• The Journal of Korean Physical Therapy
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• 제27권4호
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• pp.275-280
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• 2015

Purpose: This study was conducted to investigate the effect of cigarette smoking on physical fitness (dominant hand grip power, dominant isokinetic leg muscle strength, abdominal muscle endurance, flexibility, cardiopulmonary endurance) and depression in patients with chronic low back pain. Methods: This study was a cross sectional study and subjects consisted of 60 young males with chronic low back pain. The subjects were allocated to two groups following a self-report survey: cigarette smoking group (n=25) or non-smoking group (n=35). Physical fitness (dominant hand grip power, dominant isokinetic leg muscle strength, abdominal muscle endurance, flexibility, cardiopulmonary endurance) were measured using objective methods and depression in patients with chronic low back pain was measured using the Korean version of center for epidemiologic studies depression (CES-D) scale. Results: The results of this study were as follows: In physical fitness, the cigarette smoking group showed a significant decrease in abdominal muscle endurance, flexibility, and cardiopulmonary endurance compared with the non-smoking group. Depression index (CES-D scale score) was significantly higher in the cigarette smoking group than in the non-smoking group. Conclusion: These results suggest that cigarette smoking had a negative effect on abdominal muscle endurance, flexibility, and cardiopulmonary endurance in patients with chronic low back pain. In addition, depression of patients with chronic low back pain was affected by cigarette smoking. Thus, we suggested that cigarette smoking may play a significant role in the deterioration of physical fitness and depression of chronic low back pain patients.

• 한국의학물리학회지:의학물리
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• 제31권3호
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• pp.54-62
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• 2020

Dose calculation algorithms play an important role in radiation therapy and are even the basis for optimizing treatment plans, an important feature in the development of complex treatment technologies such as intensity-modulated radiation therapy. We reviewed the past and current status of dose calculation algorithms used in the treatment planning system for radiation therapy. The radiation-calculating dose calculation algorithm can be broadly classified into three main groups based on the mechanisms used: (1) factor-based, (2) model-based, and (3) principle-based. Factor-based algorithms are a type of empirical dose calculation that interpolates or extrapolates the dose in some basic measurements. Model-based algorithms, represented by the pencil beam convolution, analytical anisotropic, and collapse cone convolution algorithms, use a simplified physical process by using a convolution equation that convolutes the primary photon energy fluence with a kernel. Model-based algorithms allowing side scattering when beams are transmitted to the heterogeneous media provide more precise dose calculation results than correction-based algorithms. Principle-based algorithms, represented by Monte Carlo dose calculations, simulate all real physical processes involving beam particles during transportation; therefore, dose calculations are accurate but time consuming. For approximately 70 years, through the development of dose calculation algorithms and computing technology, the accuracy of dose calculation seems close to our clinical needs. Next-generation dose calculation algorithms are expected to include biologically equivalent doses or biologically effective doses, and doctors expect to be able to use them to improve the quality of treatment in the near future.

• 대한방사성의약품학회지
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• 제9권1호
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• pp.49-55
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• 2023

Tumors are encircled by various non-cancerous cell types in the extracellular matrix, including fibroblasts, endothelial cells, immune cells, and cytokines. Fibroblasts are the most critical cells in the tumor stroma and play an important role in tumor development, which has been highlighted in some epithelial cancers. Many studies have shown a tight connection between cancerous cells and fibroblasts in the last decade. Regulatory factors secreted into the tumor environment by special fibroblast cells, cancer-associated fibroblasts (CAFs), play an important role in tumor and vessel development, metastasis, and therapy resistance. This review addresses the development of FAP inhibitors, emphasizing the first, second, and latest generations. First-generation inhibitors exhibit low selectivity and chemical stability, encouraging researchers to develop new scaffolds based on preclinical and clinical data. Second-generation enzymes such as UAMC-1110 demonstrated enhanced FAP binding and better selectivity. Targeted treatment and diagnostic imaging have become possible by further developing radionuclide-labeled fibroblast activation protein inhibitors (FAPIs). Although all three FAPIs (01, 02, and 04) showed excellent preclinical and clinical findings. The final optimization of these FAPI scaffolds resulted in FAPI-46 with the highest tumor-to-background ratio and better binding affinity.

• Physical Therapy Rehabilitation Science
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• 제5권1호
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• pp.34-39
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• 2016

Objective: Hip abductors play a role in providing stability and movement to the lower limbs. The purpose of this study was to examine the effects of hip abductor fatigue on static balance and gait in the general population. Design: One group pre-test post-test design. Methods: Thirteen university students in their twenties volunteered for the study and had underwent a functional assessment. To induce fatigue, the subjects were instructed to raise their dominant lower extremity up against a load of 50% of 1 repetition maximum while producing hip abduction in a side-lying position. Subjects were instructed to maintain an abduction speed of 30 repetitions per minute to induce fatigue. Muscle fatigue was considered to be established when subjects were unable to perform hip abduction three consecutive times along with the metronome. A post-test of balance and gait was performed immediately in order to prevent fatigue recovery. The center of pressure (COP) distance area was measured using the Zebris FDM-S Multifunction Force measuring plate. Gait performance was analyzed using the GAITRite. Results: The COP distance was increased after fatigue was induced. There was a significant increase in the standard deviation of the medio-lateral and antero-posteror distance (p<0.05). Although there was no significant difference in gait parameters, there was a significant decrease in single support time after fatigue was induced (p<0.05). Conclusions: There was an increase in static balance instability and a significant decrease in single support time during gait due to hip abductor muscle fatigue.

• 대한세포병리학회지
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• 제11권2호
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• pp.103-108
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• 2000

Pulmonary alveolar proteinosis(PAP) is a rare disease in which the alveolar spaces are filled with an eosinophilic, PAS-positive material, whereas the interstitial architecture of the lung usually remains unaffected. Although a definitive diagnosis is usually made by an open lung biopsy, bronchoalveolar lavage(BAL) cytology may play a decisive role in the diagnosis and therapy of these patients and may spare a patient a more invasive diagnostic procedure. The author presents a patient in whom BAL cytology specimen contained the characteristic globules of amorphous proteinaceous PAS-positive material accompanied by background of rare macrophages and inflammatory cells. Ultrastructural study using BAL specimen can confirm the diagnosis of PAP.

• IMMUNE NETWORK
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• 제23권1호
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• pp.9.1-9.15
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• 2023

Cancer immunotherapies continue to face numerous obstacles in the successful treatment of solid malignancies. While immunotherapy has emerged as an extremely effective treatment option for hematologic malignancies, it is largely ineffective against solid tumors due in part to metabolic challenges present in the tumor microenvironment (TME). Tumor-infiltrating CD8⁺ T cells face fierce competition with cancer cells for limited nutrients. The strong metabolic suppression in the TME often leads to impaired T-cell recruitment to the tumor site and hyporesponsive effector functions via T-cell exhaustion. Growing evidence suggests that mitochondria play a key role in CD8⁺ T-cell activation, migration, effector functions, and persistence in tumors. Therefore, targeting the mitochondrial metabolism of adoptively transferred T cells has the potential to greatly improve the effectiveness of cancer immunotherapies in treating solid malignancies.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권1호
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• pp.26-30
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• 2007

This practice parameter for non-pharmacological treatment for attention-deficit hyperactivity disorder (ADHD) review the domestic and international literature on the psychosocial treatment of children and adolescents with ADHD. This parameter include the parental training & education, cognitive behavior therapy(group or individual), social skill training, family therapy, play therapy (individual psychotherapy) and non-traditional therapy (art therapy, herbal therapy et al). Among them, there is some proven evidence only in parental training & education and cognitive behavior therapy. So, this parameter describes some details only in the field of parental training & education and cognitive behavior therapy. The efficacy or effectiveness, especially, cost-effectiveness of specific psychosocial treatment method for ADHD cannot be fairly assessed due to the scarcity of controlled clinical data. Based on the clinical expert consensus and limited evidence, we cautiously suggest the practice recommendations about the non-pharmacological psychosocial treatment fur children and adolescents with ADHD.

• 대한물리치료과학회지
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• 제11권1호
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• pp.20-27
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• 2004

It is widely accepted that smooth muscle contraction is triggered by intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) released from intracellular $Ca^{2+}$ stores such as sarcoplasmic reticulum (SR) and from the extracellular space, The increased $[Ca^{2+}]_i$ can phosphorylate the 20-kDa myosin light chain ($MLC_{20}$) by activating MLC kinase (MLCK), and this initiates smooth muscle contraction. In addition to the $[Ca^{2+}]_i$-MLCK-tension pathway, a number of intracellular signal molecules, including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), and Rho-associated coiled coil-forming protein kinase (ROCK), play important roles in the regulation of smooth muscle contraction. However, the mechanisms regulating contraction of caldesmon (CaD), actin-binding protein, are not entirely elucidated in the presence of $Ca^{2+}$. It is known that CaD tightly interacts with actin and inhibits actomyosin ATPase activity. Therefore, the purpose of the present study was to investigate the roles of $Ca^{2+}$-dependent CaD in smooth muscle contraction. Endothelin-1 (ET-1), G-protein coupled receptor agonist and vasoconstrictor, increased both vascular smooth contraction and phosphorylation of CaD in the presence of $Ca^{2+}$. These results suggest that ET-1 induces contraction and phosphorylation of CaD in rat aortic smooth muscle, which may he mediated by the increase of $[Ca^{2+}]_i$.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.152-155
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• 2013

Orbital metastasis from hepatocellular carcinoma is very rare, with only 14 biopsy-proven cases from hepa tocellular carcinoma cases reported in English literature and three cases reported in Korea. Common symptoms of orbital metastasis are proptosis, visual loss, ocular pain and oculomotor dysfunction. For its precise diagnosis, we can perform fine needle aspiration biopsy, orbit CT or MRI, and ultrasonography. Radiotherapy is the mainstay in the treatment of orbital metastasis. In addition, chemotherapy, hormonal therapy and surgical intervention can play a role in the treatment of orbital metastasis according to the primary cancer and symptoms. However, the prognosis of orbital metastasis is poor. We report herein a rare case of a patient with orbital metastasis from hepatocellular carcinoma, which was treated with various modalities that included resection, and who had good clinical and radiological responses to radiation therapy and sorafenib (Nexavar, Bayer HealthCare).

• 한국산학기술학회논문지
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• 제17권6호
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• pp.98-105
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• 2016

집단사회성놀이는 놀이를 통한 사회성 증진을 목적으로, 그룹활동을 통하여 일상생활에서 필요로 하는 목적 있는 활동, 인지, 신체움직임 등 여러 요소들을 잘 조합하여 자유롭게 자아를 표현시키는 치료적 방법이다. 이를 타인과의 의사소통 능력이 저하된 자폐청소년들에게 적용하여 궁극적으로 자폐청소년들의 대인관계 개선과 사회성을 증진을 유도함으로써 그 효과를 검증하고자 본 연구를 실시하였다. 본 연구는 대전 소재 주간보호센터를 이용하는 사회성에 결함을 가지고 있는 8명의 자폐청소년을 대상으로 단일군 전후실험설계를 적용하였다. 집단사회성놀이 프로그램은 2013년 10월부터 12월까지 주 2회씩 7주간(총 14회기), 한 회기 당 60분씩 시행하였고 중재 전후의 사회성을 Wilcoxon 순위검정을 실시하여 비교분석 하였다. 연구결과 이화-자폐 아동 행동 발달 평가(E-CLAC)와 사회성숙도 검사의 점수의 총점이 $39.88{\pm}6.78$에서 $47.00{\pm}4.28$, $49.96{\pm}28.00$에서 $61.36{\pm}21.75$로 각각 통계적으로 유의한 변화가 있었음을 확인할 수 있었다. 세부적으로는 집단에서의 적응, 지시 따르기, 행동 빈도 증진 등의 하위항목에서 유의한 변화가 크게 나타났다. 결론적으로 집단사회성놀이에 포함된 집단활동 요소와 대상자들의 발달을 고려한 놀이 활동 요소가 복합적으로 작용하여 자폐청소년의 사회성 증진 효과에 효과적으로 나타났음을 확인할 수 있었다.