• Advances in Traditional Medicine
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• v.8 no.1
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• pp.47-52
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• 2008

The plant Eclipta prostrata, a member of the Compositae family, has folkloric reputation of being used as a medicinal agent in Bangladesh. In the present investigation, attempt was taken to explore the antimicrobial potency and cytotoxicity of its extractives and purified compounds. The methanolic extract of the whole plant, its n-hexane, carbon tetrachloride, chloroform, aqueous soluble fractions and two purified compounds, eclalbasaponin I (1) and II (2), obtained from Eclipta prostrata were subjected to screening for inhibition of microbial growth by the disc diffusion method at 300 and 100 ${\mu}g$/disc for extracts and pure compounds, respectively. In this case, the carbon tetrachloride and chloroform soluble fractions of the methanolic extract appeared very potent in terms of both zone of inhibition and spectrum of activity. However, all the extractives were also subjected to brine shrimp lethality bioassay for preliminary cytotoxicity evaluation. Here, the carbon tetrachloride soluble fraction of methanolic extract revealed the strongest cytotoxicity having $LC_{50}$ of 1.318 ${\mu}g$/ml.

• Natural Product Sciences
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• v.13 no.4
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• pp.317-321
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• 2007

Phytochemical investigation of the aerial parts of Lotus ornithopodioloides L. resulted in the isolation of six known compounds. The structures were determined utilizing physical, chemical, spectral methods as well as direct comparison with reference materials whenever possible. The compounds were identified as: ${\beta}$-sitosterol; the two triterpenes oleanolic and betulinic acids; the two cyanogenic glycosides lotaustralin and linamarin in addition to the flavonol diglycoside kaempferitin.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.3
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• pp.197-206
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• 2021

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.198.1-198.1
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• 2003

As part of our systematic study for Korean Compositae plants, we have studied Saussurea nutans, collected at Gangwon Province on August 2001. Phytochemical studies on various species of genus Saussurea have resulted in the isolation sesquiterpene, triterpene and flavonoid$\^$1)/. S. nutans has been used for the treatment of rheumatic arthritis and dysmenorrhea in the Chinese folk medicine$\^$2)/. However, chemical constituents of this plant have not been reported until now. The MeOH extract of the aerial parts of this source was solvent fractionated into n-hexane, methylene chloride, ethyl acetate and BuOH soluble portions. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.193.2-193.2
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• 2003

Phytochemical examination of Sophorae Fructus yielded six phenolic compounds. The structures were elucidated as genistein(1), genistin(2) and genistein 7-O-${\alpha}$- L-rhamnopyranoside(3) by phytochemical and spectral evidences. The other compounds(4, 5, 6) are understudied by 2D-NMR. Nitric Oxide and PGE$_2$ production inhibitory activities in INF-${\gamma}$, LPS stimulated RAW 264.7 cell were examined. Compound 2 and 4 showed significant nitrogen monoxide(NO) production inhibitory activity in IFN-${\gamma}$, LPS stimulated RAW 264.7 cell. (omitted)

• Proceedings of the Korean Society of Life Science Conference
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• 2005.09a
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• pp.44-44
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• 2005

• YAKHAK HOEJI
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• v.35 no.2
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• pp.142-145
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• 1991

Two flavonoids have been isolated from the leaves of Machilus thunbergii Sieb. et Zucc. (Lauraceae) and identified as hyperin and isoquercitrin.

• Proceedings of the Korean Journal of Food and Nutrition Conference
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• 2004.12a
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• pp.1-46
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• 2004

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.226.2-226.2
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• 2000

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.239.1-239.1
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• 2000