• Archives of Pharmacal Research
• /
• v.26 no.4
• /
• pp.258-263
• /
• 2003

Colon-specific delivery of glucocorticoids is highly desirable for the efficient treatment of inflammatory bowel disease. We synthesized prednisolone 21-sulfate sodium (PDS) as a colon-specific prodrug of prednisolone (PD) and investigated its properties using rats as test animals. We expected that introduction of sulfate ester as a sodium salt might increase the hydrophilicity and restrict the absorption in the GI tract. If PDS is stable and nonabsorbable in the upper intestine, it will be delivered to the colon as an intact form, where it hydrolyze by the sulfatase to release PD. Compared with PD, the solubility of PDS increased and the apparent partition coefficient decreased greatly. PDS was stable on incubation with pH 1.2 and 6.8 buffer solutions and with the contents of the stomach and small intestine. On incubation with the cecal contents, PDS decreased to 9.6％ of the dose in 10 h producing PD. The amount of PD increased to give a maximum 54％ of the dose and decreased. As a control, when PD was incubated with the cecal contents, it decreased to 29％ of the dose in 8 h, which implied that reduction of PD proceeded under such conditions. These results suggested that hydrolysis of PDS took place to produce and accumulate PD, which decreased by reduction as the incubation period extended. Our results suggested that PDS can be a promising colon-specific prodrug of PD, and sulfate ester group might serve as a potential colon-specific promoiety, especially for the drugs which are resistant to reduction in the colon.

• Journal of Preventive Medicine and Public Health
• /
• v.46 no.3
• /
• pp.134-138
• /
• 2013

This road map aims to establish a stable and integrated healthcare system for the Korean Peninsula by improving health conditions and building a foundation for healthcare in North Korea through a series of effective healthcare programs. With a basic time frame extending from the present in stages towards unification, the roadmap is composed of four successive phases. The first and second phases, each expected to last five years, respectively, focus on disease treatment and nutritional treatment. These phases would thereby safeguard the health of the most vulnerable populations in North Korea, while fulfilling the basic health needs of other groups by modernizing existing medical facilities. Based on the gains of the first two phases, the third phase, for ten years, would prepare for unification of the Koreas by promoting the health of all the North Korean people and improving basic infrastructural elements such as health workforce capacity and medical institutions. The fourth phase, assuming that unification will take place, provides fundamental principles and directions for establishing an integrated healthcare system across the Korean Peninsula. We are hoping to increase the consistency of the program and overcome several existing concerns of the current program with this roadmap.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.18 no.4
• /
• pp.31-46
• /
• 2016

This study would inquire into the fashion image and design characteristics of Peng Liyuan, the first lady of China that has a mighty influence on the recent global economy and consumption. For this purpose, first, this study investigated the fashion image of Peng Liyuan according to the role which she performs as a first lady and analyzed how the fashion image appears and changes by year and role type. Second, this study analyzed the design characteristics of Peng Liyuan's fashion image, focusing on the silhouette, fashion items, coordinated items, colors, and textile patterns. The scope of the research was limited to the dresses worn by Peng Liyuan from March 14, 2013 to September 30, 2015. The fashion image of Peng Liyuan changed from classic and elegant image to modern image till 2015, and she reduced ethnic image and emphasized romantic image. In international diplomatic visits, she tried to express the confidence and potential of China through classic, ethnic and modern image, while in formal events of China, she showed an intention to communicate with the Chinese public with soft intimacy through elegant and ethnic images. As design characteristics in her fashion image, she flexibly changed her fashion image by the composition of silhouettes and items, which could cover her mid-life body type and made use of the form and detail of Chinese traditional qipao, appropriate coordination of scarves and brooches, the combination of chromatic color and achromatic color, appropriate uses of textile patterns and the delivery of China's image according to place and purpose. The study of Peng Liyuan's fashion image has significance to understand the fashion trend as a role model of fashion for the Chinese people and can help the domestic fashion industry that aims at the Chinese market in the future by predicting Chinese women' Fashion trend.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.21 no.3
• /
• pp.25-35
• /
• 2015

Purpose: Signs that are installed at unnoticeable places or that disconnect before the destination can bring errors of location information delivery. Therefore, this study aims to find out the spatial relation between structure of space and signs in the perspective of visual exposure possibility, operating arrangement and assesment by applying spatial structure theory. Methods: Effectiveness of organization of guidance signs was evaluated after the four way-finding factors(Plan Configuration, Sign System, Perceptual Access, Architectural Difference) that G.D.Weisman suggested were interpreted by spatial structure theory(J-Graph analysis, Space Syntax, Visual Graph Analysis) under the premise that it is closely related to the structure of space. Results: 1) Because the south corridor that connects each department of outpatient division is located in the hierarchy center of the space, and walking density is expected to be high, guidance signs need to be organized at the place with high integration value. 2) The depth to the destination space can be estimated through J-Graph analysis. The depth means a switch of direction, and the guidance signs are needed according to the number. 3) According to visibility graph analysis, visual exposure can be different in the same hierarchy unit space according to the shape of the flat surface. Based on these data, location adjustment of signs is possible, and the improvement effect can be estimated quantitatively. Implications: Spatial structure theory can be utilized to design and evaluate sign systems, and it helps to clearly understand the improvement effect. It is desirable to specify design and estimation of sign systems in the order of J-Graph analysis${\rightarrow}$Space Syntax Theory${\rightarrow}$visibility graph analysis.

• The Research Journal of the Costume Culture
• /
• v.8 no.5
• /
• pp.629-637
• /
• 2000

This paper focuses on the development of a fashion design educational program that will foster the talent and aesthetic consciousness of fashion design students. The goal of progressive educational methods with cutting edge technology is to elevate educational efficiency, and ultimately rear creative designers. To fulfill its objective, this paper presents a courseware program on fashion design education utilizing hyper media that include animation, photographs, pictures, sounds and characters. By the utilization of such comprehensive source of information media, a hypermedia courseware was developed for elementary education in fashion design with the following conclusions : 1. The program enables the students to customize their fashion design education. The students of fashion design education programs are able to choose and adjust their own programs to suit their requirements and intellectual level. 2. The program effectively motivates. Much like a constant sequence of various images on a screen that can provoke profound heart-felt emotions and inspire creativity, the program can stimulate and motivate the students. 3. The program provides a consistent education. To advance the overall quality of fashion design education, the problem of dissonance in educational content should be resolved and possible individual errors in delivery rectified. The present program will solve such problems, and establish coherent standards that will withstand the test of time regardless of time or place. 4. The program is cost effective. Since the present program frees the teacher from the time consuming drudgery of preparing various texts and lesson plans, have the materials delivered and handled, it reduces the time and cost previously required. 5. The program has the capability to be upgraded. The accumulated know-how of teachers and the total experience of the program can be linked with other programs for limitless expansion.

• Journal of Digital Contents Society
• /
• v.15 no.1
• /
• pp.53-60
• /
• 2014

Even if shots in frames may be variable in both movies and animations, close-up reveals the significance of the subject in the focus. Because directors and animators take the place the actor as character in animation while performance of actor plays an important role in the close-up in the movies, it is significant to understand the close-up in the animation. In the present study we investigate the dramatic effect of close-up in the animation narrative in animations for theaters. Among the various dramatic effects of the close-up, the natural flow of the narrative and the induction of immersing in emotion are focused. Descriptive close-up is analyzed as a dramatic effect of inducing the natural flow of the narrative. Psychological close-up is analyzed as the induction of immersing emotion by effective delivery of internal mental state of a character. By analyzing symbolic close-up as the induction of immersing in the play by producing a dramatic effect, we expect that the close-up contribute to the advance of animation narrative structure.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
• /
• v.49
• /
• pp.3-41
• /
• 2011

In this article, the author have studied on main revisions and some recommendations of the Incoterms(R) 2010. Main revisions are as belows. 1. Two new Incoterms rules -DAT and DAP- have replaced the Incoterms 2000 rules DAF, DES, DEQ and DDU. 2. New classification of the Incoterms(R) 2010 are adopted. First class is Rules for any mode or modes of transport(EXW, FCA, CPT, CIP, DAT, DAP and DDP belong to this class.) and second class is rules for sea and inland waterway transport(FAS, FOB, CFR and CIF belong to this class.). 3. Incoterms(R) 2010 rules formally recognizes that they are available for application to both international and domestic sale contracts. 4. The Guidance Notes and Introduction are not part of the actual Incoterms(R) 2010 rules. 5. Under the FOB, CFR and CIF, all mention of the ship's rail as the point of delivery has been omitted in preference for the goods being delivered when they are "on board" the vessel. 6. Incoterms(R) 2010 rules include the obligation to 'procure goods shipped' as an alternative to the obligation to ship goods in the relevant Incoterms rules. 7. Incoterms(R) 2010 rules give electronic means of communication the same effect as paper communication. 8. Incoterms(R) 2010 rules have allocated obligations between the buyer and seller to obtain or to render assistance in obtaining security-related clearances. such as chain-of custody information. Some recommendations are as belows. 1. The parties must incorporate the Incoterms(R) 2010 rules into their contract of sale. 2. The parties must choose the appropriate Incoterms(R) 2010 rules. 3. Specify the place or port as precisely as possible in their contract of sale. 4. Remember that Incoterms(R) 2010 rules do not give the parties a complete contract of sale. 5. Incoterms(R) 2010 rules do not prohibit alteration of Incoterms rule, but there are dangers in so doings. In order to avoid any unwelcome surprises, the parties would need to make the intended effect of such alterations extremely clear in their contract.

• The Journal of the Korea Contents Association
• /
• v.20 no.5
• /
• pp.536-544
• /
• 2020

Artists using exhibition spaces can select exhibition spaces considering marketing activities provided by operators or organizations of exhibition spaces, so it is necessary to study the relationship between marketing activities and satisfaction factors. This study examines marketing mix 7P factors, satisfaction, and prior studies as a theoretical background to demonstrate the decisive factors of the artist's exhibition hall satisfaction. As a result of analyzing the questionnaire collected from 144 artists used the exhibition hall, among the 7P factors of marketing mix, product, price, and progress process influenced the satisfaction of the exhibition hall, and the influence was in order of progress, product, and price. The suggestions are as follows. First, among the 7P factors in marketing mix, the fact that products, prices, and progress influencing the satisfaction of the exhibition place emphasizes factors related to the actual exhibition. Second, among the 7P factors in the marketing mix, the process had the greatest influence on the satisfaction of the exhibition hall, which means that the service delivery process is important.

• The Journal of the Korea Contents Association
• /
• v.18 no.9
• /
• pp.81-90
• /
• 2018

Reportage documentary by SBS did a great role to keep public sphere whether other programs shrinked during 2010's. I analysed with the assumption that there are some rhetorical characteristics in narrative structure of . Looking as 'Mysterious reportage documentary' I analysed the rhetorical characteristics of title, subtitle and script. Title has a perspective to suffice audience's desire and subtitles uses word 'mystery', names of place, interrogative sentences very often. This use helps to draw and keep audience's attention. I found reversal of fortune rhetoric, into depth rhetoric and admiration rhetoric salient. These results connect to the design thinking approach which shed light on importance of person, and we could get an implication of the successful development of television contents.

• Journal of the Korea Society of Computer and Information
• /
• v.12 no.1 s.45
• /
• pp.43-50
• /
• 2007

Delay in the process of Information Extraction, IE, is largely due to inability to correctly recognize the user's information requirement of particular search factors. Especially if the wrapper rules are used in a search engine, the search generally fails to classify internet documents properly and efficiently since the application of the same wrapper rules lacks extensibility throughout various types of existing internet document. In case of buying or selling a ship, if the price range, type. place of delivery, inspection site and other information relevant to the sales would be available through the internet for proper retrieval the sales could more readily succeed by using Ontology relating to sales or purchase information and by selectively searching for the desired information through the content based retrieval system. This system proposes to improve various wrapper systems existing throughout different internet sites and to eliminate unnecessary information tagged on the existing internet documents in order to create a more advanced information retrieval system.