• 대한한방소아과학회지
• /
• 제31권1호
• /
• pp.63-73
• /
• 2017

Objectives The purpose of this study is to analyze recent clinical studies on treatment for precocious puberty. Methods 28 clinical studies from January 2009 to December 2016 about precocious puberty from the China Academic Journal (CAJ), China National Knowledge Infrastructure (CNKI), were selected and reviewed: 22 case control studies and 6 case series. Results The main traditional Chinese medicine (TCM) treatment was the herbal decoctions and granules. The frequently used herbs were root of Bupleurum falcatum (柴胡), fruit of Prunella vulgaris var. aleutica (夏枯草), root stem of Anemarrhena asphodeloides (知母), dried fungus nucleus of Poria cocos (茯苓), Rehmannia glutinosa var. purpurea (生地黃), peony Paeonia suffruticosa Andrews (牧丹皮), bark of Phellodendron amurense (黃柏), roots of a plant Paeoniae lactiflora (白芍藥). On the other hand, the main western medicine (WM) for precocious puberty was Gonadotropin-releasing hormone agonist (GnRHa). Total effective rate of the TCM group was 62.96-100%, that of the WM group was 36.6-93.3% and that of the TCM-WM group was 77.8-93.75%. Conclusions Traditional Chinese medicine has been shown as an effective treatment for precocious puberty. These research results can be utilized in other clinical studies and in treatment of precocious puberty.

• 대한한방부인과학회지
• /
• 제30권3호
• /
• pp.20-28
• /
• 2017

Objectives: This review aims to report the efficacy of Oriental herbal medicine for Female Idiopathic Precocious Puberty Methods: We searched clinical study about precocious puberty from Pubmed, OASIS, Korea Traditional Knowledge Portal and National Assembly Library up to July 2017. Results: Four case reports have been identified. Six cases in total were found. And in the four cases where estradiol (E2) levels were above the normal levels in pre-treatment, the figures dropped to the normal levels in post-treatment. In the three cases with breast development and breast pain in pre-treatment, symptoms improved after the treatment. And, the sustained growth of height was reported in the four cases with the treatment duration of 30 days or more. Conclusions: It has been identified that oriental medicine assisted improvements of hormone levels and breast pain and growth of height on patients with precocious puberty, yet more case reports and well-designed studies would be necessary to guide better oriental herbal medicine treatment of precocious puberty.

• 대한한방소아과학회지
• /
• 제22권1호
• /
• pp.163-187
• /
• 2008

Objectives The aim of this study was to investigate the treatment of precocious puberty in current traditional Chinese medical journals. Methods To figure out diagnosis methods, treatment methods, treatment effects of oriental medicine about precious puberty, Chinese medical journals from China National Knowledge Infrastructure (CNKI) which was published from 1999 to 2007 were analyzed and precocious puberty was also been searched. Results 82 articles were selected. 1. Yin and purging Fire(滋陰瀉火) from traditional Chinese Medicine was usually used. 2. The herbs were almost used such as Rehmannia glutinosa(地黃), Anemarrhena asphodeloides (知母), Phellodendron amurense(黃柏), Thesium chinense(夏枯草), Paeonia suffruticosa Andrews(牧丹皮), Alisma canaliculatum(澤瀉), Testudinis Plastrum(龜板), Paeonia japonica(白芍藥), Bupleurum falcatum(柴胡), Genianae Scabrae Radix(龍膽草). 3. The total improvement rate was 72.50 to 100% Conclusions The oriental medical treatments for precocious puberty were presumed to be effective, but more studies are still needed.

• 한국산학기술학회논문지
• /
• 제18권11호
• /
• pp.653-662
• /
• 2017

본 연구 목적은 우리나라 성조숙증 여아들의 신체상 부모특성 및 행동특성이 성조숙증에 미치는 관련성을 파악하여 성조숙증 예방 및 관리를 위한 기초 자료를 제공하는 것이다. 연구대상 조사기간은 2016년 6월 1일부터 2017년 2월 25일까지였으며, 연구의 대상자는 서울시 소재 어린이전문 H한의원과 S한의원에 성조숙증으로 내원한 환자군 여아 104명과 대조군 A그룹 104명, 지방 군단위 소재 초등학교 여아의 대조군 B그룹 104명으로, 성별과 연령을 짝지은 총 312명과의 비교를 통해 성조숙증 여아와 정상 발달 여아의 신체상 부모특성 및 행동특성을 파악하고자 집단 간 특성을 t-test, $X^2test$, ANOVA 분석을 통해 비교하고, 성조숙증의 영향요인은 이항로지스틱(Multinomial logistic)회귀분석으로 분석하였다. 연구결과 성조숙증에 미치는 주요 영향요인은 첫째, 신체 및 부모특성에서 본인 신장과 어머니 초경연령이 도출되었다. 둘째, 행동특성의 식습관에서 고기류 섭취횟수와 외식빈도가 도출되었다. 셋째, 행동특성의 일상생활에서 TV시청과 스마트폰 사용시간, 수강학원 수가 도출되었다. 따라서 증가하는 여아의 성조숙증에 대해 부모와 학교 나아가 사회적 관심이 중요하며 성조숙증에 대한 발생원인과 발생빈도를 밝히는 광범위한 연구수행이 필요하다.

• 한국산학기술학회논문지
• /
• 제13권7호
• /
• pp.3123-3131
• /
• 2012

본 연구자는 만8세 미만의 초등학교 여아들의 조기성조숙 현황을 조사하고 조기성조숙에 영향을 미치는 인자에 대해서 연구하고자 하였다. 고령군에 소재한 초등학교 G, D 2개의 초등학교 1,2,3학년 여학생을 전수 253명을 대상으로 학부모의 동의를 얻어 성 발달정도 및 비만의 정도, 생활습관(운동습관, 식습관, 수면습관 등), 가정환경 등을 조사하여 조기성조숙 발현의 영향인자를 통계학적으로 분석하였다. 총 253명의 학생을 대상으로 조사하였으며 각 연령에서 성조숙 현상을 보인 여아는 6세 90명중 에서 7명(7.8%), 7세 68명 중에서 9명(13.2%), 8세 95명 중 50명(52.6%)으로 나타났고 전체 253명중 66명(26.1%)이였다. 조기성조숙에 영향을 미치는 인자로 통계적으로 유의성이 나타난 것은 비만도, 인스턴트섭취빈도, TV시청시간, 스트레스, 가족형태(결손가정)이었다. 비만도가 높을수록, 인스턴트 섭취 빈도가 높을수록, 스트레스가 많을수록, 결손가정에서 성 발달이 빨랐다. 본 연구의 결과 만8세 미만의 초등학교 저학년 여아 중 26.1%가 조기성조숙으로 나타났으며, 조기성조숙의 발현에 영향을 미치는 인자는 비만도, 인스턴트섭취 빈도, 스트레스, 가족형태(결손가정)등으로 조사 되었다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제42권
• /
• pp.30.1-30.7
• /
• 2020

Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs). Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively. Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP. Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.

• 대한한방소아과학회지
• /
• 제36권3호
• /
• pp.1-18
• /
• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.

• Clinical and Experimental Pediatrics
• /
• 제55권1호
• /
• pp.6-10
• /
• 2012

Human puberty is a complex, coordinated biological process with multiple levels of regulations. The timing of puberty varies greatly in children and is influenced by both environmental and genetic factors. The key genes of pubertal onset, $KISS1$, $GPR54$, $GNRH1$ and $GNRHR$, may be major causal factors underlying gonadotropin-releasing hormone-dependent precocious puberty (GDPP). Two gain-of-function mutations in $KISS1$ and $GPR54$ have been identified recently as genetic causes of GDPP. $GNRH1$ and $GNRHR$ are also gene candidates for GDPP; however no mutations have been identified in these genes. Presently potential genetic causes like $LIN28B$ continues to appear; many areas of research await exploration in this context. In this review, I focus primarily on the genetic causes of GDPP.

• Clinical and Experimental Pediatrics
• /
• 제46권4호
• /
• pp.400-403
• /
• 2003

진단이 지연되었거나 적절하게 치료되지 않은 선천성 부신 과형성증을 가진 남아에서 장기간 고농도의 남성호르몬에 노출될 경우 처음에는 가성 성조숙증이었다가 이후 진성 성조숙증으로 전환될 수 있으므로 선천성 부신 과형성증의 조기진단과 치료가 필요하다. 저자들은 가성 성조숙증에서 진성 성조숙증으로 전환된 선천성 부신 과형성증을 가진 남아에서 hydrocortisone과 GnRH 유도체를 사용하여 큰 부작용 없이 2차 성징의 퇴축을 가져온 1례를 경험하고 문헌고찰과 함께 보고하는 바이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제19권2호
• /
• pp.130-138
• /
• 2016

Purpose: This study was conducted to analyze the change in the obesity index in girls receiving a gonadotropin-releasing hormone agonist (GnRHa), based on treatment duration, and to aid in nutritional counseling by investigating dietary habits and lifestyle. Methods: Anthropometric examinations were conducted on 62 girls treated with GnRHa from January 2010 through July 2014. Parents were asked to fill out questionnaires on patient dietary habits and lifestyle. Results: The group taking GnRHa for over 1 year had a higher rate of obesity increase than the group taking GnRHa for less than 1 year, but they had common habits related to obesity, which should be corrected. In addition, 69.2% of the normal weight group taking GnRHa for over 1 year gained weight, and needed more intensive programs, which include physical exercise and nutritional education. Although girls with precocious puberty showed a decrease in the intake of high-calorie foods with nutritional intervention regardless of treatment duration, they still had problems that needed improvement, such as shorter meals and lack of exercise. Conclusion: Girls with precocious puberty and their parents should emphasize maintenance of proper body weight, especially when treatment for over 1 year is anticipated. Consistent education in nutrition, ways to increase intensity and duration of physical activity, and the need to slow down mealtimes are important in managing obesity; doctors need to perform regular checkups and provide nutritional counseling.