• Advances in pediatric surgery
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• 제9권1호
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• pp.19-23
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• 2003

Necrotizing Enterocolitis (NEC) is usually a disease of premature infants, but occasionally it affects the term neonate. Twenty-five infants with NEC were treated at Asan Medical Center between January 2000 and December 2002, and 13 of them were term infants. In each case, the diagnosis of NEC was established by a clinical illness fulfilling the Bell's stage II or III NEC as modified by Walsh or by surgical findings. There were six males and seven females. The birth weight was from 1,960 to 3,700 g. The age at diagnosis was from 1 to 40 days. Four patients had congenital heart disease: one of who had hypothyroidism and cleft palate. Abdominal distension was present in all, and bloody stools in four. One patient had history of hypoglycemia, three had Rota viral infection. Eight patients had leucopoenia (<$5.0{\times}10^9/L$), seven had thrombocytopenia (<$100{\times}10^9/L$), and three severe thrombocytopenia (<$50{\times}10^9/L$). Laparotomy was required in 10 of the 13 patients. Indications for operation in the acute phase were failure to respond to aggressive medical therapy in five, and perforation in three patients. There were two late phase operations for intestinal stricture and fistula. There were no operative complications. Ten of thirteen patients survived (76.9%). Two patients died of septic complication. There was a delayed death due to heart failure. There was a significant difference in survival according to platelet count ($50{\times}10^9/L$) (p<0.05). Congenital heart disease and Rota viral infection are associated with NEC in term infants and thrombocytopenia and leucopoenia may be surgical indications.

• Journal of Yeungnam Medical Science
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• 제18권2호
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• pp.287-292
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• 2001

1999년 5월부터 1999년 8월까지 영남대학교 의과대학 부속병원 산부인과에서 정상적으로 출생한 여아 68명을 대상으로 출생당시부터 출생 4일 사이의 신생아들의 음핵크기와 너비를 측정하였다. 본원에서 측정한 신생아들의 평균 음핵 길이의 크기는 $4.7{\pm}1.93$ mm, 음핵귀두의 너비는 $2.6{\pm}1.48$ mm, 음핵귀두의 길이는 $2.4{\pm}1.14$ mm였다. 본 연구에서 재태 기간과 신생아 출생 사이의 음핵 크기 사이에는 유의한 상관관계가 없었고 출생 체중과 음핵 크기 비교에 있어 저체중출생아와 정상체중출생아 사이에는 유의한 상관관계가 있었으며 과체중출생아와 정상체중출생아 사이에는 유의한 역상관관계가 있었다. 태생기에 있어 성호르몬의 분비이상은 태아 성기관의 발달에 이상을 초래하게 되어 출생시에 외생식기의 이상을 나타나게 되는 이를 근거로 성호르몬 분비이상을 확인하게 되어 조기진단에 도움을 받을 수가 있다. 이를 위해 한국 신생여아의 음핵과 음핵귀두 크기의 기준치 설립은 음핵비대여아의 조기 발견에 유용한 지표가 될 수 있다.

• Child Health Nursing Research
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• 제20권1호
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• pp.20-29
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• 2014

목적 본 연구는 미숙아를 위한 수유 프로토콜을 개발하고 적용하여 그 효과를 검증하기 위하여 시행되었다. 방법 미숙아 수유 프로토콜의 개발을 위해 전문가 집단을 구성하고, 문헌고찰과 협의를 통해 작성된 프로토콜에 대해 내용타당도 검증과 예비조사를 실시하여 확정하였다. 개발된 프로토콜은 비동등성대조군 전후시차설계로 B시의 P대학교병원에서 태어난 37주 미만의 미숙아 85명에게 적용되었다. 대조군(n=38)에게 2013년 1월부터 4월까지 일반적인 미숙아 수유관리가 시행되었고, 실험군(n=35)에게는 2013년 6월부터 9월까지 본 연구를 통해 개발된 미숙아 수유 프로토콜이 적용되었다. 수집된 자료는 SPSS 18.0 WIN program을 통하여 t-test와 ${\chi}^2$-test로 분석하였다. 결과 실험군은 대조군보다 첫 수유시간(t=2.22, p =.029)과 완전장관영양에 이르는 기간(t=2.28, p =.026)이 통계적으로 유의하게 감소하였다. 그러나 실험군과 대조군의 생후 7일째 체중 감소율(t=-1.23, p =.222)과 합병증 발생률(p >.05)은 통계적으로 유의한 차이가 없었다. 결론 미숙아 수유 프로토콜 적용을 통하여 미숙아들의 첫 수유시간과 완전장관영양에 이르는 기간이 단축되었다.

• Neonatal Medicine
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• 제25권4호
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• pp.161-169
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• 2018

Purpose: We assessed the influence of antenatal corticosteroid (ACS) on the inhospital outcomes of intrauterine growth restriction (IUGR) infants. Methods: A retrospective study was conducted with singletons born at $23^{+0}$ to $33^{+6}weeks$ of gestation at Seoul National University Hospital from 2007 to 2014. We compared clinical outcomes between infants who received ACS 2 to 7 days before birth (complete ACS), at <2 or >7 days (incomplete ACS), and those who did not receive ACS in IUGR and AGA infants. Multivariate logistic regression using Firth's penalized likelihood was performed. Results: 304 neonates with 91 IUGR neonates were eligible. Among AGA neonates, mortality (adjusted odds ratio [aOR], 0.13; 95% confidence interval [CI], 0.02 to 0.78), hypotension within 7 postnatal days (aOR, 0.20; 95% CI, 0.06 to 0.64), and severe bronchopulmonary dysplasia (BPD) or death (aOR, 0.24; 95% CI, 0.07 to 0.77) were lower in complete ACS group after adjusting for pregnancy induced hypertension and uncontrolled preterm labor. Mortality (aOR, 0.18; 95% CI, 0.04 to 0.78), hypotension (aOR, 0.26; 95% CI, 0.09 to 0.70), and severe BPD or death (aOR, 0.33; 95% CI, 0.12 to 0.92) were also lower in the incomplete ACS group. Among IUGR infants, after adjusting for birth weight and 5-minute Apgar score, inhaled nitric oxide use within 14 postnatal days was lower in both complete ACS (aOR, 0.07; 95% CI, 0.01 to 0.67) and incomplete ACS (aOR, 0.04; 95% CI, 0.01 to 0.37) groups. Conclusion: ACS was not effective in reducing morbidities in IUGR preterm infants.

• 한국축산식품학회지
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• 제38권2호
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• pp.376-390
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• 2018

Cronobacter species have been associated with disease outbreaks and sporadic infections, particularly in premature and immunocompromised infants. Cronobacter species can cause foodborne infections such as neonatal meningitis, septicaemia and necrotising enterocolitis. Accordingly, there is an urgent need to control and monitor the Cronobacter species in food, especially in powdered infant formula (PIF) and other baby foods. Therefore, in this review, the isolation and prevalence of Cronobacter species in infant food including PIF and the recent advance of detection methods are discussed for the better understanding on the current research status of Cronobacter species.

• Tuberculosis and Respiratory Diseases
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• 제55권1호
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• pp.107-112
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• 2003

A congenital cystic adenoid malformation of the lung(CCAM) is characterized by an anomalous fetal development of the terminal respiratory structures, resulting in the adenomatoid proliferation of the bronchiolar elements and cystic formation. CCAM has been detected on the fetus, premature babies and stillborn as well as infants and children. An adult presentation of CCAM is extremely rare. When cystic lesions occur with a repeated infection, an evaluation of the cystic lesions requires a differential diagnosis of CCAM, sequestration, a lung abscess, a pneumatocele and a bronchogenic cyst. The definite treatment of CCAM is the surgical removal of the involved lobe. We report a case of a CCAM in a 24-year-old female with a brief review of the relevant literature.

• Clinical and Experimental Pediatrics
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• 제52권1호
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• pp.22-27
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• 2009

Retinopathy of prematurity (ROP) is a major cause of blindness that affects premature infants. With advances in neonatology, ROP is likely to emerge as the most serious problem of vision loss in children even in developed countries; such a situation could be called the third epidemic of ROP. However, controversy and uncertainty still surround favorable outcomes of ROP. For successfully controlling ROP, timely and accurate screening is crucial because early treatment leads to favorable outcomes. Standard guidelines, including ROP classification, have provided satisfactory instructions for the screening and treatment of ROP. To improve the structural and functional outcomes of ROP, optimizing the timing of surgical interventions including cryotherapy, laser-photocoagulation, encircling, and vitrectomy is essential; these interventions can prevent the sequelae of ROP. It is essential for the neonatologist and the ophthalmologist to cooperate extensively for the successful treatment of ROP.

• Journal of Genetic Medicine
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• 제15권2호
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• pp.115-119
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• 2018

The 16p11.2 microdeletion has been reported in patients with developmental delays and intellectual disability. The distal 220- kb deletion in 16p11.2 is associated with developmental delay, autism spectrum disorder, epilepsy, and obesity at a young age. We have reported a case of distal 16p11.2 deletion syndrome in a preterm infant with unusual facial morphology and congenital heart disease. We suggest using chromosome microarray analysis to detect chromosomal abnormalities in newborns, especially preterm infants with unusual morphologies.

• Journal of Korean Neurosurgical Society
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• 제66권3호
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• pp.289-297
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• 2023

Technological advances in neonatology led to the improvement of the survival rate in preterm babies with very low birth weights. However, intraventricular hemorrhage (IVH) has been one of the major complications of prematurity. IVH is relevant to neurodevelopmental disorders, such as cerebral palsy, language and cognitive impairments, and neurosensory and psychiatric problems, especially when combined with brain parenchymal injuries. Additionally, severe IVH requiring shunt insertion is associated with a higher risk of adverse neurodevelopmental outcomes. Multidisciplinary and longitudinal rehabilitation should be provided for these children based on the patients' life cycles. During the infantile period, it is essential to detect high-risk infants based on neuromotor examinations and provide early intervention as soon as possible. As babies grow up, close monitoring of language and cognitive development is needed. Moreover, providing continuous rehabilitation with task-specific and intensive repetitive training could improve functional outcomes in children with mild-to-moderate disabilities. After school age, maintaining the level of physical activity and managing complications are also needed.

• Clinical and Experimental Pediatrics
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• 제52권11호
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• pp.1228-1233
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• 2009

목 적 : 34주 이하로 출생한 미숙아에서 병원도착시점에서 분만까지 소요된 시간이 짧은 경우 향후 뇌성마비 발생과 관련이 있는지 알아보고자 하였다. 방 법 : 34주 이하의 미숙아 142례를 대상으로 하였다. 산모의 내원시점에서 분만까지 소요된 시간(소요시간)을 측정하였고 한국형 영유아 발달 검사 및 신경학적 검사를 통해 뇌성마비를 진단하여 분만에 소요된 시간과 뇌성마비 발생과의 상관관계 여부를 알아보았다. 결 과 : 병원 도착시점에서 분만에 이르는 시간이 짧으면 짧을수록 조대운동 발달지수가 낮아지고 뇌성마비의 발현빈도가 높아지는 경향을 보인 기본적인 결과 외에 1분 및 5분 Apgar 점수가 모두 작아지는 경향을 보였고 분만까지 소요된 시간이 짧을수록, 특히 분만에 소요된 시간이 6시간 이내인 경우 RDS의 발생가능성이 높은 것으로 나왔으며 제태기간이 짧을 가능성이 높은 것으로 나왔다. 그러나 다인자 분석에서 소요시간은 뇌성마비 발생에 영향을 주지 못하는 것으로 나왔다. 결 론 : 34주 이하로 출생한 미숙아에서 병원도착시점에서 분만까지 소요된 시간은 뇌성마비의 발생에 영향을 주지 못하는 것으로 나왔다. 그러나 본 연구에서는 급박하게 이루어진 분만이 뇌성마비 발생에 영향을 줄 수 있는 가능성에 접근하는 결과를 보여 향후 추가적인 연구가 있어야 할 것으로 사료된다.