• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2631-2634
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• 2014

Background: p53 gene is a well-known tumor suppressor gene that has several polymorphisms in both its exons and introns. It has been suggested that intron 3 16 bp duplication polymorphism may affect the gene function resulting in reduction or suppression of p53 anti tumor activity. In most case control studies a duplicated allele has been noticeably more frequent in cases rather than controls but there are also conflicting results. The aim of this study was to assess the association of intron 3 16 bp duplication polymorphism of p53 with breast cancer risk among Iranian-Azeri population. We also analyzed the clinicopathological information of patients as an epidemiological description of breast cancer in the north-west of Iran. Materials and Methods: This case-control study was performed on 221 breast cancer patients and 170 controls. Genomic DNA was extracted from peripheral blood samples and tumor tissues. p53 PIN3 genotype was determined using electrophoresis of PCR products on 8% non-denaturing polyacrylamide gels and silver staining. Results: In the control and case groups, respectively, 62.9% and 61.1% had no 16 bp insertion (A1A1 genotype), 7.1% and 7.7% had insertion in both p53 alleles (A2A2) and 30% and 31.2% were heterozygous (A1A2). There was no significant difference between genotype frequencies as well as allelic frequencies in two case and control groups. Conclusions: According to the result of the present study, the intron 3 16 bp duplication polymorphism of p53 could not be assessed as a marker of risk factor for predisposition to breast cancer in Azeri population. However, a high frequency of A2 allele (22.1%) in our population suggested that intron 3 16 bp duplication polymorphism may be a valuable marker for study in other cancers with well designed large groups.

• Nuclear Engineering and Technology
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• v.26 no.3
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• pp.440-452
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• 1994

Nuclear fuel bundles are designed such that the heat flux at a-fuel pin surface should not exceed the critical heat flux (CHF) during normal operation and anticipated transient. Therefore, evaluation of the CHF for fuel bundle is demanded in an exact and reliable manner. One of the major concerns with the current application of CHF correlations is that the CHF based on circular tubes is applied to the fuel bundle subchannel analysis, mainly in terms of the hydraulic diameter with correction factors which may result in a source of possibly large uncertainties in CHF prediction. The hydraulic diameter does not recognize the local properties of fluid nor such effect as the surface curvature; the turbulence action on the convex surface is much more pronounced than that on the concave surface. Even for the tube having concave curvature, the effect of tube diameter on CHF becomes important with decreasing diameter. These facts imply that the convex curvature effect is significant and crucial to the reliable CHF prediction. This paper reviews and discusses analytical and experimental aspects of effect of transverse convex curvature in incompressible turbulent flow and heat transfer, and on CHF. Flow models to quantify this effect are briefly mentioned and future works are recommended.

• Food Science and Preservation
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• v.23 no.3
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• pp.326-334
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• 2016

Omija (Schizandra chinensis) extract (OE) was fermented by using Lactobacillus plantarum EJ2014 to produce a beverage fortified with gamma-aminobutyric acid (GABA). After 2 days of fermentation in the presence of 2% monosodium glutamate (MSG) and 0.5% yeast extract (YE), the four-fold-diluted OE showed a higher viable cell count ($2.2{\times}10^9CFU/mL$) and lower acidity (1.2%) than that of the unfermented OE. In particular, addition of MSG as a precursor resulted in a small increase in the initial pH. MSG (2%) was completely converted to GABA (0.92%) during lactic acid bacteria fermentation for 3 days. Furthermore, the acidity of the fermented OE decreased from 1.74% to 0.56%. In addition, the original red color of the OE disappeared during LAB fermentation. However, when the fermented OE was mixed with 50% of the original OE, the original red color was recovered, with 19.56 and 13.92 for Hunter L and a values, respectively. The mixture of 50% original OE and 50% fermented OE showed the highest sensory score including the highest overall preference. In conclusion, the OE fortified with GABA and probiotics was produced by fermentation with a static culture, L. plantarum EJ2014.

• Journal of the Korea Concrete Institute
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• v.18 no.5 s.95
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• pp.603-610
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• 2006

The external unbonded strengthening offers advantages in speed and simplicity of installation over other strengthening techniques. Unlike externally bonded steel plate or carbon fiber sheet, surface preparation of the concrete for installation of high-tension bar is not required and installation is not affected by environmental conditions. Anchoring pin or anchoring plate are installed at the end of beam to connect the high-tension bar to concrete beam. The deviator are used in order that supplementary external bars would follow the curvature of the tested beam. A set often laboratory tests on reinforced concrete beam strengthened using the technique are reported. The main test parameters are the section area of strengthening bar, the depth of deviator and the number of deviators. The paper provides a general description of structural behavior of beams strengthened using the technique. The test result of strengthened beam are compared with those from a reference specimen. It is shown that the reinforcing technique can provide greater strength enhancements to unstrengthened beam and that the provision of deviator enhances efficiency. The ultimate moment of specimen with two deviators was higher than that of specimens with one deviator. It is also shown that the external bars enhance strength of beams in shear.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.7
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• pp.635-645
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• 2016

In this paper, we showed the phase noise of voltage controlled oscillator(VCO) can be radically improved using FLL(Frequency Locked Loop). At first, a 5 GHz VCO is fabricated using a hair-pin resonator. The fabricated VCO shows a phase noise of -53.1 dBc/Hz at 1 kHz frequency offset. In order to improve the phase noise of the fabricated VCO, a FLL is constructed using the feedback loop that consists of the VCO, a frequency detector composed of 5 GHz resonator, loop-filter, and level shifter. The fabricated FLL is designed to oscillate at a frequency of 5 GHz, and its measured phase noise is about -120.6 dBc/Hz at 1 kHz offset frequency. As a result, the phase noise of VCO can be radically improved by about 67.5 dB applying FLL. In addition, the measured phase noise performance is close to that of crystal oscillator.

• Composites Research
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• v.29 no.6
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• pp.342-346
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• 2016

Carbon fiber reinforced plastic (CFRP), one of lightweight materials, is the fiber structure using carbon fiber. It is the composite material that has the characteristics of carbon and plastic. As for the fiber structure, it has the great strength due to fiber direction. CFRP for woven type is used mostly as such a CFRP with lightweight. Woven type is more stable when compared with unidirectional type. On the other hand, woven type is highly priced. Therefore, this study aims to analyze the fiber structure of unidirectional CFRP. In this study, as the stacking angle [0/X/-X/0], X is the variable. This is unidirectional CFRP in which the angle phase of X has been reversed and stacked. By using such a unidirectional CFRP, the analysis model which had a crack at the center as the form of panel with the thickness of 2 mm was used. On analysis, the load is applied on the upper and lower parts being connected with a pin. The damage in the area near center crack was investigated. As for the analysis model, 3D surface model was designed by using CATIA. For CFRP stacking, the stacking direction was determined by using ACP in ANSYS program and the analysis model with two stacks was made. Afterwards, the structural analysis was carried out.

• Journal of the Microelectronics and Packaging Society
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• v.25 no.3
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• pp.31-36
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• 2018

This research scrutinizes the reason of failure after pressure cooker test (PCT) for DRAM device. We use the physical inspecting tools, such as microscope, SEM and TEM, and finally find the discolor phenomenon, corrosion of Al and delamination of inter-metal dielectric (IMD) in the failed devices after PCT. Furthermore, we discover the abnormal $Al_XO_Y$ layer on Al through the careful additional measurements. To find the reason, we evaluate the effect of package ball size and pinhole in passivation layer. Unfortunately, those aren't related to the problems. We also estimate halide effect of Al. The halogens such like Cl are contained within EMC material. Those result in the slight improving of PCT characteristics but do not perfectly solve the problems. We make a hypothesis of Galvanic corrosion. We can find the residue of Ti at the edge of pad open area. We can see the improving the PCT characteristics by the time split of repair etch. The possible mechanism of the PCT failure can be deduced as such following sequence of reactions. The remained Ti reacts on the pad Al by Galvanic corrosion. The ionized Al is easily react with the $H_2O$ supplied under PCT environment, and finally transfers to the abnormal $Al_XO_Y$ layer.

• Clinics in Shoulder and Elbow
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• v.15 no.1
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• pp.37-42
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• 2012

Purpose: To consider the proper management of proximal humerus fracture on gunshot wounds. Materials and Methods: A 28-year-old male patient, who sustained a gunshot injury on the left arm 5 days ago, was admitted through the emergency department. Although he underwent an emergency surgery (bullet fragment removal and debridement), there remained bullet fragments around the proximal humerus fracture site. The wound seemed to be infected and a partial dehiscence occurred. No neurologic deficit was noted. Immediate exploration and debridement were performed, and an external fixator was applied to restore the anatomical alignment and manage the wounds. Intravenous antibiotics were administered. On the 9th postoperative day, wound debridement was done again, and cement beads mixed with antibiotics were inserted. After two weeks, the external fixator was removed, and the pin sites were closed after debridement. One week later, the open reduction and internal fixation with locking compression plate and screws were done. Result: At 3 months after the internal fixation, the bone union was obtained with satisfactory alignment of the humerus. Conclusion: The severity of the soft tissue injury influences the fracture management plan. Further, the risk on lead toxicity should be considered.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.11
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• pp.21-30
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• 1998

In this paper, a digital current control system using a FPGA(Field Programmable Gate Array) was implemented, and the system was applied to an induction motor widely used as an industrial driving machine. The FPGA designed by VHDL(VHSIC Hardware Description Language) consists of a PWM(Pulse Width Modulation) generation block, a PWM protection block, a speed measuring block, a watch dog timer block, an interrupt control block, a decoder logic block, a wait control block and digital input and output blocks respectively. Dedicated clock inputs on the FPGA were used for high-speed execution, and an up-down counter and a latch block were designed in parallel, in order that the triangle wave could be operated at 40 MHz clock. When triangle wave is compared with many registers respectively, gate delay occurs from excessive fan-outs. To reduce the delay, two triangle wave registers were implemented in parallel. Amplitude and frequency of the triangle wave, and dead time of PWM could be changed by software. This FPGA was synthesized by pASIC 2SpDE and Synplify-Lite synthesis tool of Quick Logic company. The final simulation for worst cases was successfully performed under a Verilog HDL simulation environment. And the FPGA programmed for an 84 pin PLCC package was applied to digital current control system for 3-phase induction motor. The digital current control system of the 3 phase induction motor was configured using the DSP(TMS320C31-40 MHz), FPGA, A/D converter and Hall CT etc., and experimental results showed the effectiveness of the digital current control system.

• Transactions of the KSME C: Technology and Education
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• v.1 no.2
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• pp.167-177
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• 2013

The use of mechanical anastomosis coupler instead of sutures has been increasing in microvascular anastomosis surgery. However, non-biodegradable anastomosis coupler has problems such as not only inflammatory reaction but also remaining permanently in operation wound. Therefore, we fabricated biodegradable anastomosis coupler using injection molding process to overcome the limitation of non-biodegradable anastomosis coupler. In various injection molding process conditions, the shrinkage was calculated with different cylinder temperatures and injection molding pressures and anastomotic strength was measured. As a result, changes in shrinkage hole part larger than the pin part. In addition, the shrinkage in the cylinder at higher temperatures increase. However, the higher the injection pressure, shrinkage tends to decrease, respectively. In-vitro degradation behavior of PCL anastomotic coupler evaluated for 12 weeks, water uptake was increased and molecular weight was accompanied by a reduction in mass of the biological degradation and reduction of anastomotic strength was confirmed. However, decreased levels of anastomotic strength enough to exceed the requirements of preclinical surgery, PCL microvascular anastomosis coupler suitable candidate materials that could identify.