• Journal of Pharmaceutical Investigation
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• 제33권4호
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• pp.299-304
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• 2003

The purpose of this study was to investigate the effect of coadministration (2.5, 10, 20 mg/kg) and 3 or 7 days-pretreatment (10 mg/kg) of diltiazem on the pharmacokinetic parameters of paclitaxel (50 mg/kg) given orally in rats. The plasma concentrations of paclitaxel coadministered or pretreated with diltiazem were significantly (p<0.05 at 20 mg/kg coadmin., p<0.05 at pretreat.) increased compared to that of control, from 0.5 hr to 24 hr. Area under the plasma concentration-time curve (AUC) of paclitaxel coadministered or pretreated with diltiazem was significantly (p<0.05 at 20 mg/kg coadmin., p<0.01 at pretreat.) higher than that of control. Peak concentrations $(C_{max})$ of paclitaxel with diltiazem were significantly (p<0.05 at 20 mg/kg coadmn. and pretreat.) increased compared to that of control. Elimination rate constants $(K_{el})$ of paclitaxel with diltiazem were significantly (p<0.05 at 20 mg/kg and 7 days-pretreat.) reduced compared to those of control. Half-life $(t_{1/2})$ and mean residence time (MRT) of paclitaxel with diltiazem was significantly (p<0.05 at 20 mg/kg ad 7 days-pretreat.) prolonged compared to those of control. Absolute bioavailability (AB%) of paclitaxel with diltiazem was significantly (p<0.05 at 20 mg/kg and 3 days-pretreat, p<0.01 at 7 days -pretreat.) increased compared to that of control. Based on these results, it might be considered that diltiazem may inhibit cytochrome $P_{450}$ and P-glycoprotein, which are respectively engaged in paclitaxel absorption and metabolism in liver and gastrointestinal mucosa.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.240.1-240.1
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• 2003

The purpose of this study was to investigate the effect of nifedipine (10 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (50 mg/kg) orally coadministered and pretreated in rats. The plasma concentration of paclitaxel in combination with nifedipine was significantly (p<0.05 at 10 mg/kg coadmin., p<0.01 at pretreat.) increased compared to that of control, from 2 hr to 24 hr. Area under the plasma concentration-time curve (AUC) of paclitaxel with nifedipine was significantly (p＜0.05 at 10 mg/kg coadmin., p＜0.01 at pretreat.) higher than that of control (omitted)

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2014년도 추계 학술논문 발표대회
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• pp.49-50
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• 2014

Dredged sea soil contains various contaminants. First priority to recycle dredged sea soil is to pretreat it to remove various contaminants because recycling dredge sea soil without any pre-treatment may cause a secondary contamination due to the leaching of hazardous chemicals. In this study, pretreated dredged sea soil was used to investigate pozzolanic activity. The properties of pretreated dredged sea soil were investigated, the method for heat treatment was determined, and the compressive strength of mortar using dredged sea soil was examined to evaluate pozzolanic activity. According to the results, pretreated dredged sea soil has some possibility to work as a pozzolanic material. When dredged sea soil was heat treated for 90min at 550℃, compressive strength was shown to be comparable to that of plain cement mortar.

• 한국기계가공학회지
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• 제21권4호
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• pp.39-45
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• 2022

In this study, it was verified that carbon-ceramic brake discs can replace existing cast-iron brake discs of the same size. In addition, a method of pretreating carbon fiber to secure heat dissipation characteristics while using a small amount of carbon fiber was established. The thermal conductivity and bending strength characteristics were analyzed according to the carbon content, and brake braking tests were conducted. Through pretreatment, the maximum temperature was lowered by 16 ℃ compared to the case using only carbon fiber, and the cooling rate was improved by approximately 10% compared to metal brake discs. However, the total heat capacity increased as the mass increased owing to the reaction. Thus, the measured temperature was higher than that of the metal brake disc; therefore, additional research is required.

• Journal of Microbiology and Biotechnology
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• 제27권9호
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• pp.1593-1601
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• 2017

Vibrio species are generally recognized as pathogens predominant in seafood along coastal areas. The food industry has sought to develop efficient microbial detection methods. Owing to the limits of conventional methods, this study aimed to establish a rapid identification method for Vibrio isolated from Korea, based on matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Four different preparation procedures were compared to determine the appropriate means to pretreat Vibrio species, using 17 isolates and five reference strains. Extended direct transfer and full formic acid extraction methods using bacterial colonies on agar plates revealed very low identification rates. Formic acid and trifluoroacetic acid (TFA) extractions using bacterial broth cultures were also performed. All Vibrio isolates and reference strains prepared by TFA extraction were successfully identified to the species level (17/22, 77.3%) and to the genus level (5/22, 22.7%). Thus, TFA extraction was considered the most appropriate method to pretreat Vibrio species for MALDI-TOF MS. The remaining 33 isolates and two reference strains were prepared by TFA extraction and analyzed by MALDI-TOF MS. Overall, 50 isolates were identified to the species level (40/50, 80%) and to the genus level (10/50, 20%). All isolates were identified as 43 V. alginolyticus, six V. parahaemolyticus, and one V. vulnificus species. V. alginolyticus and V. parahaemolyticus were isolated from fish offal (87.5% and 12.5%, respectively), seawater (91.3%, 8.7%), and shellfish (62.5%, 37.5%), whereas V. alginolyticus and V. vulnificus were isolated from sediment (90.9% and 9.1%, respectively). This study established a reliable system of MALDI-TOF MS preparation and analysis for Vibrio identification.

• 한국물환경학회지
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• 제32권3호
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• pp.303-309
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• 2016

This study aimed to assay the biological removal of TDS (total dissolved solids) from RO (reverse osmosis) rejected water. Following bio-sorption of TDS with AGS (aerobic granular sludge), the effects of TDS on biological nitrogen removal were examined. The bio-sorption of TDS after AGS treatment was confirmed by checking for TDS removal efficiency and surface analysis of microorganisms with SEM and EDS. Then, the effects of TDS on biological nitrogen removal and the denitrification efficiency were evaluated using the MBR reactor. According to the results, the bio-sorption of TDS with AGS was 0.1 mg TDS/mg AGS, and we confirmed that the microorganism surfaces had adsorbed the TDS. Biological nitrogen removal efficiency was measured at inhibiting denitrification at 4,000 mg/L of TDS-injected material. Based on this study, it is necessary to pretreat TDS-containing RO rejected water and to maintain TDS concentration lower than a specific value (≤4,000 mg/L), when considering biological nitrogen removal.

• Journal of the Korean Wood Science and Technology
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• 제46권4호
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• pp.368-379
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• 2018

Objective of this work is to study the effects of a saline solution used to pretreat lignocellulosic material derived from champak timber. The native lignocellulosic solids, in powder form, were mixed with saline water solutions of three different concentrations and maintained for 2 weeks without stirring. The treated solids were washed, recovered, and then dried under sunlight. The substrates were characterized using X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The crystallinity (CrI), lateral order index (LOI), total crystallinity index (TCI), and surface morphologies of all the samples were determined. The treated biomass structures were compared with controls. The data show that the structures of all the treated substrates changed, as indicated by CrI. CrI of the treated substrates decreased significantly compared with that of the original wood, as did LOI and TCI quantities, whereas the HBI parameter increased. The results indicate that the saline water pretreatment modified the wood samples.

• The Journal of Korean Physical Therapy
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• 제8권1호
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• pp.15-20
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• 1996

The purpose of this study were to 1) determine the analgesic effect of 632.8 nm of helium-neon (He-Ne) laser stimulation on acupuncture point in rat and 2) determine the reversal of analgesic effect by naloxone injection. Eighteen Sprague-Dawley rats were devided into three groups : control (n=6) : laser (n=6), laser stimulation at $3.58\;J/cm^2$ ; and naloxone (n=6), 1 mg/kg of naloxone chloride inject into peritoneum before laser stimulation at $3.63J/cm^2$. Tail-flick latency were measured pretreat and posttreat with hot plate $(55^{\circ}C)$. Data were analyzed using one-way ANOVA and paired t-teat for tail-flick latency. No significant change was noted in the tail-flick latency in either control or naloxone groups. But significant increased in tail-flick latency in taller group. The results suggest that He-Ne laser induced analgesic effect, and endogenous opioids may be involved in He-Ne laser induced analgesia.

• 공업화학
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• 제26권1호
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• pp.17-22
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• 2015

2013년 시리아 내전 간 사용되어 1,300명 이상의 사망자를 발생시킨 사린(GB) 등의 화학무기로 인해 화학무기에 대한 국제적 관심이 다시 한번 높아지게 되었다. 화학작용제는 자연환경에 노출이 되면 가수분해(hydrolysis) 또는 광분해(photodegradation) 과정을 거쳐 분해물질로 분해된다. 화학작용제 및 분해물질(가수분해 또는 산화된 생성물)은 통상수 ppb 정도의 낮은 농도로 존재하기 때문에 정확한 샘플분석을 위해서는 화학작용제 및 분해물질을 환경샘플로부터 분리, 추출, 농축시키는 전처리 과정이 필요하다. 용매추출법(LLE), 고체상 추출법(SPE) 등이 화학작용제의 전처리 방법으로 많이 사용되나 최근에는 사용되는 용매의 양은 줄이면서 분석효율은 높일 수 있는 liquid phase microextraction (LPME)이 개발 적용되고 있다. 본 리뷰에서는 화학작용제 및 그 분해물질의 전처리에 활용된 LPME 전처리 기법에 대해 살펴보고자 한다.

• 한국동물위생학회지
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• 제14권2호
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• pp.110-120
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• 1991

28 porcine enteroviruses were isolated from 86 pig-feces of 9 swine farms located in south region, Chung-buk, from March to September 1990. Physico-chemical properties and pathogenicity of isolates were investigated. Results obtained throughout experiments are summarized as follows. According to the age, weanlings(40-90 days), sucklings(10-30 days) and adult pigs(6 months over) showed the isolation rate of 67%. 8% and 4%, respectively. By physico-chemical tests, YD-90/22, YD-90/43 and YD-90/64 strains were found to be ether, chloroform and PH stable. Nucleic acid test suggests the virus to have a DNA genome. Most of the Isolates were not evident of hemagglutinin using erythrocytes from various mammalian & avian. 22 strains among the isolates were shown CPE type I and the remainders were CPE type II. 3 strains among isolates of CPE type I strains were neutralized with high titers to serotype 2 antiserum. In the study on virus growth curve in PK-l5 cells, YD-90/22, YD-90/43 and YD-90/64 strains showed the maximum infectivity titers($10^{6.0}-l0^{6.5} TCID({50}ml$) at 4days post inoculation(PI). When 30 day-old commercial piglets were inoculated only intraoral route with the YD-90/22 strain at $10^{6.0} TCID_{50}ml,$ piglets not showed the symptoms. But piglets inoculated by intramuscle route, intraoral and intramuscle route after pretreat with dexamethasone(2.5mg /kg) for 5 days were shown the symptoms of anorexia, diarrhea, pyrexia and ataxia at 4th-6th days PI. The viral reisolation in the virus-inoculated piglets was examined from feces. The viruses were recovered intermittently from 2nd to 16th day PI and at 4th-6th day PI, all piglets excreted viruses.