• Clinical and Experimental Reproductive Medicine
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• v.46 no.4
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• pp.197-201
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• 2019

Objective: The aim of this study was to establish whether differences in ovarian size exist between the right and the left ovary of the same individual in women with polycystic ovary syndrome. Methods: In total, 206 Korean women with polycystic ovary syndrome were included in this study. In all participants, a transvaginal or transrectal ultrasound examination was conducted in the early follicular phase of the menstrual cycle. Results: A significant linear correlation was found between the two ovaries with regard to antral follicle count and ovarian volume. The mean antral follicle count in the right ovary (26.75 ± 11.72) was significantly higher than that in the left ovary (23.98 ± 10.85), and the mean volume of the right ovary (11.06 ± 5.17 cm³) was significantly different from that of the left ovary (9.12 ± 4.89 cm³). Conclusion: Ovarian size is different between the right and the left ovary in women with polycystic ovary syndrome.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7011-7014
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• 2014

The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism and polycystic ovaries. Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development. In this mini review, we aimed to evaluate the possible relationship between polycystic ovary syndrome and endometrial cancer.

• Women's Health Nursing
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• v.20 no.4
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• pp.255-265
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• 2014

Purpose: Polycystic Ovary Syndrome Questionnaire (PCOSQ) was developed to measure health-related quality of life of women who had polycystic ovary syndrome. The purpose of this study was to exam reliability and validity of the Korean version of PCOSQ. Methods: A sample of 101 women who had polycystic ovarian syndrome was recruited from outpatient gynecology clinics. Factor analysis was carried out to verify the composition of dimensions of the Korean version of PCOSQ. Concurrent validity was examined by assessing the correlation between the PCOSQ and health related quality of life, and convergent validity was evaluated by testing correlation between PCOSQ and depression. Reliability was assessed using Cronbach's ${\alpha}$. Results: The content validitywas satisfactory (CVI=0.85). Factor analysis identified 5 factors, and factor loadings of the PCOSQ ranged from .48 to .90. Correlation was found between the PCOSQ and health related quality of life (Physical component score: r=.33, p=.001; Mental component score: r=.44, p<.001) and between the PCOSQand depression (r=-.36, p<.001). The Cronbach's ${\alpha}$ of the PCOSQ was .93, indicating reliable reliability. Conclusion: These results demonstrate that the Korean version of PCOSQ is a reliable and valid instrument for evaluating Korean-speaking women with polycystic ovarian syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.3
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• pp.175-186
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• 2020

Objectives: The purpose of this study is to report the effect of Jokyeongjongok-tang-gami in case of oligomenorrhea patients classified with gan-ulgiche and eumheo due to polycystic ovary syndrome. Methods: Three patients suffering from oligomenorrhea due to polycystic ovary syndrome were treated with korean medical treatment (herbal medicine, moxibustion, acupuncture) more than 3 months. The patients classified with gan-ulgiche and eumheo were treated with Jokyeongjongok-tang-gami. Results: Three oligomenorrhea patients recovered normal menstrual cycle more than 3 times after taking Korean medical treatment for 3~6 months. Conclusions: This 3 cases classified with gan-ulgiche and eumheo show Jokyeongjongok-tang-gami is effective on patients with rare menstruation due to polycystic ovary syndrome.

• Clinical and Experimental Reproductive Medicine
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• v.42 no.3
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• pp.86-93
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• 2015

Polycystic ovary syndrome (PCOS) is one of the most common hormonal endocrine disorders in women of reproductive age. It consists of a heterogeneous collection of signs and symptoms that together form a disorder spectrum. The diagnosis of PCOS is principally based on clinical and physical findings. The extent of metabolic abnormalities in women with PCOS varies with phenotype, body weight, age, and ethnicity. For general population, the prevalence of hyperandrogenism and oligomenorrhea decreases with age, while complications such as insulin resistance and other metabolic disturbances increase with age. Obese women with PCOS have a higher risk of developing oligomenorrhea, amenorrhea, hyperandrogenemia, insulin resistance, and lower luteinizing hormone (LH) to follicle stimulation hormone (FSH) ratios than non-obese women with PCOS. The LH to FSH ratio is a valuable diagnostic tool in evaluating Taiwanese women with PCOS, especially in the diagnosis of oligomenorrhea. Overweight/obesity is the major determinant of cardiovascular and metabolic disturbances in women of reproductive age.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.1
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• pp.9-16
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• 2005

Objective: This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome. Methods: Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS). Results: After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDL-cholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05). Conclusion: Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.3
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• pp.33-49
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• 2018

Objectives: The purpose of this study was to investigate the correlation between Pattern identification instrument and biomarkers in polycystic ovary syndrome patients. Methods: Pattern identification instrument questionnaire, Sasang constitutional test, body composition test, pulse analyzing test, laboratory test were performed and the results were analyzed. Correlation analysis was performed between pattern identification and laboratory test results. Results: Testosterone, SHBG, $17{\alpha}$-OH-progesterone, AMH were highest in the Kidney-Yang Deficiency (腎陽虛) group. LH, FSH, LH/FSH ratio were the highest in the Endogenous Heat due to Yin Deficiency (陰虛內熱) group. DHEA-S was the highest in the Dampness-Heat in Liver Meridian (肝經濕熱) group. E2, Prolactin, Cholesterol, Triglyceride, HDL-Cholesterol, LDL-Cholesterol, Glucose (FBS), Insulin, HOMA-IR ratio, HbA1c were the highest in the Phlegm-Dampness (痰濕) group. Conclusions: In this study, we obtained basic data analyzing the correlation between pattern identification instrument and biomarkers in polycystic ovary syndrome patients. If further studies are performed, we expect to be able to obtain clues to study the mechanism of polycystic ovary syndrome.

• Journal of East-West Nursing Research
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• v.28 no.2
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• pp.100-108
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• 2022

Korean medicine has traditionally provided a lot of medical care for the treatment of infertility. The combination treatment of Korean medicine and Western medicine can be effective for infertility to improve the problems caused by the extremely low fertility rate and the aging of pregnant women. In relation to female infertility, we reviewed the evidence for Korean medicine treatment for polycystic ovary syndrome, which has recently been increasing interest in female infertility, and the evidence for the collaboration between Korean and Western medicine in the treatment of polycystic ovary syndrome and infertility. Because polycystic ovary syndrome is closely related to metabolic diseases related to endocrine abnormalities, hormone treatment alone has limited therapeutic effects and has side effects. In domestic and international research, herbal medicine and acupuncture in the treatment of infertility have shown good clinical effects based on the hypothesis of various mechanisms of effect, and many cases of successful pregnancy have been reported. Although continuous research through large-scale randomized clinical studies is needed to prove efficacy, the importance of combined treatment of Korean medicine and Western medicine in infertility treatment is increasing in order to solve the extremely low fertility rate. Combining artificial insemination or in vitro fertilization with Korean medicine treatment is highly likely to be effective in increasing pregnancy success and fertility rates. In women with polycystic ovary syndrome, which is recognized as a metabolic disease due to endocrine abnormalities among the causes of female infertility, Korean medicine treatment can increase the pregnancy rate with herbal medicines and acupuncture, etc. Although well-designed large-scale clinical studies are currently lacking and meta-analysis has not provided sufficient evidence, the combination treatment of Korean medicine and Western medicine is more active to increase the pregnancy rate for solving the problem of low fertility.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.2
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• pp.75-108
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• 2024

Objectives: The purpose of this study is to review the acupuncture treatment for Polycystic ovary syndrome (PCOS) in women. Methods: We searched articles in 3 search engines with keywords related to 'Polycystic ovary syndrome', 'PCOS', and 'Stein-leventhal' in February 2024. Clinical researches and case reports that used acupuncture on PCOS were included. Animal studies and non clinical data were excluded. Data on acupuncture treatment such as methods, site, duration, frequency, and period were analyzed. Results: Of 60 selected articles, there were 51 randomized controlled trials, 5 clinical trials and 4 case reports. Studies were conducted using manual acupuncture, electro acupuncture, auricular acupuncture, thread embedding acupuncture, warm needling and laser acupuncture. Most studies used more than one acupoint, and there were 78 acupoints selected for acupuncture treatment for PCOS. The most commonly used acupoint was 三陰交 (SP6)(n=50). By analyzing the network of acupoints, 關元 (CV4), 氣海 (CV6), 中脘 (CV12), 三陰交 (SP6), 血海 (SP10), 天樞 (ST25), 足三里 (ST36) were located in center of the network. The mean treatment time, number of treatments, and duration were 28.63±4.48 minutes, 34.52±29.26 times, and 98.18±38.25 days. Conclusions: The results of this study could be useful in establishing the evidence for performing standardized acupuncture treatment for Polycystic ovary syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.2
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• pp.35-57
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• 2024

Objectives: This systematic review of animal studies was designed to examine the therapeutic mechanisms of herbal medicines of insulin resistance in Polycystic ovary syndrome and composition of them. Methods: Studies were searched from PubMed, CNKI and Medline up to February 2024. Data was extracted and organized as animal model characteristics, treatment period, experimental and control group settings, evaluation index of treatment, therapeutic mechanism of herbal medicine and Composition of prescription. Results: In the 15 studies finally selected, the herbal medicine used in the study was effective in regulating the insulin resistance index, sex hormones and blood lipid index and improving the histological morphology of the ovaries. The herbal medicine prescriptions used in each of the 15 papers were different, and Salviae Miltiorrhizae Radix (丹參), Wolfiporia cocos (茯苓) and Epimedii Herba (淫羊藿) were most frequently used herbs, 7 times. Conclusions: The results showed that herbal medicine is effective in treating insulin resistance in Polycystic ovary syndrome through several mechanisms. The herbs used in more than 4 papers had effects such as anti-inflammatory, anti-oxidant, estradiol hormone production control and glycolipid metabolism control. More diverse clinical studies on insulin resistance in Polycystic ovary syndrome are needed.