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Mechanisms of Platelet Adhesion on Elastic Polymer Surfaces: Protein Adsorption and Residence Effects

  • Insup Noh;Lee, Jin-Hui
    • Macromolecular Research
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    • 제9권4호
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    • pp.197-205
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    • 2001
  • Platelet adhesion onto elastic polymeric biomaterials was tested in vitro by perfusing human whole blood at a shear rate of 100 sec$\^$-1/ for possible verification of mechanisms of initial platelet adhesion perfusion of blood on the polymeric substrates was performed after treatments either with or without pre-adsorption of 1% blood plasma, and either with or without residence of the protein-preadsorbed substrate in phosphate buffered solution. The surfaces employed were elastic polymers such as poly(ether urethane urea), poly(ether urethane), silicone urethane copolymer, silicone rubber and poly(ether urethane) with the anti-calcifying agent hydroxyethane bisphosphate. Each polymer surface treated was exposed in vitro to the dynamic, heparinized whole blood perfused for upto 6 min and the surface area of platelets initially adhered was measured by employing in situ epifluorescence video microscopy. The blood perfusion was performed on the surfaces treated at the following three different conditions: directly on the bare surfaces, after protein pre-adsorption and after residence in buffer for 3 days of the surfaces protein pre-adsorbed for 2 h. The effects of blood plasma pre-adsorption on the initial platelet adhesion was surface-dependent. The amount of the adsorbed fibrinogen and the surface coverage area of the adhered platelets were dependent on the surface conditions whether substrates were bare surfaces or protein pre-adsorbed ones. To test an effect of possible morphological (re)orientations of the adsorbed proteins on the initial platelet adhesion, the polymeric substrate pre-adsorbed with 1% blood plasma was immersed in phosphate buffered solution for 3 days and then exposed to physiological blood perfusion. The surface area of the platelets adhered on these surfaces was significantly different from that of the surfaces treated with protein pre-adsorption only. These results indicated that platelet adhesion was dependent on the surface property itself and pre-treatment conditions such as blood perfusion without any pre-adsorption of proteins, and blood perfusion either after protein pre-adsorption or after subsequent substrate residence in buffer of the substrate pre-adsorbed with proteins. Understanding of these results may guide for better designs of blood-contacting materials based on protein behaviors.

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How do diverse precipitation datasets perform in daily precipitation estimations over Africa?

  • Brian Odhiambo Ayugi;Eun-Sung Chung
    • 한국수자원학회:학술대회논문집
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    • 한국수자원학회 2023년도 학술발표회
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    • pp.158-158
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    • 2023
  • Characterizing the performance of precipitation (hereafter PRE) products in estimating the uncertainties in daily PRE in the era of global warming is of great value to the ecosystem's sustainability and human survival. This study intercompares the performance of different PRE products (gauge-based, satellite and reanalysis) sourced from the Frequent Rainfall Observations on GridS (FROGS) database over diverse climate zones in Africa and identifies regions where they depict minimal uncertainties in order to build optimal maps as a guide for different climate users. This is achieved by utilizing various techniques, including the triple collection (TC) approach, to assess the capabilities and limitations of different PRE products over nine climatic zones over the continent. For daily scale analysis, the uncertainties in light PRE (0.1 5mm/day) are prevalent over most regions in Africa during the study duration (2001-2016). Estimating the occurrence of extreme PRE events based on daily PRE 90th percentile suggests that extreme PRE is mainly detected over central Africa (CAF) region and some coastal regions of west Africa (WAF) where the majority of uncorrected satellite products show good agreement. The detection of PRE days and non-PRE days based on categorical statistics suggests that a perfect POD/FAR score is unattainable irrespective of the product type. Daily PRE uncertainties determined based on quantitative metrics show that consistent, satisfactory performance is demonstrated by the IMERG products (uncorrected), ARCv2, CHIRPSv2, 3B42v7.0 and PERSIANN_CDRv1r1 (corrected), and GPCC, CPC_v1.0, and REGEN_ALL (gauge) during the study period. The optimal maps that show the classification of products in regions where they depict reliable performance can be recommended for various usage for different stakeholders.

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Adjustable Ghajar Guide Technique for Accurate Placement of Ventricular Catheters : A Pilot Study

  • Yoon, Sang-Youl;Kwak, Youngseok;Park, Jaechan
    • Journal of Korean Neurosurgical Society
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    • 제60권5호
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    • pp.604-609
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    • 2017
  • Objective : An adjustable Ghajar guide is presented to improve the accuracy of the original Ghajar guide technique. The accuracy of the adjustable Ghajar guide technique is also investigated. Methods : The coronal adjustment angle from the orthogonal catheter trajectory at Kocher's point is determined based on coronal head images using an electronic picture archiving and communication system. For the adjustable Ghajar guide, a protractor is mounted on a C-shaped basal plate that is placed in contact with the margin of a burrhole, keeping the central $0^{\circ}$ line of the protractor orthogonal to the calvarial surface. A catheter guide, which is moved along the protractor and fixed at the pre-determined adjustment angle, is then used to guide the ventricular catheter into the frontal horn adjacent to the foramen of Monro. The adjustable Ghajar guide technique was applied to 20 patients, while a freehand technique based on the surface anatomy of the head was applied to another 47 patients. The accuracy of the ventricular catheter placement was then evaluated using postoperative computed tomography scans. Results : For the adjustable Ghajar guide technique (AGT) patients, the bicaudate index ranged from 0.23 to 0.33 ($mean{\pm}standard$ deviation [SD] : $0.27{\pm}0.03$) and the adjustment angle ranged from $0^{\circ}$ to $10^{\circ}$ ($mean{\pm}SD:5.2^{\circ}{\pm}3.2^{\circ}$). All the AGT patients experienced successful cerebrospinal fluid diversion with only one pass of the catheter. Optimal placement of the ventricular catheter in the ipsilateral frontal horn approximating the foramen of Monro (grade 1) was achieved in 19 patients (95.0%), while a suboptimal trajectory into a lateral corner of the frontal horn passing along a lateral wall of the frontal horn (grade 3) occurred in 1 patient (5.0%). Thus, the AGT patients experienced a significantly higher incidence of optimal catheter placement than the freehand catheterized patients (95.0% vs. 68.3%, p=0.024). Moreover, none of the AGT patients experienced any tract hemorrhages along the catheter or procedure-related complications. Conclusion : The proposed adjustable Ghajar guide technique, using angular adjustment in the coronal plane from the orthogonal trajectory at Kocher's point, facilitates accurate freehand placement of a ventricular catheter for hydrocephalic patients.

유도슬롯과 주입공 배열을 이용한 수압암반절개 현장 실험 (Field Tests of Hydraulic Rock Splitting Technique Using Arrays of Injection Holes with Guide Slots)

  • 박종오;우익
    • 지질공학
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    • 제29권4호
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    • pp.405-415
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    • 2019
  • 수압암반절개에서 유도된 균열은 자유면에서 지반의 최소주응력에 수직인 방향인 자유면과 평행한 방향으로 형성되거나, 기존에 발달한 미세균열의 영향을 많이 받는다. 본 연구에서는 흑운모화강암 사면에서 시추공 축과 평행한 방향으로 유도슬롯을 생성하여 이중패커의 압력 및 인터벌 구간에 수압을 주입하는 수압암반절개 실험을 수행하고 그 결과를 분석하였다. 실험 결과, 이중패커 압력 및 인터벌 구간 내의 주입으로 형성된 균열은 유도슬롯 방향을 따라 미세하게 나타났으며, 일부 균열은 시추공을 가로질러 연장되었다. 따라서 수압암반절개는 절개할 방향으로 유도슬롯을 생성하여 보다 많은 유량을 주입하면 효율적인 유도균열 조절이 가능할 것으로 판단된다.

고혈압 및 전기고혈압 위험요인으로서의 사상체질 (Sasang Constitution may act as a Risk Factor for Hypertension and Pre-hypertension)

  • 장은수;정경식;임수은;김윤영
    • 사상체질의학회지
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    • 제34권1호
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    • pp.37-45
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    • 2022
  • Objectives The purpose of this study was to reveal that Sasang constitution(SC) was associated with hypertension and pre-hypertension and could be a risk factor. Methods We introduced this study to educational personnel in D university in Daejeon, and 275 subjects joined this study. The SC classification was conducted with KS 15 questionnaire. The subjected measured the blood pressure with Jawon medical device automatically after 10 minute rest. The hypertension and pre-hypertension was classified by the guide of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The frequency analysis and T-test was used in general characteristics, and chi-square test was also used between SC and pre-hypertension and hypertension. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence interval (95% CI) for pre-hypertension and hypertension. Results The number of Taeeumin(TE), Soeumin(SE), and Soyangin(SY) was 142, 71, and 61 respectively. There was significantly different in systolic and diastolic blood pressure among SC types(p<.001). The distribution of the normal group, pre-hypertension and hypertension group by SC types was significantly different (p<.001). The ORs of TE was significantly increased (ORs 4.039, 95% CI=2.019-8.082 in pre-hypertension and ORs 4.235, 95% CI=1.581-11.348 in hypertension) compared with SE(p<.001), and after adjusting gender and smoking habit, it was still significantly different(p<.001). Conclusions It is possible that SC, especially TE could be a risk factor both pre-hypertension and hypertension.

중소형 열병합 발전용 SCR 장치의 유동 균일화를 위한 전산유체해석 최적화 연구 (An Optimized Analysis of the Optimal Flow Uniformity in SCR Facility for Small-and Mid-Sized CHPs)

  • 이상환;신상우;김정섭
    • 플랜트 저널
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    • 제9권3호
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    • pp.48-52
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    • 2013
  • 본 연구에서는 전산유체해석(CFD)을 통하여 SCR 탈질설비 내부의 유동장 흐름을 전산모사하였다. 또한 유동장의 균일도를 분석하기 위해 기존 설비에 대한 해석을 수행하였으며 이를 통해 문제점을 도출하고 개선하였다. 개선방안으로는 곡관에 guide vane을 설치하여 곡관상에 기류를 균일하게 안내해 주었으며, baffle을 설치하여 SCR설비로 초기 유입된 기류의 균일한 공간 분포를 도출하였다. 마지막으로 porous plate를 baffle 하단에 설치하여 균일류 형성의 최적화 모델을 도출하였다.

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Effect of 360-degree Hospitalization Guide Video Content for ICU Caregivers on Anxiety, Satisfaction and Safety Perception

  • Park, Jung-Ha;Lee, Yun-Bok
    • International journal of advanced smart convergence
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    • 제10권4호
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    • pp.233-240
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    • 2021
  • The purpose of this study was to provide a 360-degree video on intensive care unit admission guidance to family members admitted to the intensive care unit, and then to identify anxiety, safety perception, and satisfaction. This study was a single-group pre-post design, and the data collection period was from October 1, 2020 to August 30, 2021. The subjects of this study were 19 people who applied 360 degree hospitalization guide video. For data analysis, SPSS WIN 24.0 program was used, and real number, percentage, mean, standard deviation, minimum value, maximum value, and Wilcoxon signed rank test were used. The subjects' anxiety before intervention was an average score of 6.21±2.30 and the anxiety after intervention was an average score of 3.95±2.46, which was statistically significant (z=4.13, p<.001). The safety consciousness of the subjects before the intervention was an average of 4.08±0.39 and the safety consciousness after the intervention was an average of 4.54±0.48, which was statistically significant (z=5.00, p=.001). The highest level of satisfaction with the 360-degree hospitalization guidance image of the subjects was 4.58±0.51 and the lowest was 4.16±0.96. In this study, when 360-degree hospitalization guide video was applied, there was a difference in anxiety and safety perception, and satisfaction was high. Based on the research results, various programs for guardian education can be developed and utilized in the future.

고등학교 지구 과학에서 야외 지질 조사의 지도 방법 (A Study on the Teaching Plan of Geologic Field Trip in the Earth Science Ecucation, High School)

  • 오민수
    • 한국과학교육학회지
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    • 제1권1호
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    • pp.45-52
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    • 1978
  • In order to normalized the Earth Science Education, experiments and geologic field trainings are very important. But it have not carried out on account of many difficulties in current High School of Korea. These difficulties are lack of time, many problems of the text book, heavy teaching load, shortage of facilities and experimental equipments, and poor quality of teacher etc. The practical training of geologic field trip is very important in Earth Science Education. Finally, wirter propose a new teaching plan of geologic field training as follows: 1. The teacher must prepare the guide paper of field geologic training. 2. Subjects of practical training must simplify. 3. The teacher must take a pre-field investigation in order to get the teaching plan and the preparation of practical field training. 4. Let students observe for themselves on this guide, as if they were geologists. 5. The teacher must conclude about practical training after the working.

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30GW급 대출력 글라스레이저의 개발연구 (A study on development of 30GW class high power glass laser system)

  • 강형부
    • 전기의세계
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    • 제31권5호
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    • pp.383-390
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    • 1982
  • The high power glass laser system was designed and constracted which consisted of a TEM$\_$00/ mode Q-switching oscillator, a pulse shaping, system, two-stage pre-amplifiers, five-stage main amplifiers, a Faraday rotator, and a uni-guide slit. The laser output of 3OGW with the pulsewidth of 2 nsec was obtained by performing the amplifiing experiment in this system. When the laser light with the pulsewidth of 10 nsec was amplified, the large factor of amplification was obtained in the beginning of pulse, but the factor of amplification decreased gradually in the later part of pulse. Therefore, the laser light which has short pulsewidth of-2nsec must be amplified in order to obtain the larger factor of amplification. When the laser beam from the high power glass laser system was irradiated to plasma, the reflected laser light from plasma which occured inevitably could be attenuated to the order of 10$\^$-4/ by using the Faraday rotator and the uni-guide slit.

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KF-DeBERTa: 금융 도메인 특화 사전학습 언어모델 (KF-DeBERTa: Financial Domain-specific Pre-trained Language Model)

  • 전은광;김정대;송민상;유주현
    • 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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    • 한국정보과학회언어공학연구회 2023년도 제35회 한글 및 한국어 정보처리 학술대회
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    • pp.143-148
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    • 2023
  • 본 논문에서는 금융 도메인 특화 사전학습 언어모델인 KF-DeBERTa(Korean Finance DeBERTa)를 제안한다. KF-DeBERTa는 대규모의 금융 말뭉치를 기반으로 학습하였으며, Transformer 아키텍처와 DeBERTa의 특징을 기반으로 구성되었다. 범용 및 금융 도메인에 대한 평가에서 KF-DeBERTa는 기존 언어모델들에 비해 상당히 높은 성능을 보였다. 특히, 금융 도메인에서의 성능은 매우 두드러졌으며, 범용 도메인에서도 다른 모델들을 상회하는 성능을 나타냈다. KF-DeBERTa는 모델 크기 대비 높은 성능 효율성을 보여주었고, 앞으로 금융 도메인에서의 활용도가 기대된다.

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