• Journal of Nutrition and Health
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• v.49 no.2
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• pp.72-79
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• 2016

Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects, including increased cancer incidence. This may be related to physicho-chemical characteristics of PteGlu. This study examines the potential effect of high concentrations of PteGlu on a population subjected to mandatory folic acid fortification using an in vitro model. Methods: Caco-2 (colorectal cancer) and MCF7 (breast cancer) cell lines were cultured at 6 different PteGlu concentrations (0, 0.1, 1, 50, 250, and $500{\mu}g/ml$) for 6 days. Cell growth was determined using thiazolyl blue tetrazolium bromide assay. The genotype of dihydrofolate reductase 19bp deletion/insertion (DHFR 19-del) was also scored in cell lines using a restriction fragment length polymorphism technique to examine whether genetic variations may factor in cell proliferation. Results: PteGlu exhibited differential growth promoting properties between cell lines. Caco-2 cells did not show a significant growth difference at low concentrations compared to control, however, at higher concentrations, the growth showed a contrasting trend in the early experimental period, while MCF7 showed enhanced cell growth at all concentrations. The DHFR 19-del genotype differed in the two cell lines. Conclusions: Altered response to PteGlu by Caco-2 and MCF7 may reflect a tissue specific disease aetiology or genotype specific differential enzyme activity, for example by DHFR, to critical levels of PteGlu. As folic acid fortification is a blanket intervention, and DHFR and other enzyme activities vary between individuals, PteGlu intake may have an as yet undefined effect on health. These findings may be relevant when considering mandatory folic acid fortification for disease prevention.

• The Korean Journal of Malacology
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• v.19 no.1
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• pp.25-32
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• 2003

To know the effects of the red tide and toxic dinoflagellates on survival and growth of larvae of the mussel, Mytilus galloprovincialis, laboratory experiments were conducted by incubating larvae with either unialgal culture of 4 dinoflagellate species (Amphidinium carterae, Prorocentrum triestinum, Gymnodinium impudicum, or Akashiwo sanguinea) or a standard food (Isochrysis galbana) for 10 days. The survival of larvae was higher than 80% when the food was A. carterae, G. impudicum, or A. sanguinea. The lowest survival (20%) was found when the food was P. triestinum. When the food was P. triestinum, the survival of larvae rapidly decreased from 87% at day 4 down to ca. 50% at day 6, and 20% at day 10. This implies that the larval population of M. galloprovincialis can seriously be affected if they are exposed to the red tide water dominated by P. triestinum for more than 4 days. Shell length of larvae either increased or decreased according to the food species. When the food was A. carterae, G. impudicum, or A. sanguinea, shell length of larvae increased. But, it decreased when the food was P. triestinum. Though shell length increased in 3 treatments, the daily increments (0.63 $\mu$ m for A. carterae, 0.46 m for $\mu$ G. impudicum, and 1.10 m for $\mu$ A. sanguinea) were smaller than that of the standard food (3.79 m for $\mu$ I. galbana). Correlation analyses chowed that the change in shell length was not significant when the food was A. carterae or G. impudicum. Therefore, all of 4 dinoflagellates affected the growth of M. galloprovincialis larvae: growth was negative for P. triestinum, nil for A. carterae and G. impudicum, and positive but lower than standard food for A. sanguinea. These imply that the dinoflagellates are less valuable as foods for M. galloprovincialis larvae. So, decreased growth rate of larvae is expected during red tides, which will consequently cause delayed metamorphosis or failure to recruitment to the adult populations. In considering the harmful effects of red tides on the aquatic ecosystem, not only the effects on adult populations of fish and shellfish, but also the effects on larval populations should be included.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.53 no.5
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• pp.699-706
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• 2020

Predictive models in food microbiology are used for predicting microbial growth or death rates using mathematical and statistical tools considering the intrinsic and extrinsic factors of food. This study developed predictive growth models for Bacillus cereus on dried laver Pyropia pseudolinearis stored at different temperatures (5, 10, 15, 20, and 25℃). Primary models developed for specific growth rate (SGR), lag time (LT), and maximum population density (MPD) indicated a good fit (R²≥0.98) with the Gompertz equation. The SGR values were 0.03, 0.08, and 0.12, and the LT values were 12.64, 4.01, and 2.17 h, at the storage temperatures of 15, 20, and 25℃, respectively. Secondary models for the same parameters were determined via nonlinear regression as follows: SGR=0.0228-0.0069*T₁+0.0005*T₁²; LT=113.0685-9.6256*T₁+0.2079*T₁²; MPD=1.6630+0.4284*T₁-0.0080*T₁² (where T₁ is the storage temperature). The appropriateness of the secondary models was validated using statistical indices, such as mean squared error (MSE<0.01), bias factor (0.99≤B_f≤1.07), and accuracy factor (1.01≤A_f≤1.14). External validation was performed at three random temperatures, and the results were consistent with each other. Thus, these models may be useful for predicting the growth of B. cereus on dried laver.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.3
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• pp.313-316
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• 2004

Ultrasonographic studies were conducted on eight Murrah buffaloes daily from day 6 postpartum (pp) onwards till day 77 pp to monitor changes in the cervix, uterine horn and ovarian follicular growth and development. The mean size of horn and cervix on day six ($9.07{\pm}0.74$ and $8.58{\pm}0.00cm$) decreased significantly to $4.09{\pm}0.09$ and $3.56{\pm}0.08cm$ by day 27 pp, respectively. Follicles in 50% of the buffaloes ovulated within 24 to 54 days pp and the size of the largest follicle on different days increased to more than 5 mm. The remaining 50 percent of animals ovulated after 65 days postpartum. Large size follicles (>8.5 mm) appeared in six out of eight buffaloes between 10 to 30 days pp and five animals had ovulated during early postpartum period. Waves pattern of follicular growth was observed during early postpartum period. Ovulatory follicles growth rate was more than the anovulatory follicles and increase in size was more as compared to the subordinate follicle. Anovulatory follicles persisted for longer period. Mean size of large follicle was more from day 6 to 41 pp and again from 50 to 65 pp in cyclic animals. Second large follicle were large during early postpartum (18days), thereafter, its size was more in acyclic animals. Small follicles population was less in cyclic animals upto day 50 postpartum. Mean medium size follicle growth pattern did not differ in cyclic and acyclic groups. Large size follicle number was more in cyclic group (5/8) during 14 to 20 days postpartum. Presence of large follicles (>8.5 mm) showed initiation of ovarian activity.

• Fisheries and Aquatic Sciences
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• v.6 no.3
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• pp.149-154
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• 2003

The characteristics of pollutant loads from the various sources and seawater quality in Kwangyang Bay were evaluated. Total flow rate was estimated to be $10,868,066.8 m^3/day$ with a flow rate of R2l (the Seomjin River) as the highest one. Total COD, TN and TP loads of the input rivers and the ditches were about 27,591.8, 25,029.6 and 586.4 kg/day, respectively. Wastewater discharging loads was the greatest contributors to pollutant loads in the inner part of Kwangyang Bay. COD values in the inner part of the bay was over 3.0 mg/L, which exceeded the seawater quality criteria III of Korea. The average values of DIN and DIP were 8.62 ${\mu}gN/L\;and\;1.26\;{\mu}gP/L$, respectively. The limiting factor for algal growth was DIN. In he total discharging loads of the watershed from unit loading estimations, BOD, TN and TP were 9,132.3, 2,727.2 and 304.2 kg/day, respectively. In addition, municipal sewage by the population as pollution sources and the city of Kwangyang as administrative district had the highest loads. For a appropriate water quality recovery of Kwangyang Bay, it is suggested that it is essential to estimate reduction rate of total pollutant loads by water quality modeling.

• Journal of Ginseng Research
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• v.17 no.1
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• pp.45-51
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• 1993

In 61 abolished ginseng fields examined in 1986, the average plant missing was 49.2%, root rusting, 34.4%, and root rot, 3.3%. Plant missing was not different among the ages of ginseng fields; however, rate of root rusting was high in 3- and 4-year-old ginseng fields, and rate of root rot was high in 5- and 6-year-old ginseng fields, suggesting that root rusting and root rot were relatively more important factors related to the abolishment of ginseng filed in younger and older ginseng fields in 1986, respectively. Out of 61 ginseng fields, 18 were infested with more than 509) alternaria blights, and out of 19 fields with root rot, 2 were caused by Sclerotinia sp., 5 by potato rot nematode, and the causal agents were not identified in 12 fields. With increase of the ridge height, root rusting was significantly decreased, and plant missing rate was significantly lower in fields with straw mulching than those without mulching. The physico-chemical characteristics of the fields with more than 50fi root rusting, the contents of $NO_3,\;P_2O_5$ and Ca were higher than those of good fields with less than 40% root rusting and plant missing. The population of Erwinia sp. was significantly corralled with plant missing.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.2
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• pp.95-104
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• 2019

Along with the economic globalization and network generalization, this provides a good opportunity to the development of cross-border e-commerce trade. Based on this background, this paper sets ASEAN countries as an example to exploit the determinants of cross-border e-commerce trade including the export and the import, respectively. The panel data from the year of 1998 to 2016 will be employed to estimate the relationship between cross-border e-commerce trade and relevant variables under the dynamic ordinary least squares and the error correction model. The findings of this paper show that there is a long-run relationship between cross-border e-commerce trade and relevant variables. Generally speaking, the GDP(+) and real exchange rate(-export & +import) have an effect on cross-border e-commerce trade. However, the population (+) and the terms of trade (-) only have an effect on cross-border e-commerce import. The empirical evidences show that the GDP and the real exchange rate always affect the development of cross-border e-commerce trade. Therefore, all ASEAN countries should try their best to develop the economic growth and focus on the exchange rate regime so as to meet the need of cross-border e-commerce trade development.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.763-769
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• 2021

The relationship between government size and unemployment is an important topic of study in economics. Large public expenditure has been blamed for causing higher unemployment contrary to the belief that it would help in reducing unemployment. More research on the topic, however, needs to be done as the available literature has been based largely on data from developed countries. The present paper examines the existence of the relationship in states of India by using panel data analysis. For more comprehensive study, public expenditure is divided into development, non-development, and aggregate expenditures, while the types of unemployment under consideration are usual status and current weekly status. Indeed, it has been observed that development and non-development expenditures increase both the types of unemployment though the impact of the latter is higher. The findings are important as it implies that a cut in expenditure can be an important fiscal tool to fight unemployment. It was further observed that unemployment was higher among states with a more educated population, which also suggests a revisiting of the education policy in the country. States ruled by left parties have higher unemployment rate. Higher income states as well as states with higher growth rate tend to have lower unemployment rate.

• Korea journal of population studies
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• v.33 no.2
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• pp.113-136
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• 2010

Low fertility has become quite commonplace worldwide, and Europe has experienced below replacement fertility for several decades. In addition, lowest-low fertility, defined as period total fertility rate below 1.3, has rapidly spread in Europe during the 1990s and is likely to expand further. After the turn of century, lowest-low fertility started spreading in Eastern Asia. Korea's TFR of 1.19 in 2008 is lower than most European countries, although it is higher than the Hongkong(1.02) and Taiwan(1.09). The purpose of this paper is to examine the socioeconomic determinants of lowest-low fertility in Korea. In doing so, this paper discusses the effects of female labour force participation, labour instability on family formation and fertility. The data includes female labour force participation rate, unemployment rate, age at first marriage, and total fertility rate from 1980 to 2008. First, the economic recession hindered young people's economic independence and propensity to marry. Married couples were also depressed with uncertainty toward the future and avoided to have children. Second, the growth in female labor force participation had a negative impact on fertility, under the low level of compatibility between women's work and childrearing. Moreover, this paper argues that the rising cost of children including public and private educational costs is thought to be the main reason of the recent low fertility in Korea. Policy implications and some comments on population policies are also presented in the final section.

• Economic Analysis
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• v.25 no.4
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• pp.58-108
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• 2019

This paper analyzes the determining factors in the unemployment rate among young people in their 20s by studying data from 30 OECD countries between 2000 and 2017. It identifies reasons why Korea has a higher youth unemployment rate than Japan, and assesses what implications Japan's youth unemployment measures could have on Korea. The study highlights the variables that have meaningful impacts on youth unemployment. They include the unemployment rate among the working-age population, the percentage of each age bracket in the overall population, the GDP growth rate, the percentage of wage laborers in each age group, the percentage of elderly people, and the percentage of part-time workers. This paper also finds that a decline in the youth population, especially among people in their 20s, does not help to address the issue of youth unemployment. Secondly, this paper explains the additional factors behind Korea's higher youth unemployment rates. One is Korea's disadvantageous employment environment, compared to that in Japan, in terms of wage earnings. Other factors include the existence of fewer decent corporate jobs than in Japan, and wide disparities in wages between large and small corporate jobs. Therefore, while making efforts to resolve long-term and structural problems, it is necessary to actively promote policy measures to solve short-term mismatch problems of youth employment by referring to Japanese policy examples.