• Translational and Clinical Pharmacology
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• v.26 no.3
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• pp.115-117
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• 2018

This tutorial explains the basic principles of mechanistic ligand-receptor interaction model, which is an operational model of agonism. A growing number of agonist drugs, especially immune oncology drugs, is currently being developed. In this tutorial, time-dependent ordinary differential equation for simple $E_{max}$ operational model of agonism was derived step by step. The differential equation could be applied in a pharmacodynamic modeling software, such as NONMEM, for use in non-steady state experiments, in which experimental data are generated while the interaction between ligand and receptor changes over time. Making the most of the non-steady state experimental data would simplify the experimental processes, and furthermore allow us to identify more detailed kinetics of a potential drug. The operational model of agonism could be useful to predict the optimal dose for agonistic drugs from in vitro and in vivo animal pharmacology experiments at the very early phase of drug development.

• Journal of Internet Computing and Services
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• v.23 no.1
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• pp.69-76
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• 2022

Education systems have made efforts to prepare students by providing technical and nontechnical courses. With video games, however, there is the potential to develop dedicated metaverses that can help teach soft skills even during casual pastimes. The research conducted will propose a set of design practices for metaverse and game development to promote soft skills. While there are many soft skills people can acquire, this paper will focus on certain aspects based on specific games and studies. There will be some information collected from the information to support the design model and arguments. This paper will provide developers with a starting point for imaginative game creation and impart users with soft skills to assist in their professions and social life.

• Bulletin of the Korean Chemical Society
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• v.21 no.11
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• pp.1133-1137
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• 2000

Gibbs ensemble Monte Carlo simulations were performed to calculate the vapor- liquid coexistence properties for the binary mixtures $CO_2/C_3H8$, $CO_2/CH_3OCH_3$, and $CO_2/CH_3COCH_3.$ For all the molecules the potential between sites in different molecules was simply calculated by the Lennard-Jones potential. Density of the mixture, composition of the mixture, the pressure-composition diagram, the chemical potential of component, and the radial distribution function were calculated at vapor- liquid equilibrium. The composition and the density of both vapor and liquid from simulation agreed considerably well with the experimental values over a wide range of pressures. The radial distribution functions in the liquid mixtures showed that $CO_2$ molecules tended to form cluster with each other and $C_3H8$ molecules also aggregated each other due to the weak interaction between $CO_3$ and $C_3H8$ molecule. However the interaction potentials between the same components were similar to those between the different components in the liquid mixtures $CO_2/CH_3OCH_3$ and $CO_2/CH_3COCH_3$.

• Journal of Medicine and Life Science
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• v.20 no.1
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• pp.8-14
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• 2023

Interest in the metaverse is increasing as learners participate in learning with presence, improving learning motivation, and interaction. Currently, the use of metaverse in medical education remains in a test-phase of introduction within some companies, while some medical school professors are beginning to utilize it. Therefore, it is difficult to ascertain whether the metaverse has educational potential when used in medical education. This exploratory study investigates the possibility of the educational use of the metaverse. Both the educational usefulness and the examples of its educational usage in domestic and foreign medical schools are explored. As the metaverse is expected to be introduced and utilized more actively in the future, some of its advantages and limitations in medical education have been identified. In light of the vast potential of the metaverse in medical education, the method of educating and preparing medical students should be developed by preparing a new educational foundation.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.240.2-240
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• 1998

No Abstract, See Full Text

• Journal of Korean Society of Industrial and Systems Engineering
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• v.18 no.36
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• pp.13-22
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• 1995

The phenomenal rate of growth of the design, implementation and use of interactive computer-based systems has been paralleled by an appreciation of the criticality of the human factor with regard to successful systems operation. As the pace of technological innovation quickens, and the design of user interfaces involves more complex interaction techniques, user frustration, confusion, degraded human performance, and an unwillingness on the part of users In perform interaction tasks were potential outcomes. Consequently, the important of user-centered interfaces design and use is increasing. Usability-based systems improve user acceptance and satisfaction with the systems

• Journal of the Ergonomics Society of Korea
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• v.25 no.2
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• pp.135-146
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• 2006

Multimodal interfaces are recognition-based technologies that interpret and encode hand gestures, eye-gaze, movement pattern, speech, physical location and other natural human behaviors. Modality is the type of communication channel used for interaction. It also covers the way an idea is expressed or perceived, or the manner in which an action is performed. Multimodal Interfaces are the technologies that constitute multimodal interaction processes which occur consciously or unconsciously while communicating between human and computer. So input/output forms of multimodal interfaces assume different aspects from existing ones. Moreover, different people show different cognitive styles and individual preferences play a role in the selection of one input mode over another. Therefore to develop an effective design of multimodal user interfaces, input/output structure need to be formulated through the research of human cognition. This paper analyzes the characteristics of each human modality and suggests combination types of modalities, dual-coding for formulating multimodal interaction. Then it designs multimodal language and input synchronization method according to the granularity of input synchronization. To effectively guide the development of next-generation multimodal interfaces, substantially cognitive modeling will be needed to understand the temporal and semantic relations between different modalities, their joint functionality, and their overall potential for supporting computation in different forms. This paper is expected that it can show multimodal interface designers how to organize and integrate human input modalities while interacting with multimodal interfaces.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.819-824
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• 2000

The flow inside an axial turbomachinery must be unsteady. Rotor-stator interaction by two blade rows influences performance, the generation of noise and vibration. So, it will be necessary to study the rotor-stator interaction for the design of an axial fan in which the axial gap between two blade rows is small. In this study, rotor-stator interaction is investigated by experimental methods. The research fan has one stage which consists of 24 rotor blades and 22 stator blades. Three-dimensional velocities measured using $45^{\circ}$ slanted hot wire probe and total pressure is measured using Kiel total pressure probe between rotor and stator with the axial 25%, 55%, 145% of chord length,. This study describes the influence of rotor-stator gap on the flow pattern, performance and loss. The efficiency curve show that the change of the rotor-stator gap make difference in the efficiency. And, the 3-dimensional velocity distribution show that the potential interaction between the rotor and the stator have a great effect on the flow field downstream of rotor, where there are wake flow. various vortices in hub region and leakage vortex in casing region etc.

• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.458-463
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• 2018

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.

• Bulletin of the Korean Chemical Society
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• v.6 no.1
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• pp.23-29
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• 1985

The charge-transfer complexing properties of 1-methyl nicotinamide (MNA), an acceptor, and adenine, a donor, were investigated in water and SDS micellar solutions in relation to the intramolecular interaction in nicotinamide adenine dinucleotide ($NAD^+$). The spectral and thermodynamic parameters of MNA-indole and methyl viologen-adenine complex formations were determined, and the data were utilized to evaluate the charge-transfer abilities of MNA and adenine. The electron affinity of nicotinamide was estimated to be 0.28 eV from charge-transfer energy $of{\sim}300$ nm for MNA-indole. The large enhancement of MNA-indole complexation in SDS solutions by entropy effect was attributed to hydrophobic nature of indole. The complex between adenine and methyl viologen showed an absorption band peaked near 360 nm. The ionization potential of adenine was evaluated to be 8.28 eV from this. The much smaller enhancement of charge-transfer interaction involving adenine than that of indole in SDS solutions was attributed to weaker hydrophobic nature of the donor. The charge-transfer energy of 4.41 eV (280 nm) was estimated for nicotinamide-adenine complex. The spectral behaviors of $NAD^+$ were accounted to the presence of intramolecular interaction in $NAD^+$, which is only slightly enhanced in SDS solutions. The replacement of nicotinamide-adenine interaction in $NAD^+$ by intermolecular nicotinamide-indole interaction in enzyme bound $NAD^+$, and guiding role of adenine moiety in $NAD^+$ were discussed.