• 동의신경정신과학회지
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• 제19권3호
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• pp.205-217
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• 2008

After recovery from acute carbon monoxide poisoning, some patients suffer from neuropsychiatric problems such as cognitive impairement, movement disorder, change of personality and mental disorder after lucid interval in which the patient has no symptom. This sequela of carbon monoxide poisoning is called delayed post-anoxic encephalopathy(DPE). No neuroprotective drug has yet demonstrated ecfficacy and hyperbaric oxygen treatment's effect have little scientific evidence in preventing and improving DPE. In such situation, korean traditional treatment may be helpful in treating the patient suffering from DPE. In this case report, we will describe the patient that has suffered from severe DPE involving cognitive impairment, gait disturbance and incontinence but has been improved successfully by korean traditional medicine treatment, especially Jowiseungchungtang. This case could present how we will study about DPE.

• 한국콘텐츠학회논문지
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• 제9권2호
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• pp.339-349
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• 2009

마늘은 오랫동안 그 가치가 높이 평가되고 있으며 약용, 항균 및 살균효과적인 특성으로 인해 실제로 사용되어오고 있다. 본 연구는 마늘추출물의 천연식품보존제 개발가능성을 알아보기 위해 수행되어졌으며 신선한 마늘추출물과 이를 증류수로 희석한 마늘추출물들을 사용하여 6종의 식중독균 즉, S. aureus, E. coli, S. typhimurium, V. parahemolyticus, B. subtilis, L. monocytogenes들에 대한 감수성검사를 실시하였고 그 결과를 그람양성균 치료에 사용되는 Vancomycin과 그람음성균 치료에 사용되는 Imipenem을 대조로하여 이들 균주에 대한 항균력과 비교하였다. 마늘추출물에서 6균주 모두에 대해 강한 감수성을 보이거나 혹은 중등도의 감수성을 보였는데 V. parahemolyticus만은 마늘추출물의 원액에서만 항균력이 나타났고 희석한 농도에서는 항균력이 없었다.

• 대한임상독성학회지
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• 제9권2호
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• pp.109-112
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• 2011

Aluminum phosphide is commonly used as a rodenticidal agent in agricultural workplaces. However, reported cases of aluminum phosphide poisoning in Korea are rare. Upon contact with moisture in the air, aluminum phosphide releases highly toxic phosphine gas ($PH_3$). $PH_3$ is readily absorbed through lung epithelium and into the bloodstream. Phosphine may cause denaturing of oxyhemoglobin and enzymes important to respiration and metabolism, and also may effect cellular membranes. There are numerous complications associated with acute aluminum phosphide poisoning including gastrointestinal, respiratory, and cardiac toxicities. We report the case of a 46-year-old man who suffered from respiratory and cardiac toxicities after unintentional aluminum phosphide exposure. More intensive education for prevention is recommended.

• 대한임상독성학회지
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• 제15권1호
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• pp.1-10
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• 2017

Purpose: This study was conducted to identify predictors of serious poisoning in patients with snake bite based on initial findings. Methods: We conducted a retrospective study of patients with snake bite who were treated at the emergency department between January 2010 and December 2016. The patients were divided into two groups according to the severity of symptoms based on the traditional snakebite severity grading scale. The mild poisoning group (MP) was classified as those who had a grade I snakebite severity during the hospital stay, and the severe poisoning group (SP) was classified as patients who had grade I at the time of admission, but progressed to grade II-IV during hospitalization. Initial clinical manifestations and laboratory findings of the two groups were compared. Results: Bite to hospital time intervals of SP were longer than those of MP (p=0.034), and the local effect score (LES) was higher in SP (p<0.001). Laboratory analyses revealed that creatine phosphokinase (p=0.044), creatine phosphokinase MB isoenzyme (CK-MB, p=0.011) and serum amylase (p=0.008) were significantly higher in SP. LES, CK-MB and serum amylase were significant prognostic predictors as indicated by univariate logistic regression analysis. Multivariate analysis revealed the following two significant predictors: LES (odds ratio=3.983, p<0.001) and serum amylase (odds ratio=1.020, p=0.017). Conclusion: In managing cases of snake bites, clinical manifestations and laboratory findings must be carefully evaluated. LES and serum amylase are predictive factors for severe poisoning, which is especially important to rapid determination of the intensive care of the patient.

• Journal of Preventive Medicine and Public Health
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• 제5권1호
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• pp.17-23
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• 1972

Carbon Monoxide poisoning is one of the most serious Public health problems in Korea. The incidence rate. officially reported has been known to be the highest in the world. This high incidence is mainly due to the wide prevalence of anthracite coal briquette as the domestic fuel for unique Korean heating system called 'ondol,' The coal briquette gas contains around 3-5% of Carbon Monoxide. A nation-wide effort to eliminate or reduce this serious hazards has produced little effect and the most hospitals are offering very ineffective measures such as oxygen inhalation through nasal catheter. Author has believed that this preventable accident should be approached by the secondary preventive measure because of our socio-economic status do not allow us optimistic results from primary preventive measure as far as the problem of CO poisoning is concerned. Author has treated 466 patients during 30 months period by Hyperbaric Oxygenation at Seoul National University Hospital. The results found are as follows. 1. Female has a higher incidence rate than male and the age group between 15-29 years showed highest incidence. 2. The recovery time depends on the time when the patients arrived at hospital. Earlier the arrival time, shorter the recovery time. 3. Some objective signs are representing typical physiological response to tissue hypoxia. 4. Therapeutic effectiveness of Hyperbaric Oxypenation is confirmed by such indices as recovery rate, Admission rate and average stay in hospital. Futher, these results are cocordant with other reports on the clinical value of Hyperbaric Oxygenation in the treatment of CO poisoning.

• 한국수소및신에너지학회논문집
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• 제27권6호
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• pp.670-676
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• 2016

Hydrogen town in Republic of Korea was established in 2013. Hydrogen as a byproduct produced by various processes of factories is used in hydrogen town facilities. As cell performance is affected by contaminations in fuel gas, various standards about impurities of fuel have been determined by many countries. This study shows performance degradation of single cell with impurities concentrations. Traces of carbon monoxide (CO) and hydrogen sulfide ($H_2S$)can cause considerable cell performance losses. For comparing the performances by poisoning of CO, acceleration test, I-V curve, constant current are performed. Both the CO and $H_2S$ poisoning rate are a function of their concentration. With the higher concentrations the higher poisoning rates are observed. And, it was confirmed that, oxidation behavior and side reaction generation are not affected. Under the lower $H_2S$ concentration condition, the poisoning rate is much higher than that of CO because of its different adsorption intensity. It can be possible that the result of this study can be used for enacting regulation as a baseline data.

• 대한임상독성학회지
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• 제15권2호
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• pp.79-85
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• 2017

Purpose: The purpose of this study is to evaluate the effectiveness and adverse effect of fomepizole in the management of acute ethylene glycol or methanol poisoning in children. Methods: Databases such as PubMed, Embase, Cochrane library, and KoreaMed were searched using terms related to fomepizole, ethylene glycol, methanol and pediatric. All studies, regardless of study design, reporting effectiveness or safety endpoints in children were included. Reference citations from identified publications were reviewed. Only reports written in English or Korean languages were included. The reference search was performed by two authors. Results: Twenty-two relevant literatures were finally included. They were one narrative review, 4 retrospective case series, and 17 case reports (19 cases). Case reports were classified as 5 fomepizole only, 8 fomepizole with other therapies, and 6 no fomepizole. All patients from the literatures were fully recovered without long term sequelae. Adverse effects of fomepizole were reported including anaphylaxis, thrombophlebitis and nystagmus. Conclusion: There are insufficient literatures regarding fomepizole treatment in children with ethylene glycol or methanol poisoning. The benefits or harms are not clearly established based on the clinical evidences. More prospective comparative studies are required in the future.

• 대한금속재료학회지
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• 제56권12호
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• pp.893-899
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• 2018

In the present study, we investigated the sulfur poisoning of the Ni anode in solid oxide fuel cells (SOFCs) as a function of operating conditions. Anode supported cells were fabricated, and sulfur poising tests were conducted as a function of current density, $H_2S$ concentration and humidity in the anode gas. The voltage drop was significant under the higher current density (${\sim}714mA/cm^2$) condition, while it was much reduced under the lower current density (${\sim}389mA/cm^2$) condition, at 100 ppm of $H_2S$. A secondary voltage drop, which occurred only at the high current density, was attributed to Ni oxidation in the anode. Thus, operation at high current density with high $H_2S$ concentration may lead to permanent deterioration in the anode. The effect of water content (10%) on the sulfur poisoning was also investigated through a constant current test (${\sim}500mA/cm^2$) at 10 ppm of $H_2S$. The cell operating with 10% wet anode gas showed a much smaller initial voltage drop, in comparison with a dry anode gas. The present study indicates that operating conditions, such as gas humidity and current density, should be carefully taken into account, especially when fuel cells are operated with $H_2S$ containing fuel.

• Environmental Analysis Health and Toxicology
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• 제6권1_2호
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• pp.7-23
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• 1991

The present study was undertaken to examine the effect of butylhydroxyanisole (BHA) on the lead poisoning in Wister female rats. All experimental rats except normal group were fed with diets formulated by adding BHA in a range of 0.1% to 3.2% and aqueous solution of 1% lead acetate ad libitum through the experimental period. The results obtained are summarized as follows: 1) Lead sedimentation in kidney tissue was decreased with increasing experimental period and BHA level of lead plus BHA-treated groups in comparison with that of lead-treated control group. 2) The weights of lung, spleen and left/right (L/R) kidney were significantly decreased in comparison with those of lead-treated control group after 2 weeks of experimental period, but no difference was shown with those of normal group. 3) The weights of lung, spleen and L/R kidney were increased in lead-treated control group as compared with normal group after 2 weeks of experimental period, but no difference was shown with increasing experimental period. 4) Water intake was remarkably decreased in lead-treated control group as compared with normal group, but water intake by increasing BHA level of lead plus BHA-treated groups showed no significant difference from that of normal group. 5) These results suggest that BHA is effective for reducing the toxic effect of lead in rats.

• 한국세라믹학회지
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• 제44권12호
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• pp.715-719
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• 2007

STS444 with or without $La_{0.9}Sr_{0.1}MnO_3$ (LSM)-coating was contacted to $La_{0.6}Sr_{0.4}Co_{0.2}Fe_{0.8}O_3$ (LSCF) cathode on various electrolyte materials and the polarization resistance $(R_p)$ was measured by impedance spectroscopy. By making a symmetric half-cell and contacting only one side of the cathode with the interconnect, the effect of chromium (Cr) poisoning was separated from the aging effects. When the LSCF cathode was contacted with LSM-coated STS (stainless steel), $R_p$ of LSCF was lower than that contacted with the uncoated STS. Impedance patterns measured for the working electrode (W.E.), the counter electrode (C.E.) at $600^{\circ}C$ in air were analyzed. Normalized data of net Cr effect showed that $Ce_{0.9}Gd_{0.1}O_2$ (GDC) electrolyte is more tolerant to the chromium poisoning than $La_{0.9}Sr_{0.1}Ga_{0.8}Mg_{0.2}$ (LSGM) or 8 mol% $Y_2O_3-doped$ $ZrO_2$ (YSZ) electrolytes.