• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.46-47
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• 2003

Direct numerical simulations are performed for a turbulent flow subjected to a sudden change in pressure gradient. The calculations are started from a fully-developed turbulent channel flow at $Re_{\tau}=180$. The pressure gradient of the channel flow is then changed abruptly. The responses of the turbulence quantities (e.g., turbulence intensities, Reynolds shear stress, and vorticity fluctuations) and the near-wall turbulence structure to the pressure gradient change are investigated. It is found that there are two different relaxations: a fast relaxation at the early stage and a slow one at the later stage. The early response of the velocity fluctuations shows an anisotropic response of the near-wall turbulence.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.40-48
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• 1993

Intravenous administration of saponin extracted from the root of Panax ginseng lowered the blood pressure dose-dependently (10-200 mg/kg, B.W) in anesthetized rats. Therefore, experiments were designed to study the hypothesis that the lowering of blood pressure is associated with the release of endothelium-derived relaxing factor and the accumulation of guanosine 3, 5-cyclic monophosphate (cGMP). Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber and the tissue content of cGMP was measured by radioimmunoassay. All experiments were performed in the presence of $indomethacin(10^{-5}M).$ Ginseng saponin $(10^{-5}-3{\times}10^{-6}g/ml)$ relaxed contractions induced by phenylephrine $10^{-6}M)$ in the aorta with endothelium but not in that without endothelium. Treatment of aortic rings with $N^G$ monomethyl-L-arginine (L-NMMA, $10^{-4}M$ for 30 min), a competitive inhibitor of nitric oxide synthase, and methylene blue $(MB,\;3{\times}10^{-7}M$ for 30 min). an inhibitor of soluble guanylate cyclase, diminished the relaxation induced by Ginseng saponin. Ginseng saponin $10^{-4}g/ml$ for 2 min) increased the accumulation of cGMP in rings with endothelium. L-NMMA and MB inhibited the accumulation of cGMP induced by Ginseng saponin. These data suggest that vascular relaxations induced by Ginseng saponin are mediated by release of endothelium-derived relaxing factor and the accumulation of cGMP. The effect of Ginseng saponin on endothelial function in hypercholesterolemic rabbits was examined. In hypercholesterolemic rabbits fed with $2\%$ cholesterol for 8 weeks, relaxation of aortic rings to acetylcholine was impaired. The impaired relaxations of aortic rings in hypercholesterolemic rabbits were improved by dietary supplementation of Ginseng saponin, probably because of an improved release of endothelium - derived relaxing factor.

• Membrane Journal
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• v.29 no.4
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• pp.216-222
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• 2019

In this study, permeation experiments were conducted using naturally circulating spherical beads, backwashable plate membrane and the air supplied from the bottom of the MBR. The activated sludge solution was maintained at 8,000 mg/L of MLSS and compared transmembrane pressure (TMP) with respect to FR (filtration and relaxation), FR/BW (filtration and relaxation/backwashing), SFCO (sinusoidal filtration continuous operation) and SFCO/BW (sinusoidal filtration continuous operation/backwashing). As the backwashing flux decreased from 47 to $14L/m^2{\cdot}hr$, the TMP increased generally, but the TMP of FR system increased significantly comparing with SFCO. In addition, the backwashing method reduced more TMP comparing to the cleaning method using spherical beads, and it was confirmed that the operation method using the spherical beads and the backwashing simultaneously is more effective than each method.

• Journal of People, Plants, and Environment
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• v.22 no.4
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• pp.355-364
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• 2019

This study was conducted to find out the effects of agro-healing activities and strolling on the physiological conditions of patients with chronic metabolic diseases. A total of 11 subjects participated in agro-healing activities, and their average age was 49.6±11.3. Changes in their salivary cortisol were compared and analyzed before and after participating in the agro-healing activity program, and it was found that the stress hormone decreased after participating in the program. Differences in brain wave between before and after participating in agro-healing activities and strolling were measured, and the ratio of alpha to high beta (RAHB) of subjects increased in most of the measured points after participating in agro-healing activities. In addition, the increase in the value in the temporal lobe (T3) that controls mortor skills and occipital lobe (O2) that controls visual functions indicates that the activities were effective in improving relaxation and stability. The relative low beta (RLB) power spectrum of subjects also statistically significantly decreased in the right occipital lobe (O2) that controls visual functions, the relative mid beta (RMB) and relative high beta (RHB) power spectrum decreased in the left temporal lobe (T3) and the right occipital lobe (O2). These results indicate that the activities were effective in improving relaxation under no stress and tension. The systolic and diastolic blood pressure of subjects after participating in agro-healing activities decreased from the prehypertension level to the normal level. These results indicate that horticultural activities and visual elements in healing farms, such as agro-healing activities and strolling, have positive impacts on patients with chronic metabolic diseases accompanied with diabetes or high blood pressure by increasing the brain activity and psycho-physiological conditions of participants.

• Journal of Life Science
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• v.13 no.5
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• pp.634-641
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• 2003

In order to examine whether arsenic, one of environmental stress, contribute to augumentation and relaxation of rat aorta, this study was performed in vivo and in vitro, using intacted or denuded rats aorta ring preparation, respectively. The carotid arterial pressure was recorded on an ink-writing physiograph(Grass Co. 79E) connected to strain gauge. The contractile response of vascular ring with or without endothelium preparation isolated from rat were determined in organ bath and was recorded on physiograph connected to isometric transducer. Vasopressin-,and phenylephrine- induced increase in arterial pressure significantly enhanced in arsenic-treated rats; increase of 19.1%, and 46.6%, respectively. Vascular contractile response was measured in vitro preparations exposed to 0, 0.5, 1, 2 and 4 mM of arsenic for 1, 3, 5 and 8 hours. The dose-vascular responses of phenylephrine augmented by increasing dose of arsenic in the strips exposed to arsenic for 8 hours, and did not augmented for 1, 3, 5 hours. The phenomenon was not affected by strips denuded endothelium. And the response of relaxation of rat aorta induced by nitroprusside was not influenced by arsenic stress, but acetylcholine was a little increased. compared to that of control. There were no significant difference in relaxation between control and arsenic treated rings with endothelium or denuded. All of the results, phenyleprine-induced vascular contraction was significantly enhanced in 4 mM arsenic-treated rat aortic rings compared with control, whether endothelium was present or denuded at 8 hours after arsenic treatment. It may be a mechanism by which long-term arsenic stresses play a role in development of hypertension.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2007.05a
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• pp.191-194
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• 2007

In hot embossing lithography which has shown to be a good method to fabricate polymeric patterns for IT and bio components, it is very important to determine the proper process conditions of pressure, temperature, and time. It is also a key factor for predicting the optical properties of final product to calculate residual stress distribution after the embossing process. Therefore, to design the optimum process with right conditions, the ability to predict viscoelastic behavior of polymer during and after the hot embossing process is required. The objective of the present investigation is to establish simulation technique based on constitutive modeling of polymer with experiments. To analyze deformation behavior of viscoelastic polymer, the large strain material properties were obtained from quasi-static compression tests at different strain rates and temperatures and also stress relaxation tests were executed. With this viscoelastic material model, finite element simulation of hot embossing was executed and stress distribution is obtained. Proper process pressure is very important to predict the defect and incomplete filling.

• Water for future
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• v.21 no.3
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• pp.291-291
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• 1988

The two dimensional time dependent flow past a circular cylinder is analyzed numerically. In the analysis, equations of conservation of mass and momentum are transformed to equations of stream function-vorticity and vorticity transport, and nondimensionalized by nondimensional parameters representing flow characteristics, The resulting stream function-vorticity equstion and vorticity transport equation are solved by successive over relaxation scheme and alternating direct implicit scheme. Numerical experments are performed for the flow in the range of Reynolds number 125 to 275. The time dependent streamlines, vorticities, pressure on cylinder surface, separation angle, and drag and lift coefficients are calculated, and the method for estimation of pressure on cylinder surface and the outer boundary limit are developed.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.1
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• pp.32-37
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• 2018

When designing high temperature piping system, creep phenomena must be considered. Since ASME code does not provide detailed methods of design by rule (DBR) for high temperature piping, Finite element analysis should be performed. However, In the case of piping system with frequent design changes, creep analysis of the entire piping system for every change is ineffective and practically impossible. Therefore, based on elastic and elastic-plastic analysis, which takes a relatively short time, the creep stress is predicted by using elastic follow-up factor method provided in R5 code and plastic-creep analogy presented by Hoff. The predicted creep stress for a virtual piping system was compared with the creep analysis result and the two results showed similar stress relaxation tendency in time.

• Water for future
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• v.31 no.4
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• pp.291-297
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• 1998

The two dimensional time dependent flow past a circular cylinder is analyzed numerically. In the analysis, equations of conservation of mass and momentum are transformed to equations of stream function-vorticity and vorticity transport, and nondimensionalized by nondimensional parameters representing flow characteristics, The resulting stream function-vorticity equation and vorticity transport equation are solved by successive over relaxation scheme and alternating direct implicit scheme. Numerical experiments are performed for the flow in the range of Reynolds number 125 to 275. The time dependent streamlines, vorticities, pressure on cylinder surface, separation angle, and drag and lift coefficients are calculated, and the method for estimation of pressure on cylinder surface and the outer boundary limit are developed.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.471-476
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• 2000

DA-8159, a new phosphodiesterase 5 inhibitor, was assessed for its erectogenic potential by a penile erection test in rats, the relaxation of isolated rabbit corpus cavernosum (CC), and estimation of the intracavernous pressure (ICP) in the anesthetized dog. Oral administration of DA-8159 (0.3 to 1 ${\mu}g/kg$ ) increased the number of erections in rats with increasing dosage, with the highest penile erection index at 10 ${\mu}g/kg$ DA-8159 induced the relaxation of phenylephrine (PHE)-induced contractions in the rabbit CC and decreased the $IC_{50}$ of the nitric oxide donor sodium nitroprusside (SNP) in a dose-dependent fashion. In pentobarbital-anesthetized dogs, the intravenous administration of DA-8159 (1~300 ${\mu}g/kg$ ) potentiated the increase in ICP induced by the intracavernosal SNP in a dose-related manner. These findings suggest that DA-8159 has significant therapeutic potential in the treatment of erectile dysfunction.