• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.265-270
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• 2007

Polarization imaging systems have been widely used to selectively characterize skin lesions. Nevertheless, current systems are used in single-mode due to the limitations of a fixed polarization mode and a single-working distance of light source, in which uniform light distribution is achieved on target area. To address such limitations, we developed a variable polarization imaging system based on multi-working distance of light source for various clinical diagnoses. In this study, we characterize the imaging system and present experiment results demonstrating its clinical usefulness. The imaging system consists of a CCD color camera, linear polarization filters, and a single-layered LED ring light source which provides uniform light distribution at multi-working distances. The first polarizer was placed on the light source and the second polarizer placed on objective lens provides continuous linear polarization angle from $0^{\circ}\;to\;90^{\circ}$. The clinical efficacy of the imaging system was investigated by acquiring and analyzing clinical images of skin wrinkle and dental plaque. With the experiments, we verified the potential usefulness of the imaging system for other clinical applications.

• Current Optics and Photonics
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• 제5권4호
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• pp.351-361
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• 2021

Speckle imaging is capable of dynamic data acquisition at high spatiotemporal resolution, and has played a vital role in the functional study of biological specimens. The presence of various optical scatterers within the tissue causes alteration of speckle contrast. Thus structures like blood vessels can be delineated and quantified. Although laser speckle imaging is frequently used, an optimization process to ensure the maximum speckle contrast has not been available. In this respect, we here report an experimental procedure to optimize speckle contrast via applying different combinations of varying polarization of the illuminating laser light and multiple analyzer angles. Specifically, samples were illuminated by the p-polarization, 45°-polarization, and s-polarization of the incident laser, and speckle images were recorded without and with the analyzer rotated from 0° to 180° (Δ = 30°). Following the baseline imaging of a solid diffuser and a fixed brain sample, laser speckle contrast imaging (LSCI) was successfully performed to visualize in vivo mouse-brain blood flow. For oblique laser illumination, the maximum contrast achieved with p-polarized and s-polarized light was perpendicular to the analyzer's axis. This study demonstrates the optimization process for maximizing the speckle contrast, which can improve blood-flow estimation in vivo.

• Current Optics and Photonics
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• 제3권1호
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• pp.16-21
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• 2019

We present a broad-bandwidth comb-spacing-swept source (CSWS) based on a differential polarization delay line (DPDL) for interferometric three-dimensional (3D) imaging. The comb spacing of the CSWS is repeatedly swept by the tunable DPDL in the multiwavelength source to provide depth-scanning optical coherence tomography (OCT). As the polarization differential delay of the DPDL is tuned from 5 to 15 ps, the comb spacing along the wavelength continuously varies from 1.6 to 0.53 nm, respectively. The wavelength range of various semiconductor optical amplifiers and the cavity feedback ratio of the tunable fiber coupler are experimentally selected to obtain optimal conditions for a broader 3-dB bandwidth of the multiwavelength spectrum and thus provide a higher axial resolution of $35{\mu}m$ in interferometric OCT imaging. The proposed CSWS-OCT has a simple imaging interferometer configuration without reference-path scanning and a simple imaging process without the complex Fourier transform. 3D surface images of a via-hole structure on a printed circuit board and the top surface of a coin were acquired.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.195-198
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• 2007

In this paper, we introduce a digital cross-polarization and fluorescent color imaging system for quantitative evaluation of skin lesions. We describe the characterization of the imaging systems and the quantitative image analysis methods to show the feasibility for quantitative evaluation of skin lesions. The polarization color image was used to compute erythema and melanin index image which are useful for quantitative evaluation of pigmentation and vascular skin lesions, respectively. The fluorescent color image was used to quantitatively evaluate "sebum" and "vitiligo". In quantitative evaluation of various skin lesions, we confirmed the clinical efficacy of the imaging systems for dermatological applications. Finally, we sure that the imaging systems can be utilized as important assistant tools for the evaluation of skin lesions by providing reproducible quantitative result for widely distributed skin lesions.

• Journal of the Optical Society of Korea
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• 제17권2호
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• pp.162-167
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• 2013

A two-dimensional (2D) / three-dimensional (3D) convertible display system based on integral imaging is proposed to adopt a novel switchable point light source array, which is implemented using the polarization modulator and the polarization selective scattering film that transmits or scatters the incident light due to its polarization direction. The 2D and the 3D display modes of the proposed system can be modulated by controlling the polarization direction of back light using the polarization modulator. We explain the basic principles of the proposed system and verify the feasibility of the system through preliminary experiments.

• Journal of the Optical Society of Korea
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• 제13권4호
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• pp.472-477
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• 2009

A Stokes polarimetry imaging (SPI) system was developed and utilized to detect tendon tears by constructing the degree of linear polarization (DOLP) image maps after linearly polarized light illumination. The micro and partial-thickness tears of turkey tendons were made and imaged by the SPI system at different incident polarization angles (IPA) with different mechanical loads on the tendon. The micro and partial-thickness tendon tears were detected by the DOLP images due to weak birefringence around the tears. The tendon tears were detected by a highest DOLP contrast at longest visible wavelength (Red, 650 ${\pm}$ 50 nm). All polarized images showed modulated DOLP as the incident polarization angle (IPA) was varied. The varying DOLP allowed the optimal detection of the micro and partial-thickness tendon tears at a certain IPA. The SPI system with variable IPA and spectral information can improve the detection of the tendon tears by higher visibility of fiber orientations, and thereby improve diagnosis and treatment of the tendon related injuries.

• 천문학회보
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• 제36권2호
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• pp.111.1-111.1
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• 2011

We present near-IR imaging polarimetry of the observed $5{\times}9$ fields (${\sim}39'{\times}69'$) in the Large Magellanic Cloud (LMC), using the InfraRed Survey Facility (IRSF). We obtained polarimetry data in J, H, and Ks bands using the JHKs-simultaneous imaging polarimeter SIRPOL. We measured Stokes parameters of point-like sources to derive the degree of polarization and the polarization position angle. We show a polarization vector map in the reduced 45 fields and the statistical distribution of the polarization degrees and angles. This poster presents the preliminary results to show the physical properties of the magnetic field in the observed LMC regions.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.453-456
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• 2009

We present a new generation of imaging colorimeter that ensures improved accuracy and sensitivity for shorter measurement times. The imaging optics is telecentric on the sensor and allows measurements at any distances without additional calibration. A new technology is used to make the color filters and flat densities. Imaging polarimetry at fixed wavelength is also possible with the same instrument.

• Journal of the Optical Society of Korea
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• 제7권4호
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• pp.234-239
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• 2003

Objective methods to assess quantitatively port wine stain (PWS) blanching in response to laser therapy are needed to improve laser therapeutic outcome. Previous studies have attempted to assess objectively PWS color based on point measurement devices. To date, these approaches have typically been limited by a number of factors such as small test area and need for contact. To address these issues, a polarization spectral imaging system and an image analysis method have been developed to evaluate quantitatively erythema and melanin content distribution in skin. The developed polarization spectral imaging system minimizes artifacts such as glaring, shadowing, and non-uniform illumination that interfere with image fidelity. Furthermore, the image analysis method has been employed to get images of skin melanin and erythema indices from the acquired color images for quantitative analysis. Finally, using PWS patient color image, the effectiveness in laser treatment of PWS was evaluated by calculating relative erythema index image that is the relative erythema index of PWS region to the normal region. The developed device and analysis method appears to be a simple and effective method for quantitative analysis of PWS blanching.

• 대한방사성의약품학회지
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• 제7권1호
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• pp.41-49
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• 2021

Diversity and flexibility are two typical hallmarks of macrophages. Two types of macrophages, M1(classically activated macrophages) and M2(alternatively activated macrophages) exist at both ends of the commonly known macrophage polarization. M1 macrophages have inflammatory properties and are primarily responsible for defending against invading bacteria in our body. On the other hand, M2 macrophages are involved in anti-inflammatory responses and tissue remodeling. Polarized migration of macrophages is of increasing interest in regulating the initiation, generation, and resting phases of inflammatory diseases. In this review, it intend to discuss the properties and functions of tumor-associated macrophages based on polarized macrophages that affect inflammatory diseases. In addition, the purpose of this study is to investigate a molecular imaging approach that targets macrophages that affect tumor growth by controlling the polarization of macrophages that affect tumor diagnosis and treatment.