• BMB Reports
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• v.55 no.9
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• pp.465-471
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• 2022

Understanding and monitoring virus-mediated infections has gained importance since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Studies of high-throughput omics-based immune profiling of COVID-19 patients can help manage the current pandemic and future virus-mediated pandemics. Although COVID-19 is being studied since past 2 years, detailed mechanisms of the initial induction of dynamic immune responses or the molecular mechanisms that characterize disease progression remains unclear. This study involved comprehensively collected biospecimens and longitudinal multi-omics data of 300 COVID-19 patients and 120 healthy controls, including whole genome sequencing (WGS), single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA(+scTCR/BCR)-seq), bulk BCR and TCR sequencing (bulk TCR/BCR-seq), and cytokine profiling. Clinical data were also collected from hospitalized COVID-19 patients, and HLA typing, laboratory characteristics, and COVID-19 viral genome sequencing were performed during the initial diagnosis. The entire set of biospecimens and multi-omics data generated in this project can be accessed by researchers from the National Biobank of Korea with prior approval. This distribution of large-scale multi-omics data of COVID-19 patients can facilitate the understanding of biological crosstalk involved in COVID-19 infection and contribute to the development of potential methodologies for its diagnosis and treatment.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1525-1527
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• 2015

Objective: To investigate the clinical effect of riboflavin sodium phosphate on prevention of radiotherapy related esophagitis (RRE). Methods: This retrospective study involved 55 patients with middle and advanced esophageal cancer who were divided into an experimental group of 28 and a control group of 27 patients. Those in the experimental group were treated with riboflavin sodium phosphate combined with conventional symptomatic treatment during radiotherapy; while patients in control group received the latter alone. The incidence and degree of RRE were compared after radiotherapy. Results: The incidences of RRE in experimental and control group were 53.5% and 81.4%, respectively (p<0.05); the incidence of stages III and IV RRE in the experimental group was 17.8%, while in the control group it was 44.4% (p<0.05). Conclusion: Riboflavin sodium phosphate could significantly prevent RRE and reduce the incidence of stage III and IV disease. These results were worthy of further confirmation by randomized controlled trials.

• Journal of Advanced Engineering and Technology
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• v.11 no.4
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• pp.273-277
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• 2018

In the field of forest disaster prevention, drones are expected to save higher human resources than the existing manpower has, and produce high-efficiency results over time. However, operational limitations brought by short flight times have brought the environment of limited use of the various capabilities of the drone, and the existing development systems operating the multi-drone are mainly for performance purpose, so it is a difficult to use for forest disaster prevention. The purpose of this paper is to design the concept based on multi-drone operation procedure through analysis of mission of ground control system for forest disaster prevention.

• Journal of the Korean Society of School Health
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• v.26 no.3
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• pp.144-157
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• 2013

Purpose: Health management programs should provide comprehensive health services for students and staffs at schools. Health management programs are critical for helping students become adults with physically, mentally, and socially good health conditions. The aim of this study was to identify the past and present history of health management programs and health laws to help schools develop future health plans. Methods: This study was conducted by analyzing reference data collected using data from Ministry of Education and Science Technology, Korean Educational Development Institute, Korea Centers for Disease Control and Prevention, and National Statistical Office as well as legal documents from the Legislative Office related to school health from 2001 to 2010. Results: Health management programs in schools included three sections: disease prevention and control, physical examinations, and prevention of communicable diseases. Disease prevention and controls consisted of obesity control, drug abuse prevention and control,and management of students' mental health. Various strategies and services were developed to improve health status of students for 10 years from 2001 to 2010. School health laws and systems have been established for disease prevention, physical examinations and communicable disease control as well, to improve students' health as well. Conclusion: The history of health management programs has a number of implications to help design future plans for school health programs and services for students and staffs.

• Journal of Korean Academy of Nursing
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• v.47 no.6
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• pp.744-755
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• 2017

Purpose: This study was performed to develop an infection prevention education program for child care teachers and to verify its effects. Methods: The study was conducted using a nonequivalent control group with a pretest-posttest design. Four private daycare centers (2 centers per city) that were alike in terms of the number of children by age, number of child care teachers, and child care environment were chosen. Participants were assigned to the experimental group (n=20) or control group (n=20). As a part of the program, visiting education (90 min) was provided in the 1st week, and smartphone application education (10 min) was provided thrice a week, in the 2nd and 3rd weeks. Results: Child care teachers' self-efficacy for infection prevention revealed a significant interaction effect between the group and time of measurement (F=21.62, p<.001). In terms of infection prevention behavior, a significant difference was observed between the experimental and control groups (z=-5.36, p<.001). Conclusion: The program implemented in this study was effective in improving the infection prevention self-efficacy and infection prevention behavior of child care teachers. Thus, this program may be effective in enhancing their infection control.

• Korean Journal of Health Education and Promotion
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• v.27 no.4
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• pp.17-27
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• 2010

Objectives: The aim of this study was to compare the knowledge and attitudes about AIDS between an activity-oriented and a lecture-oriented AIDS prevention education in middle school boys. Methods: Each of 60 middle school boys in M city, Gyeongsangnam-do, was assigned to the experimental or control group. The activity-oriented AIDS prevention education in experimental group and the lecture-oriented education in control group were provided for a 45 minutes class per week for 4 weeks, respectively. Date were collected with questionnaires and analyzed through $x^2$-test, t-test, and repeated measures ANOVA. Results: The experimental group and control group were homogeneous in knowledge and attitudes about AIDS prevention before the study. In AIDS prevention knowledge, there was no significant interaction of times by groups (F=0.033, p=.930); but the main effect of times was significant (F=63.950, p<.001). In attitudes toward AIDS, there was a significant interaction of times by groups (F=8.892, p<.001). Conclusion: The activity-oriented AIDS prevention education was an effective teaching strategy to foster positive attitudes toward AIDS prevention in middle school boys. Therefore, systematic and sustained development of AIDS prevention education reflecting learners' characteristics is required.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1471-1475
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• 2014

Background: The epidemiological patterns of cancer incidence have been investigated widely in western countries. Nevertheless, information is quite limited in Jiangxi province, southern China. Materials and Methods: All data were reported by 6 population-based cancer registries in Jiangxi Province. The results were presented as incidence rates of cases by site (ICD-10), sex, crude rate (CR), age-standardized rates (ASRs) and truncated incidence rate (TR) per 100,000 person-years, using the direct method of standardization to the world population. Results: 8,765 new cancer cases were registered in our study during the period 2009-2011. Diagnosis of cancer was based on histopathology in 61.0%, clinical or radiology findings in 4.87% and death certificate only (DCO) in 3.0% of the cases. The median age at diagnosis was 62.0 years (mean, 61; standard deviation, 15). The ASRs were 170.8 per 100,000 for men and 111.2 for women. The ASRs for all invasive cancers from the urban areas (145.7 per 100,000) was higher than that of rural areas (137.1). Incidence rates for lung cancer were higher in rural (35.8) than in urban areas (27.0). Similarly, relatively high rates were observed for stomach cancer in rural (20.1) relative to urban areas (15.5). Conclusions: Our results reveal that the most common cancers were breast and lung in women and lung and liver in men. Interestingly, this study suggested a higher incidence rates for lung and stomach cancer in rural males than in urban population, which may suggest other potential causes, such as over-consumption of smoked meats and high prevalence of Helicobacter pylori infection, respectively. Public education and the promotion of healthy lifestyles should be actively carried out.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.7
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• pp.646-654
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• 2010

This paper describes an integrated chassis control for a maneuverability, a lateral stability and a rollover prevention of a vehicle by the using of the ESC and AFS. The integrated chassis control system consists of a supervisor, control algorithms and a coordinator. From the measured and estimation signals, the supervisor determines the vehicle driving situation about the lateral stability and rollover prevention. The control algorithms determine a desired yaw moment for lateral stability and a desired longitudinal force for the rollover prevention. In order to apply the control inputs, the coordinator determines a brake and active front steering inputs optimally based on the current status of the subject vehicle. To improve the reliability and to reduce the operating load of the proposed control algorithms, a multi-core ECU platform is used in this system. For the evaluation of this system, a closed loop simulations with driver-vehicle-controller system were conducted to investigate the performance of the proposed control strategy.

• International Journal of Safety
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• v.7 no.2
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• pp.23-26
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• 2008

This study focuses on the issue of control performance of safety budget for preventing and reducing industrial accidents in Korea. The effect of safety budget such as industrial accident prevention fund on the safety performance is statistically examined first. The role and control performance of industrial accident prevention fund is particularly addressed to reduce the related accidents. The effectiveness of the industrial accident prevention fund-industrial accident relationship is then explained with a simple PI control mechanism.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.216-216
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• 2000

In this paper, we introduce a new roadway-departure prevention algorithm and the developed Hardware-in-the-Loop-Simulator (HiLS) for applying the new algorithm. A sliding-mode controller is used for lateral position control. And, the HiLS consists of real car elements, a micro-control board, and a self-aligning torque generator Finally from the display module, the perspective view and bird view of the animated vehicle can be seen simultaneously.