• 제목/요약/키워드: Polycaprolactone Scaffold

검색결과 21건 처리시간 0.017초

이중층 자가조립 공정을 활용한 롤형태의 생체의료용 마이크로섬유 구조체 제작 (Fabrication of Microfibrous Structures with Rolled-Up Forms using a Bilayer Self-Assembly Process)

  • 김영서;박석희
    • 한국기계가공학회지
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    • 제21권2호
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    • pp.79-86
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    • 2022
  • Numerous fabrication techniques have been used to mimic cylindrical natural tissues, such as blood vessels, tendons, ligaments, and skeletal muscles. However, most processes have limitations in achieving the biomimetic properties of multilayered and porous architectures. In this study, to embrace both features, a novel self-assembly method was proposed using electrospun microfibrous sheets. A bilayer microfibrous structure, comprising two sheets with different internal stresses, was fabricated by electrospinning a polycaprolactone (PCL) sheet on a uniaxially stretched thermoplastic polyurethane (TPU) sheet. Then, by removing the stretching tension, the sheet was rolled into a hollow cylindrical structure with a specific internal diameter. The internal diameter could be quantitatively controlled by adjusting the thickness of the PCL sheet against that of the TPU sheet. Through this self-assembly method, biomimetic cylindrical structures with multilayer and porous features can be manufactured in a stable and controllable manner. Therefore, the resulting structures may be applied to various tissue engineering scaffolds, especially vascular and connective tissues.