• 가정과삶의질연구
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• 제25권4호
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• pp.181-196
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• 2007

The present study was to investigate child care teather's and parents's recognition and need about child counseling and to analyse differences between them. The subjects for this study were 244 child care teachers and 260 mothers of the day care centers. The major finding were as follows; Most child care teachers are aware of child counseling through lecture, pre-service education, and internet. Most mothers hear about child counseling through internet. They think that child counseling is very effective for young children, especially for negative experience and emotion. Most child care teachers think that they can administer child counseling. especially daycare centers. But mothers think that special facilities is the most appropriate place by child counseling. Child care teachers and mothers regard the credibility of human being as personal characteristics required for child counseling. Counseling specialists are to be the most appropriate person for followed by child care teather's and parents. And they think that special training is needed for child counseling. but few of them receive special training. They perceive the necessity of professional education in child counseling. but they rarely experience related education of child counseling. Especially, they feel lack of time and information. They also want to apply to child counseling children education after learning it through counseling association or by observing real situations in child counseling center using morning time or during weekends. Most mothers and child care teachers know play therapy, art therapy. bibliotherapy, sand play therapy.

• 대한약침학회지
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• 제25권2호
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• pp.88-100
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• 2022

Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection.

• BMB Reports
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• 제47권3호
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• pp.167-172
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• 2014

Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcription-independent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcription-independent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.

• 한국전문물리치료학회지
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• 제2권2호
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• pp.73-84
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• 1995

Spasticity has been defined as a motor disorder characterised by a velocity-dependent increase in tonic stretch reflexes with exaggerated tendon jerks resulting in hyperexcitability of the stretch reflexes as one component of the upper motor neuron syndrome. Weakness and loss of dexterity, however, are considered to be more disabling to the patient than changes in muscle tone. The discussion includes the important role that alterations in the physiology of motor units, notably changes in firing rates and muscle fiber atrophy, play in the manifestation of muscle weakness. This paper considers both the neural and mechanical components of spasticity and discusses, in terms of clinical intervention, the implications arising from recent research. Investigations suggest that the resistance to passive movement in individuals with spasticity is due not only to neural mechanisms but also to changes in mechanical properties of muscle. The emphasis is on training the individual to gain control over the muscles required for different tasks, and on preventing secondary and adaptive soft tissue changes and ineffective adaptive motor behaviours.

• Radiation Oncology Journal
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• 제33권4호
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• pp.265-275
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• 2015

Despite the increasing use of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) in recent years, the biological base of these high-dose hypo-fractionated radiotherapy modalities has been elusive. Given that most human tumors contain radioresistant hypoxic tumor cells, the radiobiological principles for the conventional multiple-fractionated radiotherapy cannot account for the high efficacy of SBRT and SRS. Recent emerging evidence strongly indicates that SBRT and SRS not only directly kill tumor cells, but also destroy the tumor vascular beds, thereby deteriorating intratumor microenvironment leading to indirect tumor cell death. Furthermore, indications are that the massive release of tumor antigens from the tumor cells directly and indirectly killed by SBRT and SRS stimulate anti-tumor immunity, thereby suppressing recurrence and metastatic tumor growth. The reoxygenation, repair, repopulation, and redistribution, which are important components in the response of tumors to conventional fractionated radiotherapy, play relatively little role in SBRT and SRS. The linear-quadratic model, which accounts for only direct cell death has been suggested to overestimate the cell death by high dose per fraction irradiation. However, the model may in some clinical cases incidentally do not overestimate total cell death because high-dose irradiation causes additional cell death through indirect mechanisms. For the improvement of the efficacy of SBRT and SRS, further investigation is warranted to gain detailed insights into the mechanisms underlying the SBRT and SRS.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.79-90
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• 2006

Social deficits are the most critical and core deficits of the children with Autistic Spectrum Disorder(ASD) and they are qualitatively as well as qualitatively different from typically developing children. It is proposed that the attachment between the mother and the autistic child should be promoted foremost and early as possible, to improve social deficits, just like early social developments in normal children depend largely on interactions between the mother and the child who are attached to each other we have developed an interventional program, 'Attachment Promotion Therapy', largely based on the attachment theory. The Attachment promotion Therapy mandates the participation of both the mother and the autistic child, and consists of mutually enjoying play activities, close physical contacts and parental training on intense mother-child interactions, focusing on improving maternal sensitivity, responsiveness, and nurturing behaviors during their interactions. The program was found to be effective in improving attachment behaviors, attachment security and acquiring joint attention skills. Attachment Promotion Therapy is therefore proposed here as the important earliest intervention method for children with ASD and could become the base for many other educational and therapeutic interventions.

• 대한작업치료학회지
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• 제26권4호
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• pp.111-125
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• 2018

목적 : 본 연구는 그룹감각통합치료가 지적장애아동의 감각처리와 또래상호작용, 과제수행에 미치는 영향과 그 효과의 지속여부를 알아보고자 하였다. 연구방법 : 본 연구는 만 7세 이상 13세 미만의 아동 12명을 대상으로 주 3회 60분씩 8주 동안 진행하였다. 그룹감각통합치료는 감각처리와 놀이기술, 또래와의 상호작용이 포함된 총 24가지 주제에 맞는 활동으로 구성되었으며, 대상자를 선별하기 위하여 단축감각프로파일을 사용하였다. 결과를 측정하기 위하여 단축감각프로파일과 또래놀이 상호작용 평점척도, 캐나다 작업수행 측정을 사용하여 대상자의 감각처리와 또래상호작용, 과제수행의 사전 사후 추적 평가를 실시하였다. 측정 결과는 반복측정 분산분석을 사용하여 사전 사후 추적조사의 평균 점수 차이를 분석하였고, 윌콕슨 순위검정을 사용하여 사전 사후 추적조사의 변화의 차이를 비교하여 분석하였다. 결과 : 그룹감각통합치료 중재 이후 대상자들의 감각처리와 또래상호작용, 과제수행에 유의한 향상을 보였다(p<.05). 4주후 실시한 추적조사에서 치료의 효과가 유지되는 것을 확인하였다. 결론 : 그룹감각통합치료는 감각처리능력의 증진뿐만 아니라, 또래상호작용이 필요한 학령기 아동들에게 모방과 그룹 안에서의 연습을 제공하고, 일상생활까지 그 효과를 연결할 수 있는 효과적인 중재방법이다.

• 대한감각통합치료학회지
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• 제7권1호
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• pp.13-25
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• 2009

목적: 본 연구는 감각처리장애아동에서 그룹 감각통합치료의 적용 후에 놀이와 또래와의 상호작용에 미치는 영향을 알아보기 위한 것이다. 연구방법: 실험대상은 B지역에 거주하는 3-7세의 감각통합장애가 있는 아동 3명이었다. 평가는 그룹 감각통합치료 프로그램 전과 후에 감각처리능력과 놀이 기술, 그리고 또래와의 상호작용으로 나누어 실시하였다. 모를 통해 감각처리능력의 Sensory Profile과 또래와의 상호작용의 사회성숙도 검사를 하였고, 관찰을 통해 놀이 기술의 The Test of Playfulness와 또래와의 상호작용의 Peer Social Interactions Rating Scale을 평가하였다. 그룹 감각통합치료 프로그램 회기 동안에는 Goal Attainment Scale를 통해 감각처리능력과 놀이 기술, 그리고 또래와의 상호작용을 평가하였다. 그룹 감각통합치료 프로그램은 촉각, 전정감각, 고유수용성감각을 위주로 하여 구성하였고, 4주간 총 12회기 실시되었다. 연구결과는 SPSS/WIN 버전10.0과 엑셀을 사용하여 통계분석 하였다. 결과: 그룹 감각통합치료 프로그램 적용 전과 후에 놀이기술과 또래와의 상호작용에서 통계적으로 유의한 차이는 보이지 않았다. 그룹 감각통합치료 프로그램 동안 평가한 GAS의 결과, 놀이기술과 감각처리에서 점차 향상된 모습을 보였다. 결론: 본 연구 결과는 그룹 감각통합치료 프로그램이 감각통합장애아동에서 놀이기술과 또래와의 상호작용에 긍정적인 영향을 미친다고 명확하게 결론짓기에는 한계가 있다. 그러나 대상의 수와 실험기간을 늘려 치료를 적용한다면, 더 긍정적인 결과가 나올 것으로 예상된다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.137.2-137.2
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• 2003

Dendritic cells (DCs) are known to professional antigen presenting cell (APC). Due to the role as an effective activator of cytotoxic T Lymphocytes by expressing MHC, adhesion and co-stimulatory molecules, DCs are now widely recognized to play an important role in the immune responses to tumors.We investigated the effect of cultured DCs in murine melanoma pulmonary metastasis model. To follow the metastasis protocol, syngenic melanoma cells were inoculated intra-venously into the mouse (B16F10 into the C57BL/6)8 days prior to the first DC injection (1$\times$106 DCs/ mouse, i.p.) and the autologous tumor cell lysate pulsed-DCs were injected as a therapeutic module twice in two weeks. (omitted)

• Journal of Ginseng Research
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• 제33권1호
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• pp.26-32
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• 2009

인삼은 전통적으로 항당뇨 효과가 있는 것으로 보고되고 있다. Insulin-like growth factor (IGF)-I 역시 당뇨병성 신증의 발병 초기에 중요한 역할을 하는 것으로 알려져 있다. 이에 본 연구에서는 신장 근위세뇨관 세포에서 고포도당에 의한 IGF-I 분비에 대한 ginsenoside의 차단 효과 및 이와 관련된 신호전달계를 알아보았다. 결과는 다음과 같다. 고포도당에 의해 증가되었던 IGF-I분비 촉진 작용은 GTS, PD 및 PT 처리 시 차단되었으며, 세포 성장 작용 (세포 비대)에서도 같은 효과를 볼 수 있었다. 아울러 고포도당에 의한 cAMP 및 PKC 활성은 GTS 처리시 현저하게 차단되었으며 PD 및 PT 처리 시 역시 부분적으로 억제되는 것으로 나타났다. 이상의 결과를 볼 때 신장 근위세뇨관 세포에서 ginsenoside는 cAMP 및 PKC 활성 경로를 억제하여 고포도당에 의한 IGFs 분비 작용을 차단하는 것으로 나타났다.