• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.1-10
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• 2022

Background: Inferior alveolar nerve block (IANB) is known to have a lower success rate for anesthesia in patients with irreversible pulpitis. This calls for supplementary techniques to effectively anesthetize such patients. This systematic review aimed to evaluate the published literature for determining the success rate of anesthesia induction using post-IANB intraligamentary (IL) injection in the mandibular teeth of patients with symptomatic irreversible pulpitis. The review question was, "What is the success rate of IL injection in the mandibular teeth of patients with irreversible pulpitis as a supplementary technique for endodontic treatment?" Methods: A thorough search of electronic databases and manual searches were performed. The protocol of the review was framed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO) with a proper criterion for inclusion and exclusion of studies. The included studies were analyzed using the Cochrane Collaboration "Risk of Bias" tool. A meta-analysis that included a comparison of primary nerve block and supplemental IL injection was performed. The success rate was evaluated using the combined risk ratio (RR) with a random risk model. A funnel plot was created to measure publication bias. Results: After all analyses, four studies were included. In the forest plot representation, RRs were 3.56 (95% CI: 2.86, 4.44), which were in favor of the supplemental IL injections. Statistical heterogeneity was found to be 0%. These values suggest that supplemental IL injections provide better success rates for anesthesia. Conclusion: According to the pooled qualitative and quantitative analyses, supplemental IL injections increased anesthetic efficacy.

• 한국발생생물학회지:발생과생식
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• 제14권1호
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• pp.1-5
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• 2010

We investigated the androgenic effects of 11-ketotestosterone (11-KT) on gonadal sex reversal and spermatogenesis in honeycomb grouper Epinephelus merra by method of gonadal biopsy. 11-KT was injected intramuscularly at a concentration of 1 and $10{\mu}g$ body weight. The proportion of cross sectional area of the gonad occupied by each germ cell type was measured and compared pre- and post-injection group. During the sex change phase, the distribution ratio of oocytes was decreased in all fish of 11-KT treatment group while the distribution ratio of spermatocytes was increased than pre-injection group. In male phase, all fish of 11-KT treatment group shown the increased distribution ratio of spermatocytes, but the distribution ratio of spermatozoa was decreased than pre-injection group. The present results suggest that 11-KT can stimulate degeneration of oocytes, proliferation of spermatocytes and spermiation in honeycomb grouper.

• Toxicological Research
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• 제20권4호
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• pp.381-389
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• 2004

The toxicity of CKD-602 was investigated at doses of 3, 9, and 27 mg/kg in rats, when the same total dose of CKD-602 was administered over 24 hr-continuous infusion or bolus injection. At 3 and 9 mg/kg, the 24-hr infusion group showed a more decreased WBC count on day 3, compared with the bolus group. Administration of CKD-602 caused more toxic effects such as the significant decreases of RBC counts, hematocrit, hemoglobin, and platelet count on day 7 post-administarion in the 24-hr infusion group than in the bolus group. Administration of CKD-602 also caused histopathological changes such as extramedullary hemopoiesis of liver and spleen, hyperplasia of femoral bone marrow, and caecal dilation. These toxic effects were more severe in the 24-hr infusion group than in the bolus injection group, indicating that the toxicity of CKD-602 may be dependant upon the duration of administration.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2007년도 공동학술대회 논문집
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• pp.241-244
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• 2007

Cement-grouts are injected into limestone cavities beneath the road in the project area, in order to improve strength and reduce permeability; the extent to which grout has penetrated in cavities need to be monitored in order to determined effectiveness of cement-grout. Geophysical approaches, offer great potential for monitoring the grout injection process in a fast and cost-effective way as well as showing whether the grout has successfully achieved the target. This paper presents the ability of surface electrical resistivity to investigate the verification of the grout placement. In order to image the cement-grout, time-lapse surface electrical resistivity surveys were conducted to compare electrical resistivity images before and after injection. Cement-grout was imaged as anomalies exhibiting low resistivity than the surrounding rocks. In accordance with field monitoring, laboratory study was also designed to monitor the resistivity changes of cement-grout specimens with time-lapse. Time-lapse laboratory measurements indicated that electrical methods are good tool to identify the grouted zone. Pre-and post grouting electrical images showed significant changes in subsurface resistivity at grouted zone. The study showed that electrical resistivity imaging technology can be a useful tool for detecting and evaluating changes in subsurface resistivity due to the injection of the grout.

• Archives of Pharmacal Research
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• 제22권6호
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• pp.549-553
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• 1999

The antipruritic effect of DA-5018m a capsaicin derivative, was examined in mice. Male ICR mice were topically pretreated with Zostrix-HP (0.075% capsaicin cream), 0.1%, 0.3% DA-5018 cream or cream base (control) twice daily for 4 days. One hour after the last application, itch was induced either by compound 48/80 ($50{\mu}g$, s.c.) or leukotriene B4 (0.03 nmol, i.d.) injection into the rostral back of the animals, and the number of scratches made by the animals at the injection site was counted for 60 min post-injection. DA-5018 cream (both 0.1 and 0.3%) significantly inhibited compound 48/80-induced scratching when compared with the cream base control (p<0.01), which Zostrix-HP showed minimal inhibition of the scratching behavior. In leukotriene B4-induced itch model, Zostrix-HP and 0.3% DA-5018 cram significantly inhibited the scratching during the first 10-min period (p<0.01). The results suggest that DA-5018 cream can be used as an antipruritic agent and warrant clinical evaluation.

• Design & Manufacturing
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• 제15권4호
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• pp.8-13
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• 2021

A plastic roller for opening and closing the safety door of the injection molding machine was molded. The dimensional change of the measurement position of the roller was studied when the cooling time was applied differently among the molding conditions, and when the temperature of the coolant applied for mold cooling was also applied differently. Cooling times of 300 seconds and 400 seconds, hot and low-temperature coolant were applied. When the low-temperature coolant was applied, the measuring point of the roller shrank by 0.03 mm. However, when the high-temperature coolant was applied, the measuring point shrank by 0.3 mm. It was found that the application of low-temperature coolant among coolants was more suitable for the reference dimension of the molded article compared to the application of high-temperature coolant. Among the cooling water applied for the molding of plastic rollers, when high-temperature coolant is applied, the shrinkage rate measured immediately after ejection was smaller than when low-temperature coolant is applied. However, it was found that post shrinkage, which occurs over time, occurs much larger when high-temperature coolant is applied.

• Journal of Astronomy and Space Sciences
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• 제40권3호
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• pp.123-129
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• 2023

This paper presents an analysis of the trans-lunar trajectory insertion performance of the Korea Pathfinder Lunar Orbiter (KPLO), the first lunar exploration spacecraft of the Republic of Korea. The successful launch conducted on August 4, 2022 (UTC), utilized the SpaceX Falcon 9 rocket from Cape Canaveral Space Force Station. The trans-lunar trajectory insertion performance plays a crucial role in ensuring the overall mission success by directly influencing the spacecraft's onboard fuel consumption. Following separation from the launch vehicle (LV), a comprehensive analysis of the trajectory insertion performance was performed by the KPLO flight dynamics (FD) team. Both orbit parameter message (OPM) and orbit determination (OD) solutions were employed using deep space network (DSN) tracking measurements. As a result, the KPLO was accurately inserted into the ballistic lunar transfer (BLT) trajectory, satisfying all separation requirements at the target interface point (TIP), including launch injection energy per unit mass (C3), right ascension of the injection orbit apoapsis vector (RAV), and declination of the injection orbit apoapsis vector (DAV). The precise BLT trajectory insertion facilitated the smoother operation of the KPLO's remainder mission phase and enabled the utilization of reserved fuel, consequently significantly enhancing the possibilities of an extended mission.

• IMMUNE NETWORK
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• 제8권4호
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• pp.124-129
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• 2008

Background: The immunomodulatory effects of Korean mistletoe (Viscum album Coloratum) on the innate immune responses of eel (Anguilla japonica) were studied. Methods: Mistletoe, Freund’s complete adjuvant (FCA), or phosphate-buffered saline (PBS) as a control was injected into eel peritoneal cavities. Results: Nitroblue tetrazolium (NBT)-positive cells in the head kidney of eel were significantly augmented by the second day post-injection of mistletoe. Reactive oxygen intermediates (ROI) were more produced in mistletoe-injected fish kidney leucocytes than in FCA-injected ones. The level of lysozyme activity in the serum of fish 2 days after injection with mistletoe was also significantly higher than that in the serum of the control fish. The optimal concentration of mistletoe in inducing the highest serum lysozyme activity was revealed to 500${\mu}$g/200 g of fish. In phagocytic activity assay, mistletoe-sensitized eel kidney phagocytes captured more zymosan than did the control fish. Conclusion: Korean mistletoe appeared to be a good activator of the non-specific immune responses of eel.

• 대한후두음성언어의학회지
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• 제8권1호
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• pp.65-68
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• 1997

The mutational falsetto is failure to change from the higher pitched voice of preadolescence to the lower pitched voice of adolescence and adulthood. The one of characteristic findings is contraction of suprahyoid muscles. The large majority of young men with inappropriately high voice have excellent voice therapy prognosis. We have experienced one case of mutational falsetto treated with botulinum toxin injection on suprahyoid muscles. His suprahyoid muscles are contracted markedly simultaneously with each phonation. fundamental frequency$(F_0)$ of his vowel phonation was 332Hz. Extensive voice therapy including manual compression of thyroid notch was ineffective. Forty units of Botox$^{\circledR}$ was injected under the EMG-guidance(20U bilaterally). At seven days post-injection, his voice changed lower than before and at 40 days after procedure, his $F_0$ was 126Hz.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 추계학술대회 논문집
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• pp.46-50
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• 2001

Due to its ability in producing a net-shape product to high precision in a very shot cycle time, injection molding has become one of the most important polymer-processings in the industry today. Recently the CAE applications in the field of injection molding have provided significant contributions to the mold design and process optimization. As a part of such an application the packing process has been studied using C-PARK. The prediction of pressure variations during post-filling stage for amorphous material has been compared with an experimental observation for a simple rectangular geometry of uniform thickness. And the optimal packing processes were calculated using the cavity pressure curve near the gate. As a case study, a warpage simulation was carried out for a DY-HOLDER with the variable number of gates.