• Journal of Pharmaceutical Investigation
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• 제20권4호
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• pp.193-198
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• 1990

To increase the dissolution rate of furosemide, cogrinding or coprecipitating of furosemide with povidone was carried out. The ground mixture of furosemide with povidone was prepared by cogrinding in a ceramic ball mill and the coprecipitate was prepared by solvent method using methanol. The povidone ground mixture and the coprecipitate showed a faster and more enhanced dissolution rate than the physical mixture or intact furosemide. The IR, DTA and TGA studies showed the physicochemical modifications of furosemide from the ground mixture and the coprecipitate. An interaction, in the ground mixture and in the coprecipitate, such as association between the functional groups of furosemide and povidone might occur in the molecular level. The coprecipitating and cogrinding techniques with povidone provided a promising way to increase the dissolution rate of poorly soluble drugs.

• 한국임상수의학회지
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• 제9권1호
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• pp.277-281
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• 1992

To investigate the effect of chlorhexidine gluconate and povidone iodine on wound healing, their antimicrobial activity and their effects on wound contraction in rabbits were studied. Staphyococcus aureus (1${\times}$10$\^$7/) was inoculated on the full thickness skin defects (2${\times}$2cm) on the back. Antiseptics were applied on the defects 2 hours after Inoculation. The defects were swabbed for bacterial culture 24 and 48 hours after the application of antiseptics. Percentage of wound contraction, based on wound area measured on the day of surgery was calculated for each wound on days 1,7 and 14. The 0.5% chlorhexidine gluconate solution had more effective antimicrobial activity against Staphyococcus aureus in wounds than 0.05% chlorhexidine gluconate solution (p<0.05), and povidone iodine solution and saline (p<0.01). Percentages of wound contraction were not significantly different among different dilutions of the antiseptics and saline. Present study indicated that the antimicrobial activity of chlorhexidine gluconate in wound was superior to that of povidone iodine.

• 대한족부족관절학회지
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• 제16권3호
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• pp.190-192
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• 2012

In the extremity surgery, pneumatic tourniquet and povidone-iodine solution are commonly used to provide an aseptic, bloodless field, and their complication rate has remained low. However, chemical burn under tourniquet has been rarely reported. Patients sustained burn injuries over the dependent, weight-bearing regions such as posterior neck, back, buttocks and posterior thighs. This rare adverse complication occurred in a 22-year-old man who underwent modified Brostrom operation with arthroscopic os trigonum excision. 10% povidone-iodine was used as topical antiseptic, and full thickness burn occurred underneath the area of tourniquet application. Main causes of povidone-iodine related chemical burn are considered maceration, irritation of the skin, long term use of the tourniquet and pressure. To reduce the complications like chemical burn, awareness of the risk and the possible pathogenesis as well as the preventive measures is important in surgical practice.

• 한국임상수의학회지
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• 제24권3호
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• pp.337-341
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• 2007

This study determined the effect of postpartum intrauterine infusion of povidone-iodine solution on the subsequent reproductive performance in dairy cows. Six hundred and fifty-eight dairy cows that were around week 4 postpartum were randomly divided into two groups: (1) Cows in treated group received an intrauterine infusion of 100 to 150 ml 2% povidone-iodine solution (treated group, n=269), or (2) Cows that received no treatment were served as the controls (control group, n=389). The cows were bred at observed estrus more than 50 days after calving. Artificial insemination (AI) was done according to the a.m.-p.m. rule. The conception to AI was determined per rectum 60 days after AI by both ultrasonographical observation and manual palpation. The intervals from calving to first service and conception ($94.2{\pm}2.7$ and $144.1{\pm}4.1$ days vs. $88.0{\pm,}2.1$ and $143.5{\pm}4.6$ days, respectively), number of services per conception ($2.0{\pm}0.1$ vs. $2.1{\pm}0.1$), and cumulative pregnancy rates within 90 and 150 days postpartum (31.9 and 61.7% vs. 29.7 and 62.1%) did not differ between the control and treated groups (P>0.05), while conception rate at first service was lower (P<0.05) in the treated group (40.5%) than in the control group (49.4%). Additionally, we could not find any effect of intrauterine infusion of povidone-iodine solution according to cow parity or calving season on the reproductive performance. These results indicate that intrauterine infusion of povidone-iodine solution at week 4 postpartum does not affect the subsequent reproductive performance in dairy cows.

• 한국응용과학기술학회지
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• 제27권1호
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• pp.37-43
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• 2010

The objective of this study was to evaluate the antifungal properties of xanthorrhizol (extract from curcuma xanthorrhiza) against Candida albicans. Some of the commercial products were evaluated for their ability to inhibit growth of C. albicans. OTC product containing povidone iodide and cosmetic grade product with surfactants were tested. Antifungal activity was shown in 1.56% of OTC product, however, there was no antifungal effect in cosmetic product. For the comparison, we tested several materials. Povidone iodide, lemon tea tree oil and xanthorrhizol showed antifungal activities against C albicans in 0.25, 0.062 and 0.007%, respectively. We also tested the antifungal effects of povidone iodide and xanthorrhizol in surfactant base. Test results revealed that 2.5% of povidone iodide and 0.156% of xanthorrhizol showed similar antifungal effects. These findings support the application of xanthorrhizol for vaginal cleanser or personal cares using antifungal effect.

• Journal of Pharmaceutical Investigation
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• 제19권3호
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• pp.123-129
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• 1989

A study was made to investigate the effects of various binders on the physical properties of acetaminophen granules and tablets prepared by wet and fluidized bed granulation methods. The binders used were povidone (K-90), hydroxypropylcellulose (HPC-L) and gelatin. The fluidized bed granules were more porous than the wet massed, and the tablets prepared by fluidized system showed improved disintegration and dissolution characteristics. The dissolution rate was fast in the order of gelatin>povidone>hydroxypropylcellulose in tablets prepared by fluidized system, and povidone>hydroxypropylcellulose>gelatin in tablets prepared by wet granulation.

• Journal of Pharmaceutical Investigation
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• 제19권3호
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• pp.145-154
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• 1989

Methyl methacrylate-butyl methacrylate copolymer (MMBM)-povidone (PVP) films were investigated as a potential topical drug delivery system for the controlled release of econazole nitrate as a model drug. The effect of changes in film composition, drug concentration, film thickness, pH and temperature of release medium on the in vitro release of econazole nitrate were studied. The release rate constant was found to be increased with increasing povidone content in dry films. Drug release followed zero-order kinetics in the initial stage and then release rate increased gradually with time, espicially in the films having larger proportions of PVP. The release rate was found to be dependent on drug content, film thickness, the pH and temperature of release medium. Antimicrobial test showed that microbial growth was inhibited markedly with increasing proportions of PVP in films. Also drug content and film thickness affected the antimicrobial activity.

• 융합정보논문지
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• 제10권10호
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• pp.80-87
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• 2020

본 연구의 목적은 투관침 부위를 중심으로 복강경하 담낭절제술에 적용하는 소독제인 포비돈 아이오딘과 클로르헥시딘-에탄올에 따른 소독효과의 차이를 비교하기 위한 비동등성 대조군 사전사후설계 실험연구이다. 연구대상자는 서울 소재 1개의 대학병원 외과에 입원한 46명의 환자를 대상으로 난수표를 이용하여 무작위 할당하였으며, 균의 배양과 동정, 균 수(CFU/ml) 측정, 수술부위감염 발생 유무를 통해 소독제 효과의 차이를 비교하였다. 연구결과, 포비돈 아이오딘과 클로르헥시딘-에탄올은 소독 3분 후와 투관침 제거 전의 균 발생률, 균수 변화의 차이와 수술부위감염발생률은 통계적으로 유의한 차이가 없어 소독효과에 대한 차이는 없는 것으로 나타났다. 따라서, 적절한 소독제 선택시 소독효과 뿐만 아니라 비용적 측면과 사용의 편의성 등을 고려하는 것이 필요하다. 본 연구는 소독제의 효능과 사용방법에 대한 기초자료 및 교육 자료로 활용될 수 있으며, 소독제에 대한 이해를 높이는데 의의가 있다.

• Pediatric Infection and Vaccine
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• 제6권1호
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• pp.116-122
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• 1999

목 적 : 신생아 중환자에 대한 치료법이 급속도로 발전함에도 불구하고 신생아 감염은 여전히 큰 문제이다. 특히 정맥천자나 여러 침습적 처치가 많은 신생아 중환자에서 이를 통해 피부 상주균에 의한 패혈증이 증가하고 있다. 이는 시술상의 문제로 야기될 수 있지만 처치 전 소독제의 소독력에 문제가 있을 수 있다. 특히 병원에서 희석하여 사용하고 있는 알코올 솜은 공기중에 자주 노출되어 알코올 성분이 증발되기 쉬워 소독력에 문제가 있을 수 있다. 이에 포비돈 소독제가 알코올 소독제보다 소독력이 좋은 것이라는 가정하에 이 연구를 시행 하였다. 대상 및 방법 : 신생아 중환자실에 입원한 미숙아 및 신생아중 정맥 수액요법이 필요하였던 신생아들을 대상으로 정맥 천자가 주로 시행되는 부위의 피부에서 멸균된 면봉으로 멸균 생리 식염수를 묻혀 피부를 문질러 배양 검사를 시행하였고 피부가 마른 후 무작위로 알코올군은 병원에서 희석하여 만든 70% 알코올 솜으로 닦고 마른 후 같은 방법으로 피부를 닦아 배양검사를 하였고(20례), 포비돈군은 10% 포비돈(1% iodine) 솜으로 닦고 마른 후 70% 알코올 솜으로 다시 닦아 마른 후 피부 배양검사를 하였다(20례). 대조군은 생리 식염수 솜으로 닦은 후 배양검사를 하였다(10례). 결 과 : 소독 전 알코올 군과 포비돈군 각각 20례중 9례에서 균이 자랐고, 대조군은 10례중 8례에서 균이 검출되었다. 소독후 알코올 군은 3례, 포비돈군 2례, 대조군은 8례에서 균이 계속 자라 세군간에 유의한 차이가 있었다(p=0.0387). 포비돈군의 소독효과는 알코올군과 비슷하였고, 대조군보다는 높았지만(p=0.0156), 알코올군은 대조군과 비교하여 유의한 차이가 없었다. 결 론 : 포비돈 솜의 소독효과는 알코올 솜과 비슷하였지만, 생리식염수 솜보다는 높았다. 그러나 알코올 솜의 소독효과는 생리식염수 솜과 유의한 차이가 없었다. 병원에서 사용되는 알코올의 순도, 알코올 솜의 정도관리, 소독방법 등에 대한 재평가가 필요함을 시사한다.

• 대한간호학회지
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• 제38권1호
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• pp.39-44
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• 2008

Purpose: The purpose of this study was to compare 1% chlorhexidine-gluconate/61% ethanol (CHG/Ethanol) emollient and 7.5% povidone-iodine (PVI) scrub for antimicrobial, residual effect, and skin condition. Method: CHG/Ethanol emollient hand hygiene was performed waterless, and brushless by operating doctors and nurses (N=20). PVI hand washing was performed with water and a brush (N=20) for 5 min. The subjects were asked to press their left hand in hand-shaped agar before a surgical scrub, immediately after a surgical scrub and after the operation. The amount of isolated microorganisms were calculated by counting the number of divided areas($1{\times}1cm$, 160 cell) which were culture positive in the hand culture plate. The skin condition was evaluated. Result: The antimicrobial count of CHG/Ethanol emollient and PVI immediately post surgical scrub was 0.0 vs. 4.1 (p>.05), and after the operation was 0.1 vs. 37.8 (p>.05)respectively. The Residual effect of CHG/Ethanol emollient immediately post surgical scrub and after the operation were 0.0 vs. 0.1 (p>.05), and PVI were 4.1 vs. 37.8 (p>.05)respectively. The skin condition and satisfaction of CHG/Ethanol emollient was higher than PVI (p<.05). Conclusion: The antimicrobial effect between CHG/Ethanol emollient and PVI were the same. Considering skin condition, satisfaction and allergic reaction CHG/Ethanol emollient for surgical scrub is recommended in Korea.