• 대한의용생체공학회:의공학회지
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• 제43권6호
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• pp.441-447
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• 2022

In this paper, we propose a pill identification model using engraved text feature and image feature such as shape and color, and compare it with an identification model that does not use engraved text feature to verify the possibility of improving identification performance by improving recognition rate of the engraved text. The data consisted of 100 classes and used 10 images per class. The engraved text feature was acquired through Keras OCR based on deep learning and 1D CNN, and the image feature was acquired through 2D CNN. According to the identification results, the accuracy of the text recognition model was 90%. The accuracy of the comparative model and the proposed model was 91.9% and 97.6%. The accuracy, precision, recall, and F1-score of the proposed model were better than those of the comparative model in terms of statistical significance. As a result, we confirmed that the expansion of the range of feature improved the performance of the identification model.

• Clinical Endoscopy
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• 제57권1호
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• pp.73-81
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• 2024

Background/Aims: Upper gastrointestinal bleeding (UGIB) is a life-threatening condition that necessitates early identification and intervention and is associated with substantial morbidity, mortality, and socioeconomic burden. However, several diagnostic challenges remain regarding risk stratification and the optimal timing of endoscopy. The PillSense System is a noninvasive device developed to detect blood in patients with UGIB in real time. This study aimed to assess the safety and performance characteristics of PillSense using a simulated bleeding model. Methods: A preclinical study was performed using an in vivo porcine model (14 animals). Fourteen PillSense capsules were endoscopically placed in the stomach and blood was injected into the stomach to simulate bleeding. The safety and sensitivity of blood detection and pill excretion were also investigated. Results: All the sensors successfully detected the presence or absence of blood. The minimum threshold was 9% blood concentration, with additional detection of increasing concentrations of up to 22.5% blood. All the sensors passed naturally through the gastrointestinal tract. Conclusions: This study demonstrated the ability of the PillSense System sensor to detect UGIB across a wide range of blood concentrations. This ingestible device detects UGIB in real time and has the potential to be an effective tool to supplement the current standard of care. These favorable results will be further investigated in future clinical studies.

• BMB Reports
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• 제29권1호
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• pp.11-16
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• 1996

The present study showed that receptor-mediated activation of rabbit kidney proximal tubule cells by angiotensin II, the $Ca^{2+}$ ionophore A23187, or the protein kinase C activator phorbol myristate acetate (PMA) all stimulated phospholipase D (PLD). This was demonstrated by the increased formation of phosphatidic acid, and in the presence of 0.5% ethanol, phosphatidylethanol (PEt) accumulation. Angiotensin II leads to a rapid increase in phosphatidic acid and diacylglycerol, and phosphatidic acid formation preceeded the formation of diacylglycerol. This result suggests that some phosphatidic acid seems to be formed directly from phosphatidylcholine hydrolyzed by Pill. On the other hand, EGTA substantially attenuated angiotensin II and A23187-induced PEt formation, and when the cells were pretreated with verapamil angiotensin II-induced Pill activation was completely abolished. These results provide the evidence that calcium ion influx is essential for the agonist-induced Pill activation. In addition, staurosporine, an inhibitor of protein kinase C, strongly inhibited PMA-induced PEt formation, but was ineffective on angiotensin II-induced PEt accumulation. $GTP{\gamma}S$ also stimulates PEt formation in digitonin-permeabilized cells, but pretreatment of the cells with pertussis toxin failed to suppress angiotensin II-induced PEt formation. From these results, we conclude that in the rabbit kidney proximal tubule cells the mechanisms of angiotensin II- and PMA-induced Pill activation are different from each other and mediated via a pertussis toxin-insensitive trimeric G protein.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2007년도 6th OSONG INTERNATIONAL BIO-SYMPOSIUM
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• pp.226.2-226.2
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• 2007

• 생약학회지
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• 제40권2호
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• pp.155-160
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• 2009

The reference herbal extracts and their identification methods by Korean Pharmacopoeia IX were established based on the organic solvent extracts to detect their marker compounds. However, most of herbal medicine decoctions in the market are prepared with water as extracting solvent. As the reference herbal extracts and their identification methods are not appropriate for the practical test, new preparation of alternative reference herbal extracts and their identification test methods are essential for the correction of test methods and identification of herbal drugs. Three novel identification test methods were developed for Evodiae Fructus, Cimicifugae Rhizoma and Aurantii Fructus Immaturus. Total 10 reference herbal extracts and their identification methods were optimized for Ephedrae Herba, Schisandrae Fructus, Curcuma longae Rhizoma, Citri Unshius Pericarpium, Puerariae Radix, Corni Fructus, and Cinnamomi Cortex.

• 한국지능시스템학회논문지
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• 제16권2호
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• pp.215-221
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• 2006

본 논문은 휴머노이드 로봇에 내재되어 있는 다양한 비선형성을 제어하기 위한 비선형 제어기를 제안에 관한 것이다. 기본적으로 휴머노이드 로봇은 기구적으로 불안정성을 내포하고 있고 기어나 모터 드라이버 등에서 다양한 비선형성을 가지고 있다. 이렇게 로봇 안에 존재하는 백래쉬(Backlash)나 포화(Saturation)와 같은 다양한 종류의 비선형성을 제어하는데 있어서 기존의 퍼지 알고리즘, 외란 관측기, 지능 학습망과 같은 제어 기법으로는 다수의 비선형성을 제어하는 데에는 한계를 지닐 수밖에 없다. 이에 본 논문에서는 스위칭 PE를 이용하여 모터 드라이버에 존재하는 포화에 의한 비선형성을 제거 하였으며 백래쉬에 의해 생기는 비선형성의 영향을 제어하기 위해 듀얼 피드백을 이용하였다. 그리고 시스템의 정확한 데이터를 얻기 위해 제어 알고리즘을 적용하기 이전에 모터 시스템에 대해 유전 알고리즘을 이용하여 시스템 식별을 수행하여 모터 시스템을 정확하게 유도하였으며, 시뮬레이션 과정을 통해 최적의 스위칭 PID 제어 이득값을 얻었다. 이렇게 얻어진 모터 식별값과 스위칭 PE제어 이득값을 시뮬레이션과 제안된 로봇인 ISHURO를 이용한 실험을 통해 이를 검증하였다.

• 환경생물
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• 제24권2호
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• pp.160-165
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• 2006

The purpose of this study was to ascertain the prey composition and utilization of the Eurasian otter, Lutra lutra, in the ecosystem conservation region of the Seomjin River. The study was conducted for a 12-month period from March 2003 to February 2004 by spraints analysis and an investigation using artificial holts. We found seasonal variation in the number of spraints and composition of prey items. Fish were the main prey items throughout the period (82%), and other prey items included birds (14%), amphibians (2%) and arthropods (1%). In addition to prey identification, we investigated habitat utilization by otters through spraints distribution. The traces of otters were discovered in five of the six total artificial holts. However, the utilization of the artificial holts in the study area seemed to be limited as evidenced by the low frequency of traces in the holts.

• Journal of Plant Biotechnology
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• 제35권2호
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• pp.163-167
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• 2008

Adventitious buds appeared within 2 weeks on the base of the petiole explants and increased for two months. A maximum of regeneration (15.6%) was obtained on the medium containing $1.5\;{\mu}M$ TDZ in combination with $1\;{\mu}M$ IBA. To know which explants are the best for the induction of regeneration, three explants such as leaf, petiole and leaf-petiole were used. Among the explant types, the leaf-petiole explant was significantly more effective than leaf and petiole for promoting adventitious shoots, with leaf-petiole inducing at the highest regeneration frequency (33.7%). The regeneration frequency of adventitious shoots in the leaf-petiole explants was significantly affected by leaf size and the position of explants. The leaf-petiole smaller than 5 mm leaf in width was induced at the highest regeneration frequency (68.9%). The smaller leaf sizes, the greater regeneration frequency. Also when the leaves are nearer to the shoot tip, the regeneration frequency is higher. When the rooted micro-shoots were transferred to the soil after growing for 6 weeks in the media, the survival rate was 90%.

• 농약과학회지
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• 제13권4호
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• pp.332-335
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• 2009

유기농 인증을 받아서 3년 이상이 경과한 농가의 토양을 수집하여 근권 세균을 450균주 분리하였고, 여러 가지 식물 병원균의 균사 생장을 억제하는 세균 KB-401 균주를 선발하였다. KB-401 균주는 특히 감귤 검은점무늬병균(Diaporthe citri)의 균사 생장과 포자 발아를 억제하며, 발아하는 포자에 처리하였을 때 발아관의 선단이 팽윤되는 현상을 관찰할 수 있었다. 본 균주는 생리적인 특성과 16S rDNA의 염기서열을 분석한 결과, Bacillus subtilis로 동정되었다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 추계학술대회
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• pp.1010-1011
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• 2013

본 논문에서는 노인의 의료 서비스를 보조하기 위하여 영상 처리를 통해 알약을 구분하고 정보를 제공하기 위한 시스템을 개발하였다. 노인의 경우에는 가정에 보관하고 있는 알약의 종류가 다양하고 어떤 약인지 구분하기 힘들어 사용하지 못하고 버리거나 방치해 두는 경우가 많다. 본 논문에서는 안드로이드 폰을 사용하여 알약을 촬영하고 영상처리를 하여 약의 모양과 분할선, 색 등의 특징을 구분하고, 서버와 연동하여 약의 이름과 효과, 주의사항 등의 정보를 제공함으로써 노인들이 약을 쉽게 구분할 수 있도록 하였다.