Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Actin Filaments Regulate the Stretch Sensitivity of Large Conductance $Ca^{2+}$-Activated $K^+$ Channel in Rabbit Coronary Arterial Smooth Muscle Cells

  • Lin Piao (Department of Physiology, College of Medicine, Seoul National University) ;
  • Earm, Yung-E (Department of Physiology, College of Medicine, Seoul National University) ;
  • Wonkyung Ho (Department of Physiology, College of Medicine, Seoul National University)
  • Published : 2002.06.01
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Abstract

The large conductance $Ca^{2＋}$ -activated $K^{＋}$ channels ($BK_{Ca}$) in vascular smooth muscle have been considered to function as a negative feedback in pressure-induced vasoconstriction. In the present study, the function of cytoskeletons in the regulation of $BK_{Ca}$ and its stretch sensitivity was investigated. Using the inside-out patch clamp technique, we recorded single channel activities of $BK_{Ca}$ with 150 mM KCl in the bath solution (pCa=6.5).(omitted)itted)

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