• Annals of Clinical Neurophysiology
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• 제6권2호
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• pp.103-105
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• 2004

Horner's syndrome may rarely accompany herpes zoster ophthalmicus (HZO). A 78-year-old woman suffered from HZO accompanied ipsilateral ptosis and miosis. Before skin eruption, she was diagnosed as a paratrigeminal syndrome of Raeder. She was treated with intravenous acyclovir and prednisone for 7 days. Ptosis and miosis was not completely improved after 5 months of follow-up.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 추계학술대회
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• pp.143-143
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• 2008

• 한국임상수의학회지
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• 제28권2호
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• pp.262-266
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• 2011

체중 2.2 kg 4년령 수컷 Maltese 개가 호흡곤란과 고체온증 평가를 위해 건국대학교 부속 동물병원에 내원하였다. 신체 검사에서 호흡곤란을 확인 하였으며, 오른쪽 흉강 청진상에서 희미한 심음을 확인하였다. 방사선 검사와 CT검사에서 오른쪽 중간엽의 경화와 흉수 및 복수를 확인하였다. 탐색적 개흉술을 통해 $360^{\circ}C$ 염전 된 오른쪽 중간엽을 확인하였으며 TA 장치를 이용 염전된 폐엽을 절제하였다. 복수 원인을 확인하기 위해 탐색적 개복술을 통한 소장생검을 실시하였으며, 조직 검사를 통해 림프관 확장증을 확인 하였다. 림프관 확장증 치료를 위해 prednisone과 저지방 사료를 사용하였으며, 임상증상의 개선을 확인하였다.

• 대한수의학회지
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• 제47권4호
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• pp.475-478
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• 2007

A 4-year-old spayed female, Yorkshire terrier dog with a history of petechial and ecchymotic hemorrhages on the face, trunk and hind limb was referred to Veterinary Medical Teaching Hospital, Cheju National University. The complete blood count revealed a marked thrombocytopenia ($96{\times}10^3/{\mu}l$). The biochemical profile showed only slightly increased glucose. The coagulation profile such as prothrombin time and activated partial thromboplastin time, was within the reference range. In Giemsa staining, there were no endoparasites like as Babesia spp. on the RBC. This case was diagnosed as a idiopathic thrombocytopenia in a Yorkshire terrier dog. She was treated with prednisone (1 mg/kg BW, IM q 12 h) and cephalosporin (10 mg/kg BW, IM, q 12 h). When rechecked on day 6, the platelet was within reference range ($507{\times}10^3/{\mu}l$) and also petechial and ecchymotic hemorrhages on the body were gradually improved without any complications. The dose of prednisone was decreased to 0.5 mg/kg BW, q 24 h. On day 17, we finished treatment because all the clinical signs, blood and serum chemistry were reference range and platelet count was dramatically increased.

• 분석과학
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• 제23권4호
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• pp.405-413
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• 2010

축산물(소의 근육 및 간)중에 잔류하는 합성 글루코코티코이드 6종 (betamethasone, dexamethasone, prednisone, prednisolone, methylprednisolone, flumethasone)에 대한 동시분석방법을 확립하였다. 효과적인 기기분석을 위해서 시료는 C18 고체상 카트리지를 사용하여 에틸아세테이트 용매를 사용하여 추출/정제하였다. C18 컬럼을 사용하여 분리한 후 음이온 전기분무 질량분석법의 multiple reaction monitoring 방법을 사용하여 정량 및 정성 분석을 수행하였다. 효과적이고 감도있는 HPLC-MS/MS 분석을 위해서 0.1% 포름산이 포함된 물과 아세토나이트릴이 이동상 용매로 사용되었다. 메트릭스와 약물의 종류에 따라서 검출한계(LOD)는 $0.2-0.1\;{\mu}g$/kg, 정량한계(LOQ)는 $0.8-3.4{\mu}g$/kg 이었으며, 회수율은 89.5-119.6%이었다. 확립된 기존의 방법들에 비해 6종의 글루코코티코이드의 동시분석 방법이 간소화되었고, 좋은 정확도, 정밀도 및 회수율을 나타내었으며, 축산 육류 중에 잔류하는 글루코코티코이드들 분석하는데 사용될 수 있을 것이다.

• 한국임상약학회지
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• 제10권2호
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• pp.51-56
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• 2000

Deflazacort, an oxazoline derivative of prednisolone, has been claimed to have anti-inflammatory effects with fewer side effects compared to prednisone. The objectives of the study were to evaluate efficacy and safety of deflazacort in children with nephrotic syndrome. Eligible Patients were the children with nephrotic syndrome who were treated with deflazacort from October. 1994 to April. 1999. Nephrotic syndrome was defined as having albumin level of less than 2.5 mg/dL and 24-hour urinary protein excretion of greater than $40\;mg/m^2/hr$. The primary parameters evaluating the efficacy of deflazacort were response rate, time to respond and relapse frequency. The safety profiles were the impact on children's growth, calcium sparing effect, glucose metabolism, lipid profile and adverse drug reactions. As results, total of 60 children were evaluated (47 boys, 13 girls). Response rate was $95\%$ (57/60) for initial and late responders. Median time to respond was 12 days (range 7-110 days) and median relapse frequency was one time (range 0-6). Weight/height ratio increased from $22.05\pm3.47\;to\23.20\pm3.44\;kg/m$ (p<0.001) and plasma calcium level, from $7.55\pm3.86\;to\;9.98\pm3.77\;mg/dL$ after treatment (p<0.001). Change of fasting glucose level was not statistically significant $(91.92\pm3.53\;vs.\;98.19\pm4.78\;mg/dL,\;p=0.072)$, while change of total cholesterol was significant $(362.3\pm12.0\;vs\;251.4\pm11.5\;mg/dL$, p<0.001). In conclusion, patients on deflazacort showed similar efficacy in treatment of nephrotic syndrome as reported for prednisone with less impact on growth inhibition and metabolic side effects of hyperglycemia and hyperlipidemia.

• Pediatric Infection and Vaccine
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• 제4권1호
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• pp.174-182
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• 1997

Pneumocystis carinii pneumonia mainly occurs in immunocompromised patients and it is also known of major cause of death in children with acute lymphoblastic leukemia. After consolidation chemotherapy, acute lymphoblastic leukemia children is developed Pneumocystis carinii pneumonia frequently no an opportunistic infection but there were no controlled studies which have been performed to evaluate the usefulness of corticosteroid in Pneumocystis carinii pneumonia with acute lymphoblastic leukemia. We experienced a case of Pneumocystis carinii pneumonia in acute lymphoblastic leukemia with febrile neutropenic 6 years old girl. She was treated with trimethoprim-sulfamethoxazole and prednisone. We report this case with brief review of related literature.

• Annals of Clinical Neurophysiology
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• 제13권2호
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• pp.97-100
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• 2011

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated polyneuropathy. Corticosteroids, intravenous immunoglobulin (IVIG) and plasmapheresis have been reported to be effective treatment. Rarely, CIDP can occur in the patients with HIV infection. The clinical features and electrophysiological findings of CIDP are known to be similar in patients with and without HIV infection. We report a 30-year-old male with HIV infection associated CIDP who improved after the administration of intravenous immunoglobulin and long term oral prednisone.

• 대한수의사회지
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• 제27권5호
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• pp.288-290
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• 1991

개의 여러가지 질병상태에서 근복적인 치료나 보조적인 치료제로서의 flumethasone 투여는 아주 좋은 치료효과를 나타냈다. 우리가 병원에서 상용하는 flumethasone의 평균 투여량은 0.125$\~$0.5mg으로서 경구 또는 주사로 투여했다. 경구적으로 투여하는 주된 사용량은 1일 0.03125mg$\~$0.125mg이며 환축의 크기, 치유과정 그리고 병증의 심한 정도에 따라 양을 가감했다. 투여경로를 달리하여도 약효에 차이가 생기지는 않았다. flumethasone의 소염효과, 당신생효과 및 항독소적 치료효과에서 기존의 corticoids 투여시 나타나는 효과에 비해 정성적인 차이는 없었으나 실험실 결과와 병원에서 사용한 임상결과 flumethasone은 hydrocortisone보다 300$\~$400배 그리고 prednisone이나 prednisolone 보다는 60$\~$80배나 강한 약효를 발휘하는 것으로 나타났다. 임상적용에서 나타난 감동적인 효과에서 이러한 flumethasone의 약효에 대한 자료들이 입증되었다. 또한 치료된 동물들이 보여준 반응은 flumethasone의 약효 지속시간이 기존의 corticoids보다 더 긴 것으로 나타났다. 앞에서 언급했듯이 flumethasone 투여시는 전해질 불균형에 의해 유발되는 다음다갈증이나 다뇨증, 식욕촉진 등의 부작용이 전혀 나타나지 않았다. 이러한 flumethasone의 안전성은 기존의 corticoids로 비만동물이나 나이든 환축을 치료할때 자주 나타났던 부작용업이 장기간 치료할 수 있으므로 아주 중요하다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.395.2-395.2
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• 2002

The determination method for 11 corticosteroids (betamethasone, cortisol. cortisone, cortisone acetate. dexamethasone. cortisol acetate, isoflupredone acetate, methylprednisolone. prednisone, prednisolone, and triamcinolone acetonide) in a herbal medicinal preparation (Sibjeondaibotang) by a gas chromatography-mass spectrometric (GC-MS) method with selected ion monitoring (SIM) mode is described. Samples (4 mL) were extracted by liquid-liquid extraction with diethyl ether. (omitted)