• 지질공학
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• 제6권3호
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• pp.137-153
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• 1996

본 연구는 이미 알려져 있는 공동 지역에서 1년 6개월에 걸친 고정점 관측 및 이동 관측망에 의한 실험을 통하여 지하 매질에 공동이 존재할 때에 나타나는 지진파의 이상 현상에 의하여 지하에 존재하는 공동을 탐지 및 식별할 수 있는 가능성을 찾는데 그 목적이 있다. 한양 대학교 지진 연구소에서는 경기도 화성군 봉담면에 위치한 삼보 광산에서 고정 지진 관측을 수행하였다. 이 자료의 대부분은 인근 골재 채취장에서의 화약류 발파에 의한 것이며 본 연구에서는 이 화약류 발파에 의한 자료를 이용하였다. 고정 관측소 관측의 경우 지상 관측과 삼보 광산의 갱도 안에서의 지하 관측을 수행하였다. 이 두 자료으 경우 종파의 초동 후 150 ~ 250 msec 후에 전환파(converted phase)의 출현에 의하여 편파 특성이 매우 급격하게 변하는 양상을 보여 준다. 전환파가 발생하는 깊이는 평균 약 190m 정도로서 삼보 광산의 갱도 깊이와 잘 일치되는 결과를 보여 준다. 또한 횡파 분열(Shear-wave Splitting) 현상이 관측되었다. 빠른 횡파(fS)와 느린횡파(sS)의 시간 차이는 약 30-60ms 정도의 차이(평균 42 ms)를 보인다. 이러한 결과는 다른 연구의 결과보다는 상당히 큰 값을 보여 주는데 이는 지하 공동에 의한 균열(Crack)이 상당히 발달해 있는 것을 나타내는 결과이다. 또한 화약 발파 실험에 의한 자료는 공동에 설칠한 지진계와 비공동 지역에 설피한 지진계를 비교 분석하였다. 공동 지역에서 설치한 지진계의 경우 고정 관측소의 경우와 같이 종파의 초동후에 편파 특성이 매우 급격하게 변하는 양상을 보이나 비공동 지역에 설치한 지진계의 경우는 편파 특성이 매우 안정적인 양상을 보인다. 또한 공동 지역을 지난 지진파의 특징은 현저한 고주파수 성분의 감쇄와 탁월한 저주파의 성질을 갖는 위상이 관측되었다.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.910-916
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• 2002

Endotoxin tolerance reduces the capacity of monocytes to produce proinflammatory cytokines, results in cellular immune paralysis, and down-regulates the production of helper T (Th)1 type cytokines with a shift toward a Th2 cytokine response. Prostaglandin (PG)E$_2$ in the immune system also results in macrophage inactivation and the suppression of Th1 activation and the enhancement of Th2 activation. However, the inhibitory effects of PGE$_2$ on the altered polarization of the Th cell and macrophage interleukin (IL)-6 production characterized in part by cellular immune paralysis in a state of endotoxin tolerance is unclear. This study was undertaken, using indomethacin, to investigate the role of endogenous PGE$_2$ on the Th cytokines and macrophage IL-6 production in a state of endotoxin tolerance compared to those with endotoxemia mice, wherein, in this latter case, the increased production of proinflammatory cytokines and PGE$_2$ is exhibited. Endotoxemia was induced by injection of lipopolysaccharide (LPS; 10 mg/kg in saline) i.p. once in BALB/c mice, and endotoxin tolerance was induced by pretreatment with LPS (1 mg/kg in saline) injected i.p. daily for two consecutive days and then with LPS 10 mg/kg on day 4. Splenocytes or macrophages were obtained from endotoxemia and endotoxin tolerance models pretreated with indomethacin, and then cytokine production was induced by Con A-stimulated splenocytes for the Th cytokine assays and LPS-stimulated macrophages for the IL-6 assay. Our results showed that endotoxemia led to significantly reduced IL-2 and IL-4 production, to significantly increased IL-6 production, whereas interferon $(IFN)-{\gamma}$ production was not affected. Indomethacin in the case of endotoxemia markedly attenuated $IFN-{\gamma}$ and IL-6 production and didnt reverse IL-2 and IL-4 production. Endotoxin tolerance resulted in the significantly reduced production of IL-2 and $IFN-{\gamma}$ and the significantly increased production of IL-4 and IL-6. Indomethacin in endotoxin tolerance greatly augmented IL-2 production, significantly decreased IL-4 production, and slightly attenuated IL-6 production. These findings indicate that endogenous PGE$_2$ may mediate the suppressed Th1 type immune response, with a shift toward a Th2 cytokine response in a state of endotoxin tolerance, whereas endotoxemia may be regulated differentially. Also, endogenous PGE$_2$ may mediate macrophage IL-6 production in the case of endotoxemia to a greater extent than in the case of endotoxin tolerance.

• 전자공학회논문지D
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• 제36D권9호
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• pp.56-63
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• 1999

Cat형 SPPCM(selfpumped phase conjugate mirror)의 응답시간을 개선시키기 위한 기존의 방법은 원주면 렌즈를 사용하여 패팅 (fanning) 빔을 증가시키는 방법이었다. 그러나, 이 경우에 SPPCM의 특성들을 개선시키기 위해서는 패닝빔을 제어해 주어야 한다. 본 논문에서는 원주면 렌즈를 사용하여 입력빔을 선형으로 광굴절 결정에 접속시켜 SPPCM의 반사율을 증가시키고 응답시간을 감소시키며, 순수한 이상 편광빔 대신 혼합 편광빔을 입사시킴으로써 출력빔의 시간 불안정도를 감소시키는 방법을 제안하였다. 광실험을 통하여 제안한 SPPCM의 반사율이 2배로 증가하고 응답시간은 1/15로 감소함을 확인하였다. 또한, 혼합 편광빔의 편광 각을 $10^{\circ}$에서 $30^{\circ}$ 사이의 각도로 하였을 때 시간 불안정도가 감소함을 확인하였다. 광실험에서 전기광학 계수가 매우 큰 $45^{\circ}-cut\;BaTiO_3$ 결정을 사용하였다.

• 기술혁신연구
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• 제14권1호
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• pp.147-175
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• 2006

One of the biggest problems of Korean economy is polarization of firms for export and domestic demand and that of conglomerates and SME's achievement. One of the culprits lies weakness of intermediate industry such as machine tool. Since intermediate industry is important path where export performance affects domestic demand and whose actor usually is SMEs with high spill over effect in labor market. Especially, intermediate industry Is vulnerable because of industrial policy biased In backward linkage effect. However if a country fails to develop intermediate industry above some critical point, that country would fall in low-tech equilibrium without growth. In case of benign circle where final goods industry growth leads growth of intermediate industry and again it leads that of final goods industry, it can reach high-tech equilibrium. By contrast, in opposite case where in industrialization latecomer fails to link industries likewise above some critical point that country would fall in low-tech equilibrium without growth. Moreover, for several reasons, machine tool firms of Korea have difficulty in catching up technology above critical point. Firstly. Conglomerate demander neglects their product. Secondly, even after success of development overcoming difficulties they fail to get market share for response of dumping of foreign competitors. And the last one is patent litigation of foreign competitors that incapacitate the technology development. For these, Korean machine tool firms fell in 'middle-income country trap' itself, since they stuck in some extent when they technologically catch up. Consequently, for latecomer country in machine tool industry to leapfrog meaningfully policy support is necessary, Weak intermediate industry does not Induce domestic firms and remained fragile. Therefore, localization, policy should reflect condition of technological catch up more than before, in order to be effective and fruitful. There should be turning point over relationship between conglomerates, major demander of machine tool and SME's, for only with active purchasing of conglomerate Korean machine industry can grow.

• 한국세라믹학회지
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• 제55권3호
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• pp.244-260
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• 2018

Issues in the electrical characterization of semiconducting photoanodes in a photoelectrochemical (PEC) cell, such as the cell geometry dependence, scan rate dependence in DC measurements, and the frequency dependence in AC measurements, are addressed, using the example of a $TiO_2$ photoanode. Contrary to conventional constant phase element (CPE) modeling, the capacitive behavior associated with Mott-Schottky (MS) response was successfully modeled by a Havriliak-Negami (HN) capacitance function-which allowed the determination of frequency-independent Schottky capacitance parameters to be explained by a trapping mechanism. Additional polarization can be successfully described by the parallel connection of a Bisquert transmission line (TL) model for the diffusion-recombination process in the nanostructured $TiO_2$ electrode. Instead of shunt CPEs generally employed for the non-ideal TL feature, TL models with ideal shunt capacitors can describe the experimental data in the presence of an infinite-length Warburg element as internal interfacial impedance - a characteristic suggested to be a generic feature of many electrochemical cells. Fully parametrized impedance spectra finally allow in-depth physicochemical interpretations.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.1058-1061
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• 2004

Recently, According to companies of TFT LCD are making large sized products more and more. In the vortex of Products with a monitor and LCD TV is applied in a technique of a high viewing angle(FFS, IPS, VA). Also, as a high luminance, high speed response time, high degree of a color purity, and so on are continuing to develop a high performance, it is necessary to improve a specific character of high luminance that apply to LCD TV as a LCD BLU. Because a LCD panel for TV usually has a lower resolution that compare to a monitor, the structure of present backlight system can't put out its power even though it has a merit in transmission. Therefore, the examination of improvement about the high luminance direct typed BLU for LCD TV that presupposes several uses of CCFL(Cold Cathode Fluorescent Lamp) or EEFL(External Electrode Fluorescent Lamp)is actively being progressed. Although it is necessary to increase the number of lamps for applying high performance by the direct type, in this case, because we can design the character of luminance for adoption of high performance. We can satisfy with a level of luminance for LCD TV. Accordingly, we analyzed a change of the number of CCFL, mechanical and optical character to produce the direct typed backlight in 32inches spec. Consequently, we achieved luminance of 6597nit,which was including polarization film, and secured the standard for LCD TV.

• 대한기계학회논문집B
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• 제38권10호
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• pp.845-851
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• 2014

유전영동(DEP)이란 비균질의 전기장과 그에 따라 입자 내부에 형성되는 극성힘에 의해 용매에 분산되어 있는 입자에 야기되는 운동을 의미하며, 세포, 바이러스, 나노입자 등의 트래핑, 입자분류, 셀분리 등과 같은 다양한 생물학적 응용에 이용되어 왔다. 지금까지 유전영동트랩에 대한 해석은 주기평균 ponderomotive force 에 기반한 정특성 해석이 주를 이루고 있으며, 동특성에 대해서는 많은 연구가 이루어져 있지 않다. 이는 지금까지 유전영동트랩이 적용된 입자들의 크기가 상대적으로 매우 크기 때문으로, 분석입자의 크기가 매우 작은 나노단위 분석에서는 적절하지 않다. 본 연구에서는, 다양한 시스템 파라미터들에 대한 트래핑의 동역학적 반응 및 그들의 트래핑 안정성에 대한 영향을 심도깊게 관찰하고자 한다. 특히, 입자의 전도율에 따른 입자의 동특성의 변화 또한 관찰하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2439-2445
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• 2014

Cryptotanshinone (CPT), is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Numerous researchers have found that it could work as a potent antitumor agent to inhibit tumor growth in vitro, buith there has been much less emphasis on its in vivo role against breast tumors. Using a mouse tumor model of MCF7 cells, we showed that CPT strongly inhibited MCF7 cell growth in vivo with polarization of immune reactions toward Th1-type responses, stimulation of naive CD4+ T cell proliferation, and also increased IFN-${\gamma}$ and perforin production of CD4+ T cells in response to tumor-activated splenocytes. Furthermore, data revealed that the cytotoxic activity of CD4+ T cells induced by CPT was markedly abrogated by concanamycin A(CMA), a perforin inhibitor, but not IFN-${\gamma}$ Ab. On the other hand, after depletion of CD4+ T cells or blocked perforin with CMA in a tumor-bearing model, CPT could not effectively suppress tumor growth, but this phenomenon could be reversed by injecting naive CD4+ T cells. Thus, our results suggested that CPT mainly inhibited breast tumor growth through inducing cytotoxic CD4+ T cells to secrete perforin. We further found that CPT enhanced perforin production of CD4+ T cells by up-regulating JAK2 and STAT4 phosphorylation. These findings suggest a novel potential therapeutic role for CPT in tumor therapy, and demonstrate that CPT performs its antitumor functions through cytotoxic CD4+ T cells.

• 자원환경지질
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• 제53권3호
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• pp.259-269
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• 2020

The use of the geophysical method in mining prospecting has been studied in the Asdaf region (South-East of Morocco). The objective of the study is to examine the aptitude of the electrical technique, in this case induced polarization (IP) and electric tomography, combined with the electromagnetic method (VLF), in the exploration of barite . The result obtained by the pseudo-sections of electrical tomography and that of KH filtration highlighted anomalies of resistant contact (greater than 400Ω.m) and of high charge chargeability (5mV / V). These contacts are hosted in less resistant Devonian age shale and sandstone. The resistivity response obtained at their level is characteristic of the venous structures associated with barite mineralization. The direction of the mineralized veins is parallel to the direction of the fractured zones (NE-SW), which indicates that the mineralization in place is due to the tectonic movements of the Hercynian orogeny (from Devonian to Permian). These veins are aligned with the locations of abandoned mine shafts and with surface mining areas. Geophysical technique therefore seems to play a key role in barite mining exploration.

• 한국콘텐츠학회논문지
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• 제21권4호
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• pp.628-644
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• 2021

이 연구는 유튜브 시사정치채널 이용자들의 뉴스 인식에 영향을 미치는 변인들을 탐색하는데 주된 목적이 있다. 기존 연구들은 언론과 유사한 역할을 수행하는 유튜브 채널들의 여론 영향력을 정치적 양극화, 가짜뉴스, 확증 편향 등의 측면에서 살펴보고 규범적 비판을 제공하는 데 치중되어 있다. 이 연구는 그러나 유튜브 등장과 더불어 이용자 뉴스 인식에 나타난 변화와 의미를 살펴보고자 했다. 이를 위해 유튜브 시사정치채널 이용 경험이 있는 이용자 대상 온라인 서베이를 시행했다. 연구 결과 유튜브 시사정치채널 이용자들의 뉴스 관점은 전문직 저널리즘 관점에서의 뉴스 인식과 더불어 디지털 환경에서 새롭게 추가된 뉴스 인식이 혼재되어 있는 것으로 나타났다. 이 결과를 토대로 연구자는 플랫폼 환경에 대한 전문직주의 언론의 대응 방향에 관한 함의를 검토해 보았다.