• 대한한방내과학회지
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• 제16권1호
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• pp.181-196
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• 1995

The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.

• 동의신경정신과학회지
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• 제3권1호
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• pp.25-45
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• 1992

Many phychiatrists have reported that the change of serotonin concentration would cause mental disorder and affect the pathological conditions such as schizophrenia, depression and eating behabior. The end product of serotonin metabolism was excreted as 5-HIAA in urine. Serum lipids, according to the report, were concerned with obesity, said it was. This study aims to observe the changes of plasma serotonin, urinary 5-HIAA and serum lipids, making use of Fat Cell Mass rate of 27 normal persons and 42 psychosomatic patients. For this, I also observed the change of serotonin, 5-HIAA and lipids of the psychosomatic patients by the use of 3 kinds of herbs as treatment medication on the basis of physical symptoms and the results were obtained as follows; 1. Urinary 5-HIAA is correlated with the body water rate(r=0.381), while reversely correlated with the Fat Cell Mass rate(r=-0.330). 2. Compared the control group with the patients group for the serum lipids value, they showed the significant results ; $146.4{\pm}5.71$ mg/dl and $166.9{\pm}6.56$ mg/dl in the total cholestrol value over- weights, $471.2{\pm}42.99$ mg/dl in the total lipid value, and $158.1{\pm}6.50$ mg/dl and $181.1{\pm}6.30$ mg/dl in the phospholipid of the obesity, respectively. 3. With comparison of each group to other group to the others for Fat Cell Mass rate, the total cholesterol showed the significant differences when the Fat Cell Mass rate was 20% or more, HDL-cholesterol value when 30% or more, and triglyceride when 30% or more, respectively. 4. there was significant variations in the relations between Fat Cell Mass rate and body water, which body mass index was increased as the body water was decreased. 5. Fat Cell Mass rate was correlated with Cholesterol(r = 0.420), triglyceride (r = 0.443), and $\beta$-lipoprotein(r = 0.450) of serum lipids, while reversely correlated with HDL -Cholesterol(r = -0.354) and urinary 5- HIAA had the correlation coefficient of -0.330. 6. What related with body water rate urinary 5-HIAA (r = 0.381) and $\beta$-lipoprotein(r = -0.405). 7. there were significant changes in the total cholesterol value and HDL-Cholesterol Value of serum lipids after dose of Ondamtang, significant increase in the 5-HIAA value after dose of Samulansintang, and significant devrease in the Trigylceride value of serum lipids after dose of Shihosogansan. As a result, it was seen that there was direct correlations among the Fat Cell Mass, urinary 5-HIAA, and serum lipids and stress from the mental conditions was not correlated directly to Serotonin, 5-HIAA, and serum lipids. I would like to conclude, therefore, that the detailed study should be performed on the function of serotonin of hypothalamus.

• 생물정신의학
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• 제3권2호
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• pp.262-268
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• 1996

It has been known that clozapine is more selective mesolimbic dopamin $D_2$ receptor antagonist and related to 5-HT receptor. In this study, we wxamined the plasma homovanillic acid(HVA), serotonin(5-HT), and 5-hydroxyindoleacetic acid(5-HIM) levels in refractory schizophrenics during clozapine treatment. And we assessed the effects of clozapine on these plasma monoamine metabolites and their association with psychopathology and treatment response. Eight refractory schizophrenic patients(DSM-IV) have entered the study for 3 months during clozapine treatment. Patients were admitted to the inpatient sevice and withdrawn from all neuroleptics for 7-14 days but exceptionally occasional doses of lorazepam was given if needed for behavioral control. The dose of clozapine was titrated as tolerated to 800mg/day. The plasma HVA. 5-HIM and 5-HT levels were measured before treatment and following 2nd week, 4th week, 8th week, and 12th during treatment. Psychopathology was assessed with Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Synrome Scale(PANSS) before and during clozapine treatment. During clozapine treatment, no statistically significant changes were found in plasma HVA, 5-HIM, 5-HT levels, and HVA/5-HIM ratio between baseline and following 2nd week, 4th week, 8th week, 12th week. However, the change in plasma 5-HIAA/5-HT ratio from baseline to 4th week was statistically significant. Generally, changes of plasma HVA, 5-HIAA, 5-HT levels and HVA/5-HIAA ratio were not associated with psychopathology but 5-HIAA was associated with in positive symptoms and general psychopathology of PANSS. These results suggest that clozapine has been found to have relatively weak dopaminergic blokade and stronger serotonergic antagonism.

• 약학회지
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• 제56권2호
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• pp.86-91
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• 2012

The objective of this study is to examine how different concentration of neurotransmitters in plasma between patients with dementia and normal people regarding the inhalation of lavender oil. This study subjects were 9 elderly patients with dementia who live in nursing home and 9 normal women. Before and after inhalation, they were collected blood sample. Norepinephrine (NE), serotonin (5-HT), dopamine (DA), and r-aminobutyric acid (GABA) concentration analysis were performed. Before inhalation, dementia patients were significantly different with the normal group in GABA and DA, NE. Following inhalation in experimental group, dementia patients and normal group were only significantly increased in 5-HT. But it did not significantly change in the other neurotransmitters. After inhalation, dementia patients were significantly different with the normal group in GABA and 5-HT. This result suggests that the increase of 5-HT release by the inhalation of lavender oil related to reduce the behavioral and psychological symptoms of dementia.

• 여성건강간호학회지
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• 제5권1호
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• pp.51-64
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• 1999

Dance movement program. Psychological wellbeing, Middle aged women, Wellbeing with depression tendency, 율동적 동작 프로그램, 우울성향 중년여성 %600an This study was designed to confirm the effects of the Dance Movement Program on psychological health in middle-age women with depression tendency. 67 women with mile to moderate depression scoring between 16-25 were selected among 235 responded to CES-D (Radloff, 1977, Cho and Kim, 1993). The 46 volunteered to participate in the study were assigned the control. 7 attritions occurred during the course of the experiment leaving thirty-nine subject : nineteen experimental and twenty control, for the final analysis. Research subjects revealed to be homogenous demographically and by health-related variables. The 50-minute Dance Movement Program was performed by the experimental group 3 times a week for eight weeks, from October 6 to November 29, 1997. Depression, life satisfaction, self efficacy were measured before and after the course of Dance Movement Program. Plasma serotonin was measured to identify its relationship with depression, Homogeneity tests revealed satisfactory level on relevant research variables. Data were analyzed by $x^2$-test, paired and unpaired t-tests. The results are as follows : 1) The hypothesis that depresson score of experimental group will decreased than control group was supported by t-test(t=2.20, P=.0021) 2) The hypothesis that life satisfaction score of experimental group will increased than control group was supported by t-test(t=1.42, P=.0049). 3) The hypothesis that self-efficacy score of experimental group will increased than control group was not supported by t-test(t=6.20, P=.0616). 4) The hypothesis that level of plasma serotonin will increased than control group was not supported by t-test(t=1.88, P=.0524) Thus, the effects of the Dance Movement Program for the improvement of psychological health gram for the improvement of psychological health for the middle-aged women with depression tendency are scientifically confirmed by this study.

• 대한간호학회지
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• 제36권1호
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• pp.15-24
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• 2006

Purpose: This study was to examine the effects of foot reflexion massage on sleep disturbance, depression disorder, and the physiological index of the elderly in nursing homes. Method: The research design was a non-equivalent control group pretest-posttest quasi-experimental study. The subjects in this study were 50 elderly people who resided in two different nursing homes in the same region. An experimental group and a control group were organized with 25 subjects respectively, and foot reflexion massage was provided for 12 sessions, 30 minutes per session. The selected dependent variables were sleep disturbance, depression disorder, and physiological indices(blood plasma serotonin, serum cortisol), which were all measured before and after foot reflexion massage was offered. Data analysis included $x^{2}$-test, t-test, paired t-test, and ANCOVA, using the SPSS program package. Result: 1. The experimental group improved sleep quality more than the control group. 2. The experimental group had less depression disorder than the control group. 3. The experimental group had higher serotonin levels than the control group. Conclusion: It's necessary to give foot reflexion massage as a successful nursing intervention to elderly who undergo a change in sleep, and suffer from a depression disorder due to a deterioration in sleep.

• Biomolecules & Therapeutics
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• 제4권1호
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• pp.7-18
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• 1996

5-Hydroxytryptamine(5-HT, serotonin), when given into the vein, produced antidiuretic action accompanied with reduction of glomerular filtration(GFR), renal plasma flow(RPF), osmolar clearance(Cosm) and amounts of sodium or potassium excreted in urine( $E_{Na}$ , $E_{K}$), with the augmented reabsorption rates of sodium and potassium in renal tubules. 5-HT, when infused into a renal artery, exhibited diuretic action accompanied with the augmented RPF and increased $E_{Na}$ and $E_{K}$ in only infused kidney. Antidiuretic action of 5-HT infused into the vein was not influenced by ketanserin, 5-H $T_2$receptor blockade, given into a renal artery, vein or carotid artery, by methysergide, 5-H $T_1$receptor blockade, given into a renal artery, whereas above antidiuretic action was inhibited by methysergide given into vein or carotid artery. Diuretic action of 5-HT infused into a renal artery in only experimental kidney was blocked by ketanserin injected into a renal artery, was not influenced by methysergide administered into a renal artery. Above results suggest that 5-hydroxytryptamine(5-HT) produced the antidiuretic action through central 5-H $T_1$receptor and the diuretic action through 5-H $T_2$receptor located in renal tubules of kidney.ney.

• Animal Bioscience
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• 제36권11호
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• pp.1769-1774
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• 2023

Objective: Resting comfort may influence sleep-related lying postures in cattle. This study aimed to investigate the effects of bed cleanliness on tucked (TSP) and extended (ESP) head positions in sleep-related lying postures. Methods: The study was conducted over two experimental periods. In each period, four Japanese Black fattening cattle were assigned to the cleaning treatment (CL), in which bedding material was replaced once during each experimental period. Four cattle were assigned to the control treatment (CON) with no bed cleaning. Daily duration, bout frequency, and bout length of sleep-related lying postures were measured, and bed moisture, ammonia concentration in the air, plasma cortisol, and serotonin concentration were also measured within one week before and after cleaning treatment in each period. Results: The bed moisture and ammonia concentrations decreased in CL after bed cleaning. Following bed cleaning, the duration and bout frequency of TSP in CL decreased compared to that observed in CON, whereas ESP in CL increased after bed cleaning. Total duration of sleep-related lying postures and cortisol and serotonin levels did not differ between CL and CON. Conclusion: These results suggest that cattle in sleep-related lying postures shifted from tucked head positions to extended head positions in response to improved bed cleanliness.

• 한국식품영양과학회지
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• 제44권8호
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• pp.1105-1113
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• 2015

혈행 개선 기능성을 평가하기 위하여 8주 동안 일반식이와 고지방식이를 제공하는 그룹에 오메가-3 지방산과 복분자종자유를 일정량 제공하는 실험을 실시하였다. 실험군은 일반식이 그룹과 고지방식이 그룹으로 나누어 각 그룹 내에 음성대조군, 양성대조군(오메가-3 지방산), 복분자종자유(2 g, 4 g/2,000 kcal) 급이군으로 구성하였다. 양성대조군과 복분자종자유는 매일 경구 투여되었고 실험기간 종료 후 동물을 희생시켜 혈액과 장기를 얻어 혈중중성지방 및 콜레스테롤, 혈행 개선에 관련된 바이오마커(coagulation factor7, 12, serotonin과 TXB2)를 측정하였는데, 그 결과 복분자종자유는 혈중지질의 농도 개선을 통해 혈액의 점도를 감소시키고 혈액의 응고를 억제하여 혈행을 개선하는 기능성이 있는 것을 확인하게 되었다. 따라서 복분자종자유를 이용한 건강기능식품 개발은 혈관질환 환자들에게 혈행 개선을 통한 건강증진 효과를 보여줄 것으로 판단된다.

• Biomolecules & Therapeutics
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• 제4권2호
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• pp.154-161
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• 1996

General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/kg, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/kg, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephme. The administration of LB-00014 (601, 600, 6000 IU/kg, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 lU/kg, iv). It showed no direct effect at 100 and 1000IU/m1 in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/kg, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/kg, iv. Its administration (60, 600, 6000 lU/kg, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.