• The Korean Journal of Pain
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• v.26 no.4
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• pp.327-335
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• 2013

For those of us who have read the 2 recently published articles by a Danish - British research group, it might appear that we are observing an impending paradigm shift on the origins of chronic low back pain. The results of this research indicate, that chronic low back pain associated with bone marrow edema in vertebral endplates that are adjacent to herniated intervertebral discs may be caused by infections with anaerobic bacteria of low virulence. According to these articles, treatment with certain antibiotics is significantly more effective than placebo against this low back pain. If these findings are to hold true in repeat studies by other researchers, they stand to fundamentally change our concepts of low back pain, degenerative disc disease and in consequence the suitable therapies for these entities. It may in fact require pain specialists to become familiarized with the details of antibiotic treatments and their specific risks in order to be able to properly counsel their patients. While this seems hard to believe at first glance, bacteria have been implicated in the pathogenesis of other conditions that do not primarily impose as infectious diseases such as gastric ulcers. While the authors refer to a few previous studies pointing into the same direction, the relevant research is really only from one group of collaborating scientists. Therefore, before we start prescribing antibiotics for chronic low back pain, it is imperative that other researchers in different institutions confirm these results.

• The Journal of Korea Robotics Society
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• v.15 no.1
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• pp.16-23
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• 2020

This paper describes an alignment algorithm that estimates the initial heading angle of AUVs (Autonomous Underwater Vehicle) for starting navigation in a sea area. In the basic dead reckoning system, the initial orientation of the vehicle is very important. In particular, the initial heading value is an essential factor in determining the performance of the entire navigation system. However, the heading angle of AUVs cannot be measured accurately because the DCS (Digital Compass) corrupted by surrounding magnetic field in pointing true north direction of the absolute global coordinate system (not the same to magnetic north direction). Therefore, we constructed an experimental constraint and designed an algorithm based on extended Kalman filter using only inertial navigation sensors and a GPS (Global Positioning System) receiver basically. The value of sensor covariance was selected by comparing the navigation results with the reference data. The proposed filter estimates the initial heading angle of AUVs for navigation in a sea area and reflects sampling characteristics of each sensor. Finally, we verify the performance of the filter through experiments.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.7
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• pp.640-646
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• 2007

Actuator-induced disturbance is one of the crucial factors of spacecraft attitude pointing and stability in fine attitude control problems. The control moment gyros (CMGs) are known as very attractive actuators from the point of high power and low weight. In order to develop a CMG as an actuator for fine controls, CMG-induced disturbances should be analyzed. Therefore, this paper aims to develop an analytic model and predict the effect of disturbances of CMGs by assuming static and dynamic imbalances. The proposed model is induced by the Lagrangian method on the basis of the small signal assumption.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.7
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• pp.733-737
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• 2008

Business process modeling is to represent the business activities in a graphical notation that enterprises use to achieve their customer's requirements. Nowadays, lots of requirements are changed quickly and variously. Therefore, business process models should provide the means which can prepare for changes by analyzing (pointing) elements of business process that are likely to alter. In this paper, we propose a business process family model (BPFM) which represents the commonalities and the variabilities of a set of business processes. In addition, we propose the process which develops the tools for BPFM based on Eclipse Plug-In Graphical Modeling Framework (GMF). The variabilities of Business Process are modeled by using expanded model elements of UML2.0 activity diagram.

• Earthquakes and Structures
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• v.8 no.5
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• pp.1191-1214
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• 2015

The Theory of Plastic Mechanism Control (TPMC) has been recently extended to the case of Eccentrically Braced Frames (EBFs) with inverted Y-scheme, i.e., EBFs with vertical links. In this paper a further validation of the design procedure, based on TPMC, is provided by means of Incremental Dynamic Analyses (IDA) pointing out the fulfilment of the design goal, i.e., the development of a pattern of yielding consistent with the collapse mechanism of global type where all the links are yielded and all the beams are yielded at their ends while all the columns and the diagonal braces remain in elastic range with the only exception of the base sections of first storey columns. In particular, a study case is designed according to both TPMC and Eurocode 8 provisions and the corresponding seismic performances are investigated by both push-over and IDA analyses. The results show the different performances obtained in terms of pattern of yielding, maximum interstorey drift, link plastic rotation demand and sharing of the seismic base shear between the moment-resisting part and the bracing part of the structural system. The seismic performance improvement obtained by means of TPMC, compared to Eurocode 8 provisions, is pointed out.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10495-10500
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• 2015

Background: To evaluate the effects of bufalin in A549 human lung adenocarcinoma epithelial cells in vitro and assess the underlying mechanisms. Materials and Methods: Human A549 non-small cell lung cancer (NSCLC) cells were treated with various concentrations of bufalin. Cell proliferation was measured by CCK-8 assay, apoptotic cell percentage was calculated by flow cytometry and morphological change was observed by inverted phase contrast microscopy/transmission electron microscopy. In addition, the membrane potential of mitochondria was detected by JC-1 fluorescence microscopy assay, and the related protein expression of cytochrome C and caspase-3 was analyzed by Western blotting. Results: Bufalin could inhibit the proliferation of A549 cells via induction of apoptosis, with the evidence of characteristic morphological changes in the nucleus and mitochondria. Furthermore, bufalin decreased the mitochondrial membrane potential with up-regulation of cytochrome C in the cytosol, and activation of caspase-3. Conclusions: Bufalin inhibits the proliferation of A549 cells and triggers mitochondria-dependent apoptosis, pointing to therapeutic application for NSCLC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1241-1245
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• 2014

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

• The Journal of the Korea Contents Association
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• v.10 no.6
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• pp.378-385
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• 2010

The purpose of this study is finding the way of vitalizing local festival of Chung-buk through successful local festivals and local festivals of Chung-buk. Therefore this study analyzed case of local festivals Young dong with reference definitude, participation, foundation, organizing, capability of calling the people. And It is pointing out the problems of the local festivals and suggesting the ways of vitalizing local festival in Chung-buk.

• Journal of Astronomy and Space Sciences
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• v.22 no.1
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• pp.35-46
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• 2005

This paper addresses the design and analysis results of a 2-axes magnetometer for attitude determination of small satellite. A low-cost and efficient 2-axes fluxgate magnetometer was selected as the most suitable attitude sensor for LEO microsatellites which require a low-to-medium level pointing accuracy. An optimization trade-off study has been performed for the development of 2-axes fluxgate magnetometer. All the relevant parameters such as permeability, demagnetization factor, coil diameter, core thickness, and number of coil turns were considered for the sizing of a small satellite magnetometer. The magnetometer which is designed, manufactured, and tested in-house as described in this paper satisfies linearity requirement for determining attitude position of small satellites. On the basis of magnetometer which is designed in Space System Research Lab. (SSRL), commercial magnetometer will be developed.

• Journal of Astronomy and Space Sciences
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• v.22 no.1
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• pp.47-58
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• 2005

This paper addresses development of the ultra-light analog sun sensors for small satellite applications. The sun sensor is suitable for attitude determination for small satellite because of its small, light, low-cost, and low power consumption characteristics. The sun sensor is designed, manufactured and characteristic-tested with the target requirements of ${\pm}60^{\circ}$ FOV (Field of View) and pointing accuracy of ${\pm}2^{\circ}$. Since the sun sensor has nonlinear characteristics between output measurement voltage and incident angle of sunlight, a higher order calibration equation is required for error correction. The error was calculated by using a polynomial calibration equation that was computed by the least square method obtained from the measured voltages vs. angles characteristics. Finally, the accuracies of 1-axis and 2-axes sun sensors, which consist of 2 detectors, are compared.