• BMB Reports
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• v.40 no.5
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• pp.662-669
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• 2007

Although the function of cellular prion protein (PrP$^C$) and the pathogenesis of prion diseases have been widely described, the mechanisms are not fully clarified. In this study, increases of the portion of non-glycosylated prion protein deposited in the hamster brains infected with scrapie strain 263K were described. To elucidate the pathological role of glycosylation profile of PrP, wild type human PrP (HuPrP) and two genetic engineering generated non-glycosylated PrP mutants (N181Q/N197Q and T183A/T199A) were transiently expressed in human astrocytoma cell line SF126. The results revealed that expressions of non-glycosylated PrP induced significantly more apoptosis cells than that of wild type PrP. It illustrated that Bcl-2 proteins might be involved in the apoptosis pathway of non-glycosylated PrPs. Our data highlights that removal of glycosylation of prion protein provokes cells apoptosis.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.12
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• pp.2453-2461
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• 2009

Faults caused by medium-voltage customers have been increased and enlarged their portion in total distribution faults even though we have done many efforts. In the previous paper, we suggested the fault prediction model and fault prevention method for these distribution line faults. However we can't directly apply this prediction model in the field. Because we don't have an useful program to predict those customers causing distribution line faults. This paper presents the construction method of data warehouse in ERP system and the program to find customers who cause distribution line faults in medium-voltage customer's electric facility management applying data mining techniques. We expect that this data warehouse and prediction program can effectively reduce faults resulted from medium-voltage customer facility.

• Journal of the Korean Society of Industry Convergence
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• v.27 no.3
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• pp.581-590
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• 2024

This study aims to extract key topics through text mining of incident records (incident history, post-incident measures, preventive measures) from construction safety accident case data available on the public data portal. It also seeks to provide fundamental insights contributing to the establishment of manuals for disaster prevention by identifying correlations between these topics. After pre-processing the input data, we used the LDA-based topic modeling technique to derive the main topics. Consequently, we obtained five topics related to incident history, and four topics each related to post-incident measures and preventive measures. Although no dominant patterns emerged from the topic pattern analysis, the study holds significance as it provides quantitative information on the follow-up actions related to the incident history, thereby suggesting practical implications for the establishment of a preventive decision-making system through the linkage between accident history and subsequent measures for reccurrence prevention.

• Journal of the Korea Convergence Society
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• v.11 no.11
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• pp.75-80
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• 2020

Since the Fourth Industrial Revolution, important technologies such as big data analysis, robotics, Internet of Things, and the artificial intelligence have been used in various fields. Generally speaking it is understood that the big-data technology consists of gathering stage for enormous data, analyzing and processing stage and distributing stage. Until now crime records which is one of useful big-sized data are utilized to obtain investigation information after occurring crimes. If crime records are utilized to predict crimes it is believed that crime occurring frequency can be lowered by processing big-sized crime records in big-data framework. In this research the design is proposed that the smart system can provide the users of smart devices crime occurrence probability by processing crime records in big-data analysis. Specifically it is meant that the proposed system will guide safer routes by displaying crime occurrence probabilities on the digital map in a smart device. In the experiment result for a smart application dealing with small local area it is showed that its usefulness is quite good in crime prevention.

• Korean Journal of Health Education and Promotion
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• v.22 no.4
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• pp.107-122
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• 2005

Objectives: To prevent smoking among adolescents, we should facilitate school-based smoking prevention programs and provide supports for teachers to participate actively in these programs. This study investigated Korean middle teachers' intentions, perceptions, and attitudes toward participating in smoking prevention programs. Methods: The study design was cross-sectional. Our conceptual framework utilized the Theory of Planned Behavior by Fishbein and Ajzen. We conducted open-ended elicitation interviews with teachers. We developed the survey questionnaire contents with data from these interviews, and distributed the questionnaires in 2002 to 194 school teachers from four schools in Seoul and Kyounggi-Do. Teachers' beliefs(behavioral, normative & control) and intentions about participating in smoking prevention programs were measured by 7-point scales. Results: The majority of teachers surveyed reported participating in adolescents' smoking prevention programs, while only less than 10% teachers reported having educational training for such programs. Teachers' attitudes toward participating in smoking prevention programs were positive, but they did not feel strong subjective norms about participating in the programs. They reported several barriers as well as facilitating conditions in participating in those programs. In correlation analysis, teachers' subjective norms and attitudes toward participating in smoking prevention were significantly correlated with their intentions to participating in those programs. Teachers with positive perceptions about smoking prevention programs were more likely to have strong intentions to participation in them, while teachers who received educational training and instructions on how to teach in smoking prevention programs were more likely to have positive perceptions than those who did not. Conclusion: We concluded that smoking prevention programs for adolescents can be made more effective by increasing societal expectations that teachers participate in these programs, and by providing additional resources dedicated to facilitating teachers' active participation in them.

• Child Health Nursing Research
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• v.25 no.4
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• pp.388-397
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• 2019

Purpose: This study aimed to identify the degree of accident prevention behavior, self-esteem, self-regulation ability, and social support among middle-school students, and investigate factors influencing their practice of accident prevention behaviors. Methods: The participants were 174 students from two middle schools located in J city. Data were collected from December 28, 2017 to February 9, 2018 using self-reported questionnaires. Results: The mean score were $3.08{\pm}0.37$ of 4 for practice of accident prevention behaviors, $3.07{\pm}0.57$ of 4 for self-esteem, $3.69{\pm}0.48$ of 5 for self-regulation ability, and $3.38{\m}0.75$ of 5 for social support. Positive correlations were found among self-regulation ability, self-esteem, social support, and practice of accident prevention behaviors. The factors influencing the practice of accident prevention behaviors were personality (being 'haste') (${\beta}=-.20$, p=.003), self-regulation ability (${\beta}=.48$, p<.001), and social support (${\beta}=.23$, p<.001). These factors explained 39.0% of the variance in practice of accident prevention behaviors. Conclusion: It was found that the middle-school students engaged in prevention behavior to an extent that was insufficient to prevent accidents. Therefore, it is necessary to develop intervention strategies to improve the practice of accident prevention behavior among middle-school students, considering self-regulation ability, social support, and personality, which affect the practice of accident prevention behaviors.

• Journal of Korean Society of Disaster and Security
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• v.14 no.2
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• pp.13-23
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• 2021

This study intended to assess the reliability of topographic data using satellite imaging data. The topographical data using actual instrumentation data and satellite image data were established and applied to the rainfall-leak model, S-RAT, and the topographical data and outflow data were compared and analyzed. The actual measurement data were collected from the Water Resources Management Information System (WAMIS), and satellite image data were collected from MODIS observation sensors mounted on Terra satellites. The areas subject to analysis were selected for two rivers with more than 80% mountainous areas in the Han River basin and one river basin with more than 7% urban areas. According to the analysis, the difference between instrumentation data and satellite image data was up to 50% for peak floods and up to 17% for flood totals in rivers with high mountains, but up to 13% for peak floods and up to 4% for flood totals. The biggest difference in the video data is Landuse, which shows that MODIS satellite images tend to be recognized as cities up to 60% or more in urban streams compared to WAMIS instrumentation data, but MODIS satellite images are found to be less than 5% error in forest areas.

• Women's Health Nursing
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• v.15 no.3
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• pp.177-185
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• 2009

Purpose: This study was done to examine the effects of an incontinence prevention program on postpartum women. Methods: The study design was a nonequivalent control pretest-posttest design. The subjects were 49 postpartum women with a normal vaginal delivery, 25 in the experimental group and 24 in the control group. Data was collected from lune 1. 2007 to April 30. 2008 at a postpartum women's care center located in Jeonju, Korea. For the experimental treatment, an incontinence prevention program was carried out for 24 weeks. Measures included maximum pressure of pelvic floor muscle contraction and duration of pelvic floor muscle contraction at pre-treatment, 5 weeks postpartum and 24 weeks postpartum. Data was analyzed by Repeated ANOVA using the SPSS/WIN 14.0 program. Results: The mean maximum pressure of pelvic floor muscle contraction (F = 8.95, p < .001) and mean duration of pelvic floor muscle contraction (F = 22.01, p < .001) were significantly different between the groups, and significantly increased as time passed. Conclusion: Practice of an incontinence prevention program is considered an effective intervention for the results of fewer urinary incontinence symptoms in postpartum women.

• Korean Journal of Occupational Health Nursing
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• v.26 no.2
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• pp.74-84
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• 2017

Purpose: This study aimed to assess the risk of developing cardiovascular disease (CVD) and to evaluate the effects of intervention for CVD prevention in construction workers. Methods: A total of 497 workers participated the health status survey and finally 90 workers were analyzed for evaluation of the intervention with the one-group pretest-posttest design. The data were collected from the questionnaires and health examinations in the healthcare service for road constructor's CVD prevention as secondary analysis. The intervention of the healthcare was composed of CVD prevention education for all workers and face to face counselling for the high risk group of CVD risk during 6 months in workplace. Data were analyzed with descriptive statistics, $x^2$ test, Wilcoxon signed rank test, and paired t-test. Results: The moderate and high risk groups of CVD were 9.7% and 0.8%. After the intervention, the physical activity (MET-min/week) significantly increased (Z=-5.46, p<.001). But, there were no significant differences in blood pressure, fasting glucose, body mass index, and CVD risk appraisals between pre and post intervention. Conclusion: The findings imply that it is necessary to develop the health promotion program for construction workers which fully reflects the characteristics of individuals and the organization.

• Korean Journal of Adult Nursing
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• v.28 no.4
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• pp.482-490
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• 2016

Purpose: The purpose of the study was to examine the impact of self-efficacy in the prevention of sexually transmitted diseases (STD), knowledge of and susceptibility to STD, and the role of gender in sexual autonomy. Methods: Data were collected from 267 college students using self-report questionnaires during the period from the first to the twentieth of June 2015. Data were analyzed using $x^2$ test, Fisher's exact test, t-test, Pearson correlation coefficients, simple and multiple regression techniques with the PASW/WIN 20.0 program. Mediation analysis was performed according to the Baron and Kenny method and Sobel test. Results: In male students, self-efficacy for STD prevention showed a full mediating effect in the relationship between STD susceptibility and sexual autonomy (${\beta}$=-.08, p=.370). But in female students, it had a partial mediating effect (${\beta}$=-.25, p=.001). And self-efficacy for STD prevention showed partial mediating effects in the relationship between knowledge of STD and sexual autonomy in the both male (${\beta}$=.25, p=.005) and female students (${\beta}$=.33, p<.001). Conclusion: To enhance college students' sexual autonomy, it may be useful to build effective strategies enhancing students' knowledge about and susceptibility to STD and to develop a self-efficacy promotion program for college students.