• Archives of Pharmacal Research
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• 제26권7호
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• pp.559-563
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• 2003

Cytokines produced by immune cells infiltrating pancreatic islets have been incriminated as important mediators of $\beta$-cell destruction in insulin-dependent diabetes mellitus. In non insulin-dependent diabetes, cytokines are also associated with impaired $\beta$-cell function in high glucose condition. By the screening of various natural products blocking $\beta$-cell destruction, we have recently found that epigallocatechin gallate (EGCG) can prevent the in vitro destruction of RINm5F cell, an insulinoma cell line, that is induced by cytokines. In that study we suggested that EGCG could prevent cytokine-induced $\beta$-cell destruction by down-regulation of nitric oxide synthase (NOS) through inhibition of NF-kB activation. Here, to verify the in vivo antidiabetogenic effect of EGCG, we examined the possibility that EGCG could also prevent the experimental autoimmune diabetes induced by the treatment of multiple low doses of streptozotocin (MLD-STZ), which is recognized as an inducer of type I autoimmune diabetes. Administration of EGCG (100 mg/day/kg for 10 days) during the MLD-STZ induction of diabetes reduced the increase of blood glucose levels caused by MLD-STZ. Ex vivo analysis of $\beta$-islets showed that EGCG downregulates the MLD-STZ-induced expression of inducible NOS (iNOS). In addition, morphological examination showed that EGCG treatment ameliorated the decrease of islet mass induced by MLD-STZ. In combination these results suggest that EGCG could prevent the onset of MLD-STZ-induced diabetes by protecting pancreatic islets. Our results therefore revealed the possible therapeutic value of EGCG for the prevention of diabetes mellitus progression.

• Journal of Korean Biological Nursing Science
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• 제13권1호
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• pp.16-22
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• 2011

Purpose: Hand washing has received renewed emphasis in recent years as Swine flu epidemic threaten health of public. This study aimed to describe measures used to prevent new types of influenza (NTI); describe hand washing frequency; and analyze the relationship of hand washing to locus of control, uncertainty, and state anxiety. Methods: One hundred thirty three adults participate in the questionnaire survey in which participants indicated measures they used to prevent NTI, frequency of handwashing for the prevention of NTI. They also responded to questions related to locus of control, uncertainty and state anxiety. Data were analyzed using descriptive statistics, Pearson correlation and multiple regression. Results: A majority (66.9%) of the participants indicated that handwashing was an important measure to prevent NTI. Importance of hand-washing was related the highest among the measures they used and it was significantly related to participants who had high score in internal locus of control. Other significant factor to the hand-washing behavior was state anxiety, which explained 6.9% of the frequency. Conclusion: According to the results of this study, majority of participants indicated that handwashing was one of the most important measures to prevent NTI. Nurses need to continue educating public the importance of handwashing and pay attention to personal characteristics such as internal locus of control and anxiety to promote hand-washing.

• 대한기계학회논문집B
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• 제29권10호
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• pp.1156-1162
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• 2005

In this study, a noble method is proposed to prevent the edge overcoating (EOC) that may develop near the edge of the steel strip in the gas wiping process of continuous hot-dip galvanizing. In our past study (Trans. of the KSME (B), Vol. 27, No. 8, pp. $1105\~1113$), it was found that EOC is caused by the alternating vortices which are generated by the collision of two opposed jets in the region outside the steel strip. When the two opposed jets collide at an angle much less than $180^{o}$, non-alternating stable vortices are established symmetrically outside the steel strip, which lead to nearly uniform pressure on the strip surface. In order to deflect both jets downward by a certain angle, a cylinder with small diameter is installed tangentially to the exit of the lower lip of the two-dimensional jet. In order to find an optimum cylinder diameter, the three dimensional flow field is analysed numerically by using the commercial code, STAR-CD. And the coating thickness is calculated by using an integral analysis method to solve the boundary layer momentum equation. In order to compare the present noble method with the conventional baffle plate method to prevent the EOC, the flow field with a baffle plate is also calculated. The calculation results show that the tangentially installed cylinder at the bottom lip of the jet exit is more effective than the baffle plate to prevent EOC.

• 대한의용생체공학회:의공학회지
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• 제36권2호
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• pp.48-53
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• 2015

Sudden infant death syndrome(SIDS) continues to be general cause of infant death. Also, apnea is supposed to be one of the main risk factor of SIDS. Therefore, Infant's respiratory monitoring and real-time apnea detection is very important to prevent SIDS. In this study, we proposed a non-contact home monitoring system for infant's respiration using Doppler radar in order to prevent SIDS. The respiration data were acquired from a commercialized baby simulator(Simbaby$^{TM}$) using a Doppler radar. To evaluate a performance of the proposed system, the simulator was placed in a supine and prone position and the chest belt was used simultaneously as a reference signal. As a result, correlation coefficients between respiration rates of Doppler radar and the chest belt in each position were 0.95(p < 0.001) and 0.98(p < 0.001), respectively. The averages of difference were $-0.29{\pm}5.21(mean{\pm}1.96{\cdot}$ standard deviation) in supine and $-0.12{\pm}3.05$ in prone from Bland-Altman analysis. The results indicated an excellent performance in detecting apnea with a sensitivity of 100% and a positive predictive value of 100% in each posture respectively. These results demonstrated that a proposed Doppler radar system is suitable for non-contact respiratory monitoring in order to prevent SIDS of infant.

• 대한한방소아과학회지
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• 제30권4호
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• pp.99-110
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• 2016

Introduction Jaundice is one of the most common conditions found in neonatal period. Phototherapy is one of the main treatments for neonatal jaundice. However, several adverse effects of the phototherapy have been reported, including DNA damage recently. Therefore, a variety of treatments have been conducted to shorten the duration of phototherapy. Meanwhile, it has been hardly tried to prevent neonatal jaundice, but diverse approaches have been tried in traditional Chinese medicine (TCM) for many years. Therefore, this study aims to analyze the studies for the treatments to prevent neonatal jaundice based on TCM. Materials and Methods Various literatures have been searched via CNKI, and PubMed using the terms "neonatal jaundice" (新生儿黄疸, 胎黃, 胎疸) in category of 'Traditional Chinese Medicine', 'Traditional Chinese Medicinal Herbs' and 'Combination of Traditional Chinese Medicine With Western Medicine'. The search range included randomized controlled trials (RCTs), controlled clinical trials (CCTs), case reports, reviews and animal experiments published from 2013 to 2015. Results A total of 104 studies were found. 93 articles were excluded by reviewing the titles and abstracts. Out of the remaining 11 studies, 9 articles were RCTs, 2 articles were CCTs. The treatment used in neonatal babies in the studies were, using herbal remedies (meditation 5, bath 3 and retention enema 1) and the acupressure. All treatments were initiated within the first 24-48 hours after their birth. Then, there was a study that the subjects taken the herbal medicine were women during pregnancy. The outcome assessments used were the serum total bilirubin (TB), transcutaneous bilirubin measurement (TCB), the incidence of the hyperbilirubinemia, the duration time of the jaundice. Especially, TB, TCB and the incidence of the hyperbilirubinemia have decreased significantly more than that of the control group in the most of the results. No severe adverse events were reported in all articles reviewed. Conclusions Conventional treatment such as, herbal medicine in TCM, seems to be the effective way to prevent neonatal jaundice or hyperbilirubinemia. Therefore, the conventional treatment may be favorable choice for preventive treatment for neonatal jaundice.

• 한국식품조리과학회지
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• 제28권2호
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• pp.149-158
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• 2012

The purpose of this study was to investigate differences in the perception and attitudes of middle school students toward food safety between those who possess high behavioral intentions to prevent contracting a foodborne illness and those who do not. The survey collected 871 usable data from several middle schools in Seoul, Korea in July 2007. Using six behavioral intention measurement items, a two-step cluster analysis approach was conducted resulting in a strong intention group and a weak intention group. Perception and attitudes toward foods safety were different between the two groups. Students with strong behavioral intentions to prevent foodborne illness tended to possess a stronger perception and attitude toward various food safety issues. Students with strong intentions were more certain of consumer's right to purchase safe foods, more concerned about foodborne illness and food safety, believed that the government should put more efforts toward establishing a safe food chain, possess more distrust for food suppliers, were more aware of specific foodborne illness pathogens, had more food safety education/training, and washed their hands more frequently than those with less strong intentions. No significant differences were found between the groups but,overall, chemical residues and food additives were perceived as more harmful and more serious food safety issues than those of foodborne illness pathogens despite that microorganisms are the main cause of foodborne illness outbreaks in schools. Participants seemed to underestimate the importance of temperature control for preventing foodborne outbreaks. Several implications and suggestions on how to improve the behavioral intentions of middle school students to prevent possible foodborne illness were provided.

• Molecules and Cells
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• 제43권6호
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• pp.517-529
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• 2020

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.

• 정보보호학회논문지
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• 제24권6호
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• pp.1225-1241
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• 2014

고객정보 유출 방지를 위해 금융기관은 DLP(Data Leaks Prevention) 관련 정보보호 제품을 도입하고 내부통제 정책을 강화하고 있다. 그러나 정보의 수집, 제공, 이용, 저장 과정의 핵심적 역할을 담당하는 응용프로그램에 대한 관리 및 기술적 통제는 매우 미흡한 실정이며, 응용프로그램을 통한 정보유출 사고를 예방하거나 대책 마련을 위한 내부통제 정책의 이행에 어려움을 겪고 있다. 본 논문에서는 금융기관의 개인정보 취급 및 주요 유통 경로 현황 분석을 통해 문제점을 제기하고 정보유출 방지를 위한 효율적인 내부통제 보안기술의 필요성을 제시하였다. 이에 따라 가상화 및 모바일 분야에서 부분적으로 사용되고 있는 컨테이너 기술을 응용하여 클라이언트 PC 응용프로그램의 보안 취약점을 보완하고 정보유출 방지 기능을 제공하는 새로운 보안 컨테이너를 설계 구현하였으며, 실제 금융기관 업무시스템에 적용하여 정보유출 방지 및 IT 컴플라이언스 내부통제와 관련된 정책 수행능력의 효과성을 검증하였다. 또한 정책 설정을 통해 보안 컨테이너에 추가 보안 기능을 제공하고 보안 컨테이너를 재사용함으로써 보안 취약점 대응 비용 및 시간을 줄여 IT 컴플라이언스 규제 준수를 위한 보안 컨테이너의 효용 가치를 높였다.

• 한국정보통신학회논문지
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• 제20권11호
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• pp.2131-2136
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• 2016

산업 4.0 이전의 많은 제조 방식들이 단순히 생산 라인의 단점을 극복하는 것이 목적이라면, 산업 4.0은 생산 설비 스스로 작업 방식을 결정하여야 한다. 이러한 과정 속에서 FMS, AMS, MAS 등의 제조 방식들이 발전하여 왔으나, 이러한 제조방식들은 기계, agent, 자원 공유 등의 이유로 교착상태가 발생할 수 있다. 이를 해결하기 위해 여러 연구가 진행되어 왔지만, 사람의 개입으로 인해 제조 방식이 동적으로 재구성되는 상황에서 발생되는 교착상태를 방지하는 연구는 미비하다. 본 논문에서는 동적으로 재구성되는 상황의 모델을 제시하며, 이러한 상황에서 발생하는 교착상태를 방지하는 기법을 제안한다. 제안하는 기법은 사람이 개입한 기계의 제조 시간이 변경될 경우 주변 기계들에게 오차 시간 메시지를 브로드캐스트함으로써 생산 제조 시간을 조절한다. 이를 통해 생산 라인의 상황이 변화하더라도 교착상태는 방지할 수 있을 것이라 예상된다.

• 한국정보통신학회논문지
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• 제23권7호
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• pp.829-836
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• 2019

IoT 장치들은 네트워크 구성에 많이 사용되고 있고, 증가하고 있다. 데이터는 필요에 따라서 이기종의 IoT 장치를 통하여 전송된다. 본 논문에서는 Bluetooth 5를 이용하여 내부 네트워크를 구성하고, LoRa(Long Range)를 통하여 데이터 전송할 때 발생하는 전송 데이터 손실을 방지하기 위한 기법을 제안한다. Bluetooth 5가 LoRa의 데이터 전송 속도에 비해 빠르므로 LoRa를 통하여 데이터를 전송할 때 데이터 손실 문제가 발생한다. 본 논문에서 제안하는 전송 데이터 손실 방지 기법은 Bluetooth 5와 LoRa 뿐 아니라 이기종의 IoT 장치의 데이터 전송 속도 차이로 인해 발생하는 데이터 손실을 방지할 수 있을 것으로 기대한다. 또한 본 논문에서는 제안하는 데이터 손실 방지 기법을 적용하여 시뮬레이션 결과를 보인다. 2가지 방법으로 시뮬레이션 했을 때 전송 성능과 저장에 필요한 메모리 양 을 보인다.