• Asian-Australasian Journal of Animal Sciences
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• 제18권12호
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• pp.1675-1683
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• 2005

In the process of crossbreeding, the linkage disequilibria between the quantitative trait loci (QTL) and their linked markers were reduced gradually with increasing generations. To study the potential of QTL mapping using the crossbred population, we presented a mixed effect model that treated the mean allelic value of the different founder populations as the fixed effect and the allelic deviation from the population mean as random effect. It was assumed that there were fifty QTLs having effect on the trait variation, the population mean and variance were divided to each QTL in founder generation in our model. Only the additive effect was considered in this model for simulation. Six schemes (S1-S6) of crossbreeding were studied. The selection index was used to evaluate the synthetic breeding value of two traits of the individual in the scheme of S2, S4 and S6, and the individuals with high selection index were chosen as the parents of the next generation. Random selection was used in the scheme of S1, S3 and S5. In this study, we premised a QTL explained 40% of the genetic variance was located in a region of 20 cM by the linkage analysis previously. The log likelihood ratio (log LR) was calculated to determine the presence of a QTL at the particular chromosomal position in each of the generations from the fourth to twentieth. The profiles of log LR and the number of the highest log LR located in the region of 5, 10 and 20 cM were compared between different generations and schemes. The profiles and the correct number reduced gradually with the generations increasing in the schemes of S2, S4 and S6, but both of them increased in the schemes of S1, S3 and S5. From the results, we concluded that the crossbreeding population undergoing random selection was suitable for improving the resolution of QTL mapping. Even experiencing index selection, there was still enough variation existing within the crossbred population before the fourteenth generation that could be used to refine the location of QTL in the chromosome region.

• Journal of Animal Science and Technology
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• 제57권9호
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• pp.31.1-31.11
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• 2015

Background: This study was conducted to investigate the potential association of variation in the insulin-like growth factor binding protein 2 (IGFBP2) gene with growth, carcass and meat quality traits in pigs. IGFBP2 is a member of the insulin-like growth factor binding protein family that is involved in regulating growth, and it maps to a region of pig chromosome 15 containing significant quantitative trait loci that affect economically important trait phenotypes. Results: An IGFBP2 polymorphism was identified in the Michigan State University (MSU) Duroc ${\times}$ Pietrain $F_2$ resource population (n = 408), and pigs were genotyped by MspI PCR-RFLP. Subsequently, a Duroc pig population from the National Swine Registry, USA, (n = 326) was genotyped using an Illumina Golden Gate assay. The IGFBP2 genotypic frequencies among the MSU resource population pigs were 3.43, 47.06 and 49.51 % for the AA, AB and BB genotypes, respectively. The genotypic frequencies for the Duroc pigs were 9.82, 47.85, and 42.33 % for the AA, AB and BB genotypes, respectively. Genotype effects (P < 0.05) were found in the MSU resource population for backfat thickness at $10^{th}$ rib and last rib as determined by ultrasound at 10, 13, 16 and 19 weeks of age, ADG from 10 to 22 weeks of age, and age to reach 105 kg. A genotype effect (P < 0.05) was also found for off test Longissimus muscle area in the Duroc population. Significant effects of IGFBP2 genotype (P < 0.05) were found for drip loss, 24 h postmortem pH, pH decline from 45 min to 24 h postmortem, subjective color score, CIE $L^*$ and $b^*$, Warner-Bratzler shear force, and sensory panel scores for juiciness, tenderness, connective tissue and overall tenderness in MSU resource population pigs. Genotype effects (P < 0.05) were found for 45-min pH, CIE $L^*$ and color score in the Duroc population. Conclusions: Results of this study revealed associations of the IGFBP2 genotypes with growth, carcass and meat quality traits in pigs. The results indicate IGFBP2 as a potential candidate gene for growth rate, backfat thickness, loin muscle area and some pork quality traits.

• Asian-Australasian Journal of Animal Sciences
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• 제15권4호
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• pp.470-476
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• 2002

Random amplified polymorphic DNA (RAPD) analysis based on numerous polymorphic bands have been used to investigate genetic similarity and diversity among and within two cultured and wild populations represented by the species crucian carp (Carassius carassius). From RAPD analysis using five primers, a total of 442 polymorphic bands were obtained in the two populations and 273 were found to be specific to a wild population. 169 polymorphic bands were also produced in wild and cultured population. According to RAPD-based estimates, the average number of polymorphic bands in the wild population was approximately 1.5 times as diverse as that in cultured. The average number of polymorphic bands in each population was found to be different and was higher in the wild than in the cultured population. Comparison of banding patterns in the cultured and wild populations revealed substantial differences supporting a previous assessment that the populations may have been subjected to a long period of geographical isolation from each other. The values in wild population altered from 0.21 to 0.51 as calculated by bandsharing analysis. Also, the average level of bandsharing values was $0.40{\pm}0.05 $ in the wild population, compared to $0.69{\pm}0.08$ in the cultured. With reference to bandsharing values and banding patterns, the wild population was considerably more diverse than the cultured. Knowledge of the genetic diversity of crucian carp could help in formulating more effective strategies for managing this aquacultural fish species and also in evaluating the potential genetic effects induced by hatchery operations.

• 한국인구학
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• 제14권2호
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• pp.1-17
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• 1991

While various fiscal measures have been used to influence regional capital inflow or industrial location, the effect of fiscal variables on labor mobility has been little understood. Understanding the relationship between the composition of local public and urban migration would enhance the city govenment's ability to pursue an appropriate population policy. In order to examine the potential for local public finance to be utilized as a policy tool in directing urban population growth, this paper analyzes the impact of local government financial structure on urban migration. In examining the data on local government finance and the changes in population of Korean cities during the last ten years, it was found that cities with high per capita expenditure in regional development have experienced high population growth rates. In this study migration equations were constructed using various fiscal variables such as the proportion of special account expenditures which are mostly spent for local development purposes, per capita regional development expenditure, degree of local financial independence and per capita net fiscal benefit, along with other explanatory variables. The results of regression analysis showed that city government's regional development expenditure variables have a positive effect on urban net migration and a negative effect on outmigration. Fiscal independence and per capita net fiscal benefit had mixed effects on in and out migration variables, implying that local tax burden does not consistently deter inmigration or induce outmigration. Based on the results of this study some important policy implications can be found regarding local government's fiscal policies. Those cities seeking to attract higher population inflow should make a greater effort in appropriating local expenditures for regional development purposes such as infrastructure, housing, and transportation. city governments should not be too concerned about high local tax burden or necessarily seek to enhance financial independence for these factors do not exert a clear influence on urban population growth or labor supply.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 추계학술발표대회
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• pp.3.2-3.2
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• 2009

Microfluidics and BioMEMStechnology has increasingly been used as a tool for studying small volumes oftissue and even individual cells. One of the most important benefits ofmicrofluidic technology is the potential to build devices that analyze and sortmammalian cells. The "sorting problem" typically requires that a fewcells be selected and isolated from a larger population of hundreds, thousandsor even millions of other cells. For example, cancer tumor cells may resideamong a large population of healthy cells, but it would be of great interest toidentify, isolate and study only the cancer cells. In another application, onemay want to determine the number of white blood cells within a sample of blood.We have developed microfluidic devices that enable researchers to select cellsfrom a population by a variety of methods, including antibody staining,dielectrophoretic selection, and physical size selection. These devices haveapplications in cancer research where cancer cells must be identified fromnormal tissue, but where only small samples of tissue are available. In thistalk, we will present some of our microfluidic cell sorting devices, discusstheir physical principles, and their use in biological applications.

• 한국환경과학회지
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• 제20권2호
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• pp.155-161
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• 2011

In application and discussion of population structure and phenotypic divergence in plant community, the classic Lotka-Volterra models of competition and spatial model are conceived as a mechanism that is composed by multiple interacting processes. Both the Lotka-Volterra and spatial simulation formulae predict that species diversity increases with genotypic richness (GR). The two formulae are also in agreement that species diversity generally decreases within increasing niche breadth (NB) and increases with increasing potential genotypic range (PGR). Across the entire parameter space in the Lotka-Volterra model and most of the parameter space in the spatial simulations, variance in community composition decreased with increasing genotypic richness. This was, in large part, a consequence of selecting genotypes randomly from a set pool.

• 대한치과의사협회지
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• 제49권10호
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• pp.609-617
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• 2011

The geriatric population is the most rapidly growing part of the general population, which leads to an increase of chronic conditions and illnesses that will influence both oral and systemic health. The most common chronic diseases in elderly population are arthritis, hypertension, heart diseases, diabetes, and cognitive impairment. Chronic impairments such as visual, hearing, orthopedic, and speech disorders are also prevalent among older adults. All these chronic conditions have potential oral complications and the treatments of systemic diseases also has implications for the maintenance of oral health. Therefore, oral health care professionals should catch up with increasing knowledge in this field and can modify the treatment strategy for older adults. In addition, oral health care professionals should understand the changing need of oral health problems in this age and prepare the future demand.

• 한국인구학
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• 제9권2호
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• pp.13-29
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• 1986

This study was carried out to calculate working life expectancy and its potential gains according to the degree of reduction in the specific causes of death. It sought to ascertain what potential gains in labor force longevity might be reasonably achieved through efforts to reduce mortality from injuries and poisoning, diseases of circulatory system, neoplasms and the other causes of death. The data were drawn from the three sources such as "The 1982 Causes of Death Statistics," "Abridged Life Table for Korea 1978~'79" and "The 1982 annual Report of Economically Active Population" issued by Economic Planning Board. Analytical tools used in this study were the cause-deleted life table and the Wolfbein Wool's working life table method. Partial life expectancy was adopted as an index of this study, This application will be widely used as a good demographic tool for analyzing the dynamics of labor force and causes of death. Some of the findings are summerized as follows. 1. Partial life expectancies from initial age 15, 25, and 45 respectively to terminal age 65 are 44.86, 35.59 and 17.41 year in life expectancy itself, 37.08, 32.83 and 15.21 year in working life expectancy, 7.78, 2.76 and 2.20 years in inactive life years. 2. Potential gains in working expectancy from initial age 15, 25 and 45 to terminal age 65 by the complete elimination of the specific causes of death are 1.36, 0.94 and 0.27 years in injuries and poisoning, 0.88, 0.83 and 0.54 years in diseases of circulatory system, 0.56, 0.54 and 0.37 years in neoplasms, 1.13, 1.02 and 0.58 years in the other causes of death. The relationship between degree of reduction in causes of death and potential gains in working life years is in direct proportion. The prime orders of reduction effectiveness in age groups by the causes of death are injuries and poisoning in age 15-24, the other causes of death in age 25-49 and diseases of circulatory system in age 50 and over. 3. If it were possible to reduce 25%, 50% and 75% in mortality condition 1978~'79, the average length of working life would be 38.08, 39.13 and 40.17 years in age 15, and 33.68, 34.57 and 35.44 years in age 25, and 15.67, 16.14 and 16.63 years in age 45.

• 한국지리정보학회지
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• 제27권1호
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• pp.52-66
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• 2024

본 연구는 공간구조의 체계정립 및 계획 실효성 확보를 위하여, 부산광역시를 대상으로 도시기본계획에서 설정된 도시 중심지의 경계를 설정하고 중심지의 역할과 위상을 진단함으로써 중심지의 공간 체계와 특성을 파악하는데 목적이 있다. 이를 위하여 선행연구를 통해 중심지의 특성을 나타내는 4개의 지표를 선정하였고 지리적 경계 분석에 강점이 있는 공간통계기법으로 중심지 경계를 도출하였다. 또한 도출된 중심지 경계를 활용하여 각 중심지가 부산광역시 공간구조에서 가지는 영향력과 잠재력을 진단하기 위해 중심지 특성 지표와 인구잠재력 함수를 이용하였다. 분석 결과 중심지에 따라서 규모의 차이가 크게 발생하였으며, 용도지역상 상업지역이 활성화되지 않은 미활용지역과, 상업지역을 넘어 주거·공업지역으로 확산되는 확장지역이 도시 중심지마다 다르게 나타났다. 중심지의 흡인력을 나타내는 잠재력 측정 결과에서도 인구잠재력이 강한 지역과 약한 지역이 나타났다. 따라서 중심지 기능 강화를 위해서는 중심지 위계특성과 영향력 측정 결과를 기반으로 체계적인 관리 및 계획적인 육성전략이 필요하다. 본 연구에서 분석된 결과는 지속가능한 도시성장체계 구축과 균형발전 및 중심지 기능 강화를 위한 역세권개발계획 및 공간혁신구역과 함께 미래의 다양한 도시계획 수요와 정책의 변화에 대응하기 위한 자료로 활용 가능할 것이다.

• 한국유기농업학회지
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• 제31권4호
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• pp.343-355
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• 2023

Dairy processing experience tourism, that combines production, processing, and services, can be a good alternative to increase added value in Mongolian livestock industry. In addition, in order to successfully pursue this, it is necessary to first identify consumers' potential demand for the experience tourism and the factors affecting demand. Accordingly, this study estimated consumers' potential demand for dairy processing experience tourism using data from 758 people obtained through an online survey targeting Ulaanbaatar residents. As a result of the estimation, it was found that the variables that affect potential demand are the experience fees, average monthly household income, gender, age, arol consumption, and education level. The potential demand for dairy processing experience tourism was measured by multiplying the population of Ulaanbaatar by the estimated probability of accepting the experience tourism, and the total revenue was maximum at 32.303 million Tuk when the experience fee was 50,000 Tuk. The implications based on the analysis results are that, in order to promote participation in the experience tourism, it is necessary to promote it primarily to people with high average monthly household income, high level of education, younger age groups, and male. It can be said that preference is high and sufficient potential demand exists, but it is suggested that appropriate setting of experience fees is important.