• Archives of Pharmacal Research
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• 제8권1호
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• pp.15-20
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• 1985

Strong anti-inflammatory saponins Phytolacca americana (Phytolaccaceae) wereobtained from callus mass derived from the stems and also from that derived from the roots of cultivated Phytolacca americana (which were designated as PAS and PAR, respectively). The callus were grown on Linsmair and Skoog's agar medium supplemented with 1ppm OF 2, 4-dichlorophenoxyacetic acid. Phytol accoside B and D were obtained from PAS and phytolaccoside A and B from PAR. The thin layer chromatograms of the crude saponins from PAS and PAR were similar to those of original plants. PAS contained phytolaccoside B as a major component while phytolaccoside E was a major saponin in original plants.

• 대한임상독성학회지
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• 제2권1호
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• pp.27-30
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• 2004

Phytolaccaceae had been used as a pharmaceutical drugs or food in Korea. Nowadays, it is rarely used due to its toxicity, and then, case reports as to poisoning also are rare. Recently, Authors experienced a case of an occurrence in a group intoxication after ingestion of roots of phytolacca american a misidentifying as arrowroot. We report this case with review of phytolacca radix poisoning.

• Archives of Pharmacal Research
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• 제9권3호
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• pp.153-156
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• 1986

The triterpenoid isolated from the seeds of Phytolacca plants was confirmed to be acetylaleuritolic acid rather than acetylepialeuritolic acid by direct comparison with synthetic compounds.

• 생약학회지
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• 제17권1호
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• pp.55-61
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• 1986

Direct comparison of the triterpenoids isolated from the seeds of Phytolacca sp. and synthetic compounds confirmed that the natural products were acetylaleuritolic acid and 3-acetylmyricadiol rather than epiacetylaleuritolic acid, acetyloleanolic acid and phytolaccanol.

• 약학회지
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• 제17권3호
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• pp.161-166
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• 1973

A glucoside mixture of ${\alpha}$-spinasterol and ${\delta}^7$-stigmastenol was isoated from the roots of Phytolacca esculenta $_{VAN}$ H$_{OUTTE}4. This the first reported occurrence of these glucosides in Phytolaccaceae family.

• 약학회지
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• 제17권3호
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• pp.152-160
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• 1973

Phytolaccagenin, as a minor free terpenoid, was isolated from the roots of phytolacca esculenta van Houtte. A mixture of sterols was also isolated and identified as ${\alpha}$-spinasterol and ${\delta}^7$-stigmastenol, which never seemed to have been found in phytolaccaceae.

• 생약학회지
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• 제7권1호
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• pp.69-71
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• 1976

New or noteworthy medicinal plants were found in Korea, such as 1. Magnolia sieboldii K. KOCH f. dupliflora $C_{HI}$ (Magnoliaceae) 2. Peucedanum insolens $K_{ITAGAWA}$ (Umbelliferae) 3. Panax japonicus C.A. $M_{EYER}$ (Araliaceae) 4. Phytolacca americana L. (Phytolaccaceae) 5. Polygonum ellipticum $M_{IGO}$ (Polygonaceae).

• Archives of Pharmacal Research
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• 제8권3호
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• pp.139-147
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• 1985

Americal A from the seeds of Phytolacca americana, was investigated for the antiinflammatory activity. The compound significantly inhibited edema induction, granuloma formation, arthritis induction and leucocyte emigration in CMC-pouch. But its anticarrageenin activity was not exhibited in adrenalectomized rats. These findings together with decrease in the contents of ascorbic acid and cholesterol in adrenals by administration of the compound suggest that its activity is mediated through stimulation of the pituitary-adrenal axis. The acute toxicity of the compound is very weak and gastric ulceration was not produced by the compound.

• 식물분류학회지
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• 제37권4호
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• pp.431-446
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• 2007

섬자리공(Phytolacca insularis Nakai)의 분류학적 위치를 재검토하기 위해 외부형태와 종자 및 화분의 형태를 관찰하고 ITS 염기서열을 조사하였다. 섬자리공은 곧게 서는 줄기와 화서, 이생심피, 8개의 수술과 암술, 분홍색의 약을 가져 자리공과 유사성을 가졌으나, 합생심피와 l0개의 수술과 암술을 가진 미국자리공과는 뚜렷이 구별되었다. 섬자리공의 화분은 유공의 크기가 작고 유공의 수와 미세미립돌기의 수가 적어 자리공과 유사성을 보였으나, 미국자리공은 유공의 크기가 크고 그 수가 많았다. 섬자리공과 자리공의 종자무늬는 불규칙한 굴곡무늬로 서로 비슷했으나, 망상무늬를 갖는 미국자리공과 뚜렷이 구별되었다. ITS 염기서열은 섬자리공이 자리공과 완전히 같았으나, 미국자리공과는 뚜렷이 구별되었다. 본 연구결과는 섬자리공을 별개의 종으로 취급하는 것보다는 자리공의 품종으로 격하하는 것이 타당함을 지지해 주었다.

• 동의생리병리학회지
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• 제16권2호
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• pp.311-315
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• 2002

Cellular death by apoptosis is an active process, depending on gene transcription and protein synthesis. It was reported that nitric oxide can induce apoptosis in several cancer cell-lines. We studied effects of Phytolacca esculentum van Houtt (Phytolaccaceae) Radix water extract (PRE) on the proliferation of transplanted-L1210 cells in mice. When PRE (500 mg/kg) was administered orally once a day for 7 days after transplantation of L1210 cells to mice, DNA fragmentation of transplanted-L1210 cells was induced and mitochondrial transmembrane potential of those cells was reduced. Additionally, DNA fragmentation of L1210 cells was induced by the treatment of PRE in vitro. Also, DNA fragmentation of L1210 cells was enhanced by co-culture with the peritoneal macrophages obtained from PRE-administered mice and was partly inhibited by L-NMMA in vitro. PRE enhanced the production of nitric oxide and tumor necrosis factor-α from peritoneal rnacrophages. These results suggest that PRE induces apoptosis of transplanted-L1210 cells via directive action on L1210 cells and stimulation of nitric oxide and tumor neaosis factor-α from macrophages.