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http://dx.doi.org/10.7732/kjpr.2022.35.2.380

Anti-Obesity Effect of Parthenocissus tricuspidata (Siebold & Zucc.) Planch Stem Extracts  

Yeo, Joo Ho (Department of Medicinal Plant Resources, Andong National University)
Yu, Ju Hyeong (Department of Medicinal Plant Resources, Andong National University)
Choi, Min Yeong (Department of Medicinal Plant Resources, Andong National University)
Lee, Jae Won (Department of Medicinal Plant Resources, Andong National University)
Geum, Na Gyeong (Department of Medicinal Plant Resources, Andong National University)
An, Mi-Yun (National Forest Seed and Variety Center)
Jung, Chuleui (Department of Plant Medicals, Andong National University)
Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.35, no.2, 2022 , pp. 380-384 More about this Journal
Abstract
In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.
Keywords
Adipocytes; Anti-obesity activity; Parthenocissus tricuspidata (Siebold & Zucc.) Planch;
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