• Journal of Biomedical Engineering Research
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• v.18 no.1
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• pp.25-36
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• 1997

To regulate cardiac output of the Total Artificial Heart(TAH) physiologically, the hemodynamic information must be toed back to the controller. So far, our group has developed an automatic cardiac output control algorithm using the motor current waveform, It is, however difficult to detect the preload level such as a filling status of ventricular inflow and the variation of atrial pressures within normal physiologic range(0-15 mmHg) by analyzing the motor current which simultaneously reflects the afterload effect. On the other hin4 the interventricular volume pressure(IVP) which is not influenced by arterload but by preload is a good information source for the estimation of preload states. In order to find the relationship between preload and IVP waveform, we set up the artificial heart system on the Donovan type mock circulatory system and measured the IVP waveform, right and left atrial pressures, inflow and outflow waveforms and the signals represented the information of moving actuator's position. We shows the feasibility of estimating the hemodynamic changes of inflow by using IVP waveform. fife found that the negative peak value of IVP waveform is linearly related to atrial pressures. And we also found that we could use the time to reach the negative peak in IVP waveform, the time to open outflow valve, the area enclosed IVP waveform as unfu parameters to estimate blood filling volume of diastole ventricle. The suggested method has advantages of avoiding thrombogenesis, bacterial niche formation and increasing longterm reliability of sensor by avoiding direct contact to blood.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.11
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• pp.770-775
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• 2007

Although these days application of heat recovery ventilation and improved kitchen ventilation system came into wide use in mixed-use residential buildings and exclusive residences, there are not enough ventilation systems except the local ventilation of kitchens and rest rooms. It is very important part to regulate and distribute correct air flow rate for controlling air change rate. The purpose of this study is to investigate the application of distributor at house ventilation system by comparing a duct system with out distributor and with distributor. The results of this study are as follows. (1) When using distributor though the size of duct diameter is reduced rapidly, the pressure loss doesn't rise largely. The pressure loss without distributor is 4.08 mmAq, the pressure loss with distributor 4.10 mmAq. (2) To use distributor can reduce materials of duct and secure enough ceiling space by reducing duct diameter. (3) Diameters and air flow paths of distributor on the design stage are important part for accurate air flow rate.

• Molecules and Cells
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• v.37 no.1
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• pp.81-87
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• 2014

Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development of next-generation RNA sequencing has improved our understanding of the qualitative signatures associated with alternative splicing in various biological conditions. However, the role of alternative splicing in cardiac hypertrophy is yet unknown. The present study employed RNA-Seq and a bioinformatic approach to detect the RNA splicing regulatory elements involved in alternative splicing during pressure-overload cardiac hypertrophy. We found GC-rich exonic motifs that regulate intron retention in 5' UTRs and AT-rich exonic motifs that are involved in exclusion of the AT-rich elements that cause mRNA instability in 3' UTRs. We also identified motifs in the intronic regions involved in exon exclusion and inclusion, which predicted splicing factors that bind to these motifs. We found, through Western blotting, that the expression levels of three splicing factors, ESRP1, PTB and SF2/ASF, were significantly altered during cardiac hypertrophy. Collectively, the present results suggest that chronic pressure-overload hypertrophy is closely associated with distinct alternative splicing due to altered expression of splicing factors.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3259-3263
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• 2007

This paper describes the proceedings of creating countermeasures after analysis and maintenance be able to conduct operation safely in a power plant. in order to operate the power plant in a stable and reliable way, the best condition of the govemor system can be maintained through the response characteristic analysis of the control device for the pitch blade control hydraulic actuator. The fan pitch blade control hydraulic actuator of a 500MW large-scale boiler is frequently operated under normal operation conditions. Common problems or malfunctions of the pitch blade control hydraulic actuators leads to the decline of boiler thermal efficiency and unexpected power plant trip. The inlet and outlet gas can be controlled by using the fan pitch blade control hydraulic actuator in order to regulate the internal pressure of the furnace and control the frequency in the power plant facility which utilizes soft coals as a power source.

• Proceedings of the KSME Conference
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• 2001.06c
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• pp.263-268
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• 2001

MCPs means Micro Cellular Plastics. The micro-cells are generated in the products by the difference of dissolution through the pressure drop after super critical fluid of CO2 or N2 dissolves into polymer. We have developed injection molding process adopting MCPs and applied it to a broad range of injection molded thermoplastic materials and applications. It can prevent the leakage of impact strength and increase the thermal conductivity, moreover regulate the thermal conductivity. Then we can develop the high strength foaming plastics. Also, it can be gained a competitive advantage by utilizing its processing benefits, e.g. the lightweight products and significant reductions in material consumption.

• Proceedings of the KIEE Conference
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• 2004.07d
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• pp.2260-2262
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• 2004

After steam turbines in power plant drives generator and maintains it at rated speed using high temperature and high pressure steam energy, they regulate the output of generator when synchronized in parallel with the power system. By the way, as the steam flow into turbine can not be reduced fast even though the electrical load is lost, the turbine gets into dangerous situation due to the increase of its speed. At this time, the duty of the turbine governor is "how to limit the speed within its overspeed trip setpoint and escape from danger." For the purpose of it, there are various ways known. Some overspeed protection methods for steam turbines now being operating in korea are introduced in this paper.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1661-1662
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• 2008

After steam turbines in power plant drives generator and maintains it at rated speed using high temperature and high pressure steam energy, they regulate the output of generator when synchronized in parallel with the power system. By the way, as the steam flow into turbine can not be reduced fast even though the electrical load is lost, the turbine gets into dangerous situation due to the increase of its speed. At this time, the duty of the turbine governor is "how to limit the speed within its overspeed trip setpoint and escape from danger." In order to implement this purpose, there are various ways different from valve position control. So, in this paper, the various methods for overspeed protection are introduced in comparison with valve position control.

• Transactions of The Korea Fluid Power Systems Society
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• v.4 no.2
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• pp.28-33
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• 2007

In the power plant facility which use soft coal as a power source the fan pitch blade control hydraulic actuator is used to control the inlet and outlet gas to regulate the internal pressure of the furnace and control the frequence. Sometimes malfunctions of this equipment lead to the decline of boiler thermal efficiency and unexpected power plant trip. In order to localize the fan pitch blade control hydraulic actuator specially for the 500MW large scale boiler, Analysis and modelling of the system is carried out mathematically. The responses of the system are examined by using matlab simulation fur the variation of the major parameters in view of reverse engineering. Consequently the validity of the established parameters are examined.

• 한국신재생에너지학회:학술대회논문집
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• 2008.10a
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• pp.6-9
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• 2008

The efficiency and life time of the proton exchange membrane (PEM) fuel cell system is critically changed with its humidity which should be maintained properly during dynamic operation. Membrane humidifier is required to regulate proper humidity level for the design point of the PEMFC system. In this study, we presented the performance of the cylindrical membrane humidifier which is operated as water-to-gas. Dry air pressure, liquid water flow temperature, and air flow rate were chosen as the operating parameters. Humidity level is expressed with dew point.

• Proceedings of the Korean Biophysical Society Conference
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• 2002.06b
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• pp.35-35
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• 2002

The large conductance $Ca^{2＋}$ -activated $K^{＋}$ channels ($BK_{Ca}$) in vascular smooth muscle have been considered to function as a negative feedback in pressure-induced vasoconstriction. In the present study, the function of cytoskeletons in the regulation of $BK_{Ca}$ and its stretch sensitivity was investigated. Using the inside-out patch clamp technique, we recorded single channel activities of $BK_{Ca}$ with 150 mM KCl in the bath solution (pCa=6.5).(omitted)itted)