• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.118-123
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• 2005

Positron emission tomography (PET) serves as a gold standard for noninvasive in vivo measurement of myocardial blood flow (MBF) and coronary flow reserve (CFR). CFR can be defined as the ratio of maximally vasodilated MBF over its basal flow. It is an important parameter for the evaluation of functional severity of coronary stenosis and prognositification in various diseases such as dilated cardiomyopathy. $^{13}NH_3,\;H_2^{15}O,\;^{82}Rb$ are widely used radiopharmaceuticals for measuring MBF and CFR, This review introduces imaging techniques and its clinical utility. Cardiac application or PET and PET/CT is expected to be increased in near future.

• The Korean Journal of Nuclear Medicine
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• v.32 no.3
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• pp.211-224
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• 1998

The role of scintigraphic imaging has moved from the detection of lesions to the tissue-specific characterization of lesions over the past 2 decades. Major advances in nuclear medicine imaging include: 1) positron imaging, 2) improved instrumentation, such as the use of multidetector (dual or triple head) gamma cameras for single photon emission computed tomography, and 3) development of numerous new radiopharmaceuticals for positron or single photon imaging (labeled glucose analogue, amino acids, fatty acids, hormones, drugs, receptor ligands, monoclonal antibodies, etc). These advances have resulted in a significantly improved efficacy of radionuclide techniques for the evaluation of various tumors, including those within the liver. The current role of nuclear medicine in the evaluation of focal hepatic tumors is reviewed in this article with an emphasis on the clinical applications of various tracer studies and imaging findings.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.5
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• pp.505-507
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• 2009

A 60-year-old woman, who had non-small-cell lung cancer (NSCLC) in left lower lobe underwent brain F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for evaluation of cerebral metastasis. On follow-up FDG-PET/CT, only hypometaolic lesion was detected and progressed in right frontal lobe at 6 months and 10 months, later. Hypermetabolic metastasis was not detected even at last scan time of FDG-PET/CT. Brain MRI showed brain metastasis in right frontal lobe. As might be expected, the physician should take cerebral metastasis into consideration even though there is only hypometabolic change on subsequent FDG-PET/CT in patients with NSCLC.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10d
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• pp.301-303
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• 2002

Subspace analysis is a popular method for multivariate data analysis and is closely related to factor analysis and principal component analysis (PCA). In the context of image processing (especially positron emission tomography), all data points are nonnegative and it is expected that both basis images and factors are nonnegative in order to obtain reasonable result. In this paper We present a sequential EM algorithm for rectified subspace analysis (subspace in nonnegativity constraint) and apply it to dynamic PET image analysis. Experimental results show that our proposed method is useful in dynamic PET image analysis.

• Korean Journal of Digital Imaging in Medicine
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• v.16 no.1
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• pp.61-67
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• 2014

The demand of cyclotron for PET (positron emission tomography) has rapidly grown as the more use of PET or PET-CT equipment requires the increased amount of radioactive isotopes for clinical positron emission. While research on failure statistics of medical equipment used in medical centers has continued to be done, the analysis and study on failure statistics of cyclotron have rarely been conducted. However, the growing demand shows the urgency of systematical management guideline and countermeasures for device failure to minimize any supply delay of radiopharmaceuticals occurred by such failure and complains from waiting patients for PET-CT diagnosis. Therefore, this study aims to analyze the failure report from Minitrace equipped in cyclotron which is owned by the department of nuclear medicine at Yeungnam University Medical Center and draws on the data to build effective management system for cyclotron.

• Imaging Science in Dentistry
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• v.36 no.2
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• pp.111-116
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• 2006

PET/CT is a new imaging technology that combines high-quality Positron Emission Tomography (PET) and Computed Tomography (CT). This imaging provides simultaneous anatomical and metabolic information. Therefore PET/CT is useful diagnostic modality for early detection of malignant tumor, accurate staging, decision on therapeutic plan, monitoring response to therapy and rapid detection of recurrence. We report oral and maxillofacial cancers diagnosed by using PET/CT and the usefulness of PET/CT in the evaluation of postoperative recurrence.

• Proceedings of the Optical Society of Korea Conference
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• 2001.02a
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• pp.124-125
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• 2001

The electro-magnetic vector equation(F=$qv{\times}B$ ; F：force, B：magnetic field, q：plus charge, v ：velocity of the charge) explains well about the rotations of electron and positron under the magnetic field[Ref.1], as in Fig.1(a). Because the electro-magnetic wave is also a motion of the alternating charge and magnetic field as in Fig.2, the force vector has all the time inwarding direction and then the wave has a rotating motion. The positron in the proton has constant charge and alternating one at the same time[Ref.2] and then the alternating charge makes the absorbing force with the alternating charge of the rotating wave ($\pi$-ray) around the nucleus[Ref.2]. (omitted)

• Nuclear Medicine and Molecular Imaging
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• v.41 no.2
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• pp.71-77
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• 2007

Advance of neuroimaging technique has greatly influenced recent brain research field. Among various neuroimaging modalities, positron emission tomography has played a key role in molecular neuroimaging though functional MRI has taken over its role in the cognitive neuroscience. As the analysis technique for PET data is more sophisticated, the complexity of the method is more increasing. Despite the wide usage of the neuroimaging techniques, the assumption and limitation of procedures have not often been dealt with for the clinician and researchers, which might be critical for reliability and interpretation of the results. In the current paper, steps of voxel-based statistical analysis of PET including preprocessing, intensity normalization, spatial normalization, and partial volume correction will be revisited in terms of the principles and limitations. Additionally, new image analysis techniques such as surface-based PET analysis, correlational analysis and multimodal imaging by combining PET and DTI, PET and TMS or EEG will also be discussed.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.1 no.2
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• pp.95-97
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• 2015

The translocator protein (TSPO) is one of the important targets for Positron Emission Tomography (PET) imaging because it is associated with brain cancer, stroke, and neurodegeneration. Recently, a novel quinoline compound with high affinity agent for the translocator protein has been developed. In this highlight review, major studies for the quinoline compound are described.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.1
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• pp.3-8
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• 2016

Molecular imaging technologies have been used to provide a new pathway for therapies and diagnosis of human disease. Especially, imaging probes have been much development in the molecular imaging field. Combining imaging probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) have suggested the potential of multiple methods in living body. This review discusses the cancer or lymph node-targeting probes that are suitable for PET/MRI based diagnosis.