• BMB Reports
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• v.50 no.1
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• pp.1-2
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• 2017

Acquiring a selective growth advantage by breaking the proliferation barrier established by gatekeeper genes is a centrally important event in tumor formation. Removal of the mammalian Hippo kinase Mst1 and Mst2 in hepatocytes leads to rapid hepatocellular carcinoma (HCC) formation, indicating that the Hippo signaling pathway is a critical gatekeeper that restrains abnormal growth in hepatocytes. By rigorous genetic approaches, we identified an interacting network of the Hippo, Wnt/${\beta}$-catenin and Notch signaling pathways that control organ size and HCC development. We found that in hepatocytes, the loss of Mst1/2 leads to the activation of Notch signaling, which forms a positive feedback loop with Yap/Taz (transcription factors controlled by Mst1/2). This positive feedback loop results in severe liver enlargement and rapid HCC formation. Blocking the Yap/Taz-Notch positive feedback loop by Notch inhibition in vivo significantly reduced the Yap/Taz activities, hepatocyte proliferation and tumor formation. Furthermore, we uncovered a surprising inhibitory role of Wnt/${\beta}$-catenin signaling to Yap/Taz activities, which are important in tumor initiation. Genetic removal of ${\beta}$-catenin in the liver of the Mst1/2 mutants significantly accelerates tumoriogenesis. Therefore, Wnt/${\beta}$-catenin signaling, known for its oncogenic property, exerts an unexpected function in restricting Yap/Taz and Notch activities in HCC initiation. The molecular interplay between the three signaling pathways identified in our study provides new insights in developing novel therapeutic strategies to treat liver tumors.

• Quality Improvement in Health Care
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• v.22 no.2
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• pp.75-90
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• 2016

Objectives: This study measures the level of cognition of employee's patient safety culture and evaluates the current level through comparing the results to external levels. Ultimately it is performed to construct a strategic improvement plan through the basic database for patient's safety culture. Methods: A questionnaire survey of self reporting type was carried out using structured questionnaire of the patient's safety culture for employees currently employed in a hospital. Total responders was 1,129 and a response rate was 54.6%. The survey results were calculated with a percent positive response, and the current level was evaluated by comparing with the survey results of a hospital (2009 and 2014) and the survey result of The Agency for Healthcare Research and Quality(2014). Results: Sub-dimension of high percent positive response for each area were 'teamwork within hospital units' (80%), 'feedback & communication about error' (73%) and 'supervisor/manager expectations & actions promoting safety' (67%). Meanwhile, 'teamwork across hospital units' (31%), 'hospital management support for patient safety' (29%), 'staffing' (27%) and 'non-punitive response to error' (17%) were relatively low percent positive response. Compared to the survey results of AHRQ (2014) for each area, 'teamwork within hospital units' (80%), 'feedback & communication about error' (73%), 'frequency of event reporting' (66%) were at the top 50% percentile level and the remaining sub-dimensions showed a very low level in the lower 10% percentile area. Conclusion: In order to establish a system for patient safety culture within the hospital and evaluate the effect on this, it is necessary to periodically evaluate the patient's safety culture and establish regulations on hospital safety culture to comply with this.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.163-163
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• 2023

Flooding has become an increasing event which is one of the major natural disasters responsible for direct economic damage in South Korea. Driven by climate change, precipitation extremes play significant role on the flood damage and its further increase is expected to exacerbate the socioeconomic impact in the country. However, the empirical evidence associating changes in precipitation extremes to the historical flood damage is limited. Thus, there is a need to assess the causal relationship between changes in precipitation extremes and flood damage, especially in agricultural region like Chungcheong region in South Korea. The spatial and temporal changes of precipitation extremes from 10 synoptic stations based on daily precipitation data were analyzed using the ClimPACT2 tool and Mann-Kendall test. The four precipitation extreme indices consisting of consecutive wet days (CWD), number of very heavy precipitation wet days (R30 mm), maximum 1-day precipitation amount (Rx1day), and simple daily precipitation intensity (SDII), which represent changes in intensity, frequency, and duration, respectively, and the time series data on flooded area and flood damage from 1985 to 2020 were used to investigate the causal relationship in the ARDL-ECM framework and pairwise Granger causality analysis. The trend results showed that majority of the precipitation indices indicated positive trends, however, CWD showed no significant changes. ARDL-ECM framework showed that there was a long-run relationship among the variables. Further analysis on the empirical results showed that flooded area and Rx1day have significant positive impacts on the flood damage in both short and long-runs while R30 mm only indicated significant positive impact in the short-run, both in the current period, which implies that an increase in flooded area, Rx1day, and R30 mm will cause an increase in the flood damage. The pairwise Granger analysis showed unidirectional causality from the flooded area, R30 mm, Rx1day, and SDII to flood damage. Thus, these precipitation indices could be useful as indicators of pluvial flood damage in Chungcheong region of South Korea.

• International Commerce and Information Review
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• v.18 no.3
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• pp.73-100
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• 2016

This study focused on the Korean Stock Market so as to recognize the actual Korea-China FTA effect in the firm level. The result are as follows. First, lifting embargo even before the FTA actually took into effect influenced negatively to the firms listed in Korean Stock Market unlike the expectations that effectuation could influence positively to Korean economy. Secondly, the industries that China has attracted more foreign investors than Korea have shown declining returns as they positioned comparative disadvantages in Korea. In this regard, foreign shares delivered signaling effects to domestic investors in Korea. Thirdly, information for effectuation(embargo lifting) has reflected in the stock prices immediately as it leaked in the industries expecting the negative impact, while investors showed the tenancy to retain the action until the FTA actually took into effect in the industries expecting the positive impact.

• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.3
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• pp.109-121
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• 2020

Converting the agricultural land-use of rice field to upland has been increasingly conducted as farmers encourages themselves to grow higher value-added crops on rice fields under the policy support. Comparing to rice field, Upland shows different characteristic of discharge due to the slope, scale, and shape of field and characteristics of rainfall event. In this study, we designed the experiment fields reflecting flat-upland characteristics with different land scale, and tried to collect the discharge and load data. Soybeans and corn were selected as target crops considering the possibility of large-scale cultivation and crop demand. The cultivation was conducted during the growth period in 2019 with 3 different field scales. Hence, we have collected the discharge data from 17 rainfall events and the load data for 8 rainfall events. As a result, the magnitude of rainfall events and the discharge duration were found to have a strong positive correlation and field discharge occurred during the period by 55% to 83% of rainfall duration. Besides we found other relationships and characteristics of rainfall event, discharge, and pollutant load and also pointed out that continuous monitoring and more data are required to derive statistically significant results. Compared with slope-field monitoring data obtained from the precedent research, the runoff ratio of the flat-fields was significantly lower than slope-fields. Overall the discharge in the slop and flat-fields shows appreciably different characteristics so that the related researches need to be further conducted to reasonably assess environmental impact of agricultural activities at flat-field.

• Journal of Preventive Medicine and Public Health
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• v.48 no.5
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• pp.239-248
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• 2015

Objectives: The purpose of this study was to assess the inter-rater reliability and intra-rater reliability of medical record review for the detection of hospital adverse events. Methods: We conducted two stages retrospective medical records review of a random sample of 96 patients from one acute-care general hospital. The first stage was an explicit patient record review by two nurses to detect the presence of 41 screening criteria (SC). The second stage was an implicit structured review by two physicians to identify the occurrence of adverse events from the positive cases on the SC. The inter-rater reliability of two nurses and that of two physicians were assessed. The intra-rater reliability was also evaluated by using test-retest method at approximately two weeks later. Results: In 84.2% of the patient medical records, the nurses agreed as to the necessity for the second stage review (kappa, 0.68; 95% confidence interval [CI], 0.54 to 0.83). In 93.0% of the patient medical records screened by nurses, the physicians agreed about the absence or presence of adverse events (kappa, 0.71; 95% CI, 0.44 to 0.97). When assessing intra-rater reliability, the kappa indices of two nurses were 0.54 (95% CI, 0.31 to 0.77) and 0.67 (95% CI, 0.47 to 0.87), whereas those of two physicians were 0.87 (95% CI, 0.62 to 1.00) and 0.37 (95% CI, -0.16 to 0.89). Conclusions: In this study, the medical record review for detecting adverse events showed intermediate to good level of inter-rater and intra-rater reliability. Well organized training program for reviewers and clearly defining SC are required to get more reliable results in the hospital adverse event study.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.26 no.2
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• pp.155-172
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• 2015

This study, by case investigation of book review, one of user-participation services in university library, and questionnaire investigation on librarians, aims at suggesting current statuses, problems, and improvement. This study investigated the services performed at 35 4-year universities establishing the department of library and information science. This study, except 7 ones which doesn't offer the service, investigated the service offered by 28 universities, classifying with 3 contents. As a result, the publicity and method in university library including event had an influence on use. This study was performed to increase participation rate and to promote reading activity. This study judged that book review is indispensible to university libraries. Libraries presented the opinions that, for the purpose of promoting active book review, libraries have to perform positive publicity, attractive event, support in the level of schools, librarians' wills, expansion of discussion cultures, offer of unified book review among universities, and linkage method with other organization reading program.

• Journal of the Korean Data and Information Science Society
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• v.21 no.6
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• pp.1071-1079
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• 2010

The decathlon is an athletic event consisting of ten track and field events. Events are held over two consecutive days and the winners are determined by the combined performance in all. We considered the best 200 decathletes who competed in the recent Olympics games and World Championship decathlon. We have used correspondence analysis to identify the relationship between ordered individual performance and the overall performance. Canonical correlation analysis of first day events versus second day events could shed light on the change of the level of performance between the two days. Correlation analysis was used to verify relation between cumulative event rank and final decathlon rank. Therefore, we conclude that the decathlon favors those atheletes who do well at the track events to become the best players. The best players in the decathlon performed relatively poorly in the 1,500 metres, but did well in the long jump, the 400 metres and the 110-metre hurdles. Decathletes in this study have a positive correlation between overall performance and maximal excellence in a particular discipline. Thus, to compete successfully at this level, a uniform, relatively high performance in all individual disciplines is required.

• Journal of the Korea Institute of Building Construction
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• v.10 no.1
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• pp.221-228
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• 2010

A construction firm's performance is largely attributable to performance in individual projects. In this regard, the awarding of an individual project has significant implications. However, project awards have received limited attention in the construction sector from amarket assessment perspective. This event study focuses on an analysis of market responses at the time of project awarding. A total of 252 samples wereselected through a rigorous sample screening processes. Performance was measured as cumulative abnormal return, which is traditionally adopted in event analysis. Research results indicated that the overall return is positive, and that the level isstatistically significant. Equity holders realized a higher return for projects awarded from the foreign countries compared to domestic projects. No relationship was observed between project size and the level of return. Other research findings and implications were discussed in detail from a management perspective.

• Management & Information Systems Review
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• v.31 no.4
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• pp.639-661
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• 2012

The purpose of the paper is to examine sidedness effects of comparative advertising and moderating roles of the emotions of customer and product type. To test the research hypotheses, this study conducted experimental designs. One hundred ninety-two undergraduate students were assigned to one of the four experimental groups. Comparative Advertising message type and product type were manipulated as between-subject factors. There was a surprising event situation(free gift event) when participants came to laboratory for experiment, which is for the emotion manipulation. If a participant in a positive emotion group, he or she gets a free gift. The data demonstrate that comparative message type have a significant effect on both attitude toward the advertising and acceptance intention. In addition, consumers' emotion and product type play a significant moderating role between the message types and the dependent variables. The results of this study contribute to the literature as a new attempt to examine the sidedness effect of the comparative advertising message. We suggested that message types and consumer's emotion is one of very important aspects for a comparative advertising and marketers should consider people's emotion when they release a comparative advertising, which can help when marketers make their strategy for a comparative advertising.