• Asian Pacific Journal of Cancer Prevention
• /
• 제17권4호
• /
• pp.1817-1821
• /
• 2016

Objectives: To observed the effects of ginsenoside -Rh2 (GS-Rh2) on proliferation and apoptosis of side population (SP) human gastric cancer SGC-7901 cells. Materials and Methods: SGC-7901 SP and Non-SP cells were sorted by flow cytometry and assessed using the cck-8 method. Expression of apoptosis-related proteins Bax and Bcl-2 of SP before and after the intervention was determined by Western-blotting. Results: It was found that the proliferation of SP was significantly faster than that of NSP (P<0.05). In addition, GS-Rh2 inhibited proliferation of gastric cancer SP cells, induced cell cycle arrest and cell apoptosis, and changed the expression of BAX/Bcl-2 proteins in a time-dependent and concentration-dependent manner (P<0.05). Conclusions: With increase of GS-Rh2 dose, GS-Rh2 gradually inhibit the proliferation of SGC-7901 SP cells, which have high proliferation rate, through G1/G0 phase arrest, followed by apoptosis which involves the up-regulation of Bax and the down-regulation of Bcl-2.

• 한국응용곤충학회지
• /
• 제46권2호
• /
• pp.221-227
• /
• 2007

2004년부터 2005년까지 호남지방의 쌀 생산조정지를 중심으로 노린재류의 발생과 기주식물을 조사하였다. 노린재류는 총 8과 26종이 조사되었으며, 중산간지인 무안에서 시골가시허리노린재의 발생이 가장 많았고, 발생최성기는 7 월이었다. 평야지인 완주는 2004 년에는 전반적으로 노린재류의 발생량이 적었고, 2005 년에는 시골가시허리노린재 발생최성기는 7월과 8월이었다. 쌀 생산조정지에서 인근 벼 포장으로 이동하는 시기는 시골가시허리노린재 등 5종은 8월, 우리가시허리노린재 등 3종은 9월이었다. 또한, 쌀 생산조정지에서 잡초를 섭식하는 노린재 종류는 시골가시허리노린재, 우리가시허리노린재, 북쪽비 단노린재, 더듬이긴노린재, 빨강촉각장님노린재, 메추리노린재, 가시점둥글노린재, 풀색노린재였다.

• 한국시스템다이내믹스연구
• /
• 제4권2호
• /
• pp.71-94
• /
• 2003

The purpose of this dissertation is to build a development density control model and estimate optimum developmental density level for a sustainable urban growth management. To develop the model, system dynamics modeling approach was used. The model was developed to analyze how urban growth, transition, and decay occur depending on the interaction among population, houses, industry structure, land and urban infrastructure such as road, water supply, and sewage treatment facilities. The model was applied to Anyang city to estimate optimum density level. Extensive computer simulation was conducted to find out the maximum numbers of population, industry structure, houses, and cars that can be adequately sustained with the current Anyang city's infrastructure capacity. The computer simulation result shows that the city is overpopulated by some 90,000 people. It nab analyzed that 20％ increase of existing capacity of urban infrastructure is necessary to support current population of Anyang city. To reduce the population to the adequate level whereby the current urban infrastructure can sustain, the current city regulation on floor area ratio needs be strengthened at least 20％ to 35%.

• Journal of Preventive Medicine and Public Health
• /
• 제27권4호
• /
• pp.747-761
• /
• 1994

Workers' periodic health examination is the main tools used to manage the health problems of most workers in Korea. The most common health problem found in workers' periodic health examination is liver disorder. Liver disorder is also one of the most common health problems in general population and one of the leading causes of mortality in adult population. Regulation proposed by government (No. 207, Ministry of Labor, 1992) defines the criteria for selection of workers with the liver dysfunction for further evaluative examination and the examination items used for diagnosis of the workers with liver dysfunction. This study was designed to evaluate the proficiency of each examination items presently defined in Regulation and propose the optimal examination items for detection of the liver disorders found by workers' periodic health examination. Study subjects are 186 workers with abnormal liver function tests in screening examination of workers' periodic health examination. Questionnaire survey including past history of liver disorder, drinking history, height and weight was done. Physical examination by physician, routine test items defined by Regulation (SGOT, SGPT, $\gamma$-GTP, protein, albumin, total and direct bilirubin, alkaline phosphatase, $\alpha$-feto protein, HBsAg and anti-HBs), anti-HCV antibody test and liver ultrasonography were done. Results are as follows; 1. Result of evaluative examination utilizing only the items defined in Regulation was; There were 75 workers with suspected live. disorder(40.3%), 63 with no liver dysfunction (33.9%), 13 with suspected hepatitis B(7.0%), 10 workers with hepatitis B(5.4%), 10 workers with hepatitis B carrier state(5.4%), 10 with alcoholic liver disorders(5.4%), 5 with fatty liver(2.7%). When alternative diagnostic criteria applying additional examination items (drinking history, body mass index, anti-HCV antibody and ultrasonography) diagnosability of liver disorder was increased. When all four items were included, final results were; 23 workers (17.8%) with hepatitis B (10 carriers, 13 suspects and 10 hepatitis B), 10 (5.4%) with hepatitis C(4 carriers, 5 suspects and 1 hepatitis C), 13(7.0%) with alcoholic liver disorder, 45(24.2%) with fatty liver (40 suspects, 5 fatty liver), 410%) with suspected liver disorders and 44 (23.7%) with normal liver. 2. Of examination items defined by Regulation, only SGOT, SGPT, $\gamma$-GTP and HBsAg were significantly different in abnormal rate and mean value, and all other laboratory findings did not showed significant difference between two groups. Drinking history, body mass index and anti-HCV antibody test which are the items that authors included in this study, also showed significant difference between two groups. Utilization of body mass index (BMI) for abnormal liver function group in diagnosis of fatty liver had high specificity (97.6%) but sensitivity (22.3%) was low. Therefore we suggest that SGOT, SGPT, $\gamma$-GTP, HBsAg, alcohol drinking history, BMI and anti-HCV Ab were useful for diagnosis of liver disorders among worker's periodic health examination.

• 한국분무공학회지
• /
• 제21권2호
• /
• pp.71-77
• /
• 2016

Air pollutants nitrogen oxides are inevitably generated in the combustion reaction. Its amount trend is steadily increasing because the rapid modern industrialization and population growth. For this reason, NOx is controlled to reducing the harmful components in the exhaust gas. So Marine Environment Protection Committee (MEPC) take effect 'Tier I', 'Tier II' of air pollution regulation in 2005 and 2011 respectively. According to NOx emissions are strictly regulated management of the vessel through them. In addition, since 2016 the regulation enter into force in the next step 'Tier III' was confirmed by MEPC 66th committee. It's 80% enhanced emissions limits than the 'Tier I' Alternatively these emission regulation, research is actively being carried out about exhaust gas after-treatment methods through the vessel application of Selective Catalytic Reduction(SCR). Therefore depending on the basic specification of cell density according to the Area velocity, Space velocity, Linear velocity is studied the effects of NOx removal efficiency

• 한국농촌건축학회논문집
• /
• 제7권3호
• /
• pp.1-8
• /
• 2005

Decrease in Population and graying of rural area by industrialization and urbanization are gone continuously. This makes happened various rural problems and the differential of standard of living with is arising day by day. Government is unfolding rural supporting project to solve continuously these problems. Recent Projects which are choosing not top-down process by government leading but bottom-up process through village inhabitants' participation and expert consultant get positive estimation. But those have difficulties because the support is attained only in the beginning step not continuously and inhabitants' number by graying is decreasing. The Special Economic Zone for Regional Development Policy is new access that regulation can differ according to special quality of each area depending on Localization Age. Through this transfer the competence that can mitigate or reinforce various regulations according to special quality of area in local government. So, back and maintain activation systematically so that each area could be developed specially. The purpose of The Special Economic Zone for Regional Development Policy is the activation of regional economy through development that regional specific character is. And there is characteristic that local government plans and takes the lead in all project contents, government gives regulation benefit by appointing the special economic zone and do not support finance and various tax remissions. Through investigation of such new policy, I wish to recognize what long-term plan and method could be possible to success rural activation continuously.

• 환경영향평가
• /
• 제4권2호
• /
• pp.131-149
• /
• 1995

The object of this study is to suggest some alternatives for environmental management towards sustainable urban development of Chongju city in Korea. This study analyses urban environmental indicators (population density, land use, road, park, car, etc.), level of air and water pollution and solids waste generation by comparing Chongju city and other large cities. Some alternatives towards sustainable development in Chongju city would be summerized and suggested as higher concentrated land use(compact city), mixed land use, supply of mass transit, establishment of regional environmental standards, total emission regulation of air and water pollutants, the preparation of Local Agenda21 of Chongju, and the introduction of strategic environmental assessment(SEA) into environmental impact assessment.

• 보건교육건강증진학회지
• /
• 제7권1호
• /
• pp.27-32
• /
• 1990

Since the medical insurance covered the total population in Korea in July, 1989, the number of patient's visitation to the tertiary care hospital had changed because of referral regulation. In the referred patients through the secondary care hospitals such as out-patients of departments of internal medicine, general surgery, obstetrics and gynecology, pediatrics had decreased as well in-patients in these departments. However, departments of urology, dermatology, dentistry, ophthalmology and ear-nose-throat had more or less similar number of patients after medical insurance implemented for the total population. Contrarily, the number of patients visited emergency clinics and department of family medicine had increased very many. Thus, expansion of emergency clinic department, new special clinic set-ups, establishment of family medicine department in each hospital etc are strongly recommend.

• 한국환경성돌연변이발암원학회지
• /
• 제21권2호
• /
• pp.95-98
• /
• 2001

$\beta$$_2$-Adrenergic receptors($\beta$$_2$-AR) contribute to cardiovascular regulation by influencing several functions and a several studies suggest that a decreased function of the $\beta$$_2$-AR may be involved in essential hypertension. We investigated the Arg16Gly mutation of $\beta$$_2$-AR gene, which show enhanced agonist-promoted downregulation of the receptor and yielded different results in terms of association with essential hypertension. We studied the relationship between genetic variation in the $\beta$$_2$-adrenergic receptor gene and hypertension in a Korean population using Nde I restriction fragment length polymorphism (RFLP) analysis. There were significant differences in allele and genotype frequencies between essential hypertensive and normotensive group (Odds ratio(CI) = 1.71 (1.09-2.70)). Therefore, our result suggests that the Nde I RELP of the $\beta$$_2$-adrenergic receptor gene may be useful as a genetic marker in hypertension diagnostics in Korean population.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1599-1603
• /
• 2012

Objectives: Since methylenetetrahydrofolate reductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers has extensively been studied in different populations. However, information on Pakistani breast cancer patients is lacking. The MTHFR gene has two most common mutations that are single nucleotide additions which result in change of amino acids C677T to Ala222val and A1298C to Glu429Ala. Methodology: 110 sporadic breast patients with no prior family history of cancer or any other type of genetic disorders along with 110 normal individuals were screened for mutations in exons 1 to exon 9 using single strand conformational polymorphism, RFLP and sequencing analyzer. Results: The p values for the 677CC, 677CT, and 677TT genotypes were 0.223, 0.006, and 0.077, respectively. Those for the 1298AA, 1298AC, and 1298CC genotypes were 0.555, 0.009, and 0.003, respectively. Conclusions: We found an overall a significant, weak inverse association between breast cancer risk and the 677TT genotype and an inverse association with the 1298C variant. These results for MTHFR polymorphism might be population specific in sporadic breast cancer affected patients but many other factors need to be excluded before making final conclusions including folate intake, population and disease heterogeneity.