• The Korean Journal of Pain
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• 제26권4호
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• pp.327-335
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• 2013

For those of us who have read the 2 recently published articles by a Danish - British research group, it might appear that we are observing an impending paradigm shift on the origins of chronic low back pain. The results of this research indicate, that chronic low back pain associated with bone marrow edema in vertebral endplates that are adjacent to herniated intervertebral discs may be caused by infections with anaerobic bacteria of low virulence. According to these articles, treatment with certain antibiotics is significantly more effective than placebo against this low back pain. If these findings are to hold true in repeat studies by other researchers, they stand to fundamentally change our concepts of low back pain, degenerative disc disease and in consequence the suitable therapies for these entities. It may in fact require pain specialists to become familiarized with the details of antibiotic treatments and their specific risks in order to be able to properly counsel their patients. While this seems hard to believe at first glance, bacteria have been implicated in the pathogenesis of other conditions that do not primarily impose as infectious diseases such as gastric ulcers. While the authors refer to a few previous studies pointing into the same direction, the relevant research is really only from one group of collaborating scientists. Therefore, before we start prescribing antibiotics for chronic low back pain, it is imperative that other researchers in different institutions confirm these results.

• 로봇학회논문지
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• 제15권1호
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• pp.16-23
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• 2020

This paper describes an alignment algorithm that estimates the initial heading angle of AUVs (Autonomous Underwater Vehicle) for starting navigation in a sea area. In the basic dead reckoning system, the initial orientation of the vehicle is very important. In particular, the initial heading value is an essential factor in determining the performance of the entire navigation system. However, the heading angle of AUVs cannot be measured accurately because the DCS (Digital Compass) corrupted by surrounding magnetic field in pointing true north direction of the absolute global coordinate system (not the same to magnetic north direction). Therefore, we constructed an experimental constraint and designed an algorithm based on extended Kalman filter using only inertial navigation sensors and a GPS (Global Positioning System) receiver basically. The value of sensor covariance was selected by comparing the navigation results with the reference data. The proposed filter estimates the initial heading angle of AUVs for navigation in a sea area and reflects sampling characteristics of each sensor. Finally, we verify the performance of the filter through experiments.

• 한국항공우주학회지
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• 제35권7호
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• pp.640-646
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• 2007

인공위성의 정밀 자세제어 문제에서 자세지향 및 안정성을 저해하는 구동기 교란의 효과는 매우 중요한 인자 중 하나라 할 수 있다. 최근 CMG는 그 구조의 복잡성에도 불구하고 반작용휠에 비교할 때 고출력저중량이라는 장점에 근거하여 인공위성의 차세대 구동기로 많은 연구가 진행되고 있다. 정밀자세제어가 요구되는 인공위성의 구동기로 이용되기 위해서는 CMG가 위성 동체에 주게 될 교란력의 특성을 파악하는 것이 필수적이다. 본 논문에서는 CMG의 교란토크 및 교란력를 분석하기 위해 정적동적 불균형을 가정하고, 라그랑지안 방법을 이용하여 소신호 가정을 통해 해석적 모델을 유도하였다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권7호
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• pp.733-737
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• 2008

비즈니스 프로세스 모델링은 고객의 요구사항을 만족하기 위해 기업들이 취하는 일련의 행위들을 그래픽적인 요소로 표현한 것이다. 오늘날 빠르고 다양한 형태로 고객의 요구사항이 변하게 됨으로써 비즈니스 프로세스 모델에서는 일어날 가능성이 있는 변화요소들을 표현하여 급변하는 요구사항에 대해 빠르게 대처할 수 있는 능력을 제공해야 한다. 본 논문에서는 비즈니스 프로세스 모델에 소프트웨어 프로덕트 라인 공학의 공통성과 가변성을 모델링 할 수 있는 비즈니스 프로세스 패밀리 모델을 제시하고 모델링 도구의 개발을 쉽게 접근할 수 있게 해주는 이클립스 플러그인 Graphical Modeling Framework(GMF)를 사용하여 비즈니스 프로세스 패밀리 모델링을 지원하는 도구를 설계하고 개발하는 과정을 보여준다 비즈니스 프로세스의 가변성은 UML2.0 활동도의 요소를 기반으로 표현된다.

• Earthquakes and Structures
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• 제8권5호
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• pp.1191-1214
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• 2015

The Theory of Plastic Mechanism Control (TPMC) has been recently extended to the case of Eccentrically Braced Frames (EBFs) with inverted Y-scheme, i.e., EBFs with vertical links. In this paper a further validation of the design procedure, based on TPMC, is provided by means of Incremental Dynamic Analyses (IDA) pointing out the fulfilment of the design goal, i.e., the development of a pattern of yielding consistent with the collapse mechanism of global type where all the links are yielded and all the beams are yielded at their ends while all the columns and the diagonal braces remain in elastic range with the only exception of the base sections of first storey columns. In particular, a study case is designed according to both TPMC and Eurocode 8 provisions and the corresponding seismic performances are investigated by both push-over and IDA analyses. The results show the different performances obtained in terms of pattern of yielding, maximum interstorey drift, link plastic rotation demand and sharing of the seismic base shear between the moment-resisting part and the bracing part of the structural system. The seismic performance improvement obtained by means of TPMC, compared to Eurocode 8 provisions, is pointed out.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10495-10500
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• 2015

Background: To evaluate the effects of bufalin in A549 human lung adenocarcinoma epithelial cells in vitro and assess the underlying mechanisms. Materials and Methods: Human A549 non-small cell lung cancer (NSCLC) cells were treated with various concentrations of bufalin. Cell proliferation was measured by CCK-8 assay, apoptotic cell percentage was calculated by flow cytometry and morphological change was observed by inverted phase contrast microscopy/transmission electron microscopy. In addition, the membrane potential of mitochondria was detected by JC-1 fluorescence microscopy assay, and the related protein expression of cytochrome C and caspase-3 was analyzed by Western blotting. Results: Bufalin could inhibit the proliferation of A549 cells via induction of apoptosis, with the evidence of characteristic morphological changes in the nucleus and mitochondria. Furthermore, bufalin decreased the mitochondrial membrane potential with up-regulation of cytochrome C in the cytosol, and activation of caspase-3. Conclusions: Bufalin inhibits the proliferation of A549 cells and triggers mitochondria-dependent apoptosis, pointing to therapeutic application for NSCLC.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1241-1245
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• 2014

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

• 한국콘텐츠학회논문지
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• 제10권6호
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• pp.378-385
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• 2010

지역축제가 성공하고 활성화 되기 위한 기존 선행연구 검토 결과, 지역축제의 성공요인으로 주제의 명확성, 참여성, 기반성, 구조성, 집객성의 다섯 가지로 설명하고 있는데, 명확성은 독창적인 주제(테마), 명확한 주제(테마), 명확한 목표, 명확한 축제 참여 대상 선정 등으로 정의할 수 있고, 참여성은 주민의 축제 전 과정에의 참여와 축제 즐거움의 향유 등으로 정의하며, 기반성은 지역축제를 위한 인재개발 및 교육, 지역의 특성화 등으로 설명하고, 구조성은 지역축제 조직체계, 예산확보, 전문성 등으로 정의할 수 있으며, 집객성은 홍보 및 마케팅, 접근성, 친절성, 편리성, 관광지 연계성, 먹거리 및 쉴거리 등으로 설명하고 있다. 이에 본 연구에서는 충북 영동지역을 중심으로 지역축제 활성화를 위해서는 어떠한 요인에 더욱 중점을 두어야 하는지 설문조사를 토대로 하여 실증연구를 실시하여, 향후 지역축제 활성화를 위한 발전방향을 제시하였다.

• Journal of Astronomy and Space Sciences
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• 제22권1호
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• pp.35-46
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• 2005

This paper addresses the design and analysis results of a 2-axes magnetometer for attitude determination of small satellite. A low-cost and efficient 2-axes fluxgate magnetometer was selected as the most suitable attitude sensor for LEO microsatellites which require a low-to-medium level pointing accuracy. An optimization trade-off study has been performed for the development of 2-axes fluxgate magnetometer. All the relevant parameters such as permeability, demagnetization factor, coil diameter, core thickness, and number of coil turns were considered for the sizing of a small satellite magnetometer. The magnetometer which is designed, manufactured, and tested in-house as described in this paper satisfies linearity requirement for determining attitude position of small satellites. On the basis of magnetometer which is designed in Space System Research Lab. (SSRL), commercial magnetometer will be developed.

• Journal of Astronomy and Space Sciences
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• 제22권1호
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• pp.47-58
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• 2005

This paper addresses development of the ultra-light analog sun sensors for small satellite applications. The sun sensor is suitable for attitude determination for small satellite because of its small, light, low-cost, and low power consumption characteristics. The sun sensor is designed, manufactured and characteristic-tested with the target requirements of ${\pm}60^{\circ}$ FOV (Field of View) and pointing accuracy of ${\pm}2^{\circ}$. Since the sun sensor has nonlinear characteristics between output measurement voltage and incident angle of sunlight, a higher order calibration equation is required for error correction. The error was calculated by using a polynomial calibration equation that was computed by the least square method obtained from the measured voltages vs. angles characteristics. Finally, the accuracies of 1-axis and 2-axes sun sensors, which consist of 2 detectors, are compared.