• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3165-3172
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• 2012

Objective: Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. A large number of single nucleotide polymorphisms (SNPs) in the CYP2D6 gene have been reported to associate with cancer susceptibility. However, the results are controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to summarize the evidence for associations. Methods: Studies focusing on the relationship between CYP2D6 gene polymorphisms and susceptibility to cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers and the meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. Odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Results: According to the inclusion criteria, forty-three studies with a total of 7,009 cancer cases and 9,646 healthy controls, were included in the meta-analysis. The results showed that there was a positive association between heterozygote (GC) of rs1135840 and cancer risk (OR=1.92, 95%CI: 1.14-3.21, P=0.01). In addition, we found that homozygote (CC) of rs1135840 might be a protective factor for cancer (OR=0.58, 95%CI: 0.34-0.97, P=0.04). Similarly, the G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 had negative associations with cancer risk (OR=0.69, 95%CI: 0.48-0.99, P=0.04; OR=0.60, 95%CI: 0.38-0.94, P=0.03; OR=0.50, 95%CI: 0.26-0.95, P=0.03; respectively). Conclusion: This meta-analysis suggests that CYP2D6 gene polymorphisms are involved in the pathogenesis of various cancers. The heterozygote (GC) of rs1135840 in CYP2D6 gene might increase the risk while the homozygote (CC) of rs1135840, G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 might be protective factors.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.485-489
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• 2015

Purpose: The kappa angles of human eye were measured by photographs. The relationship between the dominant eye and far refractivity is studied. Methods: 112 adults participated in this study. The mean age was $22.54{\pm}5.90$ years. The kappa angles were measured by the deviation of the flash image in the photographs of eye. the dominant eye and the far refractivity were analyzed. Results: The distributions of kappa angles were 78.6% (176 eyes) in the positive angle, 15.2% (34 eyes) in the negative angle, and 6.2% (14 eyes) in the $0^{\circ}$. The kappa angles were $4.50{\pm}4.70^{\circ}$ for the dominant eye, $4.93{\pm}4.34^{\circ}$ for the non-dominant eye, $+6.00{\pm}2.22^{\circ}$ for the hypermetropia, $4.91{\pm}4.97^{\circ}$ for the emmetropia, and $+4.61{\pm}4.49^{\circ}$ for the myopia. The biggest kappa angles was odserved in the hypermetropia and the angles was getting smaller in the emmetropia, and the myopia. Conclusions: The kappa angle of the dominant eye was smaller than non-dominant eye. The kappa angle was smaller as the far refractivity is lower. The kappa angle can be directly measured by the photographic method.

• The Journal of the Korea Contents Association
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• v.16 no.3
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• pp.335-345
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• 2016

The purpose of this study is to investigate moderating effect of psychological flexibility on impact which students feel ambivalence over emotional expressiveness in interpersonal relationships. In summary, the results are as follows. Self-defence ambivalence is strong negative influence on subject well-being but concerned-relation ambivalence is not affect at subject well-being. Also, moderating effect of psychological flexibility in concerned-relation ambivalence is not appear on subjective well-bing while self-defence ambivalence is shown moderating effect of psychological at subjective well-being. These results are mean that concerned-relation itself contains psychological flexibility role and psychological flexibility is negative influence on self-defence ambivalence and positive influence at subjective well- being. Moderating effect of psychological flexibility is shown that as important role subjective well-being. So students will need to help accommodate an active experience in the field allow s college students to raise their own psychological flexibility.

• Journal of Music and Human Behavior
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• v.2 no.1
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• pp.17-33
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• 2005

Music has a vital meaning in peoples' lives, mostly as a communication medium for thoughts and feelings. Because music is nonthreatening and nonjudgmental, its viability works for everyone. The purpose of this research is firstly to compare the effectiveness of existing social rehabilitation program and music integrated social rehabilitation program for people with mental retardation. Secondly, the study purported to find out if the music integrated social rehabilitation program was effective, then how various musical activities can assist communication and expression, and further assist social interactions among the people with mental retardation. The data were collected using Emotions Assessment Tool, Social Skills Assessment, and Skills development in Music were used. Also, verbal contents, voices, gestures, nonverbal expressions were observed and analyzed. As the result, it is shown that the music integrated social rehabilitation program has enhanced communicative and expressive skills of adults with mental retardation, and further improved social interactive skills. This implies that music had positive effects to the mental patients on their social relationship activities, than the program without music integration. The results support previous findings that music can be an effective communicative and expression tool.

• Journal of radiological science and technology
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• v.23 no.1
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• pp.49-54
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• 2000

It is important to identify modifiable risk factors for breast cancer, because the breast cancer is one of the major causs of mortality among women. Some reported that obesity is a risk factor for breast cancer, but the results are not constant. Many risk factors are related to the duration of estrogenic stimulation of the breast. In general, early menarche and late menopause are positive risk factors. Human breast cancer has different characteristics according to the status of menopause(premenopause and postmenopause). In premenopausal women, about 60% of circulating estrogen is from the ovaries in the form of estradiol, and the remaining 40% is estrogen formed primarily in the adipose(fat) tissue via aromatization of androstenedion from the adrenal glands. After menopause this adipose cell production of estrone is the main source of estrogens and the level of estrone is maintained approximately at premenopausal levels. This study was undertaken to determine the role of body size and body mass index by status of menopause in development of breast cancer using retrospective case/control study. From March 1991 to February 1997 at the Wonkwang University Hospital, the breast cancer cases(n=72) and controls(n=86) were selected. By statistical analysis method, regression analysis, paired T-test and multiple logistic regression were done to estimate the influenced factors same as height, weight, BMI, age at menarche and age at menopause. The following results were obtained : 1. In premenopausal women, age at menarche was showed comparatively high correlation coefficients and BMI was described prominently highly in postmenopause. 2. At the results of multiple regression analysis, age at monarch, BMI and weight were showed as significant variables. In this method, critical factor ($R^2$) was 0.054. 3. Paired samples T-test was undertaken to test mean difference between two groups of cases and controls. The result of test performance showed a significant difference. 4. In comparison with women whose weight less than 50 kg, the ORs for the upper 5th group was 1.82(95% confidence interval). The heaviest women had a higher risk(OR=1.14, 95% confidence interval $1.12{\sim}1.31$, p=0.005). Higher body mass index was significantly associated with increased risk of premenopausal breast cancer (OR=1.01, 95% confidence interval $1.08{\sim}l.18$, p=0.05).

• Korean Journal of Social Welfare
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• v.62 no.1
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• pp.291-316
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• 2010

This study aimed to look for the possibility of dissolving social exclusion about the social vulnerable classes through the culture welfare programs. For this purpose, we analyzed interview records focused on the culture welfare practitioners applying the Modified Grounded Theory Approach worked out by Kinosita. The results showed that the culture welfare programs functionated of dissolving social exclusion about the social weaks by enhancing latent faculties and the sense of self-respect of them through providing various opportunities of culture fruition. It was appeared that the culture welfare programs promoted creative competence and the sense of self-respect, and strengthened the sense of solidarity of the participants by using the approaching strategies of offering various opportunities of creational experience, atypical operating programs centered on the process, establishing of the participants' subjecthood, and communal activities. That is, it was proved that actually the social weaks experienced the change of life with feeling emotional satisfaction, promoting family and human relationship, establishing positive identity, empowerment, participating communal activities, and so on, through the culture welfare programs. From these results we can know that if we provide the programs mixing the culture welfare programs with social welfare services which traditionally reinforced social exclusion about the social vulnerable classes by stigma, the social exclusion about them can be dissolved.

• The Korean Journal of Emergency Medical Services
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• v.14 no.1
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• pp.47-63
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• 2010

Objective : The objective of this study was to survey the job-related empowerment and job satisfaction of 119 emergency medical technicians provide emergency patients with first aid, to examine the correlation between their empowerment and job satisfaction, and to provide basic materials for developing programs to enhance 119 emergency medical technicians' empowerment and job satisfaction. Methods : The survey was conducted with 249 119 emergency medical technicians working at fire stations in an area of Gyeonggi-do during the period from June 26 to August 21, 2009. Using SPSS 14.0 program, we obtained frequencies percentages, means, and standard deviations, and performed independent two sample t-test, one way ANOVA, and Pearson correlation analysis, and Cronbach's ${\alpha}$. Results : 1) The mean score of the subjects' empowerment was 3.32, and that of their job satisfaction was 2.94. 2) As to difference according to general characteristics, no statistically significant difference was observed in empowerment but job satisfaction was statistically significantly different according to gender(t = 2.296, p = .023). 3) As to difference according to job related characteristics, empowerment was significantly different according to license type(F = 3.767, p = .011), and job satisfaction was statistically significantly different according to position(t = 3.222, p = .042), fire fighting experience(t = 2.689, p = .035), and first aid experience(t = 3.991, p = .007). 4) Empowerment was in a positive correlation with job satisfaction(r = .502, p = .000) in general, and by the sub areas of job satisfaction, the correlation with empowerment was high in order of job itself(r = .695, p = .000), interaction area(r = .493, p = .000), organizational demand area(r = .328, p = .000), working condition area(r = .153, p = .015), and wage area(r = .137, p = .031). By the sub areas of empowerment, the correlation with job satisfaction was high in order of significance(r = .424, p = .000), influence(r = .397, p = .000), competence(r = .372, p = .000), and self determination(r = .259, p = .000). Conclusion : The 119 emergency medical technicians' empowerment was in a high correlation with their job satisfaction, and had a strong effect on it. This suggests that 119 emergency medical technicians' job performance can be enhanced by improving their empowerment. These results are expected to be useful in making human resource management plans to enhance 119 emergency medical technicians' job satisfaction by empowering them.

• Journal of Korea Technology Innovation Society
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• v.21 no.2
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• pp.767-787
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• 2018

Technology-driven innovation and job-creation has each been the subject of much scholarly attention, but have largely been considered separately rather than in conjunction with each other. While the previous literature on economics pinpointed the macro effects on industry-level, this study explores the micro-level comparisons on innovation sources over the employment and financial performances. The PSM (propensity-score matching) analysis presents that firms, involved in an inward technology, tend to have higher employees with dominant technology capabilities than in-house R&D firms. The in-house R&D firms, on the contrary, have superior financial performances, suggesting that external technology commercialized firms suffer from low transformative efficiency. The mediation test analysis corroborates that the external technology-driven innovation induces more human resources in internalizing the exogenous technology. The positive relationship between R&D innovation and employment allow verification of the government's intervention in the promotion of technology commercialization in public sector. On the other hand, it also signals that the policy needs to enhance the recipient firms' commercializing capacity rather than a 'one-hit' transaction.

• Smart Media Journal
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• v.3 no.1
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• pp.52-62
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• 2014

Prevalence of common three-dimensional display progresses, increasing the demand for three-dimensional content. Starting from the year 2010 to meet increasing 2D to 3D conversion is insufficient to meet demand content was presented as an alternative. But, Convert 2D to 3D stereo effect only emphasizes content production as a three-dimensional visual fatigue and the degradation of the Quality problems are pointed out. In this study, opened in 2011 'Scenes Guan', the 13 selected Scene is made of the three-dimensional transform the content and the Quality of the transformation applied to the Depth-Map is a visual representation of three-dimensional fatigue and, the adequacy of whether the expert has group interviews and surveys were conducted. Many of the changes are applied to the motion picture of the three-dimensional configurations of Depth-Map conversion technology used in many ways before and after the analysis of the relationship of cascade configurations to create a depth map to the stage. Experiments, presented in this study is a three-dimensional configuration of Depth-Map transformation can lower the production of a three-dimensional visual fatigue and improve the results obtained for a reasonable place was more than half of the experiment accepted the expert group to show a positive reaction were. The results of this study with a rapid movement to convert 2D images into 3D images of applying Depth-map configuration cascade manner to reduce the visual fatigue, to increase the efficiency, and has a three-dimensional perception is the result derived.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.3
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• pp.219-227
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• 2005

Purpose: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 and p63 have recently been identified. They share considerable sequence homology with p53 in the transactivation, DNA binding, and oligomerization domains, indicating possible involvement in carcinogenesis. Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. The aim of this study was to analyze expression of p63 in squamous cell carcinogenesis and to compare with immunochemical markers representing cell proliferation and apoptosis. Materials and Methods: Using the Syrian hamster oral cancer model, the fraction of apoptotic (apoptotic index-AI), proliferating (mitotic index-MI) and p63 expressing keratinocytes were examined at normal, dysplastic and malignant oral epithelium using the TUNEL assay, PCNA and p63 immunostaining. Results: p63 significantly increased between normal and dysplastic epithelium and between dysplastic and malignant epithelium. PCNA significantly increased between normal and dysplastic epithelium and between normal and malignant epithelium. However, increase between dysplastic and malignant epithelium, though still increasing, was not statistically significant. The percentage of TUNEL positive cells increased from normal to dysplastic epithelium and returned to normal keratinocyte level in the malignant epithelium. However, differences between tissue types were not significant. The ratio of MI:AI increased significantly only in the dysplastic-malignant epithelial transition. The increase of p63 expression closely reflected the change in the MI:AI ratio during oral carcinogenesis. Conclusion: The p63 may be associated with the regulation of epithelial proliferation and apoptosis in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Further study is required to investigate which p63 isoforms are involved in hamster buccal pouch carcinogenesis.