• Journal of Astronomy and Space Sciences
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• 제32권4호
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• pp.305-310
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• 2015

In this study, we examined a morningside Pi2 pulsation, with a non-substorm signature, that occurred in very quiet geomagnetic conditions (Kp = 0) at 05:38 UT on December 8, 2012, using data obtained by Van Allen Probes A and B (VAP-A and VAP-B, respectively) and at a ground station. Using 1 sec resolution vector magnetic field data, we measured the X-component of the pulsation from the Abu Simbel ground station (L = 1.07, LT = UT +2 hr, where LT represents local time) in Egypt. At the time of the Pi2 event, Abu Simbel and VAP-A (L = 3.3) were in the morning sector (07:38 LT and 07:59 MLT, respectively, where MLT represents magnetic local time), and VAP-B was in the postmidnight sector (04:18 MLT and L = 5.7). VAP-A and VAP-B observed oscillations in the compressional magnetic field component (Bz), which were in close agreement with the X-component measurements of the Pi2 pulsation that were made at Abu Simbel. The oscillations observed by the satellites and on the ground were in phase. Thus, we concluded that the observed morningside Pi2 pulsation was caused by the cavity resonance mode rather than by ionospheric current systems.

• Tuberculosis and Respiratory Diseases
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• 제54권5호
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• pp.551-562
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• 2003

연구배경 : NF-${\kappa}B$는 많은 염증 유발성 물질들을 발현시키는데 필요한 전사 인자로서, 염증성 폐질환 발병에 관여한다는 사실이 확인되었다. 이러한 NF-${\kappa}B$의 활성화에는 여러 신호전달 체계가 관여한다는 사실이 밝혀지고 있으며 최근 PI3K/Akt 경로도 NF-${\kappa}B$ 활성화에 관여한다는 연구 결과가 보고되고 있으나, 실험 대상 세포주마다 활성화 기전이 다르고 호흡기 상피세포에 대한 결과도 알려져 있지 않아 호흡기 상피세포에서의 NF-${\kappa}B$ 활성화에 PI3K/Akt 경로가 관여하는지를 밝히기 위하여 본 연구를 시행하게 되었다. 방법 : 인체 기관지 상피세포주인 BEAS-2B와 폐암 세포주인 A549, NCI-H157을 사용하여 Akt 활성화와 $I{\kappa}B{\alpha}$ 분해 여부를 확인하기 위해 western blot을 시행하였다. Wortmannin, LY294002 및 DN-Akt를 이용하여 Akt 경로를 억제하였고, NF-${\kappa}B$ 활성화와 전사 활성을 측정하기 위하여 각각 EMSA와 luciferase assay를 시행하였다. 결과 : BEAS-2B, A549 및 NCI-H157 세포주에 TNF-$\alpha$ 및 insulin을 처리한 경우 Akt 활성화가 유도되었다. Insulin 으로 Akt 경로를 활성화시킨 경우 $I{\kappa}B{\alpha}$ 분해가 일어나지는 않았다. Wortmannin, LY294002 및 DN-Akt 를 이용하여 Akt 경로를 억제한 경우 TNF-$\alpha$에 의한 $I{\kappa}B{\alpha}$ 분해 및 IKK 활성화가 억제되지는 않았으며, NF-${\kappa}B$ 활성화도 억제되지 않았다. Wortmannin을 처리한 경우 TNF-$\alpha$에 의한 NF-${\kappa}B$ 전사 활성이 오히려 증가하는 양상을 보였으나, DN-Akt 이입시킨 경우에는 관찰되지 않았다. 결론 : 인체 호흡기 상피세포에서는 $I{\kappa}B$/NF-${\kappa}B$ 경로의 활성화는 PI3K/Akt 경로와 무관한 것으로 판단된다.

• 전자공학회논문지B
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• 제33B권6호
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• pp.12-22
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• 1996

A numerous designs of PI controllers have been suggested to solve out trade-off between tracing and regulating problems. We constructed the PI controller system with two-degree-of-freedom that is more analytic and a better approach to a practical one. In the conventional H$_{2}$ design of optimal PI controllers, the cost function includes only the plant output terms due to the divergent problems. Since the platn input temr is not considered in PI controller design, occasionally, the plant input thends to be either very large or saturated. To solve the prior mentioned problems, we employed a mixed $H_2/H_{\infty}$ method that combines the H$_{2}$ design method to decide optimal parameters of PI controller and the $H_2/H_{\infty}$ design method to minimize the maximum amplitude of plant input. The calculation time of the H$_{infty}$ norm was considerably reduced by the simple scalar function obtained by the wiener-hopf factorization of non-scalar functions.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제52권12호
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• pp.616-623
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• 2003

Conventional P/PI speed controller of today's servo drives should be manually tuned the controller switching set-point by trial-and-errors, which may translate the drive system down-time and loss of productivity. The adjustable drive performance is heavily dependent on the quality of the expert knowledge and becomes inadequate in applications where the operating conditions change in a wide range, i.e., tracking command, acceleration/deceleration time, and load disturbances. In this paper, the demands on simple controls/setup are discussed for industry servo drives. Analyzing the frequency content of motor torque command, P/PI control mode switching is automatically performed with some prior knowledge of the mechanical dynamics. The dynamic performance of the proposed scheme assures a desired tracking response curve with minimal oscillation and settling time over the whole operating conditions. For comprehensive comparison of traditional P/PI control scheme, extensive test is carried out on actual servo system.

• 전자공학회논문지B
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• 제30B권5호
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• pp.109-119
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• 1993

To improve limitations of fuzzy PI controllers especially when applied to systems of order higher than one, we propose a fuzzy PI controller that takes out appropriate amounts of accumulated control input according to fuzzily described situations in addition to the calculation of incremental control input as in the case of conventional fuzzy PI controllers. The structure of the proposed controller was motivated by the characteristics of fuzzy PI controller that it generally gives inevitable overshoot when one tries to reduce rise time of the response especially when a system of order higher than one is under consideration. Since the undesirable characteristics of the fuzzy PI controller is caused by integrator of the controller, even though the integrator is introduced to overcome steady state error of response, we propose a controller that fuzzily clears out integrated quantities according to situation to give reduced rise time as well as small overshoots. To show the usefulness of the proposed controller, it is applied in simulations to such systems as are difficult to stabilize or difficult to get satisfactory responses by conventional fuzzy PI controllers.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제49권10호
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• pp.637-645
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• 2000

This study was represented the improvement of the flexible position control for linear motion of hybrid type linear pulse motor(HLPM). The driving method used a minute 125 microstep drive instead of full step drive method. The digital control method was applied to the PI control for more stable position control, at this time the PI control parameters have gained by a Ziegler-Nichols turning method. The loop transfer function of control system was combined with both motor transfer function and digital PI control equation. Such, the proper for digital PI control system is verified to through the simulation and experimental result of the stability step response and bode plot with proper gain and phase margin.

• 대한수학회논문집
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• 제9권3호
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• pp.701-710
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• 1994

Suppose ${X_n}$ is a Markov process taking values in some arbitrary space $(S, \varphi)$ with n-stemp transition probability $$ P^{(n)}(x, B) = Prob(X_n \in B$\mid$X_0 = x), x \in X, B \in \varphi.$$ We shall call a Markov process with transition probabilities $P{(n)}(x, B)$ $\phi$-irreducible for some non-trivial $\sigma$-finite measure $\phi$ on $\varphi$ if whenever $\phi(B) > 0$, $$ \sum^{\infty}_{n=1}{2^{-n}P^{(n)}}(x, B) > 0, for every x \in S.$$ A non-trivial $\sigma$-finite measure $\pi$ on $\varphi$ is called invariant for ${X_n}$ if $$ \int{P(x, B)\pi(dx) = \pi(B)}, B \in \varphi $$.

• IMMUNE NETWORK
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• 제3권4호
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• pp.310-319
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• 2003

Inflammatory mediators has been recognized as an important role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is increasingly recognized as an important regulator of immune and inflammatory responses, including induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence of the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. However, the signaling pathways that regulate IL-17 production remain unknown. In the present study, we investigated the role of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway in the regulation of IL-17 production in RA. PBMC were separated from RA (n=24) patients, and stimulated with various agents (anti CD3, anti CD28, PHA, ConA, IL-15). IL-17 levels were determined by sandwich ELISA and RT-PCR. The production of IL-17 was significantly increased in cells treated with anti-CD3 antibody, PHA, IL-15 or MCP-1 (P<0.05). ConA also strongly induced IL-17 production (P<0.001), whereas TNF-alpha, IL-1beta, IL-18 or TGF-beta did not. IL-17 was detected in the PBMC of patients with osteoarthritis (OA) but their expression levels were much lower than those of RA PBMC. Anti-CD3 antibody activated the PI3K-Akt pathway and activation of the PI3K-Akt pathway resulted in a pronounced augmentation of nuclear factor kappaB ($NF-{\kappa}B$). IL-17 production by activated PBMC in RA is completely or partially blocked in the presence of $NF-{\kappa}B$ inhibitor PDTC and PI3K-Akt inhibitor, wortmannin and LY294002, respectively. Whereas the inhibition of AP-1 and extracellular signal-regulated kinase (ERK)1/2 did not affect IL-17 production. These results provide new insight into that PI3K/Akt and $NF-{\kappa}B$ dependent signal transduction pathway could be involved in the overproduction of key inflammatory cytokine, IL-17 in rheumatoid arthritis.

• 한국통신학회논문지
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• 제18권1호
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• pp.69-82
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• 1993

본 논문에서는 디지틀 이동 통신 시스템의 열악한 페이딩 채널에 적합한 변복조 반식중의 하나인${\pi}$/4-shift QPSK 성능을 논하고, 그 성능 개선을 위한 새로운 TCM(trellis-coded modulation)을 적응하여 trellis-부호화된${\pi}$/8-shift 8SPSK 방식을 제안 한다. 기존의 ${\pi}$/4-shift QPSK변조 방식에 TCM의 도입은 요구된 대역폭과 송신 전력과 전송을 그대로 유지하면서 부호화와 변조를 일체화함으로서 부호화 이득(coding gain)을 얻을 수 있다. 이동 통신 채널에서 trellis-부호화된 ${\pi}$/8-shift 8PSK방식의 시스템 성능을 추정하기 위해서, 가산 백색 가우시안 잡음과 레일레이 페이딩 현상이 존재하는 채널에서, 차량속도 변화에 따른 도플러 효과에 의한 페이딩율이 10Hz와 30Hz인 두 경우에 대해 시스템을 모델링한다. Trellis-부호화된${\pi}$/8-shift 8PSK에 대한 부호화 이득은 비트 에러 확률을 적용하여 분석하고, 기본 시스템과 새롭게 모델링 되어진 시스템의 개선된 성능을 비교하기 위해, TCM의 상태수를 4,8,16으로 선정하여 비교 구현해 본 결과, 상태수가 커질수록 더 좋은 성능을 나타내고, 기존의 ${\pi}$/4-shift QPSK보다 trellis-부호된 ${\pi}$/8-shift 8PSK는 가산 백색 가우시안 잡음채널에서는 3~4dB의 부호화 이득을 얻고, 레일레이 페이티 채널하에서 3~16dB정도의 부호화 이득을 얻음을 알 수 있다.

• 전자공학회논문지B
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• 제30B권12호
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• pp.87-97
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• 1993

To improve the limitation of fuzzy PI controller when is applied to systems of order higher than one, a fuzzy PI controller that fuzzily resets or amplifies the accumulated control input according to fuzzy rules defined on (error, change of error) space is proposed. The proposed controller structure was motivated by the characteristics of fuzzy PI controller that it generally gives unevitable large overshoot in trial of reducing rise time of response especially when a system of order higher than one is considered. Based on the observation that the undesirable characteristics of the fuzzy PI controller is caused by integrating control input excessively, even though the integrator is introduced to overcome steady state error, we propose a controller that clear out or doubles integrated control input in a fuzzy manner according to the situation to reduce rise time as well as overshoot. To show the usefulness of the proposed controller, it is applied to the systems that are difficult to stabilize or difficult to get satisfactory response by conventional fuzzy PI controllers.