• 약학회지
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• 제10권2_3호
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• pp.5-7
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• 1966

A variety plant in Polygonatum sibirieum R$_{EDOUTE}$, P. sibiricum R$_{EDOUTE}$ var. multiverticillatum R$_{IM}$ named by author, was discovered in Kang Won-Do, Korea. It was found that this plant has 4-7 whorled leaves, while the ordinary P. sibiricum R$_{EDOUTE}$ has 4 ones. De verticillato 4 vel plura usque ad 7 fo lium; Recenter invento: Haec noviter inventa varietas habet 4 vel plura usque ad folia latiora et altiora quam antea.a.

• Archives of Pharmacal Research
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• 제14권2호
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• pp.193-194
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• 1991

The purine nucleoside, adenosine, mp. $223-4^\circ$, was isolated from the rhizomes of Polygonatum sibricum. Its structure was characterized on the basis of spectral data.

• 한국약용작물학회지
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• 제28권5호
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• pp.331-338
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• 2020

Background: The aim of this study was to analyze the total phenol and total flavonoid contents and antioxidant activity of steam-treated leaves and rhizomes of Polygonatum sibiricum Redoute. In addition, we aimed to confirm their potential use as cosmetic materials by investigating their anti-aging and skin-whitening activity. Methods and Results: The leaves and rhizomes of P. sibiricum were treated with steam at different temperatures for different durations, and the antioxidant activity (DPPH and ABTS radical scavenging activity) and total phenol and total flavonoid contents of each sample were tested. The steam temperature and treatment duration siginificantly affected the antioxidant activity and, total phenol and total flavonoid content of the leaves and rhizome of P. sibiricum. Treating the P. sibiricum samples with steam at 120℃ for 12 h, yielded higher total phenol and total flavonoid contents. Comparatively, the samples treated with steam at 120℃ for 12 to 24 h showed significantly higher antioxidant activity. Further, the steamed samples of P. sibiricum demonstrated collagenase and tyrosinase inhibition activity, which indicated their anti-aging and skin-whitening properties. The samples steamed at 120℃ for 12 h, exhibited higher collagenase and tyrosinase inhibition activity. Conclusions: Leaves and rhizomes of P. sibiricum steamed at 120℃ for 12 h, showed highest antioxidant activity and, total phenol and total flavonoid contents than all other samples. Our results indicate the potential of using P. sibiricum as a cosmetic material by confirming its excellent anti-aging and whitening activity.

• 생명과학회지
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• 제9권2호
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• pp.212-215
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• 1999

본 연구에서는 황정(Polygonatum sibiricum) 추출물에서 생리활성 물질로 기대되는 새로운 화합물II를 분리하고, 분리한 화합물의 화학적인 구조를 분광학적인 방법에 의하여 확인하였다. IH-nmr, 13C-nmr, DEPT135, COSY, HMQC, HMBC 스펙트럼 및 MS 스펙트럼으로 확인하여 화합물II의 구조가 2-hydroxy-3-(9,12-(9E,12E)-octadecadienoyloxy) propanoic acid 임을 알 수 있었다.

• 한국식품영양과학회지
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• 제27권1호
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• pp.80-86
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• 1998

This work was designed to determine the optimum roasting conditions with application of a pressure roaster for improving the roasting process of the Polygonatum sibiricum tea which has been roasting with a traditional method. Soluble solid content of the Polygonatum cibiricum tea was 63.16% in the tea roasted at 0.85kgf/$\textrm{cm}^2$(roasting pressure) and 13.9min(roasting time) which were maximum point by the ridge analysis. The optimum conditions predicted for each corresponding sensory properties of the Polygonatum cibirium tea were 0.87kgf/$\textrm{cm}^2$ and 9.2min in color, 0.89kgf/$\textrm{cm}^2$ and 9.7min in sweet 0.72kgf/$\textrm{cm}^2$ and 5.4min in burnt flavor, 0.89kgf/$\textrm{cm}^2$ and 9.9min in appetizing flavor, 0.87kgf/$\textrm{cm}^2$ and 9.3min in aftertaste, 0.89kgf/$\textrm{cm}^2$ and 10.0min in aroma, and 0.88kgf/$\textrm{cm}^2$ and 9.6min in overall acceptability of the tea. The optimum conditions based on the soluble solid content and sensory properties of the Polygonatum cibiricum tea, were 0.83~0.88kgf/$\textrm{cm}^2$ and 9.7~10.4min.

• Natural Product Sciences
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• 제17권3호
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• pp.183-188
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• 2011

A bisdesmosidic cholestane glycoside was isolated from the rhizomes of Polygonatum sibiricum and the structure was elucidated by spectroscopic methods and acid hydrolysis as (22S)-cholest-5-ene-$1{\beta}$,$3{\beta}$,$16{\beta}$,22-tetrol 1-O-${\alpha}$-L-rhamnopyranosyl 16-O-${\beta}$-D-glucopyranoside. This compound exhibited weak cytotoxic activity with the $IC_{50}$ value, $63.6\;{\mu}M$ in human MCF-7 breast cancer line, whereas it failed to show agonistic activity at $100{\mu}M$ in TGR5 assay with Chinese hamster ovary (CHO) cells. This is the first report of a bisdesmosidic cholestane glycoside from Polygonatum species and the full assignments of $^1H$, $^{13}C$ NMR by HMBC, TOCSY and NOESY experiments were provided.

• 생약학회지
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• 제35권4호통권139호
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• pp.265-270
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• 2004

The phylogenetic relationship of Polygonatum species were examined by RAPD analysis. Polygonatum Rhizoma is called 'Whang-jung', and used Polygonatum sibiricum Redoute in defined as a source plant in Korean Pharmacopoeia. Polygonati Odorati Rhizoma is called 'Wui-yu', and P. odoratum Druce var. pluriflorum Ohiwi and related species are defined is source plants in Korean Herbal Pharmacopoeia. In UPGMA analysis, Polygonum was divided into two major groups. Polygonatum sibiricum and P. stenophyllum was placed in a cluster. On the other hand, P. falcatum A. Gray was included in the other cluster comprising. P. odoratum and related species, which are used as source plants for Polygonati Odorati Rhizome.

• 생명과학회지
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• 제9권2호
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• pp.207-211
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• 1999

당뇨에 대한 황정의 약효가 알려지면서 황정의 생리활성 연구가 많이 진행되고 있다. 따라서 본 연구에서는 황정 추출물의 hexane층에서 생리활성 물질로 기대되는 새로운 화합물 I를 분리하고, 분리한 화합물의 화학적인 구조를 분광학적인 방법에 의하여 확인하였다. 1H-nmr, 13C-nmr, DEPT135, COSY, HMQC, HMBC 스펙트럼 및 MS 스펙트럼으로 확인하여 화합물 I의 구조가 9,12-(9E, 12E)-octadecadienoic acid 임을 알 수 있었다.

• 한국식품저장유통학회지
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• 제11권2호
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• pp.148-153
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• 2004

둥굴레를 균일하게 열처리하여 탄내를 없애고 둥굴레차의 소비를 증가시키기 위하여 둥굴레차의 관능적 특성을 최적화 하였다. 둥굴레의 전처리 조건으로서 둥굴레의 세절두께는 2mm가 가장 적당하였다. 둥굴레 과립차의 향에 대한 최적 관능조건은 전체 농축액에 대한 둥굴레 농축액의 비율 82.17%, 전체 농축액 함량 13.16% 및 총당에 대한 포도당의 비율 39.17%에서 그 관능점수가 6.48로서 가장 높았으며, 전반적인 기호도에 대한 관능평점은 전체 농축액에 대한 둥굴레 농축액의 비율 58.82%, 전체 농축액 함량 13.65% 및 총당에 대한 포도당의 비율 51.51%에서 그 관능점수가 5.87으로써 가장 높았다.

• Food Science and Biotechnology
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• 제27권6호
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• pp.1833-1842
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• 2018

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the $GABA_A$-BDZ receptor. The chemical structure of the pure compound was determined by the $^1H$ and $^{13}C$ nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [$^3H$]-flumazenil binding to $GABA_A$-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.