osteoporosis general knowledge and awareness of their own bone mass density(BMD) and their osteoporosis health beliefs and preventive behaviors. Methods: Retrospective design using structural equation model tested seven variables by using questionnaires of osteoporosis knowledge test, osteoporosis health belief scale, osteoporosis self-efficacy scale, and osteoporosis preventive behaviors scale. 162 middle age and post-menopausal women were recruited. Results: Mediating effect of health beliefs was not significant in the relationship between BMD awareness and preventive behaviors. Instead, BMD awareness had a direct influence on the preventive behaviors that is strong and significant. Between the relationship of the BMD awareness and health beliefs, direct pathways of perceived threat, relative benefits, and self-efficacy were not significant. However, relative benefits and self-efficacy showed direct influence on the preventive behaviors. Conclusion: Having middle age women get their BMD test done in order for them to be aware of their own BMD results might be a critical strategy to promote osteoporosis preventive behaviors. There is a need to develop diverse strategies to enhance their self-efficacy which has been shown to be important to osteoporosis preventive behaviors.

• Journal of Korean Academy of Nursing
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• v.38 no.6
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• pp.813-821
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• 2008

Purpose: This study was conducted to develop an instrument measuring awareness of osteoporosis. Methods: The process included construction of a conceptual framework, generation of 86 preliminary items, verification of content validity, selection of secondary items, verification of construct validity and extraction of final items. The 86 items were reviewed for content validity by two groups of experts and were tested to evaluate inter item correlation coefficient by two groups of adult women. From June to August 2007, data were collected from 383 adult women who lived in Seoul and provinces in Korea. Data were analyzed by performing item analysis, Varimax factor analysis and Cronbach's alpha. Results: There were 31 items in the final instrument categorized into 5 factors. The factors were labeled as "preventive behaviors (10 items)", "risk factors (5 items)", "characteristics of osteoporosis (6 items)", "improving bone health (5 items)", and "bone physiology (5 items)". Cumulative percent of variance was 60.92% and eigen values ranged from 1.20 to 12.44. Cronbach's alpha was .948 and ranged from .804 to .917. Conclusion: Validity and reliability of the scale are confirmed in this study showing its utility for measuring awareness of osteoporosis for women. Utilization of the scale will also contribute to designing an appropriate prevention program for osteoporosis.

• Nutrition Research and Practice
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• v.1 no.4
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• pp.328-334
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• 2007

The purpose of this study was to examine the relationship between nutrient intake and bone mineral density (BMD) of elderly women in Daegu, Korea. In this study, the bone mineral densities of 101 elderly women in Daegu were measured, and their nutrient intake, dietary habits, and maternal factors were determined through a survey. The subjects were divided into the normal group, the osteopenia group, and osteoporosis group to find out if there is a correlation between bone mineral density and maternal factors, dietary habits, and nutrient intake through their T-scores, analyzed according to the standards of WHO. Classification by T-scores of the participants were the normal group 25.7%, the osteopenia group 39.6%, the osteoporosis group 34.7%. Menopause age of the osteoporosis group was lower, postmenopausal period was longer, and last delivery age was significantly higher than the normal group (p<0.05). Osteoporosis group had a lower percentage of 'everyday' fruit and vegetable intakes and higher percentage of 'never' dairy intake than of the normal group. Vitamin A, vitamin $B_1$, and vitamin $B_2$ intakes of participants in the osteoporosis group were lower than those in the normal group (p<0.05). In conclusion, nutritional education is necessary to encourage high intake of milk and vegetables and fruits along with calcium, vitamin A, $B_1$, and $B_1$ intakes and low intake of sodium for the prevention of elderly women's osteoporosis.