• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.320-331
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• 2022

Coronavirus disease 2019 (COVID-19) has become a major health burden worldwide, with over 450 million confirmed cases and 6 million deaths. Although the acute phase of COVID-19 management has been established, there is still a long way to go to evaluate the long-term clinical course or manage complications due to the relatively short outbreak of the virus. Pulmonary fibrosis is one of the most common respiratory complications associated with COVID-19. Scarring throughout the lungs after viral or bacterial pulmonary infection have been commonly observed, but the prevalence of post-COVID-19 pulmonary fibrosis is rapidly increasing. However, there is limited information available about post-COVID-19 pulmonary fibrosis, and there is also a lack of consensus on what condition should be defined as post-COVID-19 pulmonary fibrosis. During a relatively short follow-up period of approximately 1 year, lesions considered related to pulmonary fibrosis often showed gradual improvement; therefore, it is questionable at what time point fibrosis should be evaluated. In this review, we investigated the epidemiology, risk factors, pathogenesis, and management of post-COVID-19 pulmonary fibrosis.

• 보건행정학회지
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• 제30권2호
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• pp.139-141
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• 2020

Coronavirus disease 2019 (COVID-19) is currently in progress. Although it is difficult to predict the end of currently increasing COVID-19, it is expected to last for a long time. The COVID-19 is making a lot of changes. Due to physical distancing and living distancing, non-contacts such as wearing facial masks, online lectures, online medical services, telecommuting, and telemarketing are becoming common. In the era of post-COVID-19, online and offline will coexist. Many countries following China's lockdown strategy, which is agreed with the World Health Organization, should be changed to Taiwan's facial mask strategy for reducing the economic problems. The prolonging COVID-19 will add to the economic difficulties, and the US-China confrontation will be difficult to rebound the global economy. COVID-19, such as plaque, smallpox, and Spanish influenza, will be a historical momentum. How to respond to the crisis of COVID-19 and post-COVID-19 will determine the future of the world and Korea.

• Journal of Microbiology and Biotechnology
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• 제2권2호
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• pp.122-128
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• 1992

Post-translational modifications of the nucleocapsid protein of bovine coronavirus (Quebec strain) were investigated. Coronavirions were radiolabelled in vivo with inorganic $[^{32}P]$orthophosphate and analysed by SDS-PAGE, followed by autoradiography. A single polypeptide with a migration rate of 55 KDa was identified by metabolic phosphate labelling, demonstrating that the nucleocapsid protein of bovine coronavirus was a phosphoprotein. A gene encoding the nucleocapsid protein was inserted immediately downstream from the polyhedrin promoter of Autographa californica nuclear polyhedrosis baculovirus. Spodoptera frugiperda cells infected with this recombinant baculovirus synthesized a 55 KDa polypeptide, as demonstrated by immunoprecipitation with anti-nucleocapsid monoclonal antibody. The recombinant nucleocapsid protein synthesized in Spodoptera cells could also be labelled by $[^{32}P]$orthophosphate. Phosphoamino acid analysis showed that both serine and threonine residues were phosphorylated in authentic, as well as in recombinant nucleocapsid proteins, with a relative phosphorylation ratio of 7:3. Our studies demonstrated that the nucleocapsid protein of bovine coronavirus was a serine and threonine-phosphorylated protein and that Spodoptera insect cells were able to properly phosphorylate the relevant foreign proteins.

• Journal of Animal Science and Technology
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• 제63권1호
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• pp.125-136
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• 2021

Bovine coronavirus (BCoV) is associated with severe diarrhea, dehydration, and depression, which result in significant economic damages in the dairy and beef cattle industries worldwide. However, differences in the gut microbiota structure and their correlations with differing physiological parameters between BCoV-infected calves with diarrhea and recovered calves are not well understood. In this study, fecal specimens were collected from 10 post-weaned calves, before and after 2 months of fluid therapy, and the samples were used for microbiota analysis. Following recovery, the alpha-diversity profiles (observed operational taxonomic units [OTUs], and Chao1, Shannon, and Simpson indices) changed significantly when compared with those of calves with diarrhea. Beta-diversity analysis exhibited significant differences in gut microbiota compositions between calves with diarrhea and those in the recovered state. The abundances of eight phyla and thirteen genera in feces changed markedly after restoration of BCoV diarrhea. In addition, our correlation study clearly revealed that increased abundances of the genera Caproiciproducens, Pseudoflavonifractor, and Oscillibacter negatively correlated with serum glucose, and phosphorus levels, but positively correlated with serum chloride in calves with diarrhea, whereas increased abundances of the genera Peptostreptococcaceae;Clostridium (Clostridium cluster XI), Intestinibacter, Cellulosilyticum, Ruminococcus, Romboutsia, Paeniclostridium, Clostridiaceae;Clostridium and Turicibacter in recovered calves showed the opposite pattern. These results suggest that structural changes of the gut microbiota after recovery from BCoV infection correlate with changes in physiological parameters. In conclusion, our data provide evidence of gut microbiota-composition changes and their correlations with the physical profiles of post-weaned calves, before and after fluid therapy for BCoV-related diarrhea.

• 동서간호학연구지
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• 제28권2호
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• pp.170-178
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• 2022

Purpose: This study aimed to identify the factors influencing post-traumatic stress disorder in intensive care unit nurses in dedicated hospitals for coronavirus disease of 2019 (COVID-19) during the peak of the outbreak. Methods: This study used a cross-sectional correlational design. A total of 100 participants completed questionnaires comprising the Impact of Event Scale-Revised (IES-R), coping strategy indicator, social support, and post-traumatic growth. Post-traumatic stress disorder was classified as normal, mild risk, and high risk. Data were analyzed using 𝛘² test, Fisher's exact test, Kruskal-Wallis test with multiple comparison analysis, Pearson correlation coefficient, and multinominal logistic regression analysis. Results: Fifty seven nurses (57.0%) had a high risk of post-traumatic stress. Higher levels of post traumatic stress were associated with higher levels of social support seeking, and higher levels of avoidance, and lower levels of social support from supervisors. Higher post traumatic growth was correlated with higher social support for seeking coping, and problem solving coping strategies, and social support from supervisors and colleagues. Post-traumatic stress risk was associated with social support seeking and supervisors' social support. In addition, a higher risk of post-traumatic stress was related to COVID-19 work duration and supervisors' social support. Conclusion: Supportive programs, including increasing social support and building coping skills, may be suggested to safeguard the mental health of critical care nurses during the pandemic.

• Clinical and Experimental Pediatrics
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• 제65권4호
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• pp.209-210
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• 2022

• Korean Journal of Radiology
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• 제24권11호
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• pp.1167-1171
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• 2023

• 보건행정학회지
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• 제31권1호
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• pp.1-4
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• 2021

With this as a momentum of approval Pfizer vaccine against coronavirus disease 2019 (COVID-2019), it is changed to the era of vaccine rapidly. Most countries are trying to reserve effective vaccines and inoculate vaccines into high-risk populations for achieving community immunity. I reviewed several vaccine-related issues to be confronted for moving up to the end of COVID-2019: the efficacy and effectiveness of the approved vaccines, the priorities for vaccination into target groups, side effects, and distrust towards COVID-2019 vaccines. Evidence-based decision-making in the policy process and collaboration with professional groups are the most effective strategies for driving successful vaccination policy.

• 기독교교육논총
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• 제68권
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• pp.11-40
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• 2021

팬데믹은 코로나 이전(BC: Before Corona)과 이후(AC: After Corona)로 구분해야 할 만큼 심각하고 변화를 초래했다. 사회 관계망에서 소외되어 홀로 죽음을 맞는 개인은 물론, 일부 계층의 경제적 어려움과 의료적 불평등, 그리고 최근 서구 국가들에서 급증하는 아시아인에 대한 혐오와 폭력적 차별이 대표적인 사례들로 거론된다. 이외에도 철저하게 자국의 이익을 앞세운 국가 간 백신 확보 경쟁이 촉발한 제1세계와 제3세계 간의 현격한 백신 격차, 경제 환경과 금융시장 변화에 따른 소득 격차와 개인 및 법인의 파산에 이르기까지 팬데믹은 지구적 수준에서 '모든'(pan) '사람들'(demos)이 결코 비켜갈 수 없는 한계상황으로 기능하고 있다. 점증하는 폭력과 가난, 기근으로 위기에 처한 국가들에 팬데믹이 확산할 경우 세계가 최악의 재앙을 목격할 수 있다는 예측 역시 한편에서 제기되고 있다. 팬데믹이 초래한 사회의 일부 변화들을 검토하는 한편, 그에 따른 향후 기독교교육의 대책을 제안하기 위해 이 논문은 포스트 코로나 시대에 사회가 직면한 의료와 경제, 그리고 심리적 위기를 개략적으로 분석한다. 이어서 팬데믹 상황에서 근본적인 변화를 강력하게 요구받고 있는 기독교 신학과 선교, 그리고 예배의 변화를 차례로 살펴본다. 끝으로, 이상의 논의를 기초로 포스트 코로나 시대에 필요한 기독교교육의 새로운 방향을 제안한다.

• Journal of Preventive Medicine and Public Health
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• 제56권5호
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• pp.431-439
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• 2023

Objectives: Numerous studies have explored the causes and spread of outbreaks, yet there is a lack of research on post-coronavirus disease 2019 condition (PCC) in Korea. The goal of this study was to identify the various types of PCC and associated factors in discharged patients and to provide directions for the ongoing health management of confirmed patients. Methods: A telephone survey was conducted among 680 coronavirus disease 2019 (COVID-19) patients diagnosed between July 7, 2021 and August 26, 2021, in Dangjin, Chungnam, Korea. A descriptive analysis of characteristics, univariate analysis, and regression were performed using data from basic epidemiological surveys conducted at the time of diagnosis and post-discharge questionnaires. Results: Of the 585 patients who responded, 159 (27.2%) developed PCC. Of the 211 patients with no initial symptoms, 27 (12.8%) developed PCC, versus 132 (35.3%) of the 374 patients with initial symptoms. Among the initial symptoms, fever or chills, cough or sputum, loss of smell, and sore throat were associated with PCC. Compared to patients with less than 10 days of hospitalization, those with a hospitalization period of 21 days to 30 days (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.0 to 5.2) and 31 days or more (OR, 5.8; 95% CI, 1.9 to 18.1) had a higher risk of PCC. Conclusions: More than a quarter of COVID-19 patients, including those who had no initial symptoms, experienced PCC in Korea. People with the initial symptoms of fever, chills, and respiratory symptoms and those who had prolonged hospital stays had a high risk of PCC.