• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.96-96
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• 2018

Although the roots of Heracleum moellendorffii (HM-R) have been long treated for inflammatory human diseases, scientific evidence for the anti-inflammatory activity of HM-R is not sufficient. In this study, we investigated anti-inflammatory activity and mechanism of action of HM-R in LPS-stimulated RAW264.7 cells. HM-R blocked LPS-induced NO and PGE2 production, but not HM-L. HM-R inhibited LPS-induced overexpression of iNOS, COX-2, $IL-1{\beta}$ and IL-6 in RAW264.7 cells. HM-R inhibited LPS-induced $NF-{\kappa}B$ signaling activation through blocking $I{\kappa}B-{\alpha}$ degradation and p65 nuclear accumulation. In addition, HM-R inhibited MAPK signaling activation by attenuating the phosphorylation of ERK1/2, p38 and JNK. Furthermore, HM-R inhibited attenuated LPS-mediated overexpression of the osteoclast-specific factors such as NFATc1, cathepsin K, MCP-1 and TRAP. These results indicate that HM-R may exert anti-inflammatory activity by inhibiting $NF-{\kappa}B$ and MAPK signaling activation. From these findings, HM-R has potential to be a candidate for the development of chemopreventive or therapeutic agents for the inflammation and inflammatory diseases.

• Korean Journal of Plant Resources
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• v.31 no.5
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• pp.547-553
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• 2018

This study was conducted to investigate the effect of branch extracts of Vaccinium oldhamii (VOB) on melanin synthesis in B16F10 cells. VOB promoted melanin production in absence or presence of ${\alpha}$-melanocyte-stimulating hormone (${\alpha}-MSH$) in B16F10 cells. However, VOB did not affect the expression of tyrosinase and TRP-1 associated with melanin synthesis at the mRNA and protein levels in B16F10. But, VOB decreased TRP-2 protein level and induced tyrosinase activation in B16F10 cells. Inhibition of tyrosinase activity and tyrosinase knockdown attenuated VOB-mediated melanin synthesis. In conclusion, VOB may stimulate melanin synthesis through activating tyrosinase activity.

• Korean Journal of Plant Taxonomy
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• v.50 no.3
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• pp.356-360
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• 2020

A new distribution of Trichosanthes cucumeroides (Ser.) Maxim. ex Franch. & Sav. is discovered in Korea. This species was collected from forest margins on Ando Island, Ando-ri, Nam-myeon, Yeosu-si, in Jeollanam-do. T. cucumeroides is clearly distinguished from other species of the genus by having three- or five-lobed leaf blades, linear-lanceolate and minute bracts with entire margins, and oblong to triangular-ovoid seeds. Here, we provide precise description, a taxonomic key to the Korean Trichosanthes species, illustrations, and photographs of its habitat. The Korean name for the species is established as 'Bul-geun-ha-neul-ta-ri' considering the reddish color of its fruit.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2000.10b
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• pp.80-80
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• 2000

• Korean Journal of Plant Resources
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• v.35 no.2
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• pp.380-384
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• 2022

In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.04a
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• pp.128-129
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• 2005

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.506-507
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• 2006

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.168-169
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• 2006

• Proceedings of the Korean Society of Crop Science Conference
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• 2018.04a
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• pp.179-179
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• 2018

• Proceedings of the Korean Society of Crop Science Conference
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• 2004.04a
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• pp.96-97
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• 2004