• BMB Reports
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• v.56 no.3
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• pp.145-152
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• 2023

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular membranes or indirectly through their tethered components, provoking cellular mechanoresponses. Among others, Piezo1 mechanosensitive ion channel is a relatively novel Ca²⁺-permeable channel that is primarily present in non-sensory tissues. Recent studies have demonstrated that Piezo1 plays an important role in Ca²⁺-dependent cell death, including apoptosis and ferroptosis, in the presence of mechanical stimuli. It has also been proven that cancer cells are sensitive to mechanical stresses due to higher expression levels of Piezo1 compared to normal cells. In this review, we discuss Piezo1-mediated cell death mechanisms and therapeutic strategies to inhibit or induce cell death by modulating the activity of Piezo1 with pharmacological drugs or mechanical perturbations induced by stretch and ultrasound.

• Journal of ILASS-Korea
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• v.25 no.1
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• pp.1-7
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• 2020

In the common rail fuel injection system, which is the core of diesel high efficiency and NO_X reduction, injection strategies such as high pressure injection of fuel, accurate injection rate control, and multistage injection are important to increase fuel atomization. In this study, the bypass type piezo injector for the electronic control based common rail injection system applied to diesel fuel vehicle was studied. In particular, the injection rate and internal fuel flow characteristics of the high-pressure injector according to the piezo stacking number and applied voltage were analyzed by theoretical numerical method. When the applied voltage changes, it is determined that additional fuel flow through the bypass compensates for the reduced valve driving force due to the change in the driving voltage.

• Journal of ILASS-Korea
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• v.19 no.1
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• pp.9-14
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• 2014

Performance of DI diesel engine with high-pressure fuel injection equipment is directly related to its emission characteristics and fuel consumption. So, the electro-hydraulic injector for the common-rail injection system should be designed to meet the precise high fuel delivery control capability. Currently, most high pressure injector in use has a needle driven by the solenoid coil energy or the piezo actuator controlled by charge-discharge of output pulse current. In this study, macroscopic spray approaching method was applied under constant volume chamber to research the performance of three different injectors : solenoid, indirect-acting piezo and direct-acting piezo type for CR direct-injection. LED back illumination for Mie scattering was applied on the liquid spray visible of direct-acting piezo injector, including hydraulic-servo type solenoid and piezo-driven injectors. As main results, we found that a direct-acting piezo injector had better a spray tip penetration than hydraulic-servo injectors in spray visualization.

• Proceedings of the IEEK Conference
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• 2003.07c
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• pp.2811-2814
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• 2003

본 논문에서는 Sub-nano 수준의 위치정밀도와 분해능을 갖는 Piezo actuator 의 제어기 설계를 목적으로 하였다. 이산 시간 상태 공간에서의 Piezo actuator를 이용한 1 축 스테이지 드라이브 시스템 SISO 제어기를 설계하였다. Piezo actuator 의 소재 자체의 특성으로는 Hysteresis 가 있으며, 이는 정상상태에서 Piezo actuator 의 위치 오차를 발생하는 주요 원인이 된다. 제어기의 설계는 극점 배치 방법을 기본으로 하여 Hysteresis 에 대한 보상을 목적으로 적분제어방식과 외란 추정기를 각각 적용하였다. 모의실험을 통하여 제어기의 설계 및 시뮬레이션 하였으며, Hysteresis 에 대한 보상이 이루어짐을 보았고, 실험을 통하여 이를 증명하였다.

• International Journal of Stem Cells
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• v.15 no.4
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• pp.372-383
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• 2022

Background and Objectives: Low-intensity pulsed ultrasound (LIPUS) promotes differentiation and regulates biological functions of various stem cells, but its effect on the endothelial differentiation of periodontal ligament stem cells (PDLSCs) is unclear. This study investigated the effect of LIPUS on endothelial differentiation and angiogenesis in PDLSCs and the role of the mechanically sensitive ion channel Piezo1 in this process. Methods and Results: PDLSCs obtained from healthy people were used for endothelial induction, and 10 ㎍/ml lipopolysaccharide (LPS) was used to simulate the inflammatory state. The induced cells were treated with LIPUS (50 mW/cm², 1.5 MHz) to study its effect on the endothelial differentiation of PDLSCs and the tube formation of differentiated cells. PCR, flow cytometry, immunofluorescence, and Matrigel tube formation assays were used to detect the differentiation and tube formation of PDLSCs. GsMTx4 was used to inhibit the expression of Piezo1, and the role of the Piezo1 pathway in the endothelial differentiation and microvascular formation of PDLSCs after LIPUS treatment was studied. The data showed that LIPUS increased endothelial differentiation and angiogenesis in PDLSCs under inflammatory or noninflammatory conditions. The use of an inhibitor weakened the effect of LIPUS. Conclusions: This study demonstrated that LIPUS can activate the expression of Piezo1 and promote the endothelial differentiation and microvascular formation of PDLSCs.

• Journal of the Korean Society of Mechanical Technology
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• v.20 no.6
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• pp.783-789
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• 2018

This paper investigates the relationship of voltage and current waveform between normal piezo injector and deterioration abnormal piezo injector. The experimental methods using Pico oscilloscope and GDS scan tool are employed to measure current and voltage waveform and fuel pressure of piezo injector. The experiment is carried out during no-load condition. A summary of the important results are as follows. 1) In case of normal injector, the fluctuation of duration time of piezo injector was linearly and regularly decreased with increasing engine speed, but the that of deterioration piezo injector was irregularly decreased with increasing engine speed. 2) In main injection, the peak value of the current waveform of abnormal injector was larger than that of normal injector, the duration time of deteriorated abnormal injector was less than that of normal injector at 800rpm and 1500rpm, but the duration time of deteriorated abnormal injector was larger than that of normal injector at 2000rpm and 3000rpm. This irregularity appears to be caused by the deterioration of the injector.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.6 no.1
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• pp.51-57
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• 1981

Carriers moving in a semiconductor can impart gain or loss to an acousic wave traveling through Piezo-electric materials. In this paper, surface a coustic wave amplifiers, which employ the interaction between carriers drifting in a semiconduct or film and electic fields accompanying a Rayleigh wave propagating on a Piezoelectric substrate, are described. The effect of various electromagnetic boundary condition on th propagation of surface waves in Piezoelectrics is considered. An expression for the dependence of surface wave velocity on electic boundary conditions is derived. Calculations show that, for properly prepared material, significant amplification is expected up to the microwave frequencies. At high frequencies, gain is reduced because electro diffusion smooths out the electron bucning necessary for amplification.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.2
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• pp.17-25
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• 2013

Performance of DI diesel engine with high fuel injection method is directly related to the emission characteristics and fuel consumption. At present, diesel injection system with piezo element is replacing conventional solenoid type due to their faster electro-mechanical properties. In this study, it was investigated the sensitivity characteristics regarding internal hydraulic modeling based on the AMESim environment of piezo-driven injector The analytic parameter for this study defined such as In/Out orifice, injection hole's diameter and driven voltage on piezo stack. As the results, it was shown that these parameter influence on a fast response characteristics of piezo-driven injector. Also we found fuel pressure recovery time is faster about 0.1 ms due to larger IN orifice diameter. And larger OUT orifice diameter occurs maximum pressure drop with faster its timing of about 0.2 ms.

• ETRI Journal
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• v.29 no.1
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• pp.70-78
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• 2007

A new low-voltage CMOS interface circuit with digital output for piezo-resistive transducer is proposed. An input current sensing configuration is used to detect change in piezo-resistance due to applied pressure and to allow low-voltage circuit operation. A simple 1-bit first-order delta-sigma modulator is used to produce an output digital bitstream. The proposed interface circuit is realized in a 0.35 ${\mu}m$ CMOS technology and draws less than 200 ${\mu}A$ from a single 1.5 V power supply voltage. Simulation results show that the circuit can achieve an equivalent output resolution of 9.67 bits with less than 0.23% non-linearity error.

• Smart Structures and Systems
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• v.25 no.1
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• pp.37-45
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• 2020

This paper aims at enlightening the properties, computational and implementation issues related to Kalman filter based state estimation algorithms and sliding mode observers, by applying them for estimating the states of a smart structure system. The Kalman based estimators considered in this work are Kalman filter and information filter and, the sliding mode observers considered are Utkin observer and higher order sliding mode observer. A fourth order linear time invariant model of a piezo actuated beam is used in this work. This structure is embedded with four number of piezo patches, of which two act as sensors, one as disturbance actuator and the other as control actuator. The performance of the state estimation algorithms is evaluated through simulation, for the first two vibrating modes of the piezo actuated structure, when the structure is maintained at first mode and second mode resonance.