• Applied Chemistry for Engineering
• /
• v.3 no.2
• /
• pp.335-340
• /
• 1992

Polymerized vesicles were formed from monomeric surfactants and permeability of polymerized vesicles were compared with that of monomeric analogs. The results showed that crosslinking get the permeability of vesicle decrease. And when the vesicle was polymerized at both inside and outside of vesicle, the vesicle got the lower permeability. Packing structure in the vesicle which is dependent upon the molecular structure of alkyl group in surfactant had an effect on permeability of vesicle.

• Applied Chemistry for Engineering
• /
• v.3 no.2
• /
• pp.273-279
• /
• 1992

Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. A polymerized vesicle was formed both monomeric cholesterol-containing surfactant and monomeric surfactant containing two alkyl chain(50 : 50 weight ratio). This vesicle got the better extracting capacity compared with the vesicle which got the other weight ratio of the surfactants. This vesicle also exhibited the fastest substrate permeability. These all results showed that considerable vacant room is necessary in polymerized vesicles in order to extract more cholesterols.

• Journal of Pharmaceutical Investigation
• /
• v.23 no.1
• /
• pp.33-39
• /
• 1993

Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. To introduce spacer group into [cholesteryloxycarbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA), [5-[ (cholesteryloxy)carbonyl]pentyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-5) and [10-[(cholesteryloxy)carbonyl]decyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-10) were synthesized, In both case of polymerized vesicle with CHODAMA-5 and CHODAMA-10, the permeability was decreased and the amount of extracted cholesterol was also decreased, compared with the polymerized vesicle of CHODAMA.

• Applied Chemistry for Engineering
• /
• v.2 no.1
• /
• pp.64-69
• /
• 1991

A lipid containing a 1, 2-dithiolane group was synthesized, and polymerized vesicle was prepared from the vesicle of this lipid by ring-opening polymerization. Reaction rate of the polymerization was monitored by UV absorption, and the results showed that it followed the first order kinetics and the rate constant $3.84{\times}10^{-2}min^{-1}$. Permeation rate of sucrose through the polymerized vesicle was $4.7{\times}10^{-8}cm\;hr^{-1}$, which is 1.5 times lower than that of monomeric analog.

• Journal of Pharmaceutical Investigation
• /
• v.23 no.2
• /
• pp.89-95
• /
• 1993

Polymerized vesicles were prepared from the monomeric cholesterol-containing surfactant. Spacer groups were introduced into [(cholesteryloxy)carbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA). In case of introducing the spacer groups to the cholesterol moiety, both permeability of vesicles and that of polymerized vesicles were decreased. In case of introducing the spacer groups to monomeric moiety, permeability of vesicles was increased, while that of polymerized vesicles was decreased.

• Applied Chemistry for Engineering
• /
• v.9 no.5
• /
• pp.763-767
• /
• 1998

Cholesterol-containing surfactant was synthesized, and it was sonicated with monomer [tetradeca(ethylene glycol) diacrylate] in water to from a vesicle solution. This vesicle solution was dried to construct a membrane which had a molecular multilayer structure. The monomer which stay in this membrane was polymerized with photoinitiation, and then surfactant was extracted by organic solvent. The physical properties of the two dimensional polymer network were measured, and these physical properties are tensile strength, elongation, and swelling.

• Polymer Science and Technology
• /
• v.4 no.1
• /
• pp.45-50
• /
• 1993

• Applied Chemistry for Engineering
• /
• v.7 no.6
• /
• pp.1142-1146
• /
• 1996

Cholesterol-containing surfactant was synthesized, and it was sonicated with monomer in water to form a vesicle solution. This vesicle solution was dried to construct a membrane which had a molecular multilayer structure. Using UV irradiation the monomer in this membrane were polymerized, and then surfactant was extracted by organic solvent. Using a X-ray diffractometer, the thickness of one layer and the regularity of the multilayer were measured. And scanning electron microscopy was conducted for fractured polymer film.

• Membrane Journal
• /
• v.6 no.4
• /
• pp.213-218
• /
• 1996

Cholesterol-containing monomeric surfactants were synthesized, and sonicated in water to form a vesicle solution. This vesicle solution was dried to construct a membrane which had a molecular multilayer structure. Using UV irradiation the surfactants in this membrane were polymerized and molecular weight was determined. Using a X-ray diffractomelet, the thickness of one layer and the regularity of the multilayer were measured.

• Korean Chemical Engineering Research
• /
• v.49 no.4
• /
• pp.400-404
• /
• 2011

Many studies on polydiacetylene(PDA) have been investigated to apply to chemical and biological sensors due to their unique optical properties of color change from blue to red and fluorescence change from non-fluorescence to red fluorescence. Especially, high sensitivity against specific molecules is very important to apply polydiacetylenes to various sensors. In this study, we examined the effect of sensitivity enhancement of 10,12-pentacosadynoic acid(PCDA) vesicles in detection ${\alpha}$-cyclodextrin(CD) according to control of vesicle size by filters with different pore sizes and polymerization temperature. Colorimetric response(CR) was calculated using visible spectrometer. In order to investigate the effect of vesicle size on sensitivity of PDA vesicles, two PCDA vesicles were filtered without filtration and with 0.22 ${\mu}m$ filter. The two PCDA vesicles were polymerized at $25^{\circ}C$ and were incubated with ${\alpha}$-CD(5 mM) for 30 min. The CRs of the former and latter vesicles were 31.4% and 74.0%, respectively. Then, two PCDA vesicles filtered with 0.22 ${\mu}m$ filter were polymerized at $25^{\circ}C$ and $5^{\circ}C$ and were reacted with ${\alpha}$-CD(5 mM) for 30 min to examine the effect of polymerization temperature. The CRs of the former and latter vesicles were 74.0 and 99.2%, respectively. This suggests that vesicle sizes and polymerization temperature are key factors in enhancing the sensitivity of PDA vesicles. In addition, these results are expected to be useful to apply the PDA vesicles as biosensors to detect DNA, protein, and cells.