• 대한임상검사과학회지
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• 제38권1호
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• pp.1-8
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• 2006

The purposes of this study were to evaluate the changes in hematologic indices after plateletpheresis and to identify the preapheresis platelet count and clinical factors (age, gender, height, and weight) that showed some influence on the percentage of platelet decrement, yield and efficiency. Plateletpheresis was performed on 101 healthy donors in Bundang CHA general hospital. The data was analyzed using the SAS program with t-test, ANOVA test and Multiple regression. The mean percentage decrease after plateletpheresis was 2.0% in hemoglobin, 1.8% in hematocrit, and 29.7% in the platelet count, while a WBC count showed an increase of 2.6%. The mean percentage decrease of hemoglobin and hematocrit were 1.7% and 1.4%, in males and 3.6% and 3.7% in females, respectively. Particularly the percentage decrease of platelet count was significantly higher in females (40.0%) than in males (27.2%). The platelet decrementage and yield were significantly higher in females, but the efficiency did not differ significantly between males and females. The yield showed the lowest levels in subjects who were 40 years old or over but the platelet decrement and efficiency did not change according to age. The platelet decrement increased as height and weight increased. Also, the platelet decrement and yield increased as the initial platelet counts increased, but the efficiency did not. From multiple regression analysis, the platelet decrement was associated with gender, weight, and initial platelet count. The yield was related to the initial platelet count, but the efficiency was not related to gender, age, weight, height or initial platelet counts. This study has a limitation of the generality of the study results since this study was conducted only in a single university hospital. Further study would be necessary to find out a subpopulation that is sensitive to the hematologic change after plateletpheresis, and to determine the standard criteria for blood donation based on the subpopulation.

• 생명과학회지
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• 제24권9호
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• pp.1030-1038
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• 2014

혈소판제제는 출혈질환이나 혈소판의 기능장애 치료를 위해 사용되고 있다. 혈소판성분채집술은 혈액성분채집기를 사용하여 혈소판 성분을 채집하는 방법으로, 성분채집혈소판의 질 평가에는 다양한 지표들이 이용되고 있다. 채집된 혈소판의 생산성은 채집효율(collection efficiency)과 채집률(collection rates)로 평가되고 보관된 혈소판의 질은 in vitro 상에서 시각적 외양, 대사활성도, 양, 혈소판 수, 백혈구 수, 미세입자(microparticles), 그리고 다양한 혈소판 활성 표지자들로 평가된다. 혈소판 활성 표지자들은 여러 연구분야에서도 이용되고 있다. 수혈된 후의 혈소판의 질은 교정증가치(corrected count increment)와 혈소판회복퍼센트(percentage platelet recovery)로 평가된다. 본 논문은 혈소판성분채집술의 채집과정, 사용되는 장비, 성분채집혈소판의 질, 전반적인 효율성, 그리고 질평가 지표들에 대한 리뷰(review)와 함께 다른 혈액성분채집기 간의 기능의 차이점을 비교하였고, 또한 혈소판성분채집술은 구연산염 항응고제에 의한 부작용을 일으킬 수는 있지만 전혈 헌혈시에 실신의 전구증상이나 실신을 일으킬 위험이 있는 헌혈자들에게는 더 안전한 방법임을 보여주고 있다.

• 대한간호학회지
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• 제27권3호
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• pp.577-587
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• 1997

Purpose : To collect and interpret basic data involving the discomfort level of platelet donors and to see which nursing interventions would help make plateletpheresis more comfortable. Methods : Using "the Platelet Donor's Discomfort Scale" developed by the researcher herself and reviewed by an expert panel, the severity of discomfort as well as factors contributing to the development of this discomfort were analyzed. This scale contained 59 items and each item was scored by the 4-point Likert manner. Between March 1, 1996 and May 31, 1996, 500 platelet donors(16 years of age and older) were enrolled in this study. The Statistical methods used were factor analysis, t-test, and ANOVA. The results were as follows : 1. The mean of the platelet donor's discomfort scale was 130, range 69-207, possible score ranging from 59-236. 2. The platelet donor's discomfort scale had psychological, environmental, physical, and time-related factors. The time- related factor was the highest positive correlation with the development of the discomfort. 3. In looking at the psychological and environmental factors of the discomfort scores, the 16-20 age group had significantly higher ratings than those of the 26-30 age group. The students' group had higher scores than the soldier's group, and those who used the V-50, MCS -3P, or the PCS Plus machines had higher scores than those who used the COBE Spectra machine(P<.05, respectively), 4. In relation to the physical factor of the discomfort score, the youngest group felt significantly more discomfort, the student's group had a higher score than the soldier's group, and those who used the V-50, MCS-3P, or or the PCS Plus machines had higher scores than those who used the COBE Spectra machine(P<.05, respectively). 5. The time related factor of the discomfort score had the highest scores in every variable, however, statistically significant differences were not found between any of the variables(P>.05). Conclusion : Based on the above results, it can be oserved that the time-related factor was the most important factor influencing discomfort. The age and job of the donor, as well as the type of machine used, were significant variables in predicting the level of discomfort, regardless of psychological, environmental, and physical factors. This data could be used to determine nursing interventions that would relieve some of the discomfort of patients, as well as donors, undergoing plateletpheresis. Furthermore, consideration of the donor's time, introduction of a platelet donor pool system, publicity and education about platelet donation are required.

• 지역사회간호학회지
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• 제8권1호
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• pp.21-30
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• 1997

The purpose of the study is to establish the nurses engaged in blood donation business right cognition and supply base data to make out proper directed blood donation rule through investigation of actual condition and general issue related to directed blood donation. In this study I searched for related reference and computed the directed blood donors in seoul national university hospital blood bank. The directed blood donation in Korea have been increased for supplying fresh whole blood and plateletpheresis donor blood. The most blood donation in the blood bank belong to hospital are directed blood donation. The benefits of directed blood donation are enlargement blood donor, easy insurance a demand type of blood. But that program also give rise to recipient severe burden, additional cost and confused blood donation system. First of all for lessening the burden of the recipient and the directed blood donor, blood donation site, time, cost and procedure must be repared by proper rules. An alternative plans for the directed blood donation are autologous blood program and donor registration system.